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Journal / Genetics / Mapping Alzheimer-Krankheit Varianten zu ihren…
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Genetics

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JoVE Journal Genetics
Mapping Alzheimer-Krankheit Varianten zu ihren Zielgenen mit Hilfe der Berechnung der Chromatin-Konfiguration
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Mapping Alzheimer-Krankheit Varianten zu ihren Zielgenen mit Hilfe der Berechnung der Chromatin-Konfiguration

Article DOI: 10.3791/60428-v • 04:41 min • January 9th, 2020
January 9th, 2020 •
1,2, 3, *3,4, *1,2
1Department of Genetics, University of North Carolina, 2Neuroscience Center, University of North Carolina, 3Thurston Arthritis Research Center, University of North Carolina, 4Department of Cell Biology and Physiology, University of North Carolina
* These authors contributed equally

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Wir präsentieren ein Protokoll zur Identifizierung funktioneller Implikationen nicht-kodierender Varianten, die durch genomweite Assoziationsstudien (GWAS) anhand dreidimensionaler Chromatin-Wechselwirkungen identifiziert wurden.

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Genetik Ausgabe 155 Hi-C GWAS nicht-kodierende Varianten Genkartierung funktionelle Genomik Alzheimer-Krankheit
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