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Journal / Cancer Research / Kemisk-inducerad hud carcinogenes modell med…
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JoVE Journal Cancer Research
Kemisk-inducerad hud carcinogenes modell med Dimetylbenz [a] antracen och 12-O-Tetradecanoyl Phorbol-13-acetat (DMBA-TPA)
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Kemisk-inducerad hud carcinogenes modell med Dimetylbenz [a] antracen och 12-O-Tetradecanoyl Phorbol-13-acetat (DMBA-TPA)

Article DOI: 10.3791/60445-v • 04:12 min • December 19th, 2019
December 19th, 2019 •
*1, *1, 1,2, 1,2, 1
1Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, 2Department of Clinical Microbiology, Fimlab Laboratories
* These authors contributed equally

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Två-stegs hud cancerogenesen induceras av två topikalt applicerade kemikalier. En mutagen 7, 12-dimetylbenz [a] antracen) orsakar mutationer i epidermala celler och en kontinuerlig tillämpning av allmän tillväxt stimulator 12-O-tetradecanoyl phorbol-13-acetat accelererar hudpapillom formation.

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Cancer forskning hudcancer kemisk carcinogenes mutagen promotor DMBA-TPA papillom angiogenes inflammation tumör proliferation
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