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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Article DOI: 10.3791/61464-v • 08:50 min • June 24th, 2020
June 24th, 2020 •
1, 1, 2, 1, 3, 1,4
1Division of Neonatology, Stead Family Department of Pediatrics, University of Iowa, 2Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of Iowa, 3Division of Neonatology, Department of Pediatrics, Vanderbilt University, 4Department of Microbiology & Immunology, University of Iowa

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Summary
Automatic Translation

We developed a model of chorioamnionitis to simulate fetal exposure to maternal inflammation (FEMI) without complications of live organisms to examine the effects of FEMI on development of the offspring’s intestinal tract. This allows for study of mechanistic causes for development of intestinal injury following chorioamnionitis.

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Murine Model Fetal Exposure Maternal Inflammation Acute Chorioamnionitis Newborn Intestinal Development Long-term Effects Necrotizing Enterocolitis Sterile Inflammation Microbiome LPS Injection Appropriate LPS Dose Intraperitoneal Trauma Gestation Day E15 Pregnant Dams Normal Saline Syringe Scruffing Technique Dorsal Recumbency Position Needle Bevel Up
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