JoVE Visualize What is visualize?
Stop Reading. Start Watching.
Advanced Search
Stop Reading. Start Watching.
Regular Search
Find video protocols related to scientific articles indexed in Pubmed.
Significant impact of the MTHFR polymorphisms and haplotypes on male infertility risk.
PLoS ONE
PUBLISHED: 01-01-2013
Show Abstract
Hide Abstract
Methylenetetrahydrofolate reductase (MTHFR) converts 5,10-methylene tetrahydrofolate to 5-methyl tetrahydrofolate and affects the activity of cellular cycles participating in nucleotide synthesis, DNA repair, genome stability, maintenance of methyl pool, and gene regulation. Genetically compromised MTHFR activity has been suggested to affect male fertility. The objective of the present study was to find the impact on infertility risk of c.203G>A, c.1298A>C, and c.1793G>A polymorphisms in the MTHFR gene.
Related JoVE Video
Does the place of fall influence the time to specialist treatment in patients sustaining hip fractures? A study of 4917 patients falling in four different settings.
Acta Orthop Belg
PUBLISHED: 06-15-2011
Show Abstract
Hide Abstract
Delay to treatment is a multifactorial issue for patients sustaining hip fractures. The place of fall could possibly impact on the time to specialist care. We aimed to investigate the correlation between the place where a hip fracture occurs, and the time to initiation of specialist fracture-specific treatment. We retrospectively analysed data that had been collected on 4917 consecutive hip fracture admissions to our unit. The recorded places of fall were divided into four groups, including those falling outside home, at home, residential or nursing home, and hospital inpatients respectively. A 24-hour scale was used to record times of fall and of initiation of treatment. The latter was the time of admission to Accident & Emergency for groups 1-3, and the time of referral to the Orthopaedic team for group 4.23.5% patients fell outside their own home (group 1), and presented at only 2 hours post-injury. Patients in both group 2 (47.7%) and group 3 (23.6%) presented after 3 hours. Group 4 (4.9%) patients had to wait a median of 8 hours being referred to the Orthopaedic team. We found an interesting correlation between the place of injury and the delay in receiving treatment, in that those patients already receiving maximal healthcare attention, had to wait the longest to be referred to specialist care.
Related JoVE Video
Pressure exerted by finger traps.
J Perioper Pract
PUBLISHED: 05-13-2011
Show Abstract
Hide Abstract
It is common practice in wrist arthroscopy to suspend the patients arm using Chinese finger traps and to distract the wrist joint by applying weight to the arm at the elbow. This may apply significant pressure to the fingers, and potentially damage the digital nerves. We examined the pressure applied by finger traps and considered whether this poses a risk to the digital nerves.
Related JoVE Video
Strong association of 677 C>T substitution in the MTHFR gene with male infertility--a study on an indian population and a meta-analysis.
PLoS ONE
PUBLISHED: 04-23-2011
Show Abstract
Hide Abstract
Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate and methionine metabolism, making it crucial for DNA synthesis and methylation. The objective of this study was to analyze MTHFR gene 677C>T polymorphism in infertile male individuals from North India, followed by a meta-analysis on our data and published studies.
Related JoVE Video
The evidence of low-intensity pulsed ultrasound for in vitro, animal and human fracture healing.
Br. Med. Bull.
PUBLISHED: 03-23-2011
Show Abstract
Hide Abstract
Physical stimulation therapies are currently available to enhance fracture healing.
Related JoVE Video
Achilles tendon ruptures in elite athletes.
Foot Ankle Int
PUBLISHED: 02-04-2011
Show Abstract
Hide Abstract
The management of Achilles tendon (AT) ruptures in elite athletes can be challenging. We performed a retrospective review of prospectively collected data study to evaluate the results of percutaneous repair of an acute AT rupture in elite athletes.
Related JoVE Video
Marked pathological changes proximal and distal to the site of rupture in acute Achilles tendon ruptures.
Knee Surg Sports Traumatol Arthrosc
PUBLISHED: 05-31-2010
Show Abstract
Hide Abstract
A laboratory study was performed to evaluate the histopathological features of the macroscopically intact portion of the Achilles tendon in patients undergoing surgery for an acute rupture of the Achilles tendon. Tendon samples were harvested from 29 individuals (21 men, 8 women; mean age: 46 ± 12) who underwent repair of an Achilles tendon tear tear, and from 11 male patients who died of cardiovascular events (mean age: 61). Three pieces of tendon were harvested: at the rupture site, 4 cm proximal to the site of rupture, 1 cm proximal to the insertion of the Achilles tendon on the calcaneum. Slides were assessed using a semiquantitative grading scale assessing fiber structure and arrangement, rounding of the nuclei, regional variations in cellularity, increased vascularity, decreased collagen stainability, and hyalinization. Intra-observer reliability of the subscore readings was calculated. The pathological features were significantly more pronounced in the samples taken from the site of rupture than in the samples taken proximally and distal to it (0.008 < P < 0.01). There were no significant differences in the mean pathologic sum-scores in the samples taken proximally and distal to the site of rupture. Unruptured Achilles tendons, even at an advanced age, and ruptured Achilles tendons are clearly part of two distinct populations, with the latter demonstrating histopathological evidence of failed healing response even in areas macroscopically normal.
Related JoVE Video
Achilles tendon ruptures in diabetic patients.
Arch Orthop Trauma Surg
PUBLISHED: 01-10-2010
Show Abstract
Hide Abstract
The aim of this study is to evaluate the results of percutaneous repair of an acute AT rupture in diabetic patients.
Related JoVE Video
The effects of LIPUS on soft-tissue healing: a review of literature.
Br. Med. Bull.
PUBLISHED: 10-06-2009
Show Abstract
Hide Abstract
Ultrasound is widely used for imaging purposes and as an adjunct to physiotherapy. Low-intensity pulsed ultrasound (LIPUS), having removed the thermal component found at higher intensities, is used to improve bone healing. However, its potential role in soft-tissue healing is still under investigation.
Related JoVE Video
History and evolution in total ankle arthroplasty.
Br. Med. Bull.
PUBLISHED: 10-06-2009
Show Abstract
Hide Abstract
The current study provides an overview of history and evolution in total ankle arthroplasty.
Related JoVE Video
Modalities in prevention of flexor tendon adhesion in the hand: what have we achieved so far?
Acta Orthop Belg
PUBLISHED: 09-25-2009
Show Abstract
Hide Abstract
Several modifications in surgical techniques and various pharmacological and non pharmacological modalities have been introduced to prevent adhesions formation in surgery on flexor tendons of the hand. However, most studies have been carried out in animals with very few human trials. Only early postoperative rehabilitation is supported by clinical evidence, while the optimal rehabilitation protocol remains controversial. Innovations in surgical techniques and other modalities need to be tested with adequately powered human trials, before their potential benefit in clinical practice is accepted.
Related JoVE Video
Minimally invasive total knee arthroplasty: a systematic review.
Orthop. Clin. North Am.
PUBLISHED: 09-24-2009
Show Abstract
Hide Abstract
The concept of minimally invasive total knee arthroplasty surgery evolved to reduce quadriceps muscle strength loss and improve clinical outcome following total knee replacement. We performed a systematic review of the published literature on Minimally Invasive Total Knee Arthroplasty (MITKA) and analyzed the reported surgical outcomes. Twenty-eight studies published from January 2003 to June 2008 that met the inclusion criteria were evaluated using the modified Coleman Methodology Score (CMS). At a mean CMS of 60, most studies reporting on outcome of MITKA are of moderate scientific quality. Patients undergoing MITKA tend to have decreased postoperative pain, rapid recovery of quadriceps function, reduced blood loss, improved range of motion (mostly reported as a short-term gain) and shorter hospital stay compared with patients undergoing standard total knee arthroplasty. These benefits, however, need to be balanced against the incidence of increased tourniquet time and increased incidence of component malalignment in the MITKA group. So far, the evidence based knowledge regarding results of MITKA comes from prospective studies of moderate quality with short follow up periods. Multicenter studies with longer follow-ups are needed to justify the long-term advantages of MITKA over standard total knee arthroplasty.
Related JoVE Video
Management of calcaneal fractures: systematic review of randomized trials.
Br. Med. Bull.
PUBLISHED: 09-03-2009
Show Abstract
Hide Abstract
The optimal management of calcaneal fractures is controversial, as correlation between anatomical restoration and outcome has not been proven, and complications after surgery are frequent.
Related JoVE Video
How successful are current ankle replacements?: a systematic review of the literature.
Clin. Orthop. Relat. Res.
PUBLISHED: 07-01-2009
Show Abstract
Hide Abstract
Total ankle arthroplasty provides an alternative to arthrodesis for management of ankle arthritis. What is the outcome of total ankle arthroplasty implants currently in use? We conducted a systematic literature search of studies reporting on the outcome of total ankle arthroplasty. We included peer-reviewed studies reporting on at least 20 total ankle arthroplasties with currently used implants, with a minimum followup of 2 years. The Coleman Methodology Score was used to evaluate the quality of the studies. Thirteen Level IV studies of overall good quality reporting on 1105 total ankle arthroplasties (234 Agility, 344 STAR, 153 Buechel-Pappas, 152 HINTEGRA, 98 Salto, 70 TNK, 54 Mobility) were included. Residual pain was common (range, 27%-60%), superficial wound complications occurred in 0% to 14.7%, deep infections occurred in 0% to 4.6% of ankles, and ankle function improved after total ankle arthroplasty. The overall failure rate was approximately 10% at 5 years with a wide range (range, 0%-32%) between different centers. Superiority of an implant design over another cannot be supported by the available data.
Related JoVE Video
Supination-external rotation ankle fractures: stability a key issue.
Clin. Orthop. Relat. Res.
PUBLISHED: 07-01-2009
Show Abstract
Hide Abstract
Stability is a key issue in treating supination-external rotation ankle fractures, but we do not know how it affects functional outcome and subsequent development of radiographic osteoarthritis. With a systematic literature review, we identified 11 clinical studies (Level IV evidence) published in peer-reviewed journals reporting on at least 10 ankles. Followup was at least 1 year. Two authors independently scored the quality of the studies using the modified Coleman Methodology Score; the mean score was 58 of 100, with substantial agreement between the two examiners. Four studies used a general health assessment questionnaire. Several literature limitations (debatable fracture stability criteria, few cohort studies with heterogeneous methodology, small patient numbers and limited followup in some studies) do not allow definitive conclusions. Of 213 stable fractures treated nonoperatively, 2.8% of ankles had radiographic osteoarthritis develop (18 years mean followup) and 84% were free of symptoms. The incidence of radiographic osteoarthritis in 420 unstable fractures treated operatively was 20.9% at 5.5 years versus 65.5% at 6.8 years in 137 ankles treated nonoperatively. The complication rate in 355 operatively treated fractures was 10.4%. A medial malleolus fracture, female gender, older age, higher American Society of Anesthesiologists grade, smoking, and lower educational level negatively influenced general health outcome, physical function, and pain.
Related JoVE Video
Posterior multifragmentation of the femoral neck: does it portend a poor outcome in internally fixed intracapsular hip fractures?
Injury
PUBLISHED: 06-10-2009
Show Abstract
Hide Abstract
To establish whether posterior multifragmentation of intracapsular proximal femoral fractures leads to an increased incidence of non-union and avascular necrosis following internal fixation by contemporary methods.
Related JoVE Video
Favorable outcome of percutaneous repair of achilles tendon ruptures in the elderly.
Clin. Orthop. Relat. Res.
PUBLISHED: 06-05-2009
Show Abstract
Hide Abstract
Percutaneous repair of Achilles tendon (AT) ruptures reportedly reduces the risk of rerupture compared to nonoperative treatment and reduces the risk of wound infection compared to open surgery. We retrospectively reviewed the postoperative Achilles tendon total rupture score (ATRS), and the maximum calf circumference in 35 patients over 65 years of age who sustained an acute tear of the AT and underwent percutaneous repair of the AT. There were 26 men and nine women with a mean age at operation of 73.4 +/- 8.7 years (range, 65-86 years). Of the 35 recruited patients, we report on 27 patients for whom we have a full data set. The minimum followup was 49 months (mean, 88 months; range, 49-110 months). The ATRS had a postoperative average rating of 69.4 +/- 14 (range, 56-93). All patients were able to bear weight fully on the affected limb by the eighth postoperative week. The data suggest that percutaneous repair of the AT is a suitable option for patients older than 65, producing similar outcomes when compared to percutaneous repair in younger patients of previous reports. Level of Evidence: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
Related JoVE Video
Open tibial fractures in the paediatric population: a systematic review of the literature.
Br. Med. Bull.
PUBLISHED: 05-27-2009
Show Abstract
Hide Abstract
Open tibial fractures have been studied extensively in adults, and detailed treatment strategies have been developed: wound irrigation and debridement, fracture stabilization and delayed primary wound closure or early flap coverage are basic principles of management. No clear guidelines regarding the management of open tibial fractures in children exist.
Related JoVE Video
Prevention of adhesions in surgery of the flexor tendons of the hand: what is the evidence?
Br. Med. Bull.
PUBLISHED: 04-24-2009
Show Abstract
Hide Abstract
Despite advances in knowledge and refinements of technique, the management of flexor tendon injuries within the digital sheath continues to present a formidable challenge. This in turn has led to a massive expansion in search of modified surgical therapies and various adjuvant therapies, which could prevent adhesion formation without compromising digital function.
Related JoVE Video
Management of unstable slipped upper femoral epiphysis: a meta-analysis.
Br. Med. Bull.
PUBLISHED: 04-17-2009
Show Abstract
Hide Abstract
The management of unstable slipped upper femoral epiphysis (SUFE) is controversial, with a high risk of developing avascular necrosis (AVN). We meta-analysed two areas of concern: reduction of the slip and the timing of treatment.
Related JoVE Video
Timing of surgery for hip fractures: a systematic review of 52 published studies involving 291,413 patients.
Injury
PUBLISHED: 01-08-2009
Show Abstract
Hide Abstract
In order to define the optimum timing of surgery for a hip fracture, we performed a systematic review of published evidence. Data was extracted by two independent reviewers and the methodology of each study was assessed. Fifty-two studies involving 291,413 patients were identified. Outcomes measured were mortality, post-operative complications, length of hospital stay and percentage of patients discharged home. We found no randomised trials. For the 25 studies involving 282,470 participants that undertook adjustment for confounding factors, early surgery was associated with a reduced hospital stay. These studies produced conflicting results regarding mortality and morbidity being increased or unaffected by delaying surgery. None of these studies reported any adverse outcomes for early surgery. Those studies with more careful methodology were less likely to report a beneficial effect of early surgery, particularly in relation to mortality. In conclusion early surgery (within 48h of admission) after a hip fracture reduces hospital stay and may also reduce complications and mortality.
Related JoVE Video

What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.