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JoVE Journal
Genetics

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慢性CDK9抑制的基于小鼠细胞系的模型,研究癌症中普遍存在的非遗传转录伸长缺陷(TE肯定)
 
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慢性CDK9抑制的基于小鼠细胞系的模型,研究癌症中普遍存在的非遗传转录伸长缺陷(TE肯定)

Article DOI: 10.3791/59910-v 10:49 min September 26th, 2019
September 26th, 2019

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Summary

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该方案详细介绍了非遗传缺陷转录伸长的体外鼠癌模型。在这里,CDK9的慢性抑制用于抑制RNA Pol II沿亲炎反应基因的生产性伸长,以模仿和研究临床上过度服务的TE绝对现象,存在于大约20%的所有癌症类型中。

Tags

遗传学, 问题 151, 转录伸长, 肿瘤免疫学, CDK9, mRNA处理, 黄酮, RNA Pol II
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