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Find video protocols related to scientific articles indexed in Pubmed.
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Obesity-stroke paradox and initial neurological severity.
J. Neurol. Neurosurg. Psychiatr.
PUBLISHED: 09-12-2014
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An obesity paradox in patients with stroke has been documented. However, although the initial neurological severity (INS) is generally the most important prognostic factor, the impact of this paradox has not been considered in most previous studies. We sought to investigate the impact of obesity on INS in patients with ischaemic stroke and to investigate whether it is a significant risk factor for short-term outcomes.
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Effects of human adipose-derived stem cells on the regeneration of damaged visceral pleural mesothelial cells: a morphological study in a rabbit model.
Interact Cardiovasc Thorac Surg
PUBLISHED: 05-28-2014
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Although an alveolar air leak (AAL) after pulmonary resection is a troublesome complication that diminishes a patient's quality of life and increases medical costs, current treatment and preventive methods for AAL are not effective. Therefore, we transplanted adipose-derived stem cells (ASCs) to the damaged visceral pleura to facilitate the regeneration of mesothelial cells and investigated the possibility of cell therapy as a treatment option for AAL.
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Recurrent intractable hiccups treated by cervical phrenic nerve block under electromyography: report of a case.
Surg. Today
PUBLISHED: 03-20-2014
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Intractable or persistent hiccups require intensive or invasive treatments. The use of a phrenic nerve block or destructive treatment for intractable hiccups has been reported to be a useful and discrete method that might be valuable to patients with this distressing problem and for whom diverse management efforts have failed. We herein report a successful treatment using a removable and adjustable ligature for the phrenic nerve in a patient with recurrent and intractable hiccups, which was employed under the guidance of electromyography.
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Changes of cardiac troponin I and operative mortality of coronary artery bypass.
Asian Cardiovasc Thorac Ann
PUBLISHED: 03-04-2014
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Recently, cardiac troponin I has been used to detect myocardial injury because of its superior cardiac specificity. However, there has been debate about the appropriate timing and cutoff level of cardiac troponin I to detect perioperative myocardial injury after coronary artery bypass grafting. The objective of this study was to define the relationship between operative mortality and changes in cardiac troponin I after isolated coronary artery bypass.
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High serum alkaline phosphatase in relation to cerebral small vessel disease.
Atherosclerosis
PUBLISHED: 01-29-2014
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Vascular calcification is related with cerebral small vessel disease. We investigated whether alkaline phosphatase (ALP), a marker of vascular calcificiation, is related to cerebral small vessel disease.
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Intrapulmonary recurrence after computed tomography-guided percutaneous needle biopsy of stage I lung cancer.
J Thorac Dis
PUBLISHED: 01-06-2014
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Tumor seeding, along the needle tract after percutaneous needle biopsy, is a rare condition and most of the reported cases are implantation metastasis, which occurred in the chest wall or the pleura. We present a case of implantation metastasis that occurred in the pulmonary parenchyma, after a computed tomography-guided percutaneous needle biopsy (CT-PNB) of stage I lung cancer.
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Paradoxical effect of obesity on hemorrhagic transformation after acute ischemic stroke.
BMC Neurol
PUBLISHED: 09-18-2013
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Among the patients with established coronary artery diseases, obese patients tend to have a more favorable prognosis, which is called as obesity paradox. Interestingly, mildly obese patients who underwent coronary revascularization had a lower risk of bleeding. In this context, we have investigated the association between obesity and hemorrhagic transformation (HTf) after acute ischemic stroke.
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Tension pneumothorax, is it a really life-threatening condition?
J Cardiothorac Surg
PUBLISHED: 06-17-2013
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Tension pneumothorax is a life-threatening occurrence that is infrequently the consequence of spontaneous pneumothorax. The aim of this study was to identify the risk factors for the development of tension pneumothorax and its effect on clinical outcomes.
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Intractable hiccup accompanying pleural effusion: reversible clipping of an intrathoracic phrenic nerve.
Surg Laparosc Endosc Percutan Tech
PUBLISHED: 06-12-2013
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Hiccup is usually a self-limiting condition, and can be treated with medications and physical maneuvers. However, hiccup episodes continuing for days or weeks can be incapacitating, and disturb work, sleep, and eating. Therefore, timely therapeutic intervention is needed to achieve early resolution of this treatable condition. We report on a successful phrenic nerve block for intractable hiccups, which consisted of thoracoscopic nerve clipping under general anesthesia and reversal under local anesthesia. This method has the advantage of assured diaphragmatic functional recovery while controlling intractable hiccups.
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Reexpansion pulmonary edema after treatment of simultaneous bilateral spontaneous tension pneumothorax.
J Cardiothorac Surg
PUBLISHED: 03-26-2013
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We report a case of 46-year-old male with simultaneous bilateral spontaneous tension pneumothorax. Severe reexpansion pulmonary edema developed after bilateral tube thoracoscomy, but he was recovered after 2 days ventilator care. After bilateral wedge resection and talc pleurodesis, he was discharged without complications and had remained well and without recurrence during the 8-year follow-up.
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Detrimental effects of leptin on intracerebral hemorrhage via the STAT3 signal pathway.
J. Cereb. Blood Flow Metab.
PUBLISHED: 03-06-2013
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Leptin, one of the most important adipokines, is not only an energy regulator but also a regulator of innate immunity. Inflammation plays a key role in the tissue damage after intracerebral hemorrhage (ICH), and we sought to investigate whether leptin has a detrimental effect on ICH. After the injection of a high replacement dose (0.04?mg/kg) and two pharmacologic doses (4 and 8?mg/kg) of leptin, brain water contents increased significantly compared with that of control mice (P<0.05), which was confirmed when comparing the results with leptin-deficient ob/ob and wild-type (WT) mice (78.8%±0.6% versus 79.7%±0.6%, P<0.05). The number of Ox6-positive microglia/macrophages was increased in the leptin-injected group and decreased in ob/ob compared with WT mice. Among the candidate signal transducers, an increase in signal transduction and activator of transcription 3 (STAT3) levels was found after leptin injection. When we administered NSC74859, a specific inhibitor of phosphorylated STAT3 (pSTAT3), the water content became normalized. Activity of pSTAT3 was found mainly in Ox6-positive microglia/macrophages, but not in either neurons or astrocytes. We demonstrate that leptin plays a critical role in the secondary brain injury around a hematoma and is a novel mediator of the inflammation. This detrimental effect of leptin on ICH is mediated by the STAT3 signaling pathway in inflammatory cells.
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Risk factors for the development of reexpansion pulmonary edema in patients with spontaneous pneumothorax.
J Cardiothorac Surg
PUBLISHED: 02-26-2013
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Reexpansion pulmonary edema (REPE) is known as a rare and fatal complication after tube thoracostomy.
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Primary idiopathic silent chylopericardium.
J Cardiothorac Surg
PUBLISHED: 02-13-2013
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Chylopericardium usually occurs secondary to trauma, cardiothoracic surgery, radiation therapy, or neoplasm of the mediastinum. Idiopathic chylopericardium is extremely rare. We report a case of primary chylopericardium in a 79-year-old male patient. Although pericardial window and thoracic duct ligation are the treatment of choice, the patient has been doing well for six months since video-assisted thoracoscopic pericardial window.
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Extents of white matter lesions and increased intraventricular extension of intracerebral hemorrhage.
Crit. Care Med.
PUBLISHED: 02-08-2013
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To determine whether the extent of white matter lesions on a CT scan of acute intracerebral hemorrhage patients is associated with the prevalence and severity of intraventricular extension of hemorrhage.
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Serum uric acid levels and cerebral microbleeds in patients with acute ischemic stroke.
PLoS ONE
PUBLISHED: 01-25-2013
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Unlike experimental studies indicating a neuroprotective property of uric acid, clinical studies have shown that elevated levels of uric acid are associated with a risk of ischemic stroke. However, the association of uric acid with cerebral hemorrhage has seldom been tested. We aimed to elucidate the association between uric acid and cerebral microbleeds (CMBs), a hemorrhage-prone cerebral microangiopathy. Seven hundred twenty-four patients with ischemic stroke who were consecutively admitted to our hospital were included in this study. We collected demographic, clinical, and laboratory data, including uric acid level, and examined the presence of CMBs using T2*-weighted gradient-echo MRI. We used logistic regression analysis to examine an independent association between uric acid and CMBs. Two-hundred twenty-six patients had CMBs (31.2%). After adjusting for possible confounders, elevated uric acid was independently associated with the presence of CMBs (the highest quartile vs. lowest quartile, adjusted odd ratio [OR], 1.98; 95% confidence interval [CI], 1.16-3.39). This association retained in patients with deep or infratentorial CMBs (with or without lobar CMBs) but not among those with lobar CMBs. In addition, this association was robust among patients with hypertension (the highest quartile vs. lowest quartile, adjusted OR, 2.74; 95% CI, 1.43-5.24). In contrast, we did not find the association in patients without hypertension. We demonstrated that serum uric acid is independently associated with the presence of CMBs. In particular, the relation between uric acid and CMBs was robust in hypertensive patients.
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Recurrent cervical esophageal stenosis after colon conduit failure: use of myocutaneous flap.
World J. Gastroenterol.
PUBLISHED: 01-25-2013
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A 53-year-old male developed cervical esophageal stenosis after esophageal bypass surgery using a right colon conduit. The esophageal bypass surgery was performed to treat multiple esophageal strictures resulting from corrosive ingestion three years prior to presentation. Although the patient underwent several endoscopic stricture dilatations after surgery, he continued to suffer from recurrent esophageal stenosis. We planned cervical patch esophagoplasty with a pedicled skin flap of sternocleidomastoid (SCM) muscle. Postoperative recovery was successful, and the patient could eat a solid meal without difficulty and has been well for 18 mo. SCM flap esophagoplasty is an easier and safer method of managing complicated and recurrent cervical esophageal strictures than other operations.
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Video-assisted thoracoscopic surgery for primary spontaneous pneumothorax in children.
Pediatr. Surg. Int.
PUBLISHED: 01-23-2013
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There is controversy regarding the best way to prevent recurrences of primary spontaneous pneumothorax (PSP) in children. The purpose of this study was to evaluate the efficacy of video-assisted thoracoscopic surgery (VATS) for pediatric PSP.
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Successful treatment of catamenial hemoptysis by video-assisted thoracoscopic surgery.
Thorac Cardiovasc Surg
PUBLISHED: 01-10-2013
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We report a case of a 23-year-old woman with a 5-year history of recurrent hemoptysis during menstrual period. Catamenial hemoptysis was diagnosed using chest computed tomography and bronchoscopic examination during menstruation. The patient was managed successfully with wedge resection and has been free of recurrence for 5 years. We suggest that surgery is an effective treatment, and complete resection with accurate localization is important for the prevention of recurrence.
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Spontaneous Carotid Cavernous Fistula in a Case with Protein S Deficiency that Newly Developed Ophthalmoplegia after Embolization.
J Clin Neurol
PUBLISHED: 09-29-2011
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Carotid cavernous fistula (CCF) is an abnormal communication between the carotid artery and the cavernous sinus. The pathogenesis of spontaneous CCF remains unclear, although sinus thrombosis is known to be a predisposing factor for dural arteriovenous fistula. Because spontaneous CCFs are mainly of the dural type, we considered that thrombogenic conditions, such as, protein S deficiency might be associated with CCF.
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Dynamic temporal change of cerebral microbleeds: long-term follow-up MRI study.
PLoS ONE
PUBLISHED: 07-04-2011
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Cerebral microbleeds (MBs) are understood as an important radiologic marker of intracerebral hemorrhage. We sought to investigate the temporal changes of MBs and clinical factors associated with the changes using long-term follow-up MRI.
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Adipocytokines and ischemic stroke: differential associations between stroke subtypes.
J. Neurol. Sci.
PUBLISHED: 05-31-2011
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Experimental studies have indicated that adipocytokines are associated with vascular diseases with regard to the pathology of atherosclerotic plaque. We hypothesized that the strength of the associations between adipocytokines and stroke would differ between ischemic stroke subtypes.
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Ischemic stroke during sleep: its association with worse early functional outcome.
Stroke
PUBLISHED: 05-05-2011
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Approximately one fourth of stroke occur during sleep. Despite the clinical and radiological similarities between wake-up stroke (WUS) and non-WUS, the functional outcomes of WUS are largely unknown.
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Age-independent association of pulse pressure with cerebral white matter lesions in asymptomatic elderly individuals.
J. Hypertens.
PUBLISHED: 05-05-2011
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Brachial pulse pressure (PP) is a marker of arterial stiffness in the elderly and a useful tool for measuring vascular aging. The presence of cerebral white matter lesions (WMLs) is a radiological marker of sub-clinical ischemic brain damage. WMLs may be age-related degenerative change, but few studies have addressed the relationship between vascular aging and WMLs. In this study, we assessed whether brachial PP is associated with the presence of WMLs in the elderly.
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Pentraxin 3: a novel and independent prognostic marker in ischemic stroke.
Atherosclerosis
PUBLISHED: 05-02-2011
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Pentraxin 3 (PTX3) is one of the pattern-recognition receptors related to the initial step of the immune response with C-reactive protein, but the physiologic and pathologic functions are not fully understood. The purpose of the current study was to determine the impact of PTX3 levels on mortality after ischemic stroke.
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Body mass index, initial neurological severity and long-term mortality in ischemic stroke.
Cerebrovasc. Dis.
PUBLISHED: 04-06-2011
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Obesity is believed to increase the risks of ischemic stroke or coronary heart disease; however, regarding outcome after established vascular diseases, recent unexpected evidence has suggested that an increased body mass index (BMI) might have beneficial effects (obesity paradox). The aim of this study was to evaluate the independent association between BMI and long-term mortality after ischemic stroke.
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Morphine-sensitive paroxysmal sympathetic storm in pontine intracerebral hemorrhage.
Neurologist
PUBLISHED: 12-15-2010
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Paroxysmal sympathetic storm (PSS) is a rare complication of severe traumatic brain injury or cerebrovascular disease. Various medications have been tried in patients with PSS, but the clinical responses of the patients were variable. We report a classic case of PSS after spontaneous pontine hemorrhage in which the patients fluctuating blood pressure and body temperature were dramatically stabilized using morphine.
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Advanced coronary artery calcification and cerebral small vessel diseases in the healthy elderly.
Circ. J.
PUBLISHED: 12-10-2010
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Coronary artery calcification (CAC) scores are widely accepted to predict risk of coronary heart diseases and are associated with atherosclerosis in other vasculatures. Cerebral small vessel diseases (SVDs), including white matter lesions (WML), silent lacunar infarction (SLI) and cerebral microbleeds (CMB), are considered to develop in conjunction with pro-atherogenic conditions, measured by CAC scores.
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Bilateral subthalamic deep brain stimulation in Parkinson disease patients with severe tremor.
Neurosurgery
PUBLISHED: 07-22-2010
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Previous studies have shown that subthalamic nucleus (STN) deep brain stimulation (DBS) improves tremor in Parkinson disease (PD). However, the patients included in those studies were unselected for tremor severity.
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Elevated leukocyte count in asymptomatic subjects is associated with a higher risk for cerebral white matter lesions.
Clin Neurol Neurosurg
PUBLISHED: 05-31-2010
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Cerebral white matter lesions (WMLs) are radiologic markers of small vessel disease in brain, and inflammatory processes were related to WMLs. We propose to determine if elevated leukocyte count was associated with a higher risk of WMLs.
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Advanced coronary artery calcification is associated with ischemic stroke.
Cerebrovasc. Dis.
PUBLISHED: 03-12-2010
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Coronary artery calcification (CAC) is widely accepted as a quantitative index of subclinical atherosclerosis in the coronary artery, and is utilized as a valuable tool for the global risk assessment of cardiovascular events in individuals at intermediate risk. However, the association between CAC and ischemic stroke has not been evaluated.
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Effects of low serum triglyceride on stroke mortality: a prospective follow-up study.
Atherosclerosis
PUBLISHED: 03-02-2010
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Low serum triglyceride (TG) has been suggested as a predictor of mortality after cardiovascular disease. However, the relationship between the level of TGs and the outcome after stroke remains to be elucidated. We hypothesized that the influence of TG levels on post-stroke mortality varies according to stroke mechanism: cardioembolic (CE) vs. non-CE causes.
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Anomalous right coronary artery originated from left coronary sinus with interarterial course: evaluation of the proximal segment on multidetector row computed tomography with clinical correlation.
J Comput Assist Tomogr
PUBLISHED: 10-13-2009
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Anomalous origin of the right coronary artery (RCA) with an interarterial course is a potentially life-threatening anomaly. Clinical significance could depend on its orifice and interarterial course. We evaluated the anomalous RCA on multidetector row computed tomography (MDCT) with clinical correlation.
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Carotid cavernous fistula with cervical myelopathy.
J Clin Neurosci
PUBLISHED: 06-30-2009
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We report a patient with carotid cavernous fistula (CCF) presenting with cervical myelopathy. The patient initially presented with ocular pain accompanied by binocular diplopia and was diagnosed with Tolosa-Hunt syndrome at another institution. This patient experienced long-standing venous hypertension due to the delay in diagnosis. Posterior venous drainage from the CCF caused venous congestion in the brainstem and cervical spinal cord causing cervical myelopathy. Glue embolization using n-butyl-2-cyanoacrylate was attempted, but only partial embolization was possible because access to feeding arteries was limited. Stereotactic gamma-knife radiosurgery was performed as an alternative treatment, and effectively obliterated the CCF. However, the patient remained disabled due to cervical cord atrophy associated with long-standing venous hypertension.
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Increased expression of connexin43 on the aortic valve in the hypercholesterolemic rabbit model.
J Invest Surg
PUBLISHED: 03-14-2009
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Aortic valve sclerosis is associated with increased risk of cardiovascular death and myocardial infarction. However, the relevance of connexin43 in aortic valve sclerosis remains unclear. We hypothesized that the mechanism regulating aortic valve sclerosis is associated with the alteration of cell-to-cell communication.
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Low level of low-density lipoprotein cholesterol increases hemorrhagic transformation in large artery atherothrombosis but not in cardioembolism.
Stroke
PUBLISHED: 03-12-2009
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Low cholesterol level is known to be associated with increased cerebral hemorrhage. However, the associations of hemorrhagic transformation (HTf) after acute ischemic stroke and the low levels of total cholesterol (TC) or low-density lipoprotein cholesterol (LDLC) are largely undiscovered.
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Significant association of metabolic syndrome with silent brain infarction in elderly people.
J. Neurol.
PUBLISHED: 03-05-2009
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A silent brain infarction (SBI) can predict clinical overt stroke or dementia. Studies focusing on the elderly population, where SBI is most common, are sparse. We examined the associations between SBI and metabolic syndrome (MetS) in healthy elderly individuals. Neurologically healthy subjects (1,254 persons, 723 males) aged > or =65 years who underwent brain MRI were evaluated. MetS was diagnosed following the AHA/NHLBI-2005 criteria. We examined associations between full syndrome (at least three of the five conditions) as well as its components and SBI while controlling for possible confounders. One hundred and ninety-seven subjects (15.7%) were found to have one or more SBIs on MRI. Age (1-year difference) was found to be significantly related to SBI prevalence (OR 1.09; 95% CI 1.05-1.12). MetS was significantly associated with SBI (OR 1.68; 95% CI 1.15-2.44). The component model of MetS showed a strong significance between elevated blood pressure (OR 1.89; 95% CI 1.23-2.91) and SBI. Subjects exhibiting more components of MetS showed more prevalent SBI and multiple SBIs. MetS was found to be significantly associated with SBI in neurologically healthy elderly people. The positive trend between the number of MetS components and SBI could be used as a diagnostic tool to predict and prevent future stroke.
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Primary repair of an iatrogenic bronchial rupture under video mediastinoscopy.
Ann. Thorac. Surg.
PUBLISHED: 02-25-2009
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Complications after performing mediastinoscopy are uncommon, but they may occur even for an experienced surgeon. The major complications have the potential to be life-threatening injuries, such as major vascular or airway injury. A 51-year-old man presented to our hospital due to mediastinal node enlargement on follow-up after he had undergone gastric cancer surgery 2 years previously. An iatrogenic bronchial rupture occurred while performing mediastinoscopic biopsy, and this injury was primarily repaired with multiple direct interrupted sutures, along with the aid of a homemade knot pusher under video mediastinoscopy, and we did not have to convert to an open thoracotomy.
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A Quantitative Comparison of the Vertebral Artery and Transverse Foramen Using CT Angiography.
J Clin Neurol
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The vertebral artery (VA) is important for the development of the transverse foramen (TF). Most studies of these structures have focused on anatomical anomalies. Therefore, we investigated quantitatively the association between the relative sizes of the TF and VA.
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Impact of CHADS(2) Score on Neurological Severity and Long-Term Outcome in Atrial Fibrillation-Related Ischemic Stroke.
J Clin Neurol
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The CHADS(2) (an acronym for congestive heart failure, hypertension, age ?75 years, diabetes mellitus, and prior stroke or transient ischemic attack or thromboembolism) score is a widely used system for estimating the risk of stroke in patients with atrial fibrillation. However, how the CHADS(2) score is related to stroke severity and outcome in patients with strokes due to atrial fibrillation has not yet been elucidated.
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Successful management of a mycotic pseudoaneurysm involving an arch branch using an endovascular stent graft.
Thorac Cardiovasc Surg
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Mycotic aneurysms in the aortic arch are extremely rare and represent a challenging surgical problem. Although surgery is the standard treatment, application of endovascular repair has been extended, but this technique carries a concern regarding the interposition of an artificial graft in the infected lesion. We present the case of an infected pseudoaneurysm in the thoracic aorta which was successfully excluded by treatment with a stent graft.
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Excessive work and risk of haemorrhagic stroke: a nationwide case-control study.
Int J Stroke
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Adverse effect of excessive work on health has been suggested previously, but it was not documented in cerebrovascular diseases.
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Occlusive vascular Ehlers-Danlos syndrome accompanying a congenital cystic adenomatoid malformation of the lung: report of a case.
Surg. Today
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An 8-year-old male presented with a cystic lung lesion in the left lower lobe, which was initially detected during surgery for a spontaneous rupture of the sigmoid colon at the age of 6 years. Tissue fragility and a tendency to bleed easily were noted during the surgery, which strongly suggested vascular Ehlers-Danlos syndrome. Although there was no abnormality in the hemostasis screening test, or any suspicious hereditary problem in his pedigree, genetic gene testing for vascular Ehlers-Danlos syndrome was recommended, and showed a de novo mutation in the COL3A1 gene. This report presents the case of patient with occlusive vascular Ehlers-Danlos syndrome accompanying a congenital cystic adenomatoid malformation of lung, in addition to a duplicated infrarenal vena cava.
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Spontaneous rupture of internal iliac artery secondary to anticoagulant therapy.
Ann Thorac Cardiovasc Surg
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We present a case of spontaneous retroperitoneal hemorrhage secondary to anticoagulant therapy. A 41-year-old woman who underwent aortic valve replacement due to infective endocarditis 2 months ago was admitted for evaluation of dizziness and fatigue. Physical examination revealed the abdomen to be distended. Blood work showed a hemoglobin 4.5 and INR 3.5. Abdominal CT showed a huge intra-abdominal hematoma with right internal iliac artery rupture. In abdominal aortic angiography, rupture of right internal iliac artery was confirmed and treated with embolization. Bleeding stopped after embolization, but she developed acute renal failure secondary to a huge hematoma. On POD#4, she underwent a laparotomy and the hematoma was evacuated. The patient had an uneventful recovery and was discharged from the hospital with no further bleeding episodes.
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Ceria nanoparticles that can protect against ischemic stroke.
Angew. Chem. Int. Ed. Engl.
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Uniform 3?nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.
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Impact of smoking cessation on the risk of subarachnoid haemorrhage: a nationwide multicentre case control study.
J. Neurol. Neurosurg. Psychiatr.
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Subarachnoid haemorrhage (SAH) is the most devastating cerebrovascular disease. Cigarette smoking is one of the established risk factors for SAH, but the risk of SAH has not been properly elucidated in relation to smoking cessation.
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No significant association of aspirin use with cerebral microbleeds in the asymptomatic elderly.
J. Neurol. Sci.
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Cerebral microbleeds (CMBs) may predict future risk for intracerebral hemorrhage (ICH). ICH is one of the most important complications of aspirin use. The association between aspirin use and CMBs is still controversial. In this context, we sought to investigate whether aspirin use is associated with CMBs in subjects without previous history of stroke.
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Association of obesity with cerebral microbleeds in neurologically asymptomatic elderly subjects.
J. Neurol.
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Obesity is associated with an increased risk of cardiovascular disease, but few studies have investigated the effects of obesity on subclinical cerebrovascular disease. Cerebral microbleeds (CMBs) are radiological markers of cerebral small vessel disease and reflect underlying vasculopathy. In this context, we assessed whether obesity was related to CMBs and to CMB subtypes categorized by location. Neurologically asymptomatic elderly subjects (n = 1,251; age ? 65 years) who visited for routine health check-ups were included in this study. Cerebral microbleeds were evaluated through T2*-weighted gradient-recalled echo MRI. The subjects were categorized into two groups depending on CMB location: strictly lobar and deep or infratentorial microbleeds. Body mass index was calculated, and obesity was defined using the World Health Organization Western Pacific Regional Office criteria. A total of 120 (9.6 %) subjects were found to have CMBs. As the severity of obesity increased, the prevalence of CMBs increased. Compared with the normal weight group and after controlling possible confounders, the risk of deep or infratentorial microbleeds was significantly increased in the overweight group [odds ratio (OR) 2.32, 95 % confidence interval (CI) 1.19-4.53], and the obese group (OR 2.17, 95 % CI 1.14-4.13). However, the ORs for the strictly lobar microbleeds were not increased in either the overweight or obese groups. Obesity was associated with deep or infratentorial microbleeds. This finding suggests that obesity affects cerebral small vessels through arteriosclerotic vasculopathy. Based on our findings, we postulate that obesity is associated with the presence of subclinical and bleeding-prone cerebrovascular disease in the elderly.
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The relation between chronic kidney disease and cerebral microbleeds: difference between patients with and without diabetes.
Int J Stroke
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Cerebral microbleeds are an important radiologic marker of bleeding-prone brain and have been reported to be associated with the increased risk of intracerebral haemorrhage.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.