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Find video protocols related to scientific articles indexed in Pubmed.
Bioavailability and Kinetics of the Antihypertensive Casein-Derived Peptide HLPLP in Rats.
J. Agric. Food Chem.
PUBLISHED: 11-12-2014
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The aim of this study was to investigate the oral bioavailability and kinetics of the milk casein-derived peptide HLPLP, which had previously demonstrated antihypertensive effect in spontaneously hypertensive rats. HLPLP disposition after single intravenous (4 mg/kg body weight) and oral (40 mg/kg body weight) doses was studied in rats. Plasma concentrations of HLPLP [?-casein fragment f(134-138)], and two derived fragments found after HLPLP administration, LPLP [?-casein fragment f(135-138)] and HLPL [?-casein fragment f(134-137)] were determined by Ultrahigh Performance Liquid Chromatography (UPLC) coupled on line to a Q-TOF instrument. For HLPLP, the elimination half-lives (T1/2?) were 7.95 min after intravenous and 11.7 min after oral administration. The volume of distribution at steady state (Vss = 30.8 L/kg) suggests a considerable uptake of HLPLP into tissues. HPLPL was converted to the peptides, LPLP and HLPL. After HLPLP intravenous administration, the elimination half-lives (T1/2?) for these biotransformed peptides, LPLP and HLPL, were 8.38 and 10.9 min, respectively. After oral administration, HLPLP was rapidly absorbed with an absorption half-life (T1/2a) of 2.79 min. The oral bioavailability of HLPLP was found to be 5.18%. Our study suggest that HLPLP was rapidly absorbed and eliminated after oral administration, biotransformed into smaller fragments LPLP and HLPL, and distributed throughout the body by the circulation blood. The present pharmacokinetic information from a pre-clinical kinetic study in rats can to play an important role in designing future kinetic studies in humans for assessing HLPLP dose-response relationship.
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Chiral recognition with a benzofuran receptor that mimics an oxyanion hole.
Org. Biomol. Chem.
PUBLISHED: 11-07-2014
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A new chiral benzofuran receptor has been synthesized and its properties in the association of amino acid derivatives have been studied. X-ray structures were obtained and these corroborate the presence of an oxyanion-hole motif in these structures.
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Comparison of five wastewater COD fractionation methods for dynamic simulation of MBR systems.
J Environ Sci Health A Tox Hazard Subst Environ Eng
PUBLISHED: 08-20-2014
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Five different wastewater COD fractionation methods were employed for simulating an experimental MBR wastewater treatment plant using WEST. The predictions of dynamic simulations using as input the data obtained according to each influent characterization methodology were compared with the results of the experimental system and differences between experimental and predicted values were analyzed in order to select the fractionation method which provides the best fitting and minimizes errors. Three of these methods were based on the determination of the biodegradable fractions using respirometric assays of real wastewater filtered through 0.45- and 0.22-?m pore size filters or adding a previous flocculation step before filtration. Moreover, a method based on physicochemical analyses and another one based on theoretical coefficients were also compared. Simulated system performance and effluent quality greatly depended upon the influent characterization and the proper model calibration. Thus the importance of selecting a suitable fractionation methodology is high, especially in MBR systems working at specific operational conditions that may alter COD fractions. In this study, MLSS in the bioreactors and sludge supernatant COD concentrations were better predicted when the influent characterization was based on respirometric methods. Both the method based on theoretical coefficients and the physicochemical method underestimated the particulate inert fraction and therefore, also the MLSS concentrations. Moreover, these results showed that for a correct effluent COD prediction in MBR systems, it is necessary to take into account that the membrane retained part of the soluble inert fraction.
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Bladder endometriosis and endocervicosis: presentation of 2 cases with endoscopic management and review of literature.
Case Rep Urol
PUBLISHED: 08-12-2014
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Urinary tract endometriosis and endocervicosis are an uncommon pathologic finding, with a common embryological origin. We present 2 cases of female patients with bladder mass. The first one was a finding of a nodular formation in the bladder during study of a nonviable foetus and the second was an incidental finding of a neoformation in the fundus of the bladder during the realization of an ultrasound. In both cases, we performed a surgical management with transurethral resection. Histopathological examination revealed a bladder endometrioma in the first case and endocervicosis with associated endometriosis in the second.
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[Primary ovarian carcinosarcoma. Report of eight cases].
Ginecol Obstet Mex
PUBLISHED: 08-09-2014
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The carcinosarcoma, or Mixed Mullerian Malign Tumors, represent 1% of malignant ovarian neoplasm, they are formed by a component epithelium and another mesenquimal malignant both.
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[Cancer incidence in a Cancer Care Unit of the Mexican Social Security Institute (IMSS) in Toluca, Mexico].
Gac Med Mex
PUBLISHED: 08-08-2014
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In 2000, malignant tumors were responsible for 12% of nearly 56 million deaths that occurred in the world from all causes.
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Peptidomic study of Spanish blue cheese (Valdeón) and changes after simulated gastrointestinal digestion.
Electrophoresis
PUBLISHED: 07-16-2014
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It is increasingly evident that digestion can affect the biological activity of cheese by the release of new active peptides from their precursors or, on the contrary, giving rise to fragments without activity. The characterization of the peptidome of a Spanish blue cheese, Valdeón, has been conducted before and after gastrointestinal digestion, and the digests have been compared to those obtained from pasteurized skimmed milk powder (SMP) using a bioinformatics platform. Peptidomic profiling of digests revealed several regions that are especially resistant to digestion (among them ?-casein 60-93, 128-140, and 193-209). Some of them correspond to well-conserved regions between species (human, cow, sheep, and goat) and include peptide sequences with reported bioactivity. The great peptide homology found between both digests, cheese and SMP, suggests that the gastrointestinal digestion could bring closer the profile of products with different proteolytic state. Although most of the biologically active peptides found in cheese after digestion were also present in SMP digest, there were some exceptions that can be attributed to the absence of the relevant precursor peptide before digestion.
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Colonic Cribriform Carcinoma, a Morphologic Pattern Associated With Low Survival.
Int. J. Surg. Pathol.
PUBLISHED: 07-13-2014
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Colorectal carcinoma is one of the most common cancers in the human body. Colorectal carcinoma is a heterogeneous disease with variegated morphological patterns; some have shown themselves to have prognostic value. The World Health Organization classification recognizes many histological variants associated with adverse prognostic factors, one is the cribriform colonic carcinoma (CCC). In this work, we analyzed 18 cases of CCC compared with 228 conventional adenocarcinomas of colon, with the hypotheses that CCC compared with non-CCC have worse prognosis and decreased overall survival. CCC represent 7.3% of all colonic adenocarcinomas in this series, it presents in a median age of 56.3 years, all cases are in clinical stage III and IV, all invade subserosal adipose tissues or serosa, 90% have >5 positive lymph nodes and 89% have lymphovascular invasion. These known adverse prognostic factors reflect a lower 5-year survival, stage by stage, than conventional intestinal-type adenocarcinoma (56.8% vs 83.3%, P = .035). Cribriform carcinoma is a morphologic pattern that is underrecognized; in this work, we demonstrate its association with low survival, extensive lymphovascular invasion, and extensive lymph node metastasis, strong indicators of aggressive disease. Their proper recognition is mandatory to increase the number of cases and series to support our findings and include it in the current classifications.
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Sensitivity enhancement in the determination of volatile biomarkers in saliva using a mass spectrometry-based electronic nose with a programmed temperature vaporizer.
Anal. Chem.
PUBLISHED: 07-11-2014
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With a view to improving the sensitivity of direct coupling of a headspace sampler (HS) with a mass spectrometer (MS), here we propose the use of a programmed temperature vaporizer (PTV) in solvent-vent injection mode before the sample is introduced into the MS. This preconcentration scheme has been used for some time in many methods based on gas chromatography (GC), but to the best of our knowledge it has not yet been used in an electronic nose based on MS. The increase in the S/N ratio with the proposed instrumental configuration (HS-PTV/MS) lies between 6.9- and 22-fold. The main advantage of using this injector lies in the fact that it does not involve time-consuming steps. To check the possibilities of this methodology, saliva samples from healthy volunteers and patients with different types of illnesses (including some types of cancer) were analyzed. None of the compounds studied was detected in the samples corresponding to the healthy volunteers. One or more biomarkers, at levels ranging from 13 to 500 ?g/L, were found in five of the samples from the patients. Additionally, separative analysis by HS-PTV-GC/MS was performed for confirmatory purposes and both methods provided similar results. The main advantage of the proposed methodology is that no prior chromatographic separation and no sample manipulation are required.
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Hypomagnesaemia in critically ill patients with haematological malignancies.
Nutr Hosp
PUBLISHED: 07-01-2014
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There is currently little information regarding the incidence of hypomagnesaemia and its impact on the prognosis of critically ill patients with haematological malignancies.
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Interobserver reliability of echocardiography for prognostication of normotensive patients with pulmonary embolism.
Cardiovasc Ultrasound
PUBLISHED: 06-27-2014
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To evaluate the interobserver reliability of echocardiographic findings of right ventricle (RV) dysfunction for prognosticating normotensive patients with pulmonary embolism (PE).
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Renal function recovery after laparosocopic pyeloplasty.
Cent European J Urol
PUBLISHED: 06-23-2014
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To observe the renal function recovery measured by diuretic renography in short and medium follow-up of patients with transperitoneal Anderson-Hynes laparoscopic pyeloplasty.
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Performance indicators analysis at Brazilian and Italian women's volleyball leagues according to game location, game outcome, and set number.
Percept Mot Skills
PUBLISHED: 06-06-2014
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This study was done to investigate the advantage of playing at home in elite women's volleyball leagues and the influence of performance indicators in the game score according to set number. The sample consisted of 240 games of the Brazilian Volleyball League (n = 132 games) and the Italian Volleyball League (n = 108 games) from the 2011-2012 season. The relationship of performance indicators (including serve, attack, block, and opponents' errors) with the game outcome (win or lose) was assessed. The results showed that there was a home advantage effect in women's volleyball leagues, with a higher prevalence of victory for the home teams in Brazilian and Italian leagues (58 and 56%, respectively). When related to the performance indicators and among the aspects that were most highly correlated with victory, the attack was the technical indicator that explained most of the results of volleyball games.
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Use of artificial intelligence as an innovative donor-recipient matching model for liver transplantation: Results from a multicenter Spanish study.
J. Hepatol.
PUBLISHED: 05-23-2014
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There is an increasing discrepancy between the number of potential liver graft recipients and the number of organs available. Organ allocation should follow the concept of benefit of survival, avoiding human-innate subjectivity. The aim of this study is to use artificial-neural-networks (ANNs) for donor-recipient (D-R) matching in liver transplantation (LT) and to compare its accuracy with validated scores (MELD, D-MELD, DRI, P-SOFT, SOFT, and BAR) of graft survival.
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What makes a group worth dying for? Identity fusion fosters perception of familial ties, promoting self-sacrifice.
J Pers Soc Psychol
PUBLISHED: 05-21-2014
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We sought to identify the mechanisms that cause strongly fused individuals (those who have a powerful, visceral feeling of oneness with the group) to make extreme sacrifices for their group. A large multinational study revealed a widespread tendency for fused individuals to endorse making extreme sacrifices for their country. Nevertheless, when asked which of several groups they were most inclined to die for, most participants favored relatively small groups, such as family, over a large and extended group, such as country (Study 1). To integrate these findings, we proposed that a common mechanism accounts for the willingness of fused people to die for smaller and larger groups. Specifically, when fused people perceive that group members share core characteristics, they are more likely to project familial ties common in smaller groups onto the extended group, and this enhances willingness to fight and die for the larger group. Consistent with this, encouraging fused persons to focus on shared core characteristics of members of their country increased their endorsement of making extreme sacrifices for their country. This pattern emerged whether the core characteristics were biological (Studies 2 and 3) or psychological (Studies 4-6) and whether participants were from China, India, the United States, or Spain. Further, priming shared core values increased the perception of familial ties among fused group members, which, in turn, mediated the influence of fusion on endorsement of extreme sacrifices for the country (Study 5). Study 6 replicated this moderated mediation effect whether the core characteristics were positive or negative. Apparently, for strongly fused persons, recognizing that other group members share core characteristics makes extended groups seem "family like" and worth dying for.
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Contemplating the ultimate sacrifice: identity fusion channels pro-group affect, cognition, and moral decision making.
J Pers Soc Psychol
PUBLISHED: 04-23-2014
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Although most people acknowledge the moral virtue in sacrificing oneself to save others, few actually endorse self-sacrifice. Seven experiments explored the cognitive and emotional mechanisms that underlie such endorsements. Participants responded to 1 of 2 moral dilemmas in which they could save 5 members of their country only by sacrificing themselves. Over 90% of participants acknowledged that the moral course of action was to sacrifice oneself to save others (Experiment 1), yet only those who were strongly fused with the group preferentially endorsed self-sacrifice (Experiments 2-7). The presence of a concern with saving group members rather than the absence of a concern with self-preservation motivated strongly fused participants to endorse sacrificing themselves for the group (Experiment 3). Analyses of think aloud protocols suggested that saving others was motivated by emotional engagement with the group among strongly fused participants but by utilitarian concerns among weakly fused participants (Experiment 4). Hurrying participants' responses increased self-sacrifice among strongly fused participants but decreased self-sacrifice among weakly fused participants (Experiment 5). Priming the personal self increased endorsement of self-sacrifice among strongly fused participants but further reduced endorsement of self-sacrifice among weakly fused participants (Experiment 6). Strongly fused participants ignored utilitarian considerations, but weakly fused persons endorsed self-sacrifice more when it would save more people (Experiment 7). Apparently, the emotional engagement with the group experienced by strongly fused persons overrides the desire for self-preservation and compels them to translate their moral beliefs into self-sacrificial behavior.
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Calculating the home advantage in soccer leagues.
J Hum Kinet
PUBLISHED: 03-27-2014
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A recent article published in the Journal of Human Kinetics (Saavedra et al., 2013) was based on a flawed methodology when calculating the home advantage values in soccer leagues. This led to incorrect calculations, false conclusions and some misleading results about home advantage in 52 soccer leagues of UEFA countries over a 10 year period. The aim of this letter was to explain these flaws and to make sure future research would not be influenced by the subsequent results and conclusions that had been presented.
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Laparoscopic radical prostatectomy training for residents: Hospital Universitario La Paz model.
Cent European J Urol
PUBLISHED: 02-16-2014
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In the last decade, we have seen the advance of laparoscopic surgery in urology.All laparoscopic procedures in our department are performed by staff members and are assisted by a single resident, ensuring resident training in laparoscopic surgery. The aim of this study is to evaluate the results of the Hospital La Paz training program for residents in the field of laparoscopic surgery.
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Performance analysis of elite men's and women's wheelchair basketball teams.
J Sports Sci
PUBLISHED: 02-07-2014
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The purpose of the present study was to identify which game-related statistics discriminate winning and losing teams in men's and women's elite wheelchair basketball. The sample comprised all the games played during the Beijing Paralympics 2008 and the World Wheelchair Basketball Championship 2010. The game-related statistics from the official box scores were gathered and data were analysed in 2 groups: balanced games (final score differences ? 12 points) and unbalanced games (final score differences >13 points). Discriminant analysis allowed identifying the successful 2-point field-goals and free-throws, the unsuccessful 3-point field-goals and free-throws, the assists and fouls received as discriminant statistics between winning and losing teams in men's balanced games. In women's games, the teams were discriminated only by the successful 2-point field-goals. Linear regression analysis showed that the quality of opposition had great effects in final point differential. The field-goals percentage and free-throws rate were the most important factors in men's games, and field-goals percentage and offensive rebounding percentage in women's games. The identified trends allow improving game understanding and helping wheelchair basketball coaches to plan accurate practice sessions and, ultimately, deciding better in competition.
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[Integrity].
Cuad Bioet
PUBLISHED: 02-06-2014
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To say that someone possesses integrity is to claim that that person is almost predictable about responses to specific situations, that he or she can prudentially judge and to act correctly. There is a closed interrelationship between integrity and autonomy, and the autonomy rests on the deeper moral claim of all humans to integrity of the person. Integrity has two senses of significance for medical ethic: one sense refers to the integrity of the person in the bodily, psychosocial and intellectual elements; and in the second sense, the integrity is the virtue. Another facet of integrity of the person is la integrity of values we cherish and espouse. The physician must be a person of integrity if the integrity of the patient is to be safeguarded. The autonomy has reduced the violations in the past, but the character and virtues of the physician are the ultimate safeguard of autonomy of patient. A field very important in medicine is the scientific research. It is the character of the investigator that determines the moral quality of research. The problem arises when legitimate self-interests are replaced by selfish, particularly when human subjects are involved. The final safeguard of moral quality of research is the character and conscience of the investigator. Teaching must be relevant in the scientific field, but the most effective way to teach virtue ethics is through the example of the a respected scientist.
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Intensive care unit admission after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Is it necessary?
J Oncol
PUBLISHED: 01-29-2014
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Introduction. Cytoreductive surgery (CS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a new approach for peritoneal carcinomatosis. However, high rates of complications are associated with CS and HIPEC due to treatment complexity; that is why some patients need stabilization and surveillance for complications in the intensive care unit. Objective. This study analyzed that ICU stay is necessary after HIPEC. Methods. 39 patients with peritoneal carcinomatosis were treated according to strict selection criteria with CS and HIPEC, with closed technique, and the chemotherapy administered were cisplatin 25?mg/m(2)/L and mitomycin C 3.3?mg/m(2)/L for 90-minutes at 40.5°C. Results. 26 (67%) of the 39 patients were transferred to the ICU. Major postoperative complications were seen in 14/26 patients (53%). The mean time on surgical procedures was 7.06 hours (range 5-9 hours). The mean blood loss was 939?ml (range 100-3700?ml). The mean time stay in the ICU was 2.7 days. Conclusion. CS with HIPEC for the treatment of PC results in low mortality and high morbidity. Therefore, ICU stay directly following HIPEC should not be standardized, but should preferably be based on the extent or resections performed and individual patient characteristics and risk factors. Late complications were comparable to those reported after large abdominal surgery without HIPEC.
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Approach to kidney stones associated with ureteropelvic junction obstruction during laparoscopic pyeloplasty.
Cent European J Urol
PUBLISHED: 01-27-2014
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We have performed laparoscopic pyeloplasty (LP) in our department since 2004. Our goal is to describe, step by step, the approach of kidney stones during transperitoneal laparoscopic pyeloplasty and the outcomes after the procedure.
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Importance of tumor size in soft tissue sarcomas: a proposal for a nomogram based on a score system to staging soft tissue sarcomas in the postoperative setting.
Med. Oncol.
PUBLISHED: 01-10-2014
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In order to adequately stage patients with extremity soft tissue sarcomas (ESTS), it is mandatory to include all adverse prognostic factors and create an integral staging system. We were able to evaluate a nomogram based on a score (STSSS), to improve ESTS staging. We retrospectively evaluated 596 patients with ESTS in stages I-III, of the American Joint Committee on Cancer (AJCC), who had a complete resection. We analyzed the influence of clinicopathological factors on metastasis, recurrence, and disease-specific survival. The STSSS was based on histologic grade (HG), profundity, tumor size (TS), and surgical margins; we also compared STSSS versus AJCC systems in their ability to stage ESTS. The mean TS was 11.8 cm, with 50%>10 cm. Large TS and high HG were independent but adverse prognostic factors for metastasis. In addition, large TS, high grade, and R1 resection were independent adverse prognostic factors for decreased survival. There was a progressive decline in survival as TS increased, although AJCC staging did not correlate well between stages (IA vs. IB p=0.233, IA vs. IIA p=0.123, IA vs. IIB p=0.075, IB vs. IIA p=0.472, IB vs. IIB p=0.211). STSSS showed differences between these categories for 5-year survival (I vs. II p=0.003, II vs. III p=0.002, III vs. IV p<0.001). Surgical margins, HG, and TS are important determinants for metastases and survival. We also found a strong correlation between survival and prognosis with the use of STSSS in the immediate postoperative setting.
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In vitro surfactant and perfluorocarbon aerosol deposition in a neonatal physical model of the upper conducting airways.
PLoS ONE
PUBLISHED: 01-01-2014
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Aerosol delivery holds potential to release surfactant or perfluorocarbon (PFC) to the lungs of neonates with respiratory distress syndrome with minimal airway manipulation. Nevertheless, lung deposition in neonates tends to be very low due to extremely low lung volumes, narrow airways and high respiratory rates. In the present study, the feasibility of enhancing lung deposition by intracorporeal delivery of aerosols was investigated using a physical model of neonatal conducting airways.
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Case Report: Pneumocephalus after labor epidural anesthesia.
F1000Res
PUBLISHED: 01-01-2014
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Lumbar epidural anesthesia is commonly used for labor analgesia. The 'loss-of- resistance' to air technique (LORA) is generally employed for recognition of the epidural space. One of the rare complications of this technique is pneumocephalus (PC). Here we describe the case of a parturient who developed a frontal headache when locating the epidural space using LORA. On the second day after epidural injection, the patient exhibited occipital headaches with gradual worsening. Computed tomography scans of the brain indicated PC. Following symptomatic treatment, our patient was discharged on the 13th day. We concluded that the amount of air used to identify the epidural space in LORA should be minimized, LORA should not be used after dural puncture and the use of saline avoids PC complications.
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Nest site selection by Kentish plover suggests a trade-off between nest-crypsis and predator detection strategies.
PLoS ONE
PUBLISHED: 01-01-2014
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Predation is one of the main causes of adult mortality and breeding failure for ground-nesting birds. Micro-habitat structure around nests plays a critical role in minimizing predation risk. Plovers nest in sites with little vegetation cover to maximize the incubating adult visibility, but many studies suggest a trade-off between nest-crypsis and predator detection strategies. However, this trade-off has not been explored in detail because methods used so far do not allow estimating the visibility with regards to critical factors such as slope or plant permeability to vision. Here, we tested the hypothesis that Kentish plovers select exposed sites according to a predator detection strategy, and the hypothesis that more concealed nests survive longer according to a crypsis strategy. To this end, we obtained an accurate estimation of the incubating adult's field of vision through a custom built inverted periscope. Our results showed that plovers selected nest sites with higher visibility than control points randomly selected with regards to humans and dogs, although nests located in sites with higher vegetation cover survived longer. In addition, the flushing distance (i.e., the distance at which incubating adults leave the nest when they detect a potential predator) decreased with vegetation cover. Consequently, the advantages of concealing the nest were limited by the ability to detect predators, thus indirectly supporting the existence of the trade-off between crypsis and predator detection. Finally, human disturbance also constrained nest choice, forcing plovers to move to inland sites that were less suitable because of higher vegetation cover, and modulated flushing behavior, since plovers that were habituated to humans left their nests closer to potential predators. This constraint on the width of suitable breeding habitat is particularly relevant for the conservation of Kentish Plover in sand beaches, especially under the current context of coastal regression and increase of recreational activities.
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[Relevance of an adequate pathologic evaluation of radical rectal resection specimens].
Acta Gastroenterol. Latinoam.
PUBLISHED: 12-06-2013
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The most important prognostic factors influencing survival of patients with rectal carcinoma (RC) are lymph node metastases and mesorectal excision (ME). The adequate pathologic examination (APE) of rectal specimens is a standardized pathologic work-up that differs of the conventional colonic/intestinal pathologic work-up. The aim of this study was to determine the impact of APE on staging, lymph node retrieval and survival, with the hypotheses that APE allows high lymph node retrieval and better survival.
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Higher Moral Obligations of Tolerance Toward Other Minorities: An Extra Burden on Stigmatized Groups.
Pers Soc Psychol Bull
PUBLISHED: 11-19-2013
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In four experiments, we tested whether members of stigmatized groups are expected to be more tolerant toward other minorities than members of non-stigmatized groups and assessed the consequences of disconfirming those expectancies. Experiments 1 and 2 showed that majority group members expected members of a stigmatized group to be more tolerant toward immigrants, particularly when the stigmatized minority was perceived as having overcome the negative consequences of its victimization. When this tolerance expectation was disconfirmed, stigmatized group members were judged more immoral than members of a non-stigmatized group that held the same intolerant attitudes. Experiments 3 and 4 showed that these effects were driven by the belief that stigmatized groups should derive benefits from their suffering. These findings suggest that stigmatized groups are judged according to stricter moral standards than non-stigmatized groups because majority group members need to make meaning of the undeserved suffering experienced by victims of social stigma.
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Verification of Ingroup Identity as a Longitudinal Mediator between Intergroup Contact and Outgroup Evaluation.
Span J Psychol
PUBLISHED: 11-16-2013
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Almost six decades of research have consistently demonstrated that intergroup contact is one of the most powerful ways of improving intergroup attitudes. At least two important limitations, however, still compel researchers to continue work in this area: the issue of long-term effects of contact, and the processes underlying such effects. This report makes a theoretical and empirical contribution with regard to these two aspects introducing a new mediator of the effects of contact: verification of qualities of typical ingroup members that may or may not characterize individual group members (e.g. verification of ingroup identities). One hundred and forty-two high school students participated in a two-wave longitudinal study with 12 weeks lag in Spain. Cross-sectional and longitudinal mediational analyses using multiple imputation data showed that intergroup contact improves general outgroup evaluation through increasing verification of ingroup identities. This research demonstrates the relevance of considering verification of ingroup identity as a mediator for the positive effects of intergroup contact.
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Accuracy of Quantitative Computed Tomography Bone Mineral Density Measurements in Mandibles: A Cadaveric Study.
Clin Implant Dent Relat Res
PUBLISHED: 11-14-2013
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The aim was to investigate the accuracy of quantitative computed tomography bone mineral density (BMD) measurements in mandibles, comparing measured BMD with calibrated BMD.
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[Nutritional status of patients with cancer of oral cavity].
Nutr Hosp
PUBLISHED: 10-29-2013
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Cancer of the oral cavity ranks twelfth worldwide. This type of cancer is usually managed surgically followed by radiotherapy, which may be indicated alone or with chemotherapy; this type of therapies have significant functional side effects on the nutritional status of the patient.
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Updated clinical classification of pulmonary hypertension.
J. Am. Coll. Cardiol.
PUBLISHED: 10-15-2013
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In 1998, a clinical classification of pulmonary hypertension (PH) was established, categorizing PH into groups which share similar pathological and hemodynamic characteristics and therapeutic approaches. During the 5th World Symposium held in Nice, France, in 2013, the consensus was reached to maintain the general scheme of previous clinical classifications. However, modifications and updates especially for Group 1 patients (pulmonary arterial hypertension [PAH]) were proposed. The main change was to withdraw persistent pulmonary hypertension of the newborn (PPHN) from Group 1 because this entity carries more differences than similarities with other PAH subgroups. In the current classification, PPHN is now designated number 1. Pulmonary hypertension associated with chronic hemolytic anemia has been moved from Group 1 PAH to Group 5, unclear/multifactorial mechanism. In addition, it was decided to add specific items related to pediatric pulmonary hypertension in order to create a comprehensive, common classification for both adults and children. Therefore, congenital or acquired left-heart inflow/outflow obstructive lesions and congenital cardiomyopathies have been added to Group 2, and segmental pulmonary hypertension has been added to Group 5. Last, there were no changes for Groups 2, 3, and 4.
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Ball Possession Effectiveness in Mens Elite Floorball According to Quality of Opposition and Game Period.
J Hum Kinet
PUBLISHED: 09-30-2013
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The aim of the present study was to identify the importance of floorball tactical variables to predict ball possession effectiveness, when controlling quality of opposition and game periods. The sample was composed by 1500 ball possessions, corresponding to 14 games randomly selected from the International Championships played during 2008 and 2010 (World Championship, Four nations tournament and classificatory phases for World Championship) by teams from different competition levels (HIGH, INTERMEDIATE and LOW). The effects of the predictor variables on successful ball possessions according to the three game contexts (HIGH vs. HIGH; HIGH vs. LOW; LOW vs. LOW games) were analyzed using Binomial Logistic Regressions. The results showed no interaction with the game period. In HIGH vs. HIGH games, quality of opposition showed an association with ball possession effectiveness with ending zone, offensive system, possession duration, height of shooting and defensive pressures previous to the shot. In HIGH vs. LOW games the important factors were the starting zone, possession duration, defensive pressure previous to the last pass and to the shot, technique of shooting and the number players involved in each ball possession. Finally, in LOW vs. LOW games, the results emphasized the importance of starting and ending zones, the number of passes used and the technique of shooting. In conclusion, elite floorball performance is mainly affected by quality of opposition showing different game patterns in each context that should be considered by coaches when preparing practices and competitions.
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Synthesis of 3-tetrazolylmethyl-azepino[4,5-b]indol-4-ones in two reaction steps: (Ugi-azide/N-acylation/SN2)/free radical cyclization and docking studies to a 5-Ht(6) model.
Org. Biomol. Chem.
PUBLISHED: 08-21-2013
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A series of nine novel 3-tetrazolylmethyl-azepino[4,5-b]indol-4-ones were prepared in moderate to good overall yields in only two reaction steps. The first step consisted of a one-pot sequential process of an Ugi-azide multicomponent reaction, N-acylation and SN2 to give the xanthates. The second step was an intramolecular cyclization under free radical conditions. Also, their binding modes have been modelled using docking techniques.
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Insulin and leptin levels in obese patients with and without breast cancer.
Clin. Breast Cancer
PUBLISHED: 06-07-2013
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Leptin has been associated with progression and poor survival in BC. Moreover, it is still controversial as to whether the effect of leptin depends only on its correlation with body mass index (BMI), or could be a direct role of adipokine in the development of BC. The aim of this study was to identify if there was a difference between serum leptin levels and insulin in obese patients with and without BC.
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Impact of donor and recipient CYP3A5 and ABCB1 genetic polymorphisms on tacrolimus dosage requirements and rejection in Caucasian Spanish liver transplant patients.
J Clin Pharmacol
PUBLISHED: 06-07-2013
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Studies of liver transplant (LT) patients, mainly in Asians, have evaluated the influence of the CYP3A5*1 allele and P-glycoprotein gene ABCB1 on tacrolimus pharmacokinetics or biopsy-proven acute rejection (BPAR) incidence, with no conclusive results. To investigate these issues, 98 Caucasian Spanish LT patients with tacrolimus, mycophenolate mofetil and steroids and 88 cadaveric donors were genotyped for the SNPs CYP3A5 6986G>A, ABCB1 1236C>T, ABCB1 2677G>A/T and ABCB1 3435C>T;. On day 7 post-LT, patients with a native CYP3A5*1 allele had significantly lower tacrolimus trough concentrations C0 (P?=?.03) and dose-adjusted concentrations C0 /D (P?=?.02) than CYP3A5 *3/*3 homozygotes. Three months post-LT, patients carrying a liver with CYP3A5*1 had significantly lower C0 /D (P?=?.03) and took significantly higher tacrolimus doses (P?=?.03) than the corresponding *3/*3 homozygotes. ABCB1 SNPs showed no significant association with tacrolimus variables. The 3-month incidence of BPAR was 10.2%, with no statistically significant differences related to CYP3A5 (14.3% in expresser vs. 9.5% in non-expresser) or ABCB1 genotype of either patient or donor. We conclude that in Caucasian Spanish LT patients, a native or graft-borne CYP3A5*1 allele tends to lower tacrolimus concentrations and increase dosage needs, but has no significant impact on the incidence of BPAR.
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Ball possession effectiveness in mens and womens elite basketball according to situational variables in different game periods.
J Sports Sci
PUBLISHED: 05-17-2013
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The aim of the present study was to identify the importance of basketball performance indicators in predicting the effectiveness of ball possessions in mens and womens basketball, when controlling for situational variables and game periods. The sample consisted of 7234 ball possessions, corresponding to 40 games from the Spanish professional leagues. The effects of the predictor variables on successful ball possessions according to game period were analysed using binary logistic regressions. Results from mens teams show interactions with number of passes and ending player during the first five minutes, with starting and ending zone, defensive systems, screens used and possession duration during the middle thirty minutes, and there were interactions with passes used, possession duration and players involved during the last five minutes. Results from womens teams show interactions with starting and ending zone, passes used, defensive systems and ending player during the first five minutes, and with starting and ending zone, and screens used during the middle thirty minutes. The results show no interaction with situational variables in mens basketball, while league stage was important during the middle thirty minutes and last five minutes in womens basketball, whereas match status was only important during the last five minutes.
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Structural similarity and descriptor spaces for clustering and development of QSAR models.
Curr Comput Aided Drug Des
PUBLISHED: 04-27-2013
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In this paper we study and analyze the behavior of different representational spaces for the clustering and building of QSAR models. Representational spaces based on fingerprint similarity, structural similarity using maximum common subgraphs (MCS) and all maximum common subgraphs (AMCS) approaches are compared against representational spaces based on structural fragments and non-isomorphic fragments (NIF), built using different molecular descriptors. Algorithms for extraction of MCS, AMCS and NIF are described and support vector machine is used for the classification of a dataset corresponding with 74 compounds of 1,4-benzoquinone derivatives. Molecular descriptors are tested in order to build QSAR models for the prediction of the antifungal activity of the dataset. Descriptors based on the consideration of graph connectivity and distances are the most appropriate for building QSAR models. Moreover, models based on approximate similarity improve the statistical of the equations thanks to combining structural similarity, nonisomorphic fragments and descriptors approaches for the creation of more robust and finer prediction equations.
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Contagious agalactia due to Mycoplasma spp. in small dairy ruminants: epidemiology and prospects for diagnosis and control.
Vet. J.
PUBLISHED: 04-18-2013
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Contagious agalactia (CA) is a serious disease of small dairy ruminants that has a substantial economic impact on the goat and sheep milk industries. The main aetiological agent of the disease is Mycoplasma agalactiae, although other species, such as Mycoplasma mycoides subsp. capri, Mycoplasma capricolum subsp. capricolum and Mycoplasma putrefaciens, are pathogenic in goats. There are two clinical-epidemiological states of CA in sheep and goats; herds and flocks may exhibit outbreaks of CA or may be chronically infected, the latter with a high incidence of subclinical mastitis and only occasional clinical cases. The complex epidemiology of CA is related to the genetic characteristics and mechanisms of molecular variation of the Mycoplasma spp. involved, along with presence of CA-mycoplasmas in wild ruminant species. In goats, the situation is particularly complex and asymptomatic carriers have been detected in chronically infected herds. The coexistence of other non-pathogenic mycoplasmas in the herd further complicates the diagnosis of CA and the design of efficient strategies to control the disease. Routes of infection, such as the venereal route, may be involved in the establishment of chronic infection in herds. Current challenges include the need for improved diagnostic methods for detection of chronic and subclinical infections and for the design of more efficient vaccines.
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[Malacoplakia of the seminal vesicles. Case report and particularities].
Arch. Esp. Urol.
PUBLISHED: 04-17-2013
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Malacoplakia is a rare chronic granulomatous disorder that mostly affects the urogenital system. This article describes a case of uncommon location of this disease at the level of the seminal vesicles and the clinical, imaging and histological particularities of this medical entity.
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Home Advantage in Mens and Womens Spanish First and Second Division Water Polo Leagues.
J Hum Kinet
PUBLISHED: 03-25-2013
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The purpose of this study was to quantify the home advantage in both mens and womens First and Second Division water polo leagues, to compare the results obtained according to sex of participants and the level of competition, and to test for possible differences in home advantage when considering the interaction between these two factors. The sample comprised four seasons from 2007-2008 to 2010-2011 for a total of 1942 games analyzed. The results showed the existence of home advantage in both mens and womens First and Second Divisions. After controlling for the competitive balance of each league in each season, there was a significant difference between mens and womens leagues, with higher home advantage for mens leagues (58.60% compared with 53.70% for womens leagues). There was also a significant difference between the levels of competition, with greater home advantage for the Second Division (57.95% compared with 54.35% for First Division). No significant differences in home advantage were found when considering the interaction between sex of participants and the level of competition. The results in relation to sex of participants and the level of competition are consistent with previous studies in other sports such as football or handball.
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Development of a system based on 3D vision, interactive virtual environments, ergonometric signals and a humanoid for stroke rehabilitation.
Comput Methods Programs Biomed
PUBLISHED: 03-12-2013
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This paper presents a stroke rehabilitation (SR) system for the upper limbs, developed as an interactive virtual environment (IVE) based on a commercial 3D vision system (a Microsoft Kinect), a humanoid robot (an Aldebarans Nao), and devices producing ergonometric signals. In one environment, the rehabilitation routines, developed by specialists, are presented to the patient simultaneously by the humanoid and an avatar inside the IVE. The patient follows the rehabilitation task, while his avatar copies his gestures that are captured by the Kinect 3D vision system. The information of the patient movements, together with the signals obtained from the ergonometric measurement devices, is used also to supervise and to evaluate the rehabilitation progress. The IVE can also present an RGB image of the patient. In another environment, that uses the same base elements, four game routines--Touch the balls 1 and 2, Simon says, and Follow the point--are used for rehabilitation. These environments are designed to create a positive influence in the rehabilitation process, reduce costs, and engage the patient.
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Prediction of acid hydrolysis of lignocellulosic materials in batch and plug flow reactors.
Bioresour. Technol.
PUBLISHED: 03-05-2013
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This study unifies contradictory conclusions reported in literature on acid hydrolysis of lignocellulosic materials, using batch and plug flow reactors, regarding the influence of the initial liquid ratio of acid aqueous solution to solid lignocellulosic material on sugar yield and concentration. The proposed model takes into account the volume change of the reaction media during the hydrolysis process. An error lower than 8% was found between predictions, using a single set of kinetic parameters for several liquid to solid ratios, and reported experimental data for batch and plug flow reactors. For low liquid-solid ratios, the poor wetting and the acid neutralization, due to the ash presented in the solid, will both reduce the sugar yield. Also, this study shows that both reactors are basically equivalent in terms of the influence of the liquid to solid ratio on xylose and glucose yield.
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Higher doses of CD34+ progenitors are associated with improved overall survival without increasing GVHD in reduced intensity conditioning allogeneic transplant recipients with clinically advanced disease.
J Clin Apher
PUBLISHED: 03-04-2013
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The influence of CD34+ cell dose on the outcome of allogeneic peripheral blood stem cell (PBSC) transplantation after reduced intensity conditioning (RIC) remains controversial. The impact of the number of CD34+ hematoprogenitors infused on transplant outcome and on the incidence of graft versus host disease (GVHD) was analyzed.
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A ubiquitous NFC solution for the development of tailored marketing strategies based on discount vouchers and loyalty cards.
Sensors (Basel)
PUBLISHED: 03-04-2013
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Because of the global economic turmoil, nowadays a lot of companies are adopting a "deal of the day" business model, some of them with great success. Generally, they try to attract and retain customers through discount coupons and gift cards, using, generally, traditional distribution media. This paper describes a framework, which integrates intelligent environments by using NFC, oriented to the full management of this kind of businesses. The system is responsible for diffusion, distribution, sourcing, validation, redemption and managing of vouchers, loyalty cards and all kind of mobile coupons using NFC, as well as QR codes. WingBonus can be fully adapted to the requirements of marketing campaigns, voucher providers, shop or retailer infrastructures and mobile devices and purchasing habits. Security of the voucher is granted by the system by synchronizing procedures using secure encriptation algorithms. The WingBonus website and mobile applications can be adapted to any requirement of the system actors.
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Responses to endorsement of commonality by ingroup and outgroup members: the roles of group representation and threat.
Pers Soc Psychol Bull
PUBLISHED: 03-01-2013
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Two experiments integrated research on the roles of common identity and social norms in intergroup orientations. Experiment 1 demonstrated that learning that ingroup members categorized the ingroup (Spaniards) and outgroup (Eastern European immigrants) within a common identity (European) produced more positive intergroup orientations toward immigrants. By contrast, learning that outgroup members held the same position elicited less positive orientations compared with a condition in which the information came from a neutral source. The effects were mediated by one-group representations. Experiment 2 also found that endorsement of a common identity generated more positive intergroup orientations when it was expressed by ingroup than outgroup members and revealed how this effect may be sequentially mediated by personal one-group representations and symbolic threat.
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Immunization with an HPV-16 L1-based chimeric virus-like particle containing HPV-16 E6 and E7 epitopes elicits long-lasting prophylactic and therapeutic efficacy in an HPV-16 tumor mice model.
Arch. Virol.
PUBLISHED: 02-23-2013
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HPV L1-based virus-like particles vaccines (VLPs) efficiently induce temporary prophylactic activity through the induction of neutralizing antibodies; however, VLPs that can provide prophylactic as well as therapeutic properties for longer periods of time are needed. For this purpose, we generated a novel HPV 16 L1-based chimeric virus-like particle (cVLP) produced in plants that contains a string of T-cell epitopes from HPV 16 E6 and E7 fused to its C-terminus. In the present study, we analyzed the persistence of specific IgG antibodies with neutralizing activity induced by immunization with these cVLPs, as well as their therapeutic potential in a tumor model of C57BL/6 mice. We observed that these cVLPs induced persistent IgG antibodies for over 12 months, with reactivity and neutralizing activity for VLPs composed of only the HPV-16 L1 protein. Efficient protection for long periods of time and inhibition of tumor growth induced by TC-1 tumor cells expressing HPV-16 E6/E7 oncoproteins, as well as significant tumor reduction (57 %), were observed in mice immunized with these cVLPs. Finally, we discuss the possibility that chimeric particles of the type described in this work may be the basis for developing HPV prophylactic and therapeutic vaccines with high efficacy.
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[Imported hookworm infection in Almeria].
Enferm. Infecc. Microbiol. Clin.
PUBLISHED: 02-10-2013
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To study the clinical and epidemiological characteristics of immigrant patients diagnosed with a hookworm infection in the Tropical Medicine Unit of the Hospital de Poniente in El Ejido (Almería, Spain).
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Short communication: peptide profiling in cheeses packed using different technologies.
J. Dairy Sci.
PUBLISHED: 02-04-2013
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Peptides released during the shelf life of cheeses packaged using 2 different technologies, vacuum packaging (VP) and modified-atmosphere packaging (MAP), were identified by on-line reverse phase-HPLC-tandem mass spectrometry. A total of 22 peptides from the N-terminal domain of ?S1-casein (CN) and 26 from ?-CN were identified, the latter more evenly distributed over the whole sequence. Peptides were monitored during the shelf life of these cheeses when stored at 4°C, revealing that the peptide profile changed significantly with the storage time. Qualitative differences between VP and MAP cheeses were only found for 3 ?S1-CN peptides, which were absent in MAP cheeses. Semiquantitative analysis of peptides revealed some differences between cheeses packaged using different technologies. However, evolution of peptides during storage followed a common trend in both types of cheeses. In addition, the presence of certain peptides, which had been previously described because of their potential bioactivity, is illustrated. For instance, some of the identified peptides had been previously reported as antihypertensive peptides, such as peptide ?S1-CN (1-9) or ?-CN f(201-209).
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QSAR model based on weighted MCS trees approach for the representation of molecule data sets.
J. Comput. Aided Mol. Des.
PUBLISHED: 02-01-2013
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In this paper we propose a new method for the generation of 2D-QSAR models for the prediction of activity values of chemicals. Maximum common substructures which are extracted from the data set are used for molecule classification in a tree, where the node of the tree represents molecules or common structures to groups of molecules and the arcs of the tree represent non isomorphic substructures between two nodes of the tree. All paths between pairwise leaf nodes are used to represent the equation system used as representational space in the building of the QSAR model. The proposed model, which is based on the combining of non isomorphic structures, use of molecular descriptors for the calculation of path lengths and classification of the data set based on maximum common substructures, considerably improves the generation of QSAR models with regard to the classical model based only on the use of a set of molecular descriptors. Optimization algorithms based on genetic algorithm and differential evolution approximations have also been used, resulting in the improvement and refinement of the equations obtained.
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Executive summary. Management of influenza infection in solid-organ transplant recipients: consensus statement of the Group for the Study of Infection in Transplant Recipients (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiolo
Enferm. Infecc. Microbiol. Clin.
PUBLISHED: 01-23-2013
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Solid organ transplant (SOT) recipients are at greater risk than the general population for complications and mortality from influenza infection. We have conducted a systematic review to assess the management and prevention of influenza infection in SOT recipients. Recommendations are provided about the procurement of organs from donors with influenza infection. We highlight the importance of the possibility of influenza infection in any SOT recipient presenting upper or lower respiratory symptoms, including pneumonia. The importance of early antiviral treatment of SOT recipients with suspected or confirmed influenza infection and the necessity of annual influenza vaccination are emphasized. The microbiological techniques for diagnosis of influenza infection are reviewed. Guidelines for the use of antiviral prophylaxis are provided. Recommendations for household contacts of SOT recipients with influenza infection and health care workers are also included. Antiviral dose adjustment guidelines are presented for cases of impaired renal function and for pediatric populations.
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Removal performance of heavy metals in MBR systems and their influence in water reuse.
Water Sci. Technol.
PUBLISHED: 01-12-2013
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The removal performance of heavy metals by two experimental full-scale membrane bioreactors (microfiltration and ultrafiltration) and the influence of activated sludge total suspended solid (TSS) concentration were studied under real operational conditions. Influent and effluent Be, Sc, V, Cr, Mn, Co, Ni, Cu, Zn, As, Mo, Cd, Ba, Sn, Sb, Pb and U concentrations were analysed by inductively coupled plasma-mass spectrometry. An average contamination rate for most of the analysed heavy metals was observed in raw wastewater, resulting in effluents without limitation for reuse in agricultural destinations according to Spanish law. Removal efficiencies up to 80% were obtained regardless of whether microfiltration or ultrafiltration membranes were used, except for As, Mo and Sb. The removal yields of different heavy metals can be strengthened by increasing the activated sludge TSS concentration, mainly at concentrations above 10 g/L.
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Outcome of critically ill patients with hematological malignancies.
Ann. Hematol.
PUBLISHED: 01-04-2013
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The prognosis for patients with hematological malignancies (HMs) admitted to the intensive care unit (ICU) is poor. The objective of this study was to evaluate the clinical characteristics and hospital outcomes of critically ill patients with HMs admitted to an oncological ICU. This is a prospective, observational cohort study. A total of 102 patients with HMs admitted to ICU from January 2008 to April 2011 were included. Univariate and multivariate logistic regressions were used to identify factors associated with hospital mortality. During the study period, 3,776 patients with HM were admitted to the Department of Hematology of the Instituto Nacional de Cancerología located in Mexico City, Mexico. After being evaluated by the intensivist, 102 (2.68 %) patients were admitted to the ICU. The ICU mortality rates for patients who had two or less organ system failures and for those with three or more organ system dysfunctions were 20 % (5/25) and 70.1 % (54/77), respectively (P?106 ?mol/L (OR, 3.21; 95 % CI, 1.05-9.85, P?=?0.041). The ICU and hospital mortality rates were 46.1 and 57.8 %, respectively. The independent prognostic factors of in-hospital death were the need for invasive mechanical ventilation, the need for vasopressors, serum creatinine >106 ?mol/L, and neutropenia at the time of ICU admission.
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Dynamics of an infectious keratoconjunctivitis outbreak by Mycoplasma conjunctivae on Pyrenean Chamois Rupicapra p. pyrenaica.
PLoS ONE
PUBLISHED: 01-01-2013
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Between 2006 and 2008, an outbreak of Infectious Keratoconjunctivitis (IKC) affected Pyrenean chamois Rupicapra p. pyrenaica, an endemic subspecies of mountain ungulate that lives in the Pyrenees. The study focused on 14 mountain massifs (180,000 ha) where the species population is stable. Cases of IKC were detected in ten of the massifs and, in five of them, mortality was substantial. The outbreak spread quickly from the first location detected, with two peaks in mortality that affected one (2007) and three (2008) massifs. In the latter, the peak was seasonal (spring to autumn) and, in the former, the outbreak persisted through winter. To identify the outbreaks aetiology, we examined 105 Pyrenean chamois clinically affected with IKC. TaqMan rt-PCR identified Mycoplasma conjunctivae in 93 (88.5%) of the chamois. Another rt-PCR detected Chlamydophila spp. in 14 of chamois, and 12 of those had mixed infections with mycoplasmas. In the period 2000-2007, the chamois population increased slightly (? 1.026) but decreased significantly during the IKC outbreak (? 0.8, 2007-2008; ? 0.85, 2008-2009) before increasing significantly after the outbreak (? 1.1, 2009-2010). Sex-biased mortality shifted the adult sex ratio toward males (from 0.6 to 0.7 males per female) and reduced productivity slightly. Hunting was practically banned in the massifs where chamois experienced significant mortality and allowed again after the outbreak ended. Long-term monitoring of wild populations provides a basis for understanding the impacts of disease outbreaks and improves management decisions, particularly when species are subject to extractive exploitation.
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Gastric cancer in young people under 30 years of age: worse prognosis, or delay in diagnosis?
Cancer Manag Res
PUBLISHED: 01-01-2013
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Gastric cancer is an aggressive disease with nonspecific early symptoms. Its incidence and prognosis in young patients has shown considerable variability.
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Rejected and excluded forevermore, but even more devoted: irrevocable ostracism intensifies loyalty to the group among identity-fused persons.
Pers Soc Psychol Bull
PUBLISHED: 11-03-2011
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When people are ostrasized (i.e., rejected and excluded) by either an outgroup or an ingroup, they may either withdraw or engage in compensatory activities designed to reaffirm their social identity as a group member. The authors proposed here that individual differences in identity fusion (an index of familial orientation toward the group) would moderate the tendency for people to display such compensatory activity. Consistent with this reasoning, the results of four experiments showed that irrevocable ostracism increased endorsement of extreme, pro-group actions (fighting and dying for the ingroup) among fused persons but not among nonfused persons. This effect emerged when an outgroup ostracized fused individuals due either to their nationality (Experiment 1) or their personal preferences (Experiment 2). Similarly, ostracism by the ingroup amplified the tendency for fused persons to both endorse extreme pro-group actions, refuse to leave the group (Experiment 3), and donate money to an ingroup member (Experiment 4). Finally, compensatory activities emerged even when ostracism was based on being "too good" for the group, suggesting that a desire for self-enhancement does not mediate such activities (Experiment 4).
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Surfactant and perfluorocarbon aerosolization during different mechanical ventilation strategies by means of inhalation catheters: an in vitro study.
J Aerosol Med Pulm Drug Deliv
PUBLISHED: 11-01-2011
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Aerosol delivery of surfactant and perfluorocarbon (PFC) is a desirable therapeutic approach for the treatment of various lung diseases in patients undergoing mechanical ventilation. However, the behavior of these substances during aerosolization differs significantly from that of aqueous solutions. In particular, the high vapor pressure of many PFCs tends to result in greater evaporation during mechanical ventilation.
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Temporal bone trauma and the role of multidetector CT in the emergency department.
Radiographics
PUBLISHED: 10-15-2011
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The temporal bone anatomy is complex, with many critical structures in close association with one another. The temporal bone region comprises cranial nerves V, VI, VII, and VIII; vascular structures such as the internal carotid and middle meningeal arteries; sigmoid sinus; jugular bulb; and sensorineural and membranous structures of the inner ear. Most temporal bone fractures are a result of high-energy blunt head trauma. Multidetector computed tomography (CT) plays a fundamental role in the initial evaluation of patients with polytrauma in the emergency department. Multidetector CT may help identify important structural injuries that may have devastating complications such as sensorineural hearing loss, conductive hearing loss, dizziness and balance dysfunction, perilymphatic fistulas, cerebrospinal fluid leaks, facial nerve paralysis, and vascular injury. Although classifying temporal bone fractures helps physicians understand and predict trauma-associated complications and guide treatment, identifying injury to critical structures is more important for guiding management and determining prognosis than is simply classifying temporal bone fractures into a general category. Many temporal bone fractures and complications may be readily identified and characterized at routine cervical, maxillofacial, and head multidetector CT performed in patients with polytrauma, without the need for dedicated temporal bone multidetector CT. Dedicated temporal bone multidetector CT should be considered when there is a high degree of suspicion for temporal bone fractures and no fractures are identified at head, cervical, or maxillofacial CT.
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Acute respiratory distress syndrome caused by influenza B virus infection in a patient with diffuse large B-cell lymphoma.
Case Rep Med
PUBLISHED: 07-30-2011
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Influenza B virus infections are less common than infections caused by influenza A virus in critically ill patients, but similar mortality rates have been observed for both influenza types. Pneumonia caused by influenza B virus is uncommon and has been reported in pediatric patients and previously healthy adults. Critically ill patients with pneumonia caused by influenza virus may develop acute respiratory distress syndrome. We describe the clinical course of a critically ill patient with diffuse large B-cell lymphoma nongerminal center B-cell phenotype who developed acute respiratory distress syndrome caused by influenza B virus infection. This paper emphasizes the need to suspect influenza B virus infection in critically ill immunocompromised patients with progressive deterioration of cardiopulmonary function despite treatment with antibiotics. Early initiation of neuraminidase inhibitor and the implementation of guidelines for management of severe sepsis and septic shock should be considered.
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Morbidity and mortality of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: national cancer institute, Mexico city, Mexico.
ISRN Oncol
PUBLISHED: 05-23-2011
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Peritoneal carcinomatosis (PC) is generally considered a lethal disease, with a poor prognosis. Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as a new approach for peritoneal surface disease. This study investigated the early experience with this combined modality treatment at a single institute. From January 2007 to March 2010, 24 patients were treated After aggressive CS, with HIPEC (cisplatin 25?mg/m(2)/L and mitomycin C 3.3?mg/m(2)/L was administered for 90-minutes at 40.5°?C). These data suggest that aggressive CRS with HIPEC for the treatment of PC may result in low mortality and acceptable morbidity. Rigorous patient selection, appropriate and prudent operative procedures were associated with encouraging results in our experience.
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Analysis and study of molecule data sets using snowflake diagrams of weighted maximum common subgraph trees.
J Chem Inf Model
PUBLISHED: 05-20-2011
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Isomorphism measures based on the maximum common subgraph (MCS) calculation are widely used in computational chemistry for classifying, screening, and predicting properties and biological activity within chemical databases. The development of a weighted hierarchical structure based on the MCS is described in this paper. Furthermore, a 2D representation model is proposed as the proper tool for the study and preliminary analysis of molecule data sets. The development process of the weighted MCS tree is open to the use of different approaches. By taking into account different molecular descriptors, similarity and distance measures in the weighted MCS tree, the relationships between the molecular property or the activity, and the variables considered for the building and display of the weighted MCS tree can be observed. Besides that, the representation model based on snowflake diagrams allows to display of those relationships as well as shows any existing degeneration, in order to detect any possible outlier that could be obtained during the development of predictive models and to extract new variables that can be used in the building of quantitative structure-activity relationship models.
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[Chronic health problems in schools].
Rev Enferm
PUBLISHED: 03-25-2011
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The presence of children with chronic diseases to school can be a concern for teachers, pupils and parents. Was conducted this study using auto reply survey in the Autonomous Community of Madrid (CAM). The questionnaire was sent to 1161 teachers. Seventy three recognize have a student with chronic diseases in their classrooms and 56% believe their presence will generate some degree of doubt or insecurity about the possibility of occurrence of acute complications. The main reason for it was the absence of explicit instructions on handling certain situations. They find some conditions can induce school absenteeism, difficulties for physical activity and excursions attendance. They agree that school is a good place for health education and expressed readiness to learn to improve their knowledge and skills in this regard.
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Surfactant and perfluorocarbon aerosolization by means of inhalation catheters for the treatment of respiratory distress syndrome: an in vitro study.
J Aerosol Med Pulm Drug Deliv
PUBLISHED: 03-16-2011
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The aerosolization of perfluorocarbons or surfactant has emerged as a feasible alternative to instillation, for the treatment of experimental respiratory distress syndrome. However, the biophysical properties that make these compounds useful in such therapies, significantly affect the performance of nebulizers. Therefore, in vitro studies are required to assess the suitability of new aerosolization technologies for use with these compounds.
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Critical care for patients with cancer.
Am J Hosp Palliat Care
PUBLISHED: 03-10-2011
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Malignancies are becoming increasingly common, especially as the population ages, and patients with cancer are likely to represent an increasing proportion of ICU populations. Advances in oncological and supportive care have led to improved prognosis and extension of survival time in patients with cancer. The National Institute Cancer located in Mexico City has an oncological ICU with 6 beds. During the biennium 2008-2009, 573 patients with cancer were admitted to the ICU. The mean age was 51 ± 16.36 years and 58.6% were women. The length of stay in the ICU was 2 days (interquartile range; 1-5). The 71.6% were surgical patients. The mortality rate was 15.9%. Patients with hemato-oncological cancer had higher ICU mortality rate than subgroup of critically ill patients with solid tumors (39.5% versus 11.9%). The course of organ dysfunction over first days of life-sustaining treatment before admission to ICU could be useful for physicians who treat critically ill cancer patients to detect patients who should be admitted to ICU to try to avoid the progression to multiple organ dysfunction. On the other hand, admission to the ICU should be offered to patients with newly diagnosed cancer and acute life-threatening cancer related events. The critical care of patients with cancer contribute and support to continue the fight against cancer.
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On the nature of identity fusion: insights into the construct and a new measure.
J Pers Soc Psychol
PUBLISHED: 03-02-2011
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Previous research has documented the consequences of feeling fused with a group; here we examine the nature of identity fusion. Specifically, we sought to determine what fusion is and the mediating mechanisms that lead fused individuals to make extraordinary sacrifices for their group. Guided by the assumption that fusion emphasizes the extent to which people develop relational ties to the group, we developed a measure designed to capture feelings of connectedness and reciprocal strength with the group. In 10 studies, the newly developed scale displayed predicted relationships with related measures, including an earlier (pictorial) measure of fusion and a measure of group identification. Also as expected, fusion scores were independent of several measures of personality and identity. Moreover, the scale predicted endorsement of extreme progroup behaviors with greater fidelity than did an earlier pictorial measure of identity fusion, which was, in turn, superior to a measure of group identification. Earlier evidence that the personal and social selves of fused persons are functionally equivalent was replicated, and it was shown that feelings of agency and invulnerability mediated the effects of fusion on extreme behavior. Finally, Spanish- and English-language versions of the verbal fusion scale showed similar factor structure as well as evidence of convergent, discriminant, and predictive validity in samples of Spaniards and Americans, as well as immigrants from 22 different countries. This work advances a new perspective on the interplay between social and personal identity.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.