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Journal / Neuroscience / Consegna intratecala di Oligonucleotidi Antisense …
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JoVE Journal Neuroscience
Consegna intratecala di Oligonucleotidi Antisense nel Rat Central Nervous System
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Consegna intratecala di Oligonucleotidi Antisense nel Rat Central Nervous System

Article DOI: 10.3791/60274-v • 07:47 min • October 29th, 2019
October 29th, 2019 •
*1, *2, *1, 1, 1, 1, 1
1Biogen, Inc., 2Ionis Pharmaceuticals
* These authors contributed equally

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Qui, descriviamo un metodo per fornire farmaci al sistema nervoso centrale del ratto impiantando un catetere nello spazio lombare intrateco della colonna vertebrale. Ci concentriamo sulla consegna di oligonucleotidi antisenso, anche se questo metodo è adatto per la consegna di altre modalità terapeutiche pure.

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Neuroscienze problema 152 oligonucleotidi antisenso barriera ematoencefalica sistema nervoso centrale somministrazione intratecale ratto RNA midollo spinale
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