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Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits
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Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Article DOI: 10.3791/60126-v • 07:43 min • January 8th, 2020
January 8th, 2020 •
1, 2,3, 1, 2,4
1Department of Ophthalmology, Stony Brook University, 2Department of Medicine, Stony Brook University, 3Medicon Pharmaceuticals, Inc, 4Department of Preventive Medicine, Stony Brook University

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Summary
Automatic Translation

A novel approach is presented to induce chronic dry eye disease in rabbits by surgically removing all orbital lacrimal glands. This method, distinct from those previously reported, produces a stable, reproducible model of aqueous deficient dry eye well suited to study tear physiology and pathophysiology and ocular therapeutics.

Tags

Complete Dacryoadenectomy Severe Dry Eye Model Rabbits Aqueous Deficient Dry Eye Disease Physiology Therapeutic Interventions Lacrimal Glands Tear Production Ocular Surface Tissues Surgical Complications Lidocaine Epinephrine
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