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Journal / Developmental Biology / İnsan iPSC Tabanlı Kan-Beyin Bariyer Chip…
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Developmental Biology

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JoVE Journal Developmental Biology
İnsan iPSC Tabanlı Kan-Beyin Bariyer Chip Üretimi
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İnsan iPSC Tabanlı Kan-Beyin Bariyer Chip Üretimi

Article DOI: 10.3791/60925-v • 10:20 min • March 2nd, 2020
March 2nd, 2020 •
1,2,3, 4, 5,6, 4, 1,2,3
1The Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 2The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, 3The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 4The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 5Division of Micro and Nanosystems, KTH Royal Institute of Technology, 6AIMES, Department of Neuroscience, Karolinska Institutet

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Kan-beyin bariyeri (BBB) sıkı beyin homeostazı düzenleyen bir çok hücreli nörovasküler birimdir. İnsan iPSC'leri ve çip üzerine organ teknolojilerini birleştirerek, hastalık modellemesi ve CNS ilaç penetrite tahminleri için uygun kişiselleştirilmiş bir BBB çipi ürettik. BBB çipinin üretimi ve işletimi için ayrıntılı bir protokol açıklanmıştır.

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Gelişimbiyolojisi Sayı 157 kan beyin bariyeri BBB mikroakışkan org-on-chip OoC nörovasküler birim NVU iPSC iPS hücreleri astrositler kişiselleştirilmiş tıp hassas tıp
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