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Find video protocols related to scientific articles indexed in Pubmed.
Is thermochemotherapy with the Synergo system a viable treatment option in patients with recurrent non-muscle-invasive bladder cancer?
Int. J. Urol.
PUBLISHED: 05-09-2014
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To prospectively evaluate the outcome of combined microwave-induced bladder wall hyperthermia and intravesical mitomycin?C instillation (thermochemotherapy) in patients with recurrent non-muscle-invasive bladder cancer.
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Functional multiparametric magnetic resonance imaging of the kidneys using blood oxygen level dependent and diffusion-weighted sequences.
J. Urol.
PUBLISHED: 02-18-2014
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Little data are available on noninvasive magnetic resonance imaging based assessment of renal function during upper urinary tract obstruction. We determined whether functional multiparametric kidney magnetic resonance imaging could monitor the treatment response in cases of acute unilateral upper urinary tract obstruction.
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Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy.
Cancer Cell
PUBLISHED: 01-13-2014
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Muscle-invasive bladder cancers (MIBCs) are biologically heterogeneous and have widely variable clinical outcomes and responses to conventional chemotherapy. We discovered three molecular subtypes of MIBC that resembled established molecular subtypes of breast cancer. Basal MIBCs shared biomarkers with basal breast cancers and were characterized by p63 activation, squamous differentiation, and more aggressive disease at presentation. Luminal MIBCs contained features of active PPAR? and estrogen receptor transcription and were enriched with activating FGFR3 mutations and potential FGFR inhibitor sensitivity. p53-like MIBCs were consistently resistant to neoadjuvant methotrexate, vinblastine, doxorubicin and cisplatin chemotherapy, and all chemoresistant tumors adopted a p53-like phenotype after therapy. Our observations have important implications for prognostication, the future clinical development of targeted agents, and disease management with conventional chemotherapy.
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Unaltered oncological outcomes of radical cystectomy with extended lymphadenectomy over three decades.
BJU Int.
PUBLISHED: 06-26-2013
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To evaluate oncological outcome trends over the last three decades in patients after radical cystectomy (RC) and extended pelvic lymph node (LN) dissection.
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Stricture of the afferent isoperistaltic tubular segment: a late and rare cause of bilateral dilation of the upper urinary tract after ileal bladder substitution.
Urology
PUBLISHED: 04-10-2013
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To evaluate the etiology and treatment of bilateral hydronephrosis not responding to bladder substitute drainage after ileal bladder substitution using an afferent isoperistaltic tubular segment.
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Novel prototype sewing device, EndoSew®, for minimally invasive surgery: an extracorporeal ileal conduit construction pilot study in 10 patients.
BJU Int.
PUBLISHED: 03-15-2013
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WHATS KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: The EndoSew(®) prototype was first tested in a porcine model several years ago. The investigators found it both simple to master and reliable, its greatest advantage being a 2.4-fold time saving compared with straight laparoscopic suturing. In addition to that publication, there is a single case report describing the performance of an open EndoSew(®) suture to close parts (16?cm) of an ileal neobladder. The time for suturing the 16?cm ileum was 25?min, which is in line with our experience. The knowledge on this subject is limited to these two publications. We report on the first consecutive series of ileal conduits performed in humans using the novel prototype sewing device EndoSew(®). The study shows that the beginning and the end of the suture process represent the critical procedural steps. It also shows that, overall, the prototype sewing machine has the potential to facilitate the intracorporeal suturing required in reconstructive urology for construction of urinary diversions.
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Ureteroileal strictures after urinary diversion with an ileal segment-is there a place for endourological treatment at all?
J. Urol.
PUBLISHED: 02-13-2013
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We compared the long-term results of minimally invasive endourological intervention and open surgical revision in patients with a nonmalignant ureteroileal stricture.
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Fibroblast growth factor receptors-1 and -3 play distinct roles in the regulation of bladder cancer growth and metastasis: implications for therapeutic targeting.
PLoS ONE
PUBLISHED: 01-21-2013
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Fibroblast growth factor receptors (FGFRs) are activated by mutation and overexpressed in bladder cancers (BCs), and FGFR inhibitors are currently being evaluated in clinical trials in BC patients. However, BC cells display marked heterogeneity in their responses to FGFR inhibitors, and the biological mechanisms underlying this heterogeneity are not well defined. Here we used a novel inhibitor of FGFRs 1-3 and RNAi to determine the effects of inhibiting FGFR1 or FGFR3 in a panel of human BC cell lines. We observed that FGFR1 was expressed in BC cells that also expressed the "mesenchymal" markers ZEB1 and vimentin, whereas FGFR3 expression was restricted to the E-cadherin- and p63-positive "epithelial" subset. Sensitivity to the growth-inhibitory effects of BGJ-398 was also restricted to the "epithelial" BC cells and it correlated directly with FGFR3 mRNA levels but not with the presence of activating FGFR3 mutations. In contrast, BGJ-398 did not strongly inhibit proliferation but did block invasion in the "mesenchymal" BC cells in vitro. Similarly, BGJ-398 did not inhibit primary tumor growth but blocked the production of circulating tumor cells (CTCs) and the formation of lymph node and distant metastases in mice bearing orthotopically implanted "mesenchymal" UM-UC3 cells. Together, our data demonstrate that FGFR1 and FGFR3 have largely non-overlapping roles in regulating invasion/metastasis and proliferation in distinct "mesenchymal" and "epithelial" subsets of human BC cells. The results suggest that the tumor EMT phenotype will be an important determinant of the biological effects of FGFR inhibitors in patients.
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Lymphadenectomy for bladder cancer: indications and controversies.
Urol. Clin. North Am.
PUBLISHED: 11-03-2011
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Pelvic lymph node dissection (PLND) at the time of cystectomy remains the most accurate method of staging and can have a positive impact on cancer control, and there is general agreement as to its necessity at the time of surgery. There is, however, a lack of consensus regarding the terminology of PLND and controversy concerning the optimal extent of lymph node dissection, especially because recent investigations have suggested a survival benefit with extended PLND.
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Super extended versus extended pelvic lymph node dissection in patients undergoing radical cystectomy for bladder cancer: a comparative study.
J. Urol.
PUBLISHED: 02-17-2011
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There is evidence from retrospective studies that radical cystectomy with extended pelvic lymph node dissection provides better staging and outcomes than limited lymph node dissection. However, the optimal limits of extended lymph node dissection remain unclear. We compared oncological outcomes at 2 cystectomy centers where 2 different extended lymph node dissection templates are practiced to determine whether removing lymphatic tissue up to the inferior mesenteric artery confers an additional survival advantage.
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A prospective randomised trial comparing the modified HM3 with the MODULITH® SLX-F2 lithotripter.
Eur. Urol.
PUBLISHED: 01-14-2011
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The relative efficacy of first- versus last-generation lithotripters is unknown.
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Irrigation of continent catheterizable ileal pouches: tap water can replace sterile solutions because it is safe, easy, and economical.
Eur. Urol.
PUBLISHED: 01-03-2011
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Continent catheterizable ileal pouches require regular irrigations to reduce the risk of bacteriuria and urinary tract infections (UTIs).
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Computer aided surgery for percutaneous nephrolithotomy: Clinical requirement analysis and system design.
Conf Proc IEEE Eng Med Biol Soc
PUBLISHED: 11-25-2010
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Percutaneous nephrolithotomy (PCNL) for the treatment of renal stones and other related renal diseases has proved its efficacy and has stood the test of time compared with open surgical methods and extracorporeal shock wave lithotripsy. However, access to the collecting system of the kidney is not easy because the available intra-operative image modalities only provide a two dimensional view of the surgical scenario. With this lack of visual information, several punctures are often necessary which, increases the risk of renal bleeding, splanchnic, vascular or pulmonary injury, or damage to the collecting system which sometimes makes the continuation of the procedure impossible. In order to address this problem, this paper proposes a workflow for introduction of a stereotactic needle guidance system for PCNL procedures. An analysis of the imposed clinical requirements, and a instrument guidance approach to provide the physician with a more intuitive planning and visual guidance to access the collecting system of the kidney are presented.
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Readaptation of the peritoneum following extended pelvic lymphadenectomy and cystectomy has a significant beneficial impact on early postoperative recovery and complications: results of a prospective randomized trial.
Eur. Urol.
PUBLISHED: 09-09-2010
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Prolonged postoperative pain and delayed intestinal transit are frequent problems following extended pelvic lymph-node dissection (PLND) and cystectomy.
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A new multimodality technique accurately maps the primary lymphatic landing sites of the bladder.
Eur. Urol.
PUBLISHED: 10-09-2009
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Pathoanatomic studies have failed to map accurately the primary lymphatic landing sites of the urinary bladder.
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Noninvasive assessment of acute ureteral obstruction with diffusion-weighted MR imaging: a prospective study.
Radiology
PUBLISHED: 07-02-2009
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To prospectively assess the potential of noninvasive diffusion-weighted magnetic resonance (MR) imaging to depict changes in microperfusion and diffusion in patients with acute unilateral ureteral obstruction.
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Benign prostatic obstruction and parkinsons disease--should transurethral resection of the prostate be avoided?
J. Urol.
PUBLISHED: 03-17-2009
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According to the literature transurethral resection of the prostate in patients with Parkinsons disease has an increased risk of postoperative urinary incontinence. However, this conclusion might have been reached because some patients with multiple system atrophy incorrectly diagnosed as Parkinsons disease were included in these reports. Therefore, we investigated the outcome of transurethral prostate resection in patients with a secure neurological diagnosis of Parkinsons disease.
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Peri-interventional antibiotic prophylaxis only vs continuous low-dose antibiotic treatment in patients with JJ stents: a prospective randomised trial analysing the effect on urinary tract infections and stent-related symptoms.
BJU Int.
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To evaluate the antibiotic treatment regime in patients with indwelling JJ stents, the benefits and disadvantages of a peri-interventional antibiotic prophylaxis were compared with those of a continuous low-dose antibiotic treatment in a prospective randomised trial.
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Parenteral nutrition does not improve postoperative recovery from radical cystectomy: results of a prospective randomised trial.
Eur. Urol.
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After radical cystectomy, patients are in a catabolic state because of postoperative stress response, extensive wound healing, and ileus.
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Occlusion of seminal vesicles increases sexual activity in a mouse model.
Eur. Urol.
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Little is known about the physiologic role of seminal vesicles beyond their fertility function. It has been suggested repeatedly that seminal vesicles have an impact on sexual activity. Although this has been investigated in various animal models, such a role has never been found.
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Is bilateral extended pelvic lymphadenectomy necessary for strictly unilateral invasive bladder cancer?
J. Urol.
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We determined the necessary extent of pelvic lymph node dissection in patients with strictly unilateral bladder cancer.
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Outcome with Radical Cystectomy and Extended Lymphadenectomy Alone in Lymph Node Positive Bladder Cancer Patients Unfit for or Declining Adjuvant Chemotherapy.
BJU Int.
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? To analyze the long term outcome of lymph node (LN) positive bladder cancer patients following radical cystectomy (RC) and extended pelvic lymph node dissection (ePLND) who did not receive any adjuvant therapy PATIENTS AND METHODS: ? Retrospective, combined cohort analysis based on the two prospectively maintained cystectomy databases from the University of Southern California and the University of Bern ? Eligible patients underwent RC with ePLND for cN0M0 disease but turned out to be LN-positive ? None had neo-adjuvant therapy, all negative surgical margins ? Kaplan-Meier plots were used to estimate recurrence-free (RFS) and overall survival (OS), subgroup comparisons were performed with Log-rank tests, and multivariable analysis based on Cox proportional hazard models RESULTS: ? Of 521 LN-positive patients, 251 (48%) never received adjuvant therapy ? While pathological stage distribution was comparable, they were older and had both fewer total and positive LNs identified compared to those who underwent adjuvant therapy ? Median RFS for patients with surgery alone was 1.6y ? Recurrences mainly occurred within 2 years following RC resulting in 5- and 10-year RFS rates of 32% and 26%, respectively ? Pathological T-stage, total number of LNs and number of positive LNs identified were independent predictors of survival for RFS and OS CONCLUSIONS: ? 25% of patients with documented LN metastases not receiving adjuvant therapy were cured with RC and ePLND ? However, a few relapses may occur also later than three years ? redictors of survival are pathological T-stage, number of total LNs, and number of positive LNs identified.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.