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Immunology and Infection

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Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection
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Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Article DOI: 10.3791/60723-v • 08:15 min • January 31st, 2020
January 31st, 2020 •
1,2, 1,2, 1,2, 1, 3, 1,4, 1,2, 1,2, 1,2,5, 1,2
1Department of Clinical Medicine, Aarhus University, 2Department of Infectious Diseases, Aarhus University Hospital, 3Department of Biomedicine, Aarhus University, 4Department of Gynecology and Obstetrics, Aarhus University Hospital, 5Department of Biology, University of Nebraska at Omaha

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Summary
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We have developed a protocol for the generation and evaluation of a humanized and human immunodeficiency virus-infected NOG mouse model based on stem cell transplant, intravaginal human immunodeficiency virus exposure, and droplet digital PCR RNA quantification.

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Humanized NOG Mice Intravaginal HIV Exposure Treatment Of HIV Infection Preclinical HIV Research Viral Strains Novel HIV Interventions Stem Cell Donor CCR5 Variant Status Infect Humanized Mice With HIV Quantify Mouse Plasma Viral Loads RNA Quantification Protocol Viral RNA Sequence Genetic Screening CCR5 Delta 32 Variants PCR Mix High-fidelity DNA Polymerase Forward And Reverse Primers Agarose Gel Electrophoresis Intravaginal HIV Exposure Heating Lamp Sterile Pipette Tips
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