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Journal / Biochemistry / Charakterisierung einzelner Proteinaggregate…
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Biochemistry

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JoVE Journal Biochemistry
Charakterisierung einzelner Proteinaggregate durch Infrarot-Nanospektroskopie und Atomkraftmikroskopie
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Charakterisierung einzelner Proteinaggregate durch Infrarot-Nanospektroskopie und Atomkraftmikroskopie

Article DOI: 10.3791/60108-v • 12:58 min • September 12th, 2019
September 12th, 2019 •
1, 1,2, 1, 1, 1,3
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2Institute of Biotechnology, Life Sciences Center, Vilnius University, 3Cavendish Laboratory, Department of Physics, University of Cambridge

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Wir beschreiben die Anwendung von Infrarot-Nanospektroskopie und hochauflösender Atomkraftmikroskopie, um den Prozess der Protein-Selbstmontage in oligomere Aggregate und Amyloidfibrillen zu visualisieren, die eng mit dem Beginn und der Entwicklung verbunden sind. einer Vielzahl von neurodegenerativen Erkrankungen des Menschen.

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Biochemie Ausgabe 151 Amyloid Neurodegeneration Proteinaggregation Atomkraftmikroskopie Infrarot-Nanospektroskopie Einzelmolekülanalyse Spektroskopie
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