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A Technique for Serial Collection of Cerebrospinal Fluid from the Cisterna Magna in Mouse
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A Technique for Serial Collection of Cerebrospinal Fluid from the Cisterna Magna in Mouse

Article DOI: 10.3791/960-v • 08:08 min • November 10th, 2008
November 10th, 2008 •
1, 1
1Department of Pathology, Columbia University

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Transgenic (Tg) mouse models of AD provide an excellent opportunity to investigate how and why Aβ or tau levels in CSF change as the disease progresses in human patients. Here, we demonstrate a refined cisterna magna puncture technique for serial CSF sampling from the mouse.

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Cerebrospinal Fluid CSF Cisterna Magna Mouse Alzheimer's Disease AD Neurodegenerative Disease Amyloid Peptide Tau Protein Biochemical Changes Transgenic Mouse Models Puncture Technique Sampling Aβ42 Tau Levels Disease Progression ELISA Metabolism
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