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JoVE Journal Cancer Research
Drug Screening af primære patient afledt tumor xenografts i Zebrafish
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Drug Screening af primære patient afledt tumor xenografts i Zebrafish

Article DOI: 10.3791/60996-v • 09:50 min • April 10th, 2020
April 10th, 2020 •
1,2, 1, 1,2
1Department of Molecular and Cellular Biochemistry, University of Kentucky, 2Markey Cancer Center, University of Kentucky

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Zebrafisk xenograft modeller giver mulighed for høj-throughput narkotika screening og fluorescerende billeddannelse af menneskelige kræftceller i en in vivo mikromiljø. Vi udviklede en arbejdsgang for storstilet, automatiseret lægemiddelscreening på patientafledte leukæmiprøver i zebrafisk ved hjælp af en automatiseret fluorescensmikroskopudstyret billedenhed.

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Kræftforskning zebrafisk patient-afledt xenograft høj gennemløb narkotika skærm leukæmi automatiseret
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