专访:糖脂抗原提呈CD1d及NKT细胞活化治疗潜力

Biology

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Summary

自然杀伤T细胞(NKT),癌症autioimmunity监管,清除感染,并发展artheriosclerotic斑块的免疫反应的关键因素。在这次采访中,米奇Kronenberg讨论他的实验室的努力去了解通过糖脂抗原激活NKT细胞的机制。

Cite this Article

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Kronenberg, M. Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation. J. Vis. Exp. (10), e635, doi:10.3791/635 (2007).

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Abstract

自然杀伤T细胞(NKT细胞)的免疫反应的癌症,调节autioimmune疾病,传染性病原体的间隙,artheriosclerotic斑块的发展的关键因素。在这次采访中,米奇Kronenberg讨论他的实验室的努力去了解通过糖脂抗原激活NKT细胞的机制。这些研究的核心是CD1d - 呈现糖脂NKT细胞的抗原提呈分子。 CD1d四聚体技术的问世,由Kronenberg实验室开发出一种技术,具体糖脂反应性T细胞亚群的分类和识别的关键。米奇解释糖脂受体激动剂作为治疗药物激活NKT细胞在癌症患者中,以及如何CD1d四聚体可以用来评估在体内糖脂受体激动剂治疗后NKT细胞人口的状态。正在进行的临床试验,使用这些受体激动剂的现状进行了讨论,以及米奇的预测,在免疫学领域的地区,将出现在不久的将来的重要性。

References

  1. Khurana, A., Kronenberg, M. A Method for Production of Recombinant CD1d Protein in Insect Cells. 12/10/2007) Journal of Visualized Experiments. Forthcoming.

Comments

2 Comments

  1. i cann't see more detail in this Vedeo. Who can answer the proplem for me?

    Reply
    Posted by: siriwan W.
    February 28, 2012 - 9:15 AM
  2. I am looking for information regarding to CD1d presenting glycolipids. And I hope this video can provide a vivid presentation of the mechanism as I have limited background knowledge about this topic.

    Reply
    Posted by: Shuyi Y.
    July 16, 2012 - 9:59 PM

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