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Validiertes LC-MS/MS Panel zur Quantifizierung von 11 medikamentenresistenten TB-Medikamenten in kleinen Haarproben
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Validiertes LC-MS/MS Panel zur Quantifizierung von 11 medikamentenresistenten TB-Medikamenten in kleinen Haarproben

Article DOI: 10.3791/60861-v • 08:54 min • May 19th, 2020
May 19th, 2020 •
1, 1, 1, 2, 3, 4, 1
1Department of Obstetrics, Gynecology and Reproductive Sciences, TB Hair Analysis Laboratory, University of California San Francisco, 2Department of Epidemiology and Biostatistics, University of California San Francisco, 3Department of Medicine, Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, 4Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco

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Aktuelle Methoden zur Analyse der Patientenbindung an komplexe medikamentenresistente Tuberkulose-Therapien (DR-TB) können ungenau und ressourcenintensiv sein. Unsere Methode analysiert Das Haar, eine leicht zu sammelnde und gelagerte Matrix, auf Konzentrationen von 11 DR-TB-Medikamenten. Mit LC-MS/MS können wir Sub-Nanogramm-Medikamentenspiegel bestimmen, die verwendet werden können, um die Arzneimittelhaftung besser zu verstehen.

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Medizin Ausgabe 159 LC-MS/MS MDR-TB-Medikamente Haaranalyse Haftüberwachung Therapeutische Arzneimittelüberwachung Arzneimittelresistenz TB
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