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Chemistry
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18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
 

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography

Article DOI: 10.3791/60623-v 09:57 min January 11th, 2020
January 11th, 2020

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Summary

The synthesis of fluorine-18 (18F) labeled radiopharmaceuticals for positron emission tomography typically requires months of experience. When incorporated into a radiotracer, the silicon-fluoride acceptor (SiFA) motif enables a simple 18F-labeling protocol that is independent of costly equipment and preparatory training, while reducing precursor quantity needed and utilizing milder reaction conditions.

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18F-labeling Radiotracer Functionalized Silicon Fluoride Acceptor (SiFA) Positron Emission Tomography (PET) Ligand Fluorine-18 (F-18) Imaging Diseases Peptides Proteins Building Blocks Synthesis Macromolecules Complexity Hydrolytic Stability In-vivo Applications Imaging Agents Biomolecule
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