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JoVE Journal Neuroscience
Entrega intratecal de oligonucleótidos antisentido en el sistema nervioso central de Rata
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Entrega intratecal de oligonucleótidos antisentido en el sistema nervioso central de Rata

Article DOI: 10.3791/60274-v • 07:47 min • October 29th, 2019
October 29th, 2019 •
*1, *2, *1, 1, 1, 1, 1
1Biogen, Inc., 2Ionis Pharmaceuticals
* These authors contributed equally

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Aquí, describimos un método para suministrar medicamentos al sistema nervioso central de la rata mediante la implantación de un catéter en el espacio intratecal lumbar de la columna vertebral. Nos centramos en la entrega de oligonucleótidos antisentido, aunque este método es adecuado para la entrega de otras modalidades terapéuticas también.

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Neurociencia Número 152 oligonucleótidos antisentido barrera hematoencefálica sistema nervioso central parto intratecal rata ARN médula espinal
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