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Journal / Genetics / Karakterisering af Mutational belastning og…
JoVE Journal
Genetics

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JoVE Journal Genetics
Karakterisering af Mutational belastning og klonal sammensætning af humant blod
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Karakterisering af Mutational belastning og klonal sammensætning af humant blod

Article DOI: 10.3791/59846-v • 07:58 min • July 11th, 2019
July 11th, 2019 •
1, 1, 1, 1
1Princess Máxima Center for Pediatric Oncology

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Somatiske mutation mønstre i celler afspejler tidligere mutagene eksponering og kan afsløre udviklingsmæssige Lineage relationer. Præsenteret her er en metode til at katalogisere og analysere somatiske mutationer i individuelle hæmatopoietiske stem og stamceller.

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Genetik hæmatopoiese clonality somatiske mutationer udvikling Lineage sporing Mutations signaturer leukæmi
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