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Find video protocols related to scientific articles indexed in Pubmed.
The feasibility of using simulated targets in the stomachs of live pigs for full endoscopic submucosal dissection training.
Gut Liver
PUBLISHED: 11-15-2014
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In endoscopic submucosal dissection (ESD) training, only a flat target lesion can usually be simulated in the normal mucosa. This study aimed to evaluate the feasibility of simulated targets in the stomachs of live pigs for complete training.
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Effectiveness and Feasibility of Laparoscopic Distal Pancreatectomy on Patients at High Anesthetic Risk.
J Laparoendosc Adv Surg Tech A
PUBLISHED: 11-12-2014
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Abstract Background: Laparoscopic distal pancreatectomy (LDP) is the most acceptable procedure in laparoscopic pancreatic surgery. Nevertheless, knowledge regarding patients at a high anesthetic risk during lengthy and technically demanding LDP is controversial. This study aims to assess the feasibility and safety of LDP in patients with high anesthetic risk. Patients and Methods: We conducted a prospective collection retrospective review of patients underwent LDP and open distal pancreatectomy (ODP) from January 2011 until December 2013. By the American Society of Anesthesiologists score, patients were divided into low- and high-risk patients. We compared the clinical, perioperative, and postoperative results in these patients. Results: The cohort included 77 patients: 20 underwent LDP, and 57 underwent ODP. There were 30 patients in the low-risk group and 47 patients in the high-risk group. In high-risk patients, LDP, compared with ODP, presented a shorter operating time (mean, 220.8±101.1 minutes versus 299.4±124.3 minutes; P=.038), less blood loss (409.3±569.9?mL versus 1083.1±1583.0 mL; P=.039), higher rate of spleen preservation (73.3% versus 43.8%, P=.037), and shorter length of postoperative hospital stay (LOS) (9.5±3.0 days versus 15.7±9.4 days; P=.044). Conclusions: In conclusion, LDP provides early recovery and better cosmetic appearance. In high anesthetic risk patients, LDP shows less operative time, less perioperative blood loss, a higher rate of spleen preservation, slighter complication, and shorter LOS, which might explain why LDP is a feasible and effective procedure.
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Effect of surface Si redistribution on the alignment of Ge dots grown on pit-patterned Si(001) substrates.
Nanotechnology
PUBLISHED: 11-05-2014
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Thermally activated redistribution of Si surface atoms is found to be a crucial factor for the growth of aligned Ge dots on pit-patterned Si(001) substrates. A phenomenon of Si accumulation around the edge of pits significantly alters the substrate surface morphology. As the pit spacing is reduced to below 100 nm, a convex morphology developed between adjacent pits causes a chemical potential distribution that drives the Ge dots into the pits. In addition, the pits of an etching depth greater than 60 nm will evolve into truncated inverted pyramids with sharp base corners that provide deep potential wells for the confinement of Ge dots. Perfectly aligned Ge dots are obtained on pit-patterned Si substrates with this range of pit spacing and etching depth. We also find that the initial geometric shape of the pits does not affect the spatial arrangement of Ge dots.
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Determination of the position and orientation of a flat piezoelectric micro-stage by moving the optical axis.
Rev Sci Instrum
PUBLISHED: 11-03-2014
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A moving optical axis measurement system with six degrees-of-freedom (DOF) is proposed in this study. The system is very simple and can be placed inside a flat piezoelectric micro-stage. The system comprises three two-DOF optical measurement modules, each having a quadrant photo diode (QPD), a lens, and a laser diode. These three modules and the geometric configuration of their installation allow displacement measurements with up to six-DOF to be made. A mathematical model of this system is also presented. By analyzing the sensitivity and relationship between the displacement of the stage and each of the QPD light spots, movement can be observed. Signal feedback enables multi-axis nano-scale positioning control. We also present a new six-DOF nano stage, which uses piezoelectric actuators for displacement. This stage was used to verify the proposed six-DOF measurement system. Linear and angular resolution of the system can be down to 10 nm and 0.1 arcsec. Linear and angular displacement measurement errors of this six-DOF measurement system are in the range of ±70 nm and ±0.65 arcsec.
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In Situ Growth of Hollow Gold-Silver Nanoshells within Porous Silica Offers Tunable Plasmonic Extinctions and Enhanced Colloidal Stability.
ACS Appl Mater Interfaces
PUBLISHED: 10-17-2014
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Porous silica-coated hollow gold-silver nanoshells were successfully synthesized utilizing a procedure where the porous silica shell was produced prior to the transformation of the metallic core, providing enhanced control over the structure/composition of the bimetallic hollow core. By varying the reaction time and the precise amount of gold salt solution added to a porous silica-coated silver-core template solution, composite nanoparticles were tailored to reveal a readily tunable surface plasmon resonance that could be centered across the visible and near-IR spectral regions (?445-800 nm). Characterization by X-ray photoelectron spectroscopy, energy-dispersive X-ray spectroscopy, scanning electron microscopy, and transmission electron microscopy revealed that the synthetic methodology afforded particles having uniform composition, size, and shape. The optical properties were evaluated by absorption/extinction spectroscopy. The stability of colloidal solutions of our composite nanoparticles as a function of pH was also investigated, revealing that the nanoshells remain intact over a wide range of conditions (i.e., pH 2-10). The facile tunability, enhanced stability, and relatively small diameter of these composite particles (?110 nm) makes them promising candidates for use in tumor ablation or as photothermal drug-delivery agents.
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Is blue optical filter necessary in high speed phosphor-based white light LED visible light communications?
Opt Express
PUBLISHED: 10-17-2014
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Optical blue filter is usually regarded as a critical optical component for high speed phosphor-based white light emitting diode (LED) visible-light-communication (VLC). However, the optical blue filter plays different roles in VLC when using modulations of on-off keying (OOK) or discrete multi-tone (DMT). We show that in the DMT VLC system, the blue optical filter may be unnecessary, and even degrade the transmission performance (by reducing the optical signal-to-noise ratio (SNR)). Analyses and verifications by experiments are performed. To the best of our knowledge, this is the first time the function of blue filters in VLC is explicitly analyzed.
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Time-domain digital pre-equalization for band-limited signals based on receiver-side adaptive equalizers.
Opt Express
PUBLISHED: 10-17-2014
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We theoretically and experimentally investigate a time-domain digital pre-equalization (DPEQ) scheme for bandwidth-limited optical coherent communication systems, which is based on feedback of channel characteristics from the receiver-side blind and adaptive equalizers, such as least-mean-squares (LMS) algorithm and constant or multi- modulus algorithms (CMA, MMA). Based on the proposed DPEQ scheme, we theoretically and experimentally study its performance in terms of various channel conditions as well as resolutions for channel estimation, such as filtering bandwidth, taps length, and OSNR. Using a high speed 64-GSa/s DAC in cooperation with the proposed DPEQ technique, we successfully synthesized band-limited 40-Gbaud signals in modulation formats of polarization-diversion multiplexed (PDM) quadrature phase shift keying (QPSK), 8-quadrature amplitude modulation (QAM) and 16-QAM, and significant improvement in both back-to-back and transmission BER performances are also demonstrated.
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Rh(III)-catalyzed dual directing group assisted sterically hindered C-H bond activation: a unique route to meta and ortho substituted benzofurans.
Org. Biomol. Chem.
PUBLISHED: 10-15-2014
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A new strategy for the synthesis of highly substituted benzofurans from meta-substituted hydroxybenzenes and alkynes via a rhodium(iii)-catalyzed activation of a sterically hindered C-H bond is demonstrated. A possible mechanism involving dual directing group assisted ortho C-H bond activation is proposed.
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Development of a steel ball center alignment device based on Michelson interference concept.
Rev Sci Instrum
PUBLISHED: 10-03-2014
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This study presents a ball center alignment method based on the Michelson interferometer where one of the reflecting mirrors is replaced by a lens and steel ball. By locating the ball away from the focal length of the lens, the beam is reflected as a spherical wave. The interference ring formed by the planar and spherical waves can be clearly observed using a camera without a lens. The distance of the offset of the ball center can be enhanced by more than 140% using this method. A fast ring profile fitting method can reduce circle fitting time to around a third of that needed for Hough transformation.
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Prevalent and incident HIV diagnoses among Entamoeba histolytica-infected adult males: a changing epidemiology associated with sexual transmission--Taiwan, 2006-2013.
PLoS Negl Trop Dis
PUBLISHED: 10-01-2014
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Sexually transmitted Entamoeba histolytica infection (EHI) has been increasingly recognized among men who have sex with men (MSM). We used the National Disease Surveillance Systems (NDSS) to identify prevalent and incident HIV diagnoses among adults with EHI and to determine the associated factors.
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Multicenter study of trimethoprim/sulfamethoxazole-related hepatotoxicity: incidence and associated factors among HIV-infected patients treated for Pneumocystis jirovecii pneumonia.
PLoS ONE
PUBLISHED: 09-03-2014
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The incidence of hepatotoxicity related to trimethoprim/sulfamethoxazole (TMP/SMX) administered at a therapeutic dose may vary among study populations of different ethnicities and hepatotoxic metabolites of TMP/SMX may be decreased by drug-drug interaction with fluconazole. We aimed to investigate the incidence of hepatotoxicity and the role of concomitant use of fluconazole in HIV-infected patients receiving TMP/SMX for Pneumocystis jirovecii pneumonia. We reviewed medical records to collect clinical characteristics and laboratory data of HIV-infected patients who received TMP/SMX for treatment of P. jirovecii pneumonia at 6 hospitals around Taiwan between September 2009 and February 2013. Hepatotoxicity was defined as 2-fold or greater increase of aminotransferase or total bilirubin level from baselines. Roussel UCLAF Causality Assessment Method (RUCAM) was used to analyze the causality of drug-induced liver injuries. NAT1 and NAT2 acetylator types were determined with the use of polymerase-chain-reaction (PCR) restriction fragment length polymorphism to differentiate common single-nucleotide polymorphisms (SNPs) predictive of the acetylator phenotypes in a subgroup of patients. During the study period, 286 courses of TMP/SMX treatment administered to 284 patients were analyzed. One hundred and fifty-two patients (53.1%) developed hepatotoxicity, and TMP/SMX was considered causative in 47 (16.4%) who had a RUCAM score of 6 or greater. In multivariate analysis, concomitant use of fluconazole for candidiasis was the only factor associated with reduced risk for hepatotoxicity (adjusted odds ratio, 0.372; 95% confidence interval, 0.145-0.957), while serostatus of hepatitis B or C virus, NAT1 and NAT2 acetylator types, or receipt of combination antiretroviral therapy was not. The incidence of hepatotoxicity decreased with an increasing daily dose of fluconazole up to 4.0 mg/kg. We conclude that the incidence of TMP/SMX-related hepatotoxicity was 16.4% in HIV-infected Taiwanese patients who received TMP/SMX for pneumocystosis. Concomitant use of fluconazole was associated with decreased risk for TMP/SMX-related hepatotoxicity.
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Jarisch-Herxheimer reaction among HIV-positive patients with early syphilis: azithromycin versus benzathine penicillin G therapy.
J Int AIDS Soc
PUBLISHED: 08-28-2014
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The Jarisch-Herxheimer reaction, a febrile inflammatory reaction that often occurs after the first dose of chemotherapy in spirochetal diseases, may result in deleterious effects to patients with neurosyphilis and to pregnant women. A single 2-g oral dose of azithromycin is an alternative treatment to benzathine penicillin G for early syphilis in areas with low macrolide resistance. With its potential anti-inflammatory activity, the impact of azithromycin on the incidence of the Jarisch-Herxheimer reaction in HIV-positive patients with early syphilis has rarely been investigated.
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Comorbidities among the HIV-infected patients aged 40 years or older in Taiwan.
PLoS ONE
PUBLISHED: 08-13-2014
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With the widespread use of combination antiretroviral therapy (cART), life expectancy of HIV-infected patients has significantly prolonged. An increasing number of HIV-infected patients are aging and concurrent use of medications are not uncommon for management of metabolic complications and cardiovascular diseases related to aging and prolonged exposure to cART.
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Incidence and risk factors of skin rashes and hepatotoxicity in HIV-infected patients receiving nevirapine-containing combination antiretroviral therapy in Taiwan.
Int. J. Infect. Dis.
PUBLISHED: 08-08-2014
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To retrospectively investigate the incidence of and factors associated with skin rashes and hepatotoxicity in HIV-infected patients who initiated combination antiretroviral therapy (cART) containing nevirapine plus two nucleos(t)ide reverse-transcriptase inhibitors.
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Computed tomography angiography provides limited benefit in the evaluation of patients with pelvic fractures.
Am J Emerg Med
PUBLISHED: 08-01-2014
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Computed tomography angiography (CTA) has been applied in imaging studies for the assessment of most abdominal and pelvic injuries in some trauma centers. However, in most institutions, CTA is not routinely performed as part of the computed tomography scan protocol. In this study, we aimed to assess the efficiency of CTA in the evaluation of patients with pelvic fractures.
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Area disparity in children's perceptions of access to tobacco and cigarette purchasing experiences in Taiwan.
J Sch Health
PUBLISHED: 07-22-2014
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Adolescents who perceive easy access to tobacco are more likely to acquire cigarettes and experience smoking. This study assesses area disparities in perceptions of access to tobacco and cigarette purchasing experiences among schoolchildren.
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Monolithic NPG nanoparticles with large surface area, tunable plasmonics, and high-density internal hot-spots.
Nanoscale
PUBLISHED: 06-14-2014
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Plasmonic metal nanostructures have shown great potential in sensing, photovoltaics, imaging and biomedicine, principally due to the enhancement of local electric field by light-excited surface plasmons, i.e., collective oscillation of conduction band electrons. Thin films of nanoporous gold have received a great deal of interest due to the unique 3-dimensional bicontinuous nanostructures with high specific surface area. However, in the form of semi-infinite thin films, nanoporous gold exhibits weak plasmonic extinction and little tunability in the plasmon resonance, because the pore size is much smaller than the wavelength of light. Here we show that by making nanoporous gold in the form of disks of sub-wavelength diameter and sub-100 nm thickness, these limitations can be overcome. Nanoporous gold disks not only possess large specific surface area but also high-density, internal plasmonic "hot-spots" with impressive electric field enhancement, which greatly promotes plasmon-matter interactions as evidenced by spectral shifts in the surface plasmon resonance. In addition, the plasmonic resonance of nanoporous gold disks can be easily tuned from 900 to 1850 nm by changing the disk diameter from 300 to 700 nm. Furthermore, nanoporous gold disks can be fabricated as either bound on a surface or as non-aggregating colloidal suspension with high stability.
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Hypotension does not always make computed tomography scans unfeasible in the management of blunt abdominal trauma patients.
Injury
PUBLISHED: 05-03-2014
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Computed tomography (CT) scans have been used worldwide to evaluate patients with blunt abdominal trauma (BAT). However, CT scans have traditionally been considered to be a part of a secondary survey that can only be performed after the patient's haemodynamics have stabilised. In this study, we attempted to evaluate the role of the CT scan in managing BAT patients with hypotension.
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Optical independent-sideband modulation for bandwidth-economic coherent transmission.
Opt Express
PUBLISHED: 05-03-2014
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We proposed and implemented a bandwidth-economic coherent optical transmission technology using optical independent-sideband (O-ISB) modulation. Generation of two software-defined, 30-GBd O-ISB channels per wavelength sharing one set of transmitter hardware was demonstrated, which was made possible by digital single-sided up-conversion, channel pre-equalization and optical IQ modulation with precise amplitude and delay matching between driving signals. With 120-Gb/s PM-QPSK per O-ISB channel, we successfully delivered 16 O-ISB channels in 8 wavelengths at 3.86-bits/s/Hz over 2100 km SSMF. In addition, the system performance was evaluated by using regular and enhanced Rx DSP, respectively. For metro and regional network applications where small footprint, low power consumption and low cost are required features, the proposed two-channels-per-wavelength O-ISB modulation may be considered an economic option.
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Hepatitis B virus coinfection in human immunodeficiency virus-infected patients: A review.
World J. Gastroenterol.
PUBLISHED: 04-27-2014
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Hepatitis B virus (HBV) infection is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Due to the shared modes of transmission, coinfection with HBV and human immunodeficiency virus (HIV) is not uncommon. It is estimated that 10% of HIV-infected patients worldwide are coinfected with HBV. In areas where an HBV vaccination program is implemented, the HBV seroprevalence has declined significantly. In HIV/HBV-coinfected patients, HBV coinfection accelerates immunologic and clinical progression of HIV infection and increases the risk of hepatotoxicity when combination antiretroviral therapy (cART) is initiated, while HIV infection increases the risk of hepatitis events, cirrhosis, and end-stage liver disease related to chronic HBV infection. With the advances in antiviral therapy, concurrent, successful long-term suppression of HIV and HBV replication can be achieved in the cART era. To reduce the disease burden of HBV infection among HIV-infected patients, adoption of safe sex practices, avoidance of sharing needles and diluent, HBV vaccination and use of cART containing tenofovir disoproxil fumarate plus emtricitabine or lamivudine are the most effective approaches. However, due to HIV-related immunosuppression, using increased doses of HBV vaccine and novel approaches to HBV vaccination are needed to improve the immunogenicity of HBV vaccine among HIV-infected patients.
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Risk evaluation for the development of cervical intraepithelial neoplasia: Development and validation of risk-scoring schemes.
Int. J. Cancer
PUBLISHED: 04-25-2014
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Cervical cancer screening guidelines do not comprehensively define what constitutes high risk. This study developed and validated simple risk-scoring schemes to improve Papanicolaou smear screening for women at high risk. Four cumulative risk score (CRS) schemes were derived respectively for the development of cervical intraepithelial neoplasia grade 1 (CIN1) and grade 2 or worse (CIN2+) using community-based case-control data (n?=?1523). By calculating the area under the receiver operating characteristic (AU-ROC) curve, these schemes were validated in a Papanicolaou smear follow-up cohort (n?=?967) and a hospital-based cytology screening population (n?=?217). A high DNA load of high-risk human papillomavirus (HR-HPV) was the main predictor for CIN1 and CIN2+, although age, married status combined with the number of sexual partners, active and passive smoking and age at sexual debut also affected associated lesions. In the training set, only the HPV-testing-contained CIN2+ CRS scheme presented an excellent discrimination for identifying CIN2+ (AU-ROC?=?0.866). Using a CRS cutoff value of 4 to identify CIN2+, the sensitivity and specificity of predicting CIN2+ for the 3- and 5-year follow-ups were 100% and 90.8%, and 83.3% and 90.4%, respectively, in the validation cohort. In the hospital-based validation population, the CRS scheme showed comparable discrimination for CIN2+ detection (sensitivity 88.2% and specificity 84.6%). Women with CRS ?4 had a 5.4% and 9.1% of 3- and 5-year cumulative incidence, respectively, and a 40.5-fold hazard ratio of developing CIN2+. In conclusion, combined with HR-HPV testing and verified risk factors, a simple CRS scheme could effectively improve the implementation of CIN2+ screening.
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An outcome prediction model for exsanguinating patients with blunt abdominal trauma after damage control laparotomy: a retrospective study.
BMC Surg
PUBLISHED: 04-22-2014
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We present a series of patients with blunt abdominal trauma who underwent damage control laparotomy (DCL) and introduce a nomogram that we created to predict survival among these patients.
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Lipid levels and changes in body fat distribution in treatment-naive, HIV-1-Infected adults treated with rilpivirine or Efavirenz for 96 weeks in the ECHO and THRIVE trials.
Clin. Infect. Dis.
PUBLISHED: 04-11-2014
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Pooled ECHO/THRIVE lipid and body fat data are presented from the ECHO (Efficacy Comparison in Treatment-Naïve, HIV-Infected Subjects of TMC278 and Efavirenz) and THRIVE (TMC278 Against HIV, in a Once-Daily Regimen Versus Efavirenz) trials.
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Dimming-discrete-multi-tone (DMT) for simultaneous color control and high speed visible light communication.
Opt Express
PUBLISHED: 04-11-2014
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Visible light communication (VLC) using LEDs has attracted significant attention recently for the future secure, license-free and electromagnetic-interference (EMI)-free optical wireless communication. Dimming technique in LED lamp is advantageous for energy efficiency. Color control can be performed in the red-green-blue (RGB) LEDs by using dimming technique. It is highly desirable to employ dimming technique to provide simultaneous color and dimming control and high speed VLC. Here, we proposed and demonstrated a LED dimming control using dimming-discrete-multi-tone (DMT) modulation. High speed DMT-based VLC with simultaneous color and dimming control is demonstrated for the first time to the best of our knowledge. Demonstration and analyses for several modulation conditions and transmission distances are performed, for instance, demonstrating the data rate of 103.5 Mb/s (using RGB LED) with fast Fourier transform (FFT) size of 512.
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Development of a machine for automatically measuring static/dynamic running parallelism in linear guideways.
Rev Sci Instrum
PUBLISHED: 04-03-2014
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This work develops a machine for automatically measuring static/dynamic running parallelism for use in the linear guideway manufacturing industry. The automatic static/dynamic running parallelism measurement machine consists of a running parallelism measurement system, a linear motor, a precision granite air-suspension table, and a PC-based human-machine interface. The machine can be used simultaneously to measure the horizontal and vertical running parallelism of a linear guideway and automatically determine its accuracy. The measured parallelism is digitalized and analyzed to detect turning points in the linear guideway. The results concerning the accuracy of the running parallelism are not affected by the measurement platform. Experimental results showed that the standard deviation of the running parallelism measurement system is 0.4 ?m and the measuring time is about 10 s for every 1000 mm of length (equal to a measuring speed of 0.1 m/s); this measurement time is 80% shorter than that of a traditional measurement system (which has a maximum speed of 1 m/s, a maximum sampling frequency of 100 kHz, and a maximum measurement length of 2000 mm).
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Performance comparison of spectrum-narrowing equalizations with maximum likelihood sequence estimation and soft-decision output.
Opt Express
PUBLISHED: 03-26-2014
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Maximum likelihood sequence estimation (MLSE) offers effective equalizations for bandwidth-limited optical signal on mitigation towards inter-symbol-interference (ISI) impairment. In this paper, we provide the first comprehensive comparisons and analysis of three post-compensation algorithms on the same modeling platform for high spectral-efficiency (SE) optical systems employing the spectral prefiltering. Those algorithms include 1-tap constant modulus algorithm (CMA) and 3-tap MLSE, regular CMA and digital filter with 2-tap MLSE, and constant multi-modulus algorithm (CMMA) with 2-tap MLSE. Furthermore, a novel and effective approach is proposed and verified for the generation of both hard value and soft value at the output of MLSE in order to be compatible with the implementation of soft-decision forward error correction (SD-FEC) decoding process.
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Harmful alcohol use among Aboriginal people in southern Taiwan: the prevalence, correlates, and adverse drinking effects.
J Addict Nurs
PUBLISHED: 03-12-2014
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This cross-sectional study aims to examine the prevalence and correlates of harmful alcohol use among aboriginal people in southern Taiwan and to examine the associations between harmful alcohol use and adverse drinking effects. Four hundred forty-nine aboriginal adults were recruited from two townships in southern Taiwan to complete the questionnaires. Among the aborigines, 59.7% scored an 8 or above on the Alcohol Use Disorders Identification Test, including 26.7% who were found to be hazardous drinkers (AUDIT level II), 18.5% who were harmful drinkers (level III), and 14.5% who were with likely dependence (level IV). Male aborigines who participated less in religious activities, had stressful life events, were cigarette smokers, or were betel quid chewers were more likely to have harmful alcohol use. Harmful alcohol use was also associated with an inability to work and with arguments with other people. Our study suggests that aboriginal people in southern Taiwan experience alcohol-related risks at rates as high as other worldwide populations for which AUDIT results are available. Individuals with AUDIT scores at levels II and III are generally candidates for brief interventions delivered in generalist health settings. Individuals with AUDIT scores at level IV should be referred for an addiction specialty evaluation and possible treatment as well as lower-risk individuals (those with AUDIT levels II-III) if they have concurrent physical or psychiatric disorders.
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Skin rash related to once-daily boosted darunavir-containing antiretroviral therapy in HIV-infected Taiwanese: incidence and associated factor.
J. Infect. Chemother.
PUBLISHED: 03-10-2014
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The study aimed to investigate the incidence of and associated factors with skin rashes among HIV-infected Taiwanese patients who received once-daily darunavir (DRV) boosted by ritonavir (RTV) (800/100 mg) plus 2 nucleoside reverse-transcriptase inhibitors (NRTIs).
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Consumption of sugar-sweetened beverages is associated with components of the metabolic syndrome in adolescents.
Nutrients
PUBLISHED: 03-06-2014
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Sugar-sweetened beverages (SSBs) are the principle source of added sugar in diets. Cardiometabolic disturbances can occur from early childhood to adulthood. The aim of this cross-sectional study was to examine the gender-specific association of SSB intake with metabolic syndrome (MetS) and its components among adolescents in Taiwan. A total of 2727 adolescents aged 12 to 16 years randomly selected from three diverse economic areas in Southern Taiwan by using a multistage-sampling strategy participated in this study. Demographic, dietary, physical and anthropometric parameters were measured, and serum lipid profiles and glucose levels were determined. The International Diabetes Federation (IDF) specifies that MetS requires abdominal obesity and ?2 abnormal components, and Cook criteria for MetS require ?3 abnormal components. We applied survey-data modules to data analyses, and used multiple regression and logistic models to adjust for covariates. An increased SSB intake was linked to a greater waist circumference in both sexes and to systolic blood pressure in boys (P for trend: ?0.043). Male moderate and high consuming SSB drinkers exhibited triglyceride levels that were 8.0 and 8.2 mg/dL significantly higher, respectively, than those of nondrinkers. Compared with nondrinkers, boys who consumed >500 mL/day (high quantity) of SSBs exhibited 10.3-fold (95% confidence intervals (CIs): 1.2-90.2) and 5.1-fold (95% CIs: 1.01-25.5) risks of contracting MetS, as defined by the IDF and Cook criteria for MetS, respectively. In girls, the risk estimates for the same comparison were not significant by the IDF criteria (6.5-fold risk, 95% CIs: 0.9-?) or Cook criteria (5.9-fold risk, 95% CIs: 0.8-43.8) for MetS. High SSB consumption was also linked to 1.9-fold (95% CIs: 1.1-3.1) and 2.7-fold (95% CIs: 1.3-5.7) higher risks of being at a greater overall metabolic risk in girls and boys, respectively. In conclusion, a high SSB intake is associated with adolescent MetS among boys but not girls in Taiwan.
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Increasing incidence of recent hepatitis D virus infection in HIV-infected patients in an area hyperendemic for hepatitis B virus infection.
Clin. Infect. Dis.
PUBLISHED: 03-05-2014
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Superinfection with hepatitis D virus (HDV) may increase the risk for hepatitis flares and chronic hepatic complications in patients with chronic hepatitis B virus (HBV) infection. This retrospective observational study aimed to examine the incidence of and factors associated with recent HDV superinfection among individuals coinfected with human immunodeficiency virus (HIV) and HBV.
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Nemonoxacin (TG-873870) for treatment of community-acquired pneumonia.
Expert Rev Anti Infect Ther
PUBLISHED: 03-03-2014
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With a broad-spectrum of activity, fluoroquinolones have been widely and successfully used for decades for the treatment of and prophylaxis against various bacterial infections, including community-acquired pneumonia (CAP). However, the use of fluoroquinolones has been compromised by the emergence and spreading of bacterial resistance and the potential for adverse effects. Therefore, there is an unmet need for newer compounds that have a broader spectrum of activity to overcome existing bacterial resistance as well as the potential to minimize the risk of adverse effects. Nemonoxacin (TG-873870), a newly developed quinolone, has demonstrated broad-spectrum activity against Gram-positive, Gram-negative and atypical pathogens, including drug-resistant Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus. Results from Phases I and II studies of treatment of CAP are encouraging. This article reviews the updated data on nemonoxacin, including the bacterial susceptibility, the pharmacologic characteristics, and toxicities, and clinical trials using nemonoxacin for treatment of CAP.
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Betel-quid dependence domains and syndrome associated with betel-quid ingredients among chewers: an Asian multi-country evidence.
Addiction
PUBLISHED: 02-20-2014
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Betel-quid (BQ) contains biologically psychoactive ingredients; however, data are limited concerning the symptoms and syndrome of BQ dependence among chewers. The aims of this study were to evaluate the ingredients-associated BQ dependence syndrome and country-specific chewing features and behaviour for BQ dependence among chewers from six Asian communities.
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Joint effects of alcohol consumption and ABCG2 Q141K on chronic tophaceous gout risk.
J. Rheumatol.
PUBLISHED: 02-15-2014
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To investigate the joint effects of alcohol consumption and ABCG2 gene variants on tophaceous gout occurrence.
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Cellular DDX21 RNA helicase inhibits influenza A virus replication but is counteracted by the viral NS1 protein.
Cell Host Microbe
PUBLISHED: 02-14-2014
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Influenza A virus RNA synthesis is catalyzed by the viral polymerase comprised of the PA, PB1, and PB2 proteins. We show that the host DDX21 RNA helicase restricts influenza A virus by binding PB1 and inhibiting polymerase assembly, resulting in reduced viral RNA and protein synthesis. Later during infection, the viral NS1 protein overcomes this restriction by binding to DDX21 and displacing PB1. DDX21 binds to a region of the NS1 N-terminal domain that also participates in other critical functions. A virus mutant whose NS1 protein is unable to bind DDX21 exhibits reduced viral protein synthesis at both late and early times of infection, a phenotype converted to wild-type upon DDX21 knockdown. As sequential interaction of PB1 and NS1 with DDX21 leads to temporal regulation of viral gene expression, influenza A virus likely uses the DDX21-NS1 interaction not only to overcome restriction, but also to regulate the viral life cycle.
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Intra-abdominal injury is easily overlooked in the patients with concomitant unstable hemodynamics and pelvic fractures.
Am J Emerg Med
PUBLISHED: 01-25-2014
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Transcatheter arterial embolization (TAE) is usually necessary in the management of hemodynamically unstable patients with concomitant pelvic fractures. Given the critical conditions of such patients, TAE is at times performed only according to the results of a primary evaluation without computed tomographic (CT) imaging. Therefore, the evaluation of associated intra-abdominal injuries (IAIs) might be insufficient. Clinically, some patients have required post-TAE laparotomy due to further deterioration. In this study, we attempted to determine a feasible protocol for post-TAE observation.
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Impact of deferred surgical intervention on the outcome of external laryngeal trauma.
Ann. Thorac. Surg.
PUBLISHED: 01-17-2014
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External laryngeal trauma (ELT) can be a fatal injury. Proper management of ELT significantly affects patient survival and quality of life. The optimal timing of surgical intervention is controversial. In this study, we review the incidence, management, and outcome of ELT and attempt to analyze the risk factors and prognosis of this injury.
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Immigrant-native differences in caries-related knowledge, attitude, and oral health behaviors: a cross-sectional study in Taiwan.
BMC Oral Health
PUBLISHED: 01-07-2014
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With the growing number of transnational marriages in Taiwan, oral health disparities have become a public health issue. This study assessed immigrant-native differences in oral health behaviors of urban mothers and their children.
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Risk factors for late death of patients with abdominal trauma after damage control laparotomy for hemostasis.
World J Emerg Surg
PUBLISHED: 01-04-2014
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In this study, we explored the possible causes of death and risk factors in patients who overcame the initial critical circumstance when undergoing a damage control laparotomy for abdominal trauma and succumbed later to their clinical course.
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Revaccination with 7-valent pneumococcal conjugate vaccine elicits better serologic response than 23-valent pneumococcal polysaccharide vaccine in HIV-infected adult patients who have undergone primary vaccination with 23-valent pneumococcal polysaccharide vaccine in th
Vaccine
PUBLISHED: 01-02-2014
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HIV-infected adults who had received 23-valent pneumococcal polysaccharide vaccine (PPV23) five years or more earlier consecutively underwent revaccination with one dose of PPV23 (127 subjects) from December 2005 through October 2007, or upon change in standard of care, non-randomly one (50) or two doses (44) of 7-valent pneumococcal conjugate vaccine (PCV7) from October 2008 through June 2010. Serologic response was defined as ? 2-fold increase in the IgG level plus a level ? 1000ng/ml 48 weeks following revaccination. At week 48, the response rate was significantly higher in the 2-dose PCV7 group compared with that in the 1-dose PCV7 or PPV23 group (63.6% vs 32.0% vs 8.7%, respectively; P<0.05). Revaccination with one dose of PCV7 (AOR, 4.57), two doses of PCV7 (AOR, 22.66), and CD4 >350 cells/?l (AOR, 3.24) and undetectable viral load (AOR, 3.87) at revaccination were statistically significantly associated with a better serologic response at week 48. Despite the limitation that study arms were neither randomized nor contemporaneous, we conclude that revaccination with PCV7 appears to elicit a better serologic response than PPV23 in the HIV-infected adults who have received PPV23 five years or more earlier (clinical trial registration number: NCT00885625).
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Antiretroviral therapy (ART) management of Low-Level Viremia in Taiwan (ALLEVIATE).
J Int AIDS Soc
PUBLISHED: 01-01-2014
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This retrospective study aimed to investigate that if switch of combination antiretroviral therapy (cART) would result in viral suppression (<40 copies/mL) at 48 weeks for patients with persistent low-level viremia after having received cART for six months or more at two hospitals designated for HIV care in Taiwan.
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Seroincidence of HIV and prevalence of transmitted drug resistance of HIV-1 strains among persons seeking voluntary counselling and testing in Taiwan.
J Int AIDS Soc
PUBLISHED: 01-01-2014
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The total case number of persons who are newly diagnosed with HIV continues to increase in Taiwan and men who have sex with men (MSM) have re-emerged as the leading risk group for HIV transmission. In this study, we aimed to estimate the incidence rate of HIV infection among those individuals who sought voluntary counselling and testing (VCT) service at a university hospital.
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Incidence of recent HCV infection among persons seeking voluntary counselling and testing for HIV and sexually transmitted infections in Taiwan.
J Int AIDS Soc
PUBLISHED: 01-01-2014
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The incidence of recent hepatitis C virus infection (HCV) infection has been noted to be increasing among men who have sex with men (MSM), especially those with HIV infection, in several resource-rich settings. In Taiwan, the incidence of recent HCV infection increased from 0 in 1994-2000, 2.29 in 2001-2005 to 10.13 per 1000 person-years of follow-up (PYFU) in 2006-2010. In this study, we aimed to estimate the incidence rate of recent HCV infection among those individuals who sought voluntary counselling and testing (VCT) service at a University Hospital.
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Safety of rilpivirine plus nucleoside reverse-transcriptase inhibitors in HIV-infected Taiwanese with a higher prevalence of hepatitis virus infection.
J Int AIDS Soc
PUBLISHED: 01-01-2014
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Combination antiretroviral therapy (cART) containing rilpivirine plus 2 NRTIs are effective antiretroviral (ARV) regimens for ARV-naive HIV-infected patients who had baseline plasma HIV RNA load (PVL) <5 log10 copies/mL and as switch therapy for those with viral suppression. In this study, we aimed to assess the short-term safety of rilpivirine-containing regimens among HIV-infected patients who initiated or switched to rilpivirine plus two NRTIs in Taiwan.
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Effectiveness of a reduced dose of efavirenz plus 2 NRTIs as maintenance antiretroviral therapy with the guidance of therapeutic drug monitoring.
J Int AIDS Soc
PUBLISHED: 01-01-2014
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Wide inter-patient variation of plasma efavirenz (EFV) concentrations has been observed, and a substantial proportion of HIV-positive patients may have unnecessarily higher plasma EFV concentrations than recommended while receiving EFV-containing combination antiretroviral therapy (cART) at the currently recommended daily dose of 600 mg. A lower daily dose (400 mg) of EFV has recently been demonstrated to be as efficacious as the recommended 600 mg when combined with tenofovir/mtricitabine in a multinational clinical trial, with a lower incidence of adverse effects. We aimed to use a therapeutic drug monitoring (TDM)-guided strategy to optimize the EFV dose in HIV-positive Taiwanese patients.
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Enhanced Cytotoxicity of Natural Killer Cells following the Acquisition of Chimeric Antigen Receptors through Trogocytosis.
PLoS ONE
PUBLISHED: 01-01-2014
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Natural killer (NK) cells have the capacity to target tumors and are ideal candidates for immunotherapy. Viral vectors have been used to genetically modify in vitro expanded NK cells to express chimeric antigen receptors (CARs), which confer cytotoxicity against tumors. However, use of viral transduction methods raises the safety concern of viral integration into the NK cell genome. In this study, we used trogocytosis as a non-viral method to modify NK cells for immunotherapy. A K562 cell line expressing high levels of anti-CD19 CARs was generated as a donor cell to transfer the anti-CD19 CARs onto NK cells via trogocytosis. Anti-CD19 CAR expression was observed in expanded NK cells after these cells were co-cultured for one hour with freeze/thaw-treated donor cells expressing anti-CD19 CARs. Immunofluorescence analysis confirmed the localization of the anti-CD19 CARs on the NK cell surface. Acquisition of anti-CD19 CARs via trogocytosis enhanced NK cell-mediated cytotoxicity against the B-cell acute lymphoblastic leukemia (B-ALL) cell lines and primary B-ALL cells derived from patients. To our knowledge, this is the first report that describes the increased cytotoxicity of NK cells following the acquisition of CARs via trogocytosis. This novel strategy could be a potential valuable therapeutic approach for the treatment of B-cell tumors.
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Comparison of Serological Response to Doxycycline versus Benzathine Penicillin G in the Treatment of Early Syphilis in HIV-Infected Patients: A Multi-Center Observational Study.
PLoS ONE
PUBLISHED: 01-01-2014
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While doxycycline is recommended as an alternative treatment of syphilis in patients with penicillin allergy or intolerance, clinical studies to compare serological response to doxycycline versus benzathine penicillin in treatment of early syphilis among HIV-infected patients remain sparse.
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One Dose versus Three Weekly Doses of Benzathine Penicillin G for Patients Co-Infected with HIV and Early Syphilis: A Multicenter, Prospective Observational Study.
PLoS ONE
PUBLISHED: 01-01-2014
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One dose of benzathine penicillin G (BPG) has been recommended for HIV-infected patients with early syphilis (primary, secondary, and early latent syphilis) in the sexually transmitted diseases treatment guidelines, but clinical data to support such a recommendation are limited.
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Seroprevalence of hepatitis B virus among adults at high risk for HIV transmission two decades after implementation of nationwide hepatitis B virus vaccination program in Taiwan.
PLoS ONE
PUBLISHED: 01-01-2014
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Seroprevalence of hepatitis B virus (HBV) after implementation of universal neonatal HBV vaccination and catch-up vaccination programs remains rarely investigated among the adults who were born in the vaccination era (in or after 1986) and engaged in high-risk sexual behaviors.
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Therapeutic drug monitoring and pharmacogenetic study of HIV-infected ethnic Chinese receiving efavirenz-containing antiretroviral therapy with or without rifampicin-based anti-tuberculous therapy.
PLoS ONE
PUBLISHED: 01-01-2014
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Plasma efavirenz concentrations in HIV-infected patients with tuberculosis (TB) may be affected by cytochrome P450 (CYP) 2B6 single-nucleotide polymorphisms and concurrent rifampicin use. We aimed to investigate the effects of CYP2B6 G516T polymorphisms and concomitant rifampicin use on the plasma efavirenz concentrations in HIV-infected Taiwanese.
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Elevated serum triglyceride and retinol-binding protein 4 levels associated with fructose-sweetened beverages in adolescents.
PLoS ONE
PUBLISHED: 01-01-2014
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The metabolic effect of fructose in sugar-sweetened beverages (SSB) has been linked to de novo lipogenesis and uric acid (UA) production.
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Single-incision laparoscopic-assisted jejunostomy tube placement.
J Laparoendosc Adv Surg Tech A
PUBLISHED: 12-13-2013
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Abstract Background: Feeding jejunostomy is an alternative enteral nutritional supplementation method for patients with functional gastrointestinal tracts. In this study, we introduced the novel, safe technique of single-incision laparoscopic-assisted jejunostomy (SIL-AJ) tube placement. Subjects and Methods: We conducted a prospective record search and a retrospective review of all patients who received surgical jejunostomy tube placement in Chang Gung Memorial Hospital, Linkou, Taiwan, from October 2011 to December 2012. SIL-AJ, multiple-incision laparoscopic jejunostomy (MIL-J), and open jejunostomy (O-J) were performed concurrently. We compared the demographic data, operative time, postoperative pain control, and postoperative complications among these groups. Results: Forty patients who received surgical jejunostomy in this period were enrolled in the study. There were 14 patients with SIL-AJ, 10 with MIL-J, and 16 with O-J. There were no differences in age, sex, American Society of Anesthesiologists status, body mass index, or malignancy distribution among the SIL-AJ, MIL-J, and O-J groups. The total operative times for the SIL-AJ, MIL-J, and O-J procedures were 53.3±11.5, 117.3±45.8, and 52.9±16.1 minutes, respectively; SIL-AJ and O-J had similar operative times, which were significantly shorter than the operative times in the MIL-J group (P<.001). The proportions of patients who began feeding within 24 hours in the SIL-AJ, MIL-J, and O-J groups were 100%, 70%, and 37%, respectively; the SIL-AJ group had a higher feeding rate at 24 hours than the two other groups (P=.001). The SIL-AJ and MIL-J groups had fewer postoperative complications than the O-J group (P=.011). Conclusions: SIL-AJ is a feasible and safe procedure that can be performed in patients who require alternative enteral feeding. Reduced postoperative pain, acceptable incisions, and quick feeding were observed in patients with SIL-AJ. Transumbilical SIL-AJ uses cost-effective appliances, and it is a relatively simple technique to learn and in which togain proficiency.
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Real-time white-light phosphor-LED visible light communication (VLC) with compact size.
Opt Express
PUBLISHED: 11-13-2013
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In this demonstration, we first demonstrate a real-time phosphor-LED visible light communication (VLC) system with 37 Mbit/s total throughput under a 1.5 m free space transmission length. The transmitter and receiver modules are compact size. Utilizing our proposed pre-equalization technology, the ~1 MHz bandwidth of phosphor LED could be extended to ~12 MHz without using blue filter. Thus, the increase in bandwidth would enhance the traffic data rate for VLC transmission. The maximum bit-rate achieved by the VLC system is 37 Mbit/s, and a video transmission at 28.419 Mbit/s is demonstrated using the proposed VLC system. In addition, the relationships of received power and signal performance are discussed and analyzed.
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Right massive haemothorax as the presentation of blunt cardiac rupture: the pitfall of coexisting pericardial laceration.
Interact Cardiovasc Thorac Surg
PUBLISHED: 11-11-2013
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A 74-year old female was transferred to our institution because of blunt chest trauma. Chest X-ray and computed tomography (CT) revealed right haemothorax and little pericardial effusion. She was taken to the operating theatre for emergent operation because of hypotension and massive bleeding from the right-sided chest tube. Cardiopulmonary resuscitation was started during surgical exploration. There were three 1-cm lacerations actively bleeding from the right atrium and inferior vena cava junction, which were repaired successfully. Furthermore, we identified a 10 cm laceration in the right-side pleuropericardium and a communication existing between the pericardial space and the right pleural space.
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Virological, Serological, and Antiviral Studies in an Imported Human Case of Avian Influenza A(H7N9) Virus in Taiwan.
Clin. Infect. Dis.
PUBLISHED: 09-27-2013
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We describe the clinical course and virological characteristics of the first H7N9 influenza case in a Taiwanese patient; this patient had detectable viruses in the airway for 2 weeks, during which time an oseltamivir resistance-associated R292K mutation rapidly emerged. Anti-H7N9 antibody was detected 21 days after onset of symptoms, when H7N9 viral load declined significantly.
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Effects of push/pull perfusion and ultrasonication on the extraction efficiencies of phthalate esters in sports drink samples using on-line hollow-fiber liquid-phase microextraction.
J. Agric. Food Chem.
PUBLISHED: 08-14-2013
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In previous studies, we developed a process, on-line ultrasound-assisted push/pull perfusion hollow-fiber liquid-phase microextraction (UA-PPP-HF-LPME), combining the techniques of push/pull perfusion (PPP) and ultrasonication with hollow-fiber liquid-phase microextraction (HF-LPME), to achieve rapid extraction of acidic phenols from water samples. In this present study, we further evaluated three more-advanced and novel effects of PPP and ultrasonication on the extraction efficiencies of neutral high-molecular-weight phthalate esters (HPAEs) in sports drinks. First, we found that inner-fiber fluid leakage occurs only in push-only perfusion-based and pull-only perfusion-based HF-LPME, but not in the PPP mode. Second, we identified a significant negative interaction between ultrasonication and temperature. Third, we found that the extraction time of the newly proposed system could be shortened by more than 93%. From an investigation of the factors affecting UA-PPP-HF-LPME, we established optimal extraction conditions and achieved acceptable on-line enrichment factors of 92-146 for HPAEs with a sampling time of just 2 min.
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Gasless laparoscopic assisted surgery for abdominal trauma.
Injury
PUBLISHED: 08-08-2013
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Numerous studies have described the effectiveness of laparoscopy for trauma patients. In gas-filling laparoscopic surgery, most of the disadvantages are related to a positive pressure pneumoperitoneum that compromises the cardiopulmonary function. The main advantage of gasless laparoscopic assisted surgery (GLA) is that it does not affect the haemodynamic status, which is particularly critical for trauma patients. The purpose of this study was to investigate the feasibility and safety of GLA for abdominal trauma.
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Robust carboxylic acid-terminated organic thin films and nanoparticle protectants generated from bidentate alkanethiols.
Langmuir
PUBLISHED: 08-08-2013
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A new carboxylic acid-terminated alkanethiol having bidentate character, 16-(3,5-bis(mercaptomethyl)phenoxy)hexadecanoic acid (BMPHA), was designed as an absorbate and protectant to form thermally stable carboxylic acid-terminated organic thin films on flat gold and nanoparticles, respectively. The structural features of the organic thin films derived from BMPHA were characterized by ellipsometry, X-ray photoelectron spectroscopy (XPS), and polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS), and compared to those derived from mercaptohexadecanoic acid (MHA) and 16-(4-(mercaptomethyl)phenoxy)hexadecanoic acid (MMPHA). This study demonstrates that films derived from BMPHA are less densely packed than films derived from MHA and MMPHA. However, the results of solution-phase thermal desorption tests revealed that the carboxylic acid-terminated films generated from BMPHA exhibit an enhanced thermal stability compared to those generated from MHA and MMPHA. Furthermore, as a nanoparticle protectant, BMPHA can be used to stabilize large gold nanoparticles (~45 nm diameter) in solution, and BMPHA-protected gold nanoparticles exhibited a high thermal stability in solution thermolysis studies.
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The diminishing role of pelvic x-rays in the management of patients with major torso injuries.
Am J Emerg Med
PUBLISHED: 07-30-2013
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A pelvic x-ray (PXR) can be used as an effective screening tool to evaluate pelvic fractures and stability. However, associated intra-abdominal/retroperitoneal organ injuries and hemorrhage should also be considered and evaluated in patients with major torso injuries. An abdominal/pelvic computed tomographic (CT) scan may provide higher resolution and more information than a PXR. The role of conventional PXRs was delineated in the current study in the context of the development of the CT scan.
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Clinical characteristics, microbiology, and outcomes for patients with lung and disseminated nocardiosis in a tertiary hospital.
J. Formos. Med. Assoc.
PUBLISHED: 07-29-2013
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Nocardia are ubiquitous in the environment worldwide and cause a variety of infections. Clinical manifestations and outcomes of nocardiosis can vary with different populations, host immunity, and presentations. The purpose of this study was to analyze the differences in clinical characteristics, antimicrobial susceptibility, and outcomes for patients with skin, lung, and disseminated nocardiosis.
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Annealing effect and photovoltaic properties of nano-ZnS/textured p-Si heterojunction.
Nanoscale Res Lett
PUBLISHED: 07-19-2013
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The preparation and characterization of heterojunction solar cell with ZnS nanocrystals synthesized by chemical bath deposition method were studied in this work. The ZnS nanocrystals were characterized by X-ray diffraction (XRD) and high-resolution transmission electron microscopy (HRTEM). Lower reflectance spectra were found as the annealing temperature of ZnS film increased on the textured p-Si substrate. It was found that the power conversion efficiency (PCE) of the AZO/ZnS/textured p-Si heterojunction solar cell with an annealing temperature of 250[degree sign]C was eta = 3.66%.
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Transmission of 8 × 480-Gb/s super-Nyquist-filtering 9-QAM-like signal at 100 GHz-grid over 5000-km SMF-28 and twenty-five 100 GHz-grid ROADMs.
Opt Express
PUBLISHED: 07-12-2013
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We experimentally demonstrate a highly filtering-tolerant multi-modulus equalization (MMEQ) process for very aggressively spectrum-shaped 9-ary quadrature-amplitude-modulation (9-QAM)-like polarization division multiplexing quadrature phase shift keying (PDM-QPSK) signal to achieve 400-Gb/s wavelength-division-multiplexing (WDM) channels on the 100-GHz grid for ultra-long-haul reach and high tolerance of the filter narrowing effect caused by reconfigurable optical add-drop multiplexers (ROADMs). We successfully transmitted 8 channels 480-Gb/s super-Nyquist (channel occupancy much less than signal baud rate) WDM signals at 100-GHz grid over 25 × 200 km conventional single-mode fiber-28 (SMF-28) with post Raman amplification and 25 ROADMs at a net spectral efficiency (SE) of 4b/s/Hz, after excluding the 20% soft-decision forward-error-correction (FEC) overhead. The system performance is significantly enhanced by the MMEQ based on 9-QAM-like constellations compared to the conventional 4 point QPSK constellation. A record transmission distance over conventional SMF-28 with a large number of ROADMs is firstly reported on the 400-Gb/s channels at 100-GHz grid.
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Dual-incision laparoscopic surgery for peritoneal dialysis catheter implantation and fixation: a novel, simple, and safe procedure.
J Laparoendosc Adv Surg Tech A
PUBLISHED: 07-09-2013
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Peritoneal dialysis (PD) is an alternative modality to hemodialysis and is usually used to treat patients with end-stage renal disease. Dual-incision laparoscopic surgery (DILS) had been reported in several surgical fields; however, no report was proposed about DILS in PD catheter implantation (DILS-PD). In this study, we present DILS with a novel, simple, and safe procedure for PD catheter implantation with fixation and describe the long-term outcome.
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Investigating the interaction between heart rate variability and sleep EEG using nonlinear algorithms.
J. Neurosci. Methods
PUBLISHED: 07-04-2013
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The multi-mode modulation is a key feature of sleep EEG. And the short-term fractal property reflects the sympathovagal modulation of heart rate variability (HRV). The properties of EEG and HRV strongly correlated with sleep status and are interesting in clinic diagnosis.
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Pelvic circumferential compression devices benefit patients with pelvic fractures who need transfers.
Am J Emerg Med
PUBLISHED: 06-19-2013
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Patients with pelvic fracture usually require transfers to trauma centers for additional advanced treatment. Patient safety during the transfer should always be a priority. The noninvasive pelvic circumferential compression device (PCCD) can reportedly provide a tamponade effect, which reduces hemorrhage. In the present study, we evaluated the feasibility and efficiency of PCCD in patients with pelvic fracture who required transfer to trauma centers.
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Adenosquamous carcinoma of the ampulla of Vater - a rare disease at unusual location.
World J Surg Oncol
PUBLISHED: 05-17-2013
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Adenosquamous carcinoma is defined as a tumor in which both glandular and squamous elements are histologically malignant. Although some published studies have analyzed and discussed adenosquamous carcinomas, hybrid malignancy of the ampulla of Vater has rarely been discussed thus far in the literature. In this study, we report the case of a 64-year-old man who presented with jaundice and intermittent abdominal dull pain that persisted for several weeks. The patient was diagnosed with adenosquamous carcinoma of the ampulla of Vater and underwent pancreaticoduodenectomy. The final diagnosis was adenosquamous carcinoma of the ampulla of Vater, T3N1M0, stage IIB. Although R0 resection was performed, he had multiple liver metastases 2 months after the operation; he died 4 months later. Upon reviewing the medical records of our institute, we identified 4 patients who were diagnosed with adenosquamous carcinoma of the ampulla of Vater in the past 2 decades. We also identified only five reported cases of this lesion in the English literature. Adenosquamous carcinoma of the ampulla of Vater is a rare disease with a dismal prognosis. Surgical intervention does not appear to prolong patient survival. Early recurrence and distal metastasis may be encountered after surgery.
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Differential impact of resistance-associated mutations to protease inhibitors and nonnucleoside reverse transcriptase inhibitors on HIV-1 replication capacity.
AIDS Res. Hum. Retroviruses
PUBLISHED: 05-15-2013
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The effects of drug resistance on HIV-1 replication capacity have been studied, but data from clinical isolates are few. We accessed the patients with HIV-1 infection at the National Taiwan University Hospital who experienced virological failure. Genotypic susceptibility and replication capacity of clinical HIV-1 isolates were measured. There were 80 patients enrolled between September 2007 and August 2010. The HIV-1 replication capacity declined significantly with the increasing number of major resistance-associated mutations (RAMs) to protease inhibitors (PIs) (p<0.001); however, it did not decline significantly with the increasing RAMs to first-line nonnucleoside analogue reverse transcriptase inhibitors (NNRTIs) (p=0.098). Regarding the effects of resistance to antiretroviral drugs in salvage therapy, decreased replication capacity was noted with the increasing RAMs to darunavir/ritonavir (p<0.001) and specific RAMs (L100I, K101P, and Y181C/I/V) to etravirine (p<0.001). Although NNRTI-related RAMs have less remarkable effects, both PI- and NNRTI-related RAMs reduced replication capacity, especially RAMs to darunavir/ritonavir and etravirine, which are commonly used in salvage therapy for treatment of patients infected with highly resistant HIV. Thus, decreased viral fitness during the emergence of RAMs suggests the importance of continued optimal antiretroviral treatment even when virological failure was noted.
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ALPK1 genetic regulation and risk in relation to gout.
Int J Epidemiol
PUBLISHED: 04-10-2013
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The present study investigated whether single nucleotide polymorphisms (SNPs) in the alpha-protein kinase 1 (ALPK1) gene are associated with gout in aboriginal and Han Chinese Taiwanese.
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Factors affecting outcomes in penetrating diaphragmatic trauma.
Int J Surg
PUBLISHED: 03-19-2013
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BACKGROUDS: Diagnosing penetrating diaphragmatic rupture (PDR) is a challenging aspect of managing thoracoabdominal injuries due to the lack of a typical clinical presentation. The mortality from PDR is variable and center-specific. In this study, we identified the incidence and clinical presentation of PDR at our institution and analyzed the factors that affected the length of hospital stay and mortality.
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Service integrated access network using highly spectral-efficient MASK-MQAM-OFDM coding.
Opt Express
PUBLISHED: 03-14-2013
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A highly spectral-efficient M-ary amplitude shift keying M-ary quadrature amplitude modulation orthogonal frequency division multiplexing (MASK-MQAM-OFDM) was proposed for the access network. With the highly spectral-efficient characteristic of MASK-MQAM-OFDM, seamless integration among passive-optical network (PON), wireless fiber-to-the-antenna (FTTA), and optical wireless visible light communication (VLC) can be achieved without using extra bandwidth for different services. A proof-of-concept experiment was demonstrated. The relation between the spectral efficiency of the MASK-MQAM-OFDM and the upstream signal performance was also discussed.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.