Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Medicine / Validated LC-MS/MS Panel for Quantifying 11…
JoVE Journal
Medicine

A subscription to JoVE is required to view this content.

JoVE Journal Medicine
Validated LC-MS/MS Panel for Quantifying 11 Drug-Resistant TB Medications in Small Hair Samples
Surface Activation and Extracellular Matrix Coating of a PDMS-Based Gut-on-a-Chip Device (Video) | JoVE
Journal (Medicine)
Surface Activation and Extracellular Matrix Coating of a PDMS-Based Gut-on-a-Chip Device (Video) | JoVE
Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
Journal (Medicine)
Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
 

Validated LC-MS/MS Panel for Quantifying 11 Drug-Resistant TB Medications in Small Hair Samples

Article DOI: 10.3791/60861-v • 08:54 min • May 19th, 2020
May 19th, 2020 •
1, 1, 1, 2, 3, 4, 1
1Department of Obstetrics, Gynecology and Reproductive Sciences, TB Hair Analysis Laboratory, University of California San Francisco, 2Department of Epidemiology and Biostatistics, University of California San Francisco, 3Department of Medicine, Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, 4Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco

Chapters

Summary
Automatic Translation

Current methods of analyzing patients’ adherence to complex drug resistant-tuberculosis (DR-TB) regimens can be inaccurate and resource-intensive. Our method analyzes hair, an easily collected and stored matrix, for concentrations of 11 DR-TB medications. Using LC-MS/MS, we can determine sub-nanogram drug levels that can be utilized to better understand drug adherence.

Tags

Validated LC-MS/MS Panel Quantifying Drug-resistant TB Medications Small Hair Samples Patient Adherence Drug Metabolism Objective Measurement Of Drug Levels Preventing Resistance Treatment Plan Multiple Analyte Mass Spectrometry Panel Two-milligram Sample Solid Phase Extraction Filtering Step Drug Exposure Treatment Regimen Accurate Drug Concentration Level Measurement Hair Sample Collection
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter