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Journal / Developmental Biology / Geração de um chip de barreira hematoencefálica…
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JoVE Journal Developmental Biology
Geração de um chip de barreira hematoencefálica baseada no iPSC humano
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Geração de um chip de barreira hematoencefálica baseada no iPSC humano

Article DOI: 10.3791/60925-v • 10:20 min • March 2nd, 2020
March 2nd, 2020 •
1,2,3, 4, 5,6, 4, 1,2,3
1The Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 2The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, 3The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 4The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 5Division of Micro and Nanosystems, KTH Royal Institute of Technology, 6AIMES, Department of Neuroscience, Karolinska Institutet

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A barreira hematoencefálica (BBB) é uma unidade neurovascular multicelular que regula fortemente a homeostase cerebral. Ao combinar iPSCs humanos e tecnologias de organ-on-chip, geramos um chip BBB personalizado, adequado para modelagem de doenças e previsões de penetrabilidade de medicamentos CNS. Um protocolo detalhado é descrito para a geração e operação do chip BBB.

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Biologia do Desenvolvimento Edição 157 barreira cerebral sanguínea BBB microfluido órgão-on-chip OoC unidade neurovascular NVU iPSC células iPS astrócitos medicina personalizada medicina de precisão
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