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Immunology and Infection

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JoVE Journal Immunology and Infection
Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
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Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Article DOI: 10.3791/60067-v • 10:21 min • September 12th, 2019
September 12th, 2019 •
1,2,3, 4, 4, 4, 1,2
1Department of Molecular and Cellular Physiology, Albany Medical College, 2The IBD Center, Division of Gastroenterology, Department of Medicine, Albany Medical College, 3Department of Geriatrics, School of Medicine and Health Science, University of North Dakota, 4Department of Neuroscience and Experimental Therapeutics, Albany Medical College

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Summary
Automatic Translation

In this study, we describe a detailed procedure of TNBS-mediated intestinal fibrosis, which exhibits comparable pathophysiology to Crohn's fibrosis. We also discuss this approach in light of rapamycin facilitated inhibitory effects on intestinal fibrosis.

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TNBS-mediated Intestinal Fibrosis Rapamycin Inhibitory Effects Crohn's Fibrosis Pathophysiology Tissue Repair Tissue Regeneration Intervention Protocol Mice Dermal Exposure Colitis Intrarectal Administration Ethanol Enema Anesthetizing Intraperitoneally Inject
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