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JoVE Journal Developmental Biology
Realizando xenoenxertos de músculo esquelético humano em camundongos imunodeficientes
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Realizando xenoenxertos de músculo esquelético humano em camundongos imunodeficientes

Article DOI: 10.3791/59966-v • 07:48 min • September 16th, 2019
September 16th, 2019 •
1,2, 2,3, 1,2,3,4, 1,2,4
1Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, 2Department of Neurology, Johns Hopkins University School of Medicine, 3Kennedy Krieger Institute, 4Department of Neuroscience, Johns Hopkins University School of Medicine

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Doenças humanas complexas podem ser desafiadoras para modelar em sistemas de modelos laboratoriais tradicionais. Aqui, nós descrevemos uma aproximação cirúrgica para modelar a doença do músculo humano com a transplantação de biópsias humanas do músculo esqueletal em ratos immunodeficientes.

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Biologia do desenvolvimento edição 151 Xenoenxerto músculo esquelético transplante modelo NOD-Rag1nuloIL2r γcamundongosnulos imunocomprometidos miosite doença muscular
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