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A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery
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A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

Article DOI: 10.3791/60292-v • 08:05 min • November 8th, 2019
November 8th, 2019 •
1, 2, 1, 1, 1, 1, 3, 2, 1,2,3
1Department of Microsurgery, Jesús Usón Minimally Invasive Surgery Centre, 2Stem Cell Therapy Unit, Jesús Usón Minimally Invasive Surgery Centre, 3Animal Modelling Unit, Jesús Usón Minimally Invasive Surgery Centre

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Summary
Automatic Translation

Here, we describe a pre-clinical animal model for studying the pathophysiology of ischemia-reperfusion injury in reconstructive microsurgery. This free skin flap model based on the superficial caudal epigastric vessels in the rat may also allow for the evaluation of different therapies and compounds to counteract ischemia-reperfusion injury-related damage.

Tags

Ischemia-reperfusion Injury Reconstructive Microsurgery Rat Model Pre-clinical Animal Model Flap Failure Superficial Caudal Epigastric Vessels Evaluation Of Therapies Counteract Ischemia-reperfusion Injury Microsurgical Reconstructions Mandatory Period Of Ischemia Success Rate Of Microsurgical Procedures Surgical Revision Finger Avulsion Injuries Composite Tissue Re-transplantation Innate Immunity Pathophysiological Phenomenon Surgical Marker Three Centimeter By Six Centimeter Flap Abdomen Midline Skin Incision
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