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Generation af en menneskelig iPSC-baseret blod-hjerne barrierchip
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Generation af en menneskelig iPSC-baseret blod-hjerne barrierchip

Article DOI: 10.3791/60925-v • 10:20 min • March 2nd, 2020
March 2nd, 2020 •
1,2,3, 4, 5,6, 4, 1,2,3
1The Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 2The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, 3The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 4The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 5Division of Micro and Nanosystems, KTH Royal Institute of Technology, 6AIMES, Department of Neuroscience, Karolinska Institutet

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Blod - hjerne barrieren (BBB) er en multicellulær neurovaskulær enhed stramt regulere hjernen homøostase. Ved at kombinere menneskelige iPSCs og organ-on-chip teknologier, har vi genereret en personlig BBB chip, egnet til sygdom modellering og CNS narkotika penetrability forudsigelser. En detaljeret protokol er beskrevet for produktion og drift af BBB-chippen.

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Udviklingsbiologi blodhjernebarrieren BBB mikrofluidic organ-on-chip OoC neurovaskulær enhed NVU iPSC iPS-celler astrocytter personlig medicin præcisionsmedicin
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