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Find video protocols related to scientific articles indexed in Pubmed.
Timing of forearm deformity correction in a child with multiple hereditary exostosis.
Am J. Orthop.
PUBLISHED: 09-25-2014
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Multiple hereditary exostosis (MHE) can cause progressive skeletal deformities (eg, ulnar shortening, bowing, radial head dislocation) in the upper extremity. Various procedures have been used to correct forearm deformity in children with MHE. The timing of these procedures, however, is controversial. An 11-year-old boy with known MHE presented 7 months after onset of left elbow pain and loss of flexion-extension to 40° to 120°. Radiographs showed a distal ulna osteochondroma, ulnar shortening, bowing, and radial head dislocation. Eighteen months after ulnar osteotomy, radial head reduction, and external fixation, he had motion from 0° to 135°. This case demonstrates that later stage MHE-induced forearm deformities can be successfully surgically corrected. Given possible recurrence during growth, there may be an indication for waiting until the patient is closer to skeletal maturity before proceeding with corrective forearm procedures.
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Predicting the Need for Surgical Intervention in Patients With Idiopathic Clubfoot.
J Pediatr Orthop
PUBLISHED: 07-31-2014
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The purpose of this study was to determine the early factors associated with the need for surgical interventions in patients with idiopathic clubfoot treated with the Ponseti method.
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A radiographic study of pediatric ulnar anatomy.
J Pediatr Orthop
PUBLISHED: 03-05-2014
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The adult ulna has a unique bony architecture that has been described in the literature, but, to the best of our knowledge, the ulnar anatomy in children has not been described.
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Calcaneocuboid arthrodesis for recurrent clubfeet: what is the outcome at 17-year follow-up?
J Child Orthop
PUBLISHED: 01-07-2014
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Calcaneocuboid arthrodesis was used during revision clubfoot surgery in order to maintain midfoot correction. The purposes of this study were to determine: (1) functional level at 17-year follow-up compared to 5-year follow-up; (2) patients' current functional level, satisfaction, and pain; and (3) current arthropometric measurements.
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Achievement of gross motor milestones in children with idiopathic clubfoot treated with the Ponseti method.
J Pediatr Orthop
PUBLISHED: 06-19-2013
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The Ponseti method of idiopathic clubfoot treatment involves a series of weekly casts, a percutaneous Achilles tenotomy if needed, followed by wearing a foot abduction orthosis (FAO). Gross motor development of children with idiopathic clubfoot has not been examined. The purposes of this study were to determine the ages of achievement of gross motor milestones in children with clubfoot treated with Ponseti method and to compare those ages with historical normative developmental data.
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Treatment of SCFE in a healthy 5-year-old child: case report and review.
J Pediatr Orthop B
PUBLISHED: 09-29-2011
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Slipped capital femoral epiphysis is a common adolescent hip disorder and when patients present at an age younger than 10 years, it is atypical and there is often some identifiable associated metabolic or endocrinologic abnormality. We present the case of a 5-year-old boy with idiopathic bilateral slipped capital femoral epiphysis. This patient underwent staged bilateral pinning in situ using a uniquely modified screw where the distal threads were machined-off for smooth fixation across the physis. The patient had an unremarkable postoperative course and showed evidence of remodeling and patent physes at 1-year follow-up.
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Correction of clubfoot deformity associated with Weber type I tibial hemimelia using the Ponseti method.
Bull NYU Hosp Jt Dis
PUBLISHED: 12-18-2010
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The clubfoot deformity associated with Weber type I tibial hemimelia, a rare congenital disorder, is rigid and difficult to correct. Surgeons have utilized a variety of treatment methods. Since the 1960s, some adopted the Syme amputation to produce a weightbearing lower limb. Others began to explore alternatives such as the Ilizarov technique, ankle reconstruction, and casting, which salvage the foot but have produced mixed results. The current investigators suggest that the Ponseti method, a minimally invasive technique, can produce a functional weightbearing foot. Two cases were treated with the Ponseti method, including a percutaneous Achilles tenotomy and post-cast bracing. After a minimum of 2-years follow-up, both are ambulatory.
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Clubfoot classification: correlation with Ponseti cast treatment.
J Pediatr Orthop
PUBLISHED: 09-25-2010
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Many different clubfoot classification systems have been proposed, but no single one is universally accepted. Two frequently cited systems, developed by Dimeglio/Bensahel and Catterall/Pirani, are often used for evaluation purposes in the treatment of idiopathic clubfoot. Our hypothesis was that the initial scores would be positively correlated with the number of casts required for clubfoot correction, indicating to us that the more severe score would require more casts, and therefore truly show the accuracy and usefulness of the scoring system.
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Adaptive time-variant models for fuzzy-time-series forecasting.
IEEE Trans Syst Man Cybern B Cybern
PUBLISHED: 03-22-2010
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A fuzzy time series has been applied to the prediction of enrollment, temperature, stock indices, and other domains. Related studies mainly focus on three factors, namely, the partition of discourse, the content of forecasting rules, and the methods of defuzzification, all of which greatly influence the prediction accuracy of forecasting models. These studies use fixed analysis window sizes for forecasting. In this paper, an adaptive time-variant fuzzy-time-series forecasting model (ATVF) is proposed to improve forecasting accuracy. The proposed model automatically adapts the analysis window size of fuzzy time series based on the prediction accuracy in the training phase and uses heuristic rules to generate forecasting values in the testing phase. The performance of the ATVF model is tested using both simulated and actual time series including the enrollments at the University of Alabama, Tuscaloosa, and the Taiwan Stock Exchange Capitalization Weighted Stock Index (TAIEX). The experiment results show that the proposed ATVF model achieves a significant improvement in forecasting accuracy as compared to other fuzzy-time-series forecasting models.
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Phase 1 clinical trials of the safety and immunogenicity of adjuvanted plasmid DNA vaccines encoding influenza A virus H5 hemagglutinin.
Vaccine
PUBLISHED: 01-09-2010
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Development of vaccines against highly pathogenic avian influenza virus H5N1 subtypes posing a pandemic threat remains a priority. Limitations in manufacturing capacity and production time of conventional inactivated vaccines highlight the need for additional approaches.
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Outcomes analysis after routine removal of implants in healthy pediatric patients.
J Pediatr Orthop B
PUBLISHED: 07-23-2009
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Routine removal of nonspinal, orthopedic implants from pediatric patients is a debated practice. The purpose of this study was to compare preremoval and postremoval outcome measures in children. Twenty-five patients, mean age 11.6 years, completed a pain scale and the Pediatric Outcomes Data Collection Instrument (PODCI). Many patients scored in the normal range of the PODCI before and after removal. Higher postoperative PODCI scores were found in patients without preoperative pain, and in patients with upper extremity versus lower extremity implants. In summary, routine removal of implants in children was carried out without complications and with some functional benefits.
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Chronic sarcoid arthritis presenting as an intra-articular knee mass.
J Clin Rheumatol
PUBLISHED: 05-21-2009
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Patients may present with a primary complaint of intra-articular knee masses causing mechanical symptoms of snapping or locking. If the history, physical examination, laboratory tests, and imaging studies point to a benign process, acceptable treatment consists of arthroscopic excision and postoperative pathology analysis. As reported in several case series, the final diagnosis can be pigmented villonodular synovitis, localized nodular synovitis, hemangioma, lipoma, or rheumatoid nodules. In this case presentation, a 39-year-old man with no previous medical conditions and a negative preoperative chest radiograph underwent arthroscopic surgery for a single intra-articular knee mass. The unexpected diagnosis, after pathology review and further medical work-up, was arthritis secondary to chronic sarcoidosis.
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Distal fibula malunions.
J Am Acad Orthop Surg
PUBLISHED: 03-25-2009
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Anatomic reduction and fixation of unstable ankle fractures is necessary to prevent posttraumatic arthritis. Malunion of the distal fibula in unstable ankle fractures may lead to progressive talar instability. Ankle fracture malunions often present with concomitant syndesmotic widening, which can cause surgeons to overlook changes in fibula length and rotation. The decision to proceed with surgery should be made only after a careful diagnostic workup and detailed preoperative discussion with the patient. Considerations for surgical management include location and orientation of a corrective osteotomy, use of structural graft, widening of the syndesmosis, assessment of reduction, and the need for medial exposure. Good and excellent clinical results after fibular reconstruction have been reported in 67% to 92% of ankles. Proper patient selection is critical, because ankle malunions can be complicated, with coexisting fibular, syndesmotic, medial, and posterior malleolar malalignment, along with degenerative joint disease. Understanding the indications and surgical technique for revising fibular malunions may obviate a future salvage procedure.
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A CMV DNA vaccine primes for memory immune responses to live-attenuated CMV (Towne strain).
Vaccine
PUBLISHED: 01-05-2009
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CMV-seronegative subjects vaccinated intramuscularly or intradermally with a DNA vaccine encoding pp65, IE1, and gB were administered live-attenuated CMV (Towne) to characterize immune priming by the DNA vaccine. CMV-specific memory T-cells (detected by standard ELISPOT assay in only 20% of subjects) were detected by IFN-gamma cultured ELISPOT assay in 60% of subjects primed intramuscularly and correlated with immune responses after Towne. The median time to first pp65 T-cell and gB antibody response after Towne was 14 days for DNA-primed subjects vs. 28 days for controls administered Towne only (p=0.02 and 0.03, respectively). Furthermore, there was a trend toward more DNA-vaccinated subjects than controls developing a gB-specific IFN-gamma T-cell response after Towne administration (47% vs. 0%, p=0.06).
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Vaxfectin-adjuvanted plasmid DNA vaccine improves protection and immunogenicity in a murine model of genital herpes infection.
J. Gen. Virol.
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The herpes simplex type 2 (HSV-2) envelope glycoprotein (gD2) was evaluated as a potential antigen candidate for a plasmid DNA (pDNA)-based HSV-2 vaccine. The pDNA was formulated with Vaxfectin, a cationic lipid-based adjuvant, and tested in a murine HSV-2 lethal challenge model. gD2 was expressed as full-length (FL) and secreted (S) gD2 forms. A 0.1 µg pDNA dose was tested to distinguish treatment conditions for survival and a 100 µg pDNA dose was tested to distinguish treatment conditions for reduction in vaginal and latent HSV-2 copies. Vaxfectin-formulated gD2 pDNA significantly increased serum IgG titres and survival for both FL gD2 and S gD2 compared with gD2 pDNA alone. Mice immunized with FL gD2 formulated with Vaxfectin showed reduction in vaginal and dorsal root ganglia (DRG) HSV-2 copies. The stringency of this protection was further evaluated by testing Vaxfectin-formulated FL gD2 pDNA at a high 500 LD(50) inoculum. At this high viral challenge, the 0.1 µg dose of FL gD2 Vaxfectin-formulated pDNA yielded 80?% survival compared with no survival for FL gD2 pDNA alone. Vaxfectin-formulated FL gD2 pDNA, administered at a 100 µg pDNA dose, significantly reduced HSV-2 DNA copy number, compared with FL gD2 DNA alone. In addition, 40?% of mice vaccinated with adjuvanted FL pDNA had no detectable HSV-2 viral genomes in the DRG, whereas all mice vaccinated with gD2 pDNA alone were positive for HSV-2 viral genomes. These results show the potential contribution of Vaxfectin-gD2 pDNA to a future multivalent HSV-2 vaccine.
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A novel therapeutic cytomegalovirus DNA vaccine in allogeneic haemopoietic stem-cell transplantation: a randomised, double-blind, placebo-controlled, phase 2 trial.
Lancet Infect Dis
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Cytomegalovirus reactivation occurs within 6 months in 60-70% of cytomegalovirus-seropositive patients after allogeneic haemopoietic stem-cell transplantation (HSCT), mainly due to immunosuppression associated with the procedure. Pre-emptive antiviral therapy reduces incidence of cytomegalovirus disease but can be toxic. To reduce the potential for disease and subsequent need for such antiviral drugs, we aimed to assess safety and efficacy of a cytomegalovirus therapeutic DNA vaccine compared with placebo.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.