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Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction
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Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction

Article DOI: 10.3791/60351-v • 09:15 min • January 12th, 2020
January 12th, 2020 •
1,2, 3,4, 5,6, 6,7, 6,7
1Department of Pharmacology and Toxicology, University of Louisville, 2Hepatobiology and Toxicology Program, University of Louisville, 3Department of Physiology and Pharmacology, West Virginia University, 4Center for Inhalation Toxicology, West Virginia University, 5Department of Pharmacology and Chemical Biology, University of Pittsburgh, 6Pittsburgh Liver Research Center, University of Pittsburgh, 7Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh

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Summary
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The goal of this protocol was to develop a murine model of low-level toxicant exposure that does not cause overt liver injury but rather exacerbates pre-existing liver damage. This paradigm better recapitulates human exposure and the subtle changes that occur upon exposure to toxicant concentrations that are considered safe.

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Vinyl Chloride High-fat Diet Environment Obesity Liver Damage Safety Restrictions Chronic Inhalation Protocol Human Exposure Animal Stress Experimental Animals Low-fat Diet High-fat Diet Food And Water Ad Libitum Feeding Day Mice Monitoring Vinyl Chloride Inhalation Exposure System Diluent Air Control Chambers Flow Measurement Devices Temperature Monitoring Relative Humidity Monitoring Chamber Exhaust
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