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Journal / Developmental Biology / Generation av en mänsklig iPSC-baserade…
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Developmental Biology

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JoVE Journal Developmental Biology
Generation av en mänsklig iPSC-baserade Blod-Brain Barriär Chip
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Journal (Developmental Biology)
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Generating CRISPR/Cas9 Mediated Monoallelic Deletions to Study Enhancer Function in Mouse Embryonic Stem Cells
Journal (Developmental Biology)
Generating CRISPR/Cas9 Mediated Monoallelic Deletions to Study Enhancer Function in Mouse Embryonic Stem Cells
 
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Generation av en mänsklig iPSC-baserade Blod-Brain Barriär Chip

Article DOI: 10.3791/60925-v • 10:20 min • March 2nd, 2020
March 2nd, 2020 •
1,2,3, 4, 5,6, 4, 1,2,3
1The Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 2The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, 3The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 4The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 5Division of Micro and Nanosystems, KTH Royal Institute of Technology, 6AIMES, Department of Neuroscience, Karolinska Institutet

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Blod - hjärnbarriären (BBB) är en multicellulär neurovaskulär enhet som i tät en tid reglerar hjärnans homeostas. Genom att kombinera humana iPSCs och organ-on-chip-teknik har vi genererat ett personligt BBB-chip, lämpligt för sjukdomsmodellering och CNS-läkemedelspenetrability förutsägelser. Ett detaljerat protokoll beskrivs för generering och drift av BBB-chippet.

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Utvecklingsbiologi utgåva 157 blodhjärnbarriär BBB mikrofluidic organ-on-chip OoC neurovaskulär enhet NVU iPSC iPS celler astrocyter personlig medicin precisionmedicin
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