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Find video protocols related to scientific articles indexed in Pubmed.
Profiles of self-care management versus consulting behaviors in adults with heart failure.
Eur J Cardiovasc Nurs
PUBLISHED: 01-14-2015
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Patients with heart failure (HF) vary in their ability to respond to symptoms when they occur. The goal of this study was to classify common patterns of symptom response behaviors among adults with HF and identify biobehavioral determinants thereof.
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Assessment of choroidal thickness before and after steep Trendelenburg position using swept-source optical coherence tomography.
Br J Ophthalmol
PUBLISHED: 10-23-2014
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To evaluate changes in choroidal thickness before and after steep Trendelenburg position (STP, 40° head-down) using automated segmentation software to analyse swept-source optical coherence tomography (SS-OCT) data.
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Narcissism Dimensions Differentially Moderate Selective Attention to Evaluative Stimuli in Incarcerated Offenders.
Personal Disord
PUBLISHED: 10-21-2014
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Narcissistic personality disorder is associated with distinguishing traits including self-enhancement, arrogance, and intense reactivity to ego threat. Theoretical accounts of narcissism suggest these heterogeneous behaviors reflect a defensive motivational style that functions to both uphold and protect the self-concept. However, the notion that narcissism can be characterized by grandiose and vulnerable dimensions raises the possibility that these diverse behaviors represent distinct expressions of narcissistic defensiveness. The present study examined whether both dimensions exhibit a general defensive style marked by selective attention to evaluative stimuli or are differentially associated with selective attention to positive and negative information, respectively. Using a dot probe task consisting of valenced and neutral trait adjectives, we evaluated these hypotheses in a group of male offenders. Results indicated that vulnerable narcissism was associated with attention biases for both positive and negative stimuli, though the dimension was further distinguished by disengagement difficulties and a greater recognition memory bias in response to negative words. Conversely, grandiose narcissism was associated with increased accuracy when attending to positive stimuli and directing attention away from negative stimuli. Overall, these findings suggest narcissistic individuals share motivated selective attention in response to evaluative stimuli, while simultaneously highlighting important phenotypic differences between grandiose and vulnerable dimensions. (PsycINFO Database Record (c) 2014 APA, all rights reserved).
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Gender-Specific Physical Symptom Biology in Heart Failure.
J Cardiovasc Nurs
PUBLISHED: 10-18-2014
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There are several gender differences that may help explain the link between biology and symptoms in heart failure (HF).
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SUBFOVEAL CHOROIDAL THICKNESS IN IDIOPATHIC CHOROIDAL NEOVASCULARIZATION AND TREATMENT OUTCOMES AFTER INTRAVITREAL BEVACIZUMAB THERAPY.
Retina (Philadelphia, Pa.)
PUBLISHED: 10-15-2014
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To determine subfoveal choroidal thickness in idiopathic choroidal neovascularization (CNV) and evaluate visual and anatomical outcomes in patients with idiopathic CNV after intravitreal bevacizumab.
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Cardiophrenic lymph nodes in liver transplant candidates with hepatocellular carcinoma: imaging characteristics and post-transplant outcomes.
Clin Transplant
PUBLISHED: 09-22-2014
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No guidelines exist for the management of cardiophrenic lymph nodes in patients with hepatocellular carcinoma (HCC) being evaluated for liver transplantation.
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Displacement as a predictor of functional impairment in tsunami-exposed children.
Disasters
PUBLISHED: 09-19-2014
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Thirty months after the Indian Ocean tsunami of 26 December 2004, thousands of families in Aceh Province, Indonesia, remained in temporary barracks while sanitation conditions and non-governmental organisation support deteriorated. This study sought to determine the factors associated with functional impairment in a sample of 138 displaced and non-displaced Acehnese children. Using multivariate linear regression models, it was found that displacement distance was a consistent predictor of impairment using the Brief Impairment Scale. Exposure to tsunami-related trauma markers was not significantly linked with impairment in the model. Paternal employment was a consistent protective factor for child functioning. These findings suggest that post-disaster displacement and the subsequent familial economic disruption are significant predictors of impaired functioning in children's daily activities. Post-disaster interventions should consider the disruption of familiar environments for families and children when relocating vulnerable populations to avoid deleterious impacts on children's functioning.
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Design of an international multicentre RCT on group schema therapy for borderline personality disorder.
BMC Psychiatry
PUBLISHED: 09-18-2014
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BackgroundBorderline personality disorder (BPD) is a severe and highly prevalent mental disorder. Schema therapy (ST) has been found effective in the treatment of BPD and is commonly delivered through an individual format. A group format (group schema therapy, GST) has also been developed. GST has been found to speed up and amplify the treatment effects found for individual ST. Delivery in a group format may lead to improved cost-effectiveness. An important question is how GST compares to treatment as usual (TAU) and what format for delivery of schema therapy (format A; intensive group therapy only, or format B; a combination of group and individual therapy) produces the best outcomes.Methods/DesignAn international, multicentre randomized controlled trial (RCT) will be conducted with a minimum of fourteen participating centres. Each centre will recruit multiple cohorts of at least sixteen patients. GST formats as well as the orders in which they are delivered to successive cohorts will be balanced. Within countries that contribute an uneven number of sites, the orders of GST formats will be balanced within a difference of one. The RCT is designed to include a minimum of 448 patients with BPD. The primary clinical outcome measure will be BPD severity. Secondary clinical outcome measures will include measures of BPD and general psychiatric symptoms, schemas and schema modes, social functioning and quality of life. Furthermore, an economic evaluation that consists of cost-effectiveness and cost-utility analyses will be performed using a societal perspective. Lastly, additional investigations will be carried out that include an assessment of the integrity of GST, a qualitative study on patients¿ and therapists¿ experiences with GST, and studies on variables that might influence the effectiveness of GST.DiscussionThis trial will compare GST to TAU for patients with BPD as well as two different formats for the delivery of GST. By combining an evaluation of clinical effectiveness, an economic evaluation and additional investigations, it will contribute to an evidence-based understanding of which treatment should be offered to patients with BPD from clinical, economic, and stakeholders¿ perspectives.Trial registrationNetherlands Trial Register NTR2392. Registered 25 June 2010.
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Dimensionality and reliability of the self-care of heart failure index scales: further evidence from confirmatory factor analysis.
Res Nurs Health
PUBLISHED: 08-25-2014
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The Self-Care of Heart Failure Index (SCHFI) is used widely, but issues with reliability have been evident. Cronbach alpha coefficient is usually used to assess reliability, but this approach assumes a unidimensional scale. The purpose of this article is to address the dimensionality and internal consistency reliability of the SCHFI. This was a secondary analysis of data from 629 adults with heart failure enrolled in three separate studies conducted in the northeastern and northwestern United States. Following testing for scale dimensionality using confirmatory factor analysis, reliability was tested using coefficient alpha and alternative options. Confirmatory factor analysis demonstrated that: (a) the Self-Care Maintenance Scale has a multidimensional four-factor structure; (b) the Self-Care Management Scale has a two-factor structure, but the primary factors loaded on a common higher-order factor; and (c) the Self-Care Confidence Scale is unidimensional. Reliability estimates for the three scales, obtained with methods compatible with each scale's dimensionality, were adequate or high. The results of the analysis demonstrate that issues of dimensionality and reliability cannot be separated. Appropriate estimates of reliability that are consistent with the dimensionality of the scale must be used. In the case of the SCHFI, coefficient alpha should not be used to assess reliability of the self-care maintenance and the self-care management scales, due to their multidimensionality. When performing psychometric evaluations, we recommend testing dimensionality before assessing reliability, as well using multiple indices of reliability, such as model-based internal consistency, composite reliability, and omega and maximal reliability coefficients. © 2014 Wiley Periodicals, Inc.
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A qualitative insight of HIV/AIDS patients' perspective on disease and disclosure.
Health Expect
PUBLISHED: 08-20-2014
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Understanding patients' knowledge and belief towards disease could play a vital role from an outcome perspective of disease management and HIV/AIDS patients are not exception to that.
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HIV multi-drug resistance at first-line antiretroviral failure and subsequent virological response in Asia.
J Int AIDS Soc
PUBLISHED: 08-19-2014
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First-line antiretroviral therapy (ART) failure often results from the development of resistance-associated mutations (RAMs). Three patterns, including thymidine analogue mutations (TAMs), 69 Insertion (69Ins) and the Q151M complex, are associated with resistance to multiple-nucleoside reverse transcriptase inhibitors (NRTIs) and may compromise treatment options for second-line ART.
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Accuracy of Palpation-Directed Intra-articular Glenohumeral Injection Confirmed by Magnetic Resonance Arthrography.
Arthroscopy
PUBLISHED: 08-07-2014
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The aim of this study was to determine the accuracy of anatomic palpation-directed injections in the office setting.
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Dorsal muscle group area and surgical outcomes in liver transplantation.
Clin Transplant
PUBLISHED: 07-13-2014
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Better measures of liver transplant risk stratification are needed. Our previous work noted a strong relationship between psoas muscle area and survival following liver transplantation. The dorsal muscle group is easier to measure, but it is unclear if they are also correlated with surgical outcomes.
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On the rhythm of infant- versus adult-directed speech in Australian English.
J. Acoust. Soc. Am.
PUBLISHED: 07-05-2014
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The findings are reported of an investigation into rhythmic differences between infant-directed speech (IDS) and adult-directed speech (ADS) in a corpus of utterances from Australian English mothers speaking to their infants and to another adult. Given the importance of rhythmic cues to stress and word-segmentation in English, the investigation focused on the extent to which IDS makes such cues salient. Two methods of analysis were used: one focused on segmental durational properties, using a variety of durational measures; the other focused on the prominence of vocalic/sonorant segments, as determined by their duration, intensity, pitch, and spectral balance, using individual measures as well as composite measures of prominence derived from auditory-model analyses. There were few IDS/ADS differences/trends on the individual measures, though mean pitch and pitch variability were higher in IDS than ADS, while IDS vowels showed more negative spectral tilt. However, the model-based analyses suggested that differences in the prominence of vowels/sonorant segments were reduced in IDS, with further analysis suggesting that pitch contributed little to prominence. The reduction in prominence contrasts may be due to the importance of mood-regulation in speech to young infants, and may suggest that infants rely on segmental cues to stress and word-segmentation.
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Early Pelvic Fixation Failure in Neuromuscular Scoliosis.
J Pediatr Orthop
PUBLISHED: 07-04-2014
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To report on early failures of pelvic fixation in posterior spinal fusions for neuromuscular scoliosis.
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Symptom-Hemodynamic Mismatch and Heart Failure Event Risk.
J Cardiovasc Nurs
PUBLISHED: 07-03-2014
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Heart failure (HF) is a heterogeneous condition of both symptoms and hemodynamics.
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Physical and Psychological Symptom Biomechanics in Moderate to Advanced Heart Failure.
J Cardiovasc Nurs
PUBLISHED: 07-03-2014
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There is a common dissociation between objective measures and patient symptomatology in heart failure (HF).
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Trajectories of heart failure self-care management and changes in quality of life.
Eur J Cardiovasc Nurs
PUBLISHED: 07-02-2014
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Heart failure patients vary considerably in their self-care management behaviors (i.e. recognizing and responding to symptoms). The goal of this study was to identify unique patterns of change in heart failure self-care management and quantify associations between self-care management and quality of life (HRQOL) over time.
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Silent compartment syndrome in children: a report of five cases.
J Pediatr Orthop B
PUBLISHED: 06-13-2014
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Compartment syndrome does not always present classically in the pediatric population, making clinical diagnosis uniquely challenging. The purpose of this study was to identify signs and symptoms of compartment syndrome that may help risk-stratify pediatric patients upon presentation, as well as to report outcomes of 'silent' compartment syndrome in children. A retrospective review of cases of 'silent' compartment syndrome at a level I pediatric trauma center between 2000 and 2010 was conducted. Patient demographics and clinical data were reviewed, including complications and patient outcomes. Radiographs taken at presentation, on intraoperative fluoroscopy, and at postoperative follow-up were reviewed for fracture type, and severity and outcome analyses. Five patients were found to have compartment syndrome without the presence of significant pain at rest or on passive range of motion. The study included three male and two female patients with a median age of 7 years. Three upper-extremity and two lower-extremity fractures were involved. The mean time from presentation to surgery was 14?h. At presentation, three of five patients had muscle paralysis, whereas at diagnosis of compartment syndrome, four of five had paralysis. Of the classic five P's, a maximum of two were found at diagnosis. The mean clinical follow-up period was 11 months (2-26 months). Long-term complications from compartment syndrome were found in one of five patients, who at the most recent follow-up, continued to be debilitated. This study reviews a series of cases of 'silent' compartment syndrome and confirms its atypical presentation. It is recommended that caution be used when assessing fractures with high risk for compartment syndrome in children, especially those complicated by nerve injury, as they do not always present in the classic manner, with missed diagnosis leading to significant functional deficits.
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Comparison of Expert Modeling Versus Voice-Over PowerPoint Lecture and Presimulation Readings on Novice Nurses' Competence of Providing Care to Multiple Patients.
J Nurs Educ
PUBLISHED: 06-08-2014
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Due to today's complex needs of hospitalized patients, nurses' competence and strategies to improve competence are of growing importance. Simulation is commonly used to influence competence, but little evidence exists for comparing how presimulation assignments influence competence. A randomized control trial was used to compare the efficacy of three simulation preparation methods (expert modeling/intervention, voice-over PowerPoint/active control, and reading assignments/passive control) on improving competence for providing care to multiple patients among senior undergraduate novice nurses. Competence was measured at two time points (baseline and following a 5-week intervention) by two blinded raters using the Creighton Simulation Evaluation Instrument. Twenty novice nurses participated in the trial. No significant differences were noted in raw improvements in competence among the three groups, but the expert modeling (Cohen's d = 0.413) and voice-over PowerPoint methods (Cohen's d = 0.226) resulted in greater improvements in competence, compared with the passive control. [J Nurs Educ. 2014;53(11):615-622.].
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Peripheral immune response and infection in first-time and recurrent ischemic stroke or transient ischemic attack.
J Neurosci Nurs
PUBLISHED: 05-31-2014
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The aims of this study were to determine if the infection rate differs between the first and recurrent ischemic stroke/transient ischemic attack (TIA), if the pattern of the peripheral immune response (PIR) differs between the first and recurrent ischemic stroke/TIA and if infection further influenced the pattern of the PIR.
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Measuring impact: a cross-sectional multi-stage cluster survey to assess the attainment of durable solutions in post-tsunami Aceh, Indonesia.
BMC Public Health
PUBLISHED: 05-01-2014
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There exists little agreement on the choice of indicators to be used to assess the impact of humanitarian assistance. The 2004 Indian Ocean tsunami led to significant mortality and displacement in Aceh Province, Indonesia, as well as a nearly unprecedented humanitarian response. Six years after the disaster we conducted an impact assessment of humanitarian services rendered in Aceh using a comprehensive set of rights-based indicators and sought to determine modifiable predictors of improved outcomes in disaster-affected households.
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Regression of uveal melanoma after ru-106 brachytherapy and thermotherapy based on metabolic activity measured by positron emission tomography/computed tomography.
Retina (Philadelphia, Pa.)
PUBLISHED: 04-17-2014
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To evaluate regression rates of uveal melanoma after combined Ru-106 plaque radiotherapy and thermotherapy according to metabolic activity measured by positron emission tomography/computed tomography imaging.
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Thyroid Lesions Visualized on CT: Sonographic and Pathologic Correlation.
Acad Radiol
PUBLISHED: 04-08-2014
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There are no definitive guidelines for the management of incidental thyroid lesions on computed tomography (CT). The objectives of our study were to assess the association between CT and ultrasound (US) characteristics of thyroid lesions and identify CT predictors of benignity or malignancy.
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The survival of influenza A(H1N1)pdm09 virus on 4 household surfaces.
Am J Infect Control
PUBLISHED: 04-01-2014
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We investigated the survival of a pandemic strain of influenza A H1N1 on a variety of common household surfaces where multiple samples were taken from 4 types of common household fomite at 7 time points. Results showed that influenza A H1N1sw virus particles remained infectious for 48 hours on a wooden surface, for 24 hours on stainless steel and plastic surfaces, and for 8 hours on a cloth surface, although virus recovery from the cloth may have been suboptimal. Our results suggest that pandemic influenza A H1N1 can survive on common household fomites for extended periods of time, and that good hand hygiene and regular disinfection of commonly touched surfaces should be practiced during the influenza season to help reduce transmission.
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Comorbidity profiles and inpatient outcomes during hospitalization for heart failure: an analysis of the U.S. Nationwide inpatient sample.
BMC Cardiovasc Disord
PUBLISHED: 03-25-2014
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Treatment of heart failure (HF) is particularly complex in the presence of comorbidities. We sought to identify and associate comorbidity profiles with inpatient outcomes during HF hospitalizations.
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Psychometric testing on the NLN Student Satisfaction and Self-Confidence in Learning, Simulation Design Scale, and Educational Practices Questionnaire using a sample of pre-licensure novice nurses.
Nurse Educ Today
PUBLISHED: 03-24-2014
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In 2006, the National League for Nursing published three measures related to novice nurses' beliefs about self-confidence, scenario design, and educational practices associated with simulation. Despite the extensive use of these measures, little is known about their reliability and validity.
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Reconstructing the age and historical biogeography of the ancient flowering-plant family Hydatellaceae (Nymphaeales).
BMC Evol. Biol.
PUBLISHED: 02-21-2014
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The aquatic flowering-plant family Hydatellaceae has a classic Gondwanan distribution, as it is found in Australia, India and New Zealand. To shed light on the biogeographic history of this apparently ancient branch of angiosperm phylogeny, we dated the family in the context of other seed-plant divergences, and evaluated its biogeography using parsimony and likelihood methods. We also explicitly tested the effect of different extinction rates on biogeographic inferences.
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Symptom Incongruence Trajectories in Lung Cancer Dyads.
J Pain Symptom Manage
PUBLISHED: 02-12-2014
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There is little known about the pattern of change in patient-family member symptom incongruence across the lung cancer trajectory.
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Effectiveness of simulation for improvement in self-efficacy among novice nurses: a meta-analysis.
J Nurs Educ
PUBLISHED: 02-11-2014
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The influence of simulation on self-efficacy for novice nurses has been reported inconsistently in the literature. Effect sizes across studies were synthesized using random-effects meta-analyses. Simulation improved self-efficacy in one-group, pretest-posttest studies (Hedge's g = 1.21, 95% CI [0.63, 1.78]; p < 0.001). Simulation also was favored over control teaching interventions in improving self-efficacy in studies with experimental designs (Hedge's g = 0.27, 95% CI [0.1, 0.44]; p = 0.002). In nonexperimental designs, consistent conclusions about the influence of simulation were tempered by significant between-study differences in effects. Simulation is effective at increasing self-efficacy among novice nurses, compared with traditional control groups. [J Nurs Educ. 2014;53(11):607-614.].
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Characterization of starch polymorphic structures using vibrational sum frequency generation spectroscopy.
J Phys Chem B
PUBLISHED: 02-06-2014
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The polymorphic structures of starch were characterized with vibrational sum frequency generation (SFG) spectroscopy. The noncentrosymmetry requirement of SFG spectroscopy allows for the detection of the ordered domains without spectral interferences from the amorphous phase and also the distinction of the symmetric elements among crystalline polymorphs. The V-type amylose was SFG-inactive due to the antiparallel packing of single helices in crystal unit cells, whereas the A- and B-type starches showed strong SFG peaks at 2904 cm(-1) and 2952-2968 cm(-1), which were assigned to CH stretching of the axial methine group in the ring and CH2 stretching of the exocyclic CH2OH side group, respectively. The CH2/CH intensity ratios of the A- and B-type starches are significantly different, indicating that the conformation of hydroxymethyl groups in these two polymorphs may be different. Cyclodextrin inclusion complexes were also analyzed as a comparison to the V-type amylose and showed that the head-to-tail and head-to-head stacking patterns of cyclodextrin molecules govern their SFG signals and peak positions. Although the molecular packing is different between V-type amylose and cyclodextrin inclusion complexes, both crystals show the annihilation of SFG signals when the functional group dipoles are arranged pointing in opposite directions.
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An evaluation of the World Health Organization's 1997 and 2009 dengue classifications in hospitalized dengue patients in Malaysia.
J Infect Dev Ctries
PUBLISHED: 02-05-2014
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The latest revised version of the World Health Organization's dengue classification was released in 2009. A handful of studies have taken initiatives to evaluate the old and revised guidelines to determine early signs and symptoms of severe dengue. This retrospective study aimed to compare the classification of dengue using both the 1997 and 2009 guidelines in a selected cohort of dengue patients from Peninsular Malaysia between 2008 and 2012.
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Prevalence and risk factors of visual impairment and blindness in Korea: the Fourth Korea National Health and Nutrition Examination Survey in 2008-2010.
Acta Ophthalmol
PUBLISHED: 01-29-2014
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To describe the age, gender specific prevalence and risk factors of visual impairment and blindness in Korea.
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Subfoveal choroidal thickness as a potential predictor of visual outcome and treatment response after intravitreal ranibizumab injections for typical exudative age-related macular degeneration.
Am. J. Ophthalmol.
PUBLISHED: 01-21-2014
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To investigate the prognostic implication of subfoveal choroidal thickness on treatment outcome after intravitreal ranibizumab injections for typical exudative age-related macular degeneration (AMD).
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Clinical and spectral-domain optical coherence tomography findings in patients with focal choroidal excavation.
Ophthalmology
PUBLISHED: 01-16-2014
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To describe the clinical and spectral-domain optical coherence tomography (SD-OCT) findings in patients with focal choroidal excavation (FCE).
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Immunodeficiency at the start of combination antiretroviral therapy in low-, middle-, and high-income countries.
J. Acquir. Immune Defic. Syndr.
PUBLISHED: 01-15-2014
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To describe the CD4 cell count at the start of combination antiretroviral therapy (cART) in low-income (LIC), lower middle-income (LMIC), upper middle-income (UMIC), and high-income (HIC) countries.
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On the role of particle inorganic mixing state in the reactive uptake of N2O5 to ambient aerosol particles.
Environ. Sci. Technol.
PUBLISHED: 01-15-2014
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The rates of heterogeneous reactions of trace gases with aerosol particles are complex functions of particle chemical composition, morphology, and phase state. Currently, the majority of model parametrizations of heterogeneous reaction kinetics focus on the population average of aerosol particle mass, assuming that individual particles have the same chemical composition as the average state. Here we assess the impact of particle mixing state on heterogeneous reaction kinetics using the N2O5 reactive uptake coefficient, ?(N2O5), and dependence on the particulate chloride-to-nitrate ratio (nCl(-)/nNO3(-)). We describe the first simultaneous ambient observations of single particle chemical composition and in situ determinations of ?(N2O5). When accounting for particulate nCl(-)/nNO3(-) mixing state, model parametrizations of ?(N2O5) continue to overpredict ?(N2O5) by more than a factor of 2 in polluted coastal regions, suggesting that chemical composition and physical phase state of particulate organics likely control ?(N2O5) in these air masses. In contrast, direct measurement of ?(N2O5) in air masses of marine origin are well captured by model parametrizations and reveal limited suppression of ?(N2O5), indicating that the organic mass fraction of fresh sea spray aerosol at this location does not suppress ?(N2O5). We provide an observation-based framework for assessing the impact of particle mixing state on gas-particle interactions.
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A PROspective study on the Usage patterns of Doripenem in the Asia-Pacific region (PROUD study).
Int. J. Antimicrob. Agents
PUBLISHED: 01-02-2014
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Doripenem is approved in the Asia-Pacific (APAC) region for treating nosocomial pneumonia (NP) including ventilator-associated pneumonia (VAP), complicated intra-abdominal infections (cIAIs) and complicated urinary tract infections (cUTIs). Clinical usage of doripenem (500mg intravenously, infused over 1h or 4h every 8h for 5-14 days) in APAC was evaluated in a prospective, open-label, non-comparative, multicentre study of inpatients (?18 years) with NP, VAP, cIAI or cUTI. A total of 216 [intention-to-treat (ITT)] patients received doripenem: 53 NP (24.5%); 77 VAP (35.6%); 67 cIAI (31.0%); and 19 cUTI (8.8%). Doripenem MIC90 values for Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli and Klebsiella pneumoniae were 32, 32, 0.094 and 0.64?g/mL, respectively. Doripenem was used most commonly as monotherapy (86.6%) and as second-line therapy (62.0%). The clinical cure rate in clinically evaluable patients was 86.7% at the end of therapy (EOT) and 87.1% at test of cure (TOC) (7-14 days after EOT). In the ITT population, overall clinical cure rates were 66.2% at EOT and 56.5% at TOC. The median duration of hospital stay, intensive care unit (ICU) stay and mechanical ventilation was 20, 12 and 10 days, respectively. Of 146 discharged patients, 7 were re-admitted within 28 days of EOT; 1 VAP patient was re-admitted to the ICU. The all-cause mortality rate was 22.7% (49/216). The most common treatment-related adverse events were diarrhoea (1.4%) and vomiting (1.4%). Doripenem is a viable option for treating APAC patients with NP, VAP, cIAI or cUTI. [ClinicalTrials.gov: NCT 00986102].
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Impaired Bone Formation in Pdia3 Deficient Mice.
PLoS ONE
PUBLISHED: 01-01-2014
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1?,25-dihydroxyvitamin D3 [1?,25(OH)2D3] is crucial for normal skeletal development and bone homeostasis. Protein disulfide isomerase family A, member 3 (PDIA3) mediates 1?,25(OH)2D3 initiated-rapid membrane signaling in several cell types. To understand its role in regulating skeletal development, we generated Pdia3-deficient mice and examined the physiologic consequence of Pdia3-disruption in embryos and Pdia3+/- heterozygotes at different ages. No mice homozygous for the Pdia3-deletion were found at birth nor were there embryos after E12.5, indicating that targeted disruption of the Pdia3 gene resulted in early embryonic lethality. Pdia3-deficiency also resulted in skeletal manifestations as revealed by µCT analysis of the tibias. In comparison to wild type mice, Pdia3 heterozygous mice displayed expanded growth plates associated with decreased tether formation. Histomorphometry also showed that the hypertrophic zone in Pdia3+/- mice was more cellular than seen in wild type growth plates. Metaphyseal trabecular bone in Pdia3+/- mice exhibited an age-dependent phenotype with lower BV/TV and trabecular numbers, which was most pronounced at 15 weeks of age. Bone marrow cells from Pdia3+/- mice exhibited impaired osteoblastic differentiation, based on reduced expression of osteoblast markers and mineral deposition compared to cells from wild type animals. Collectively, our findings provide in vivo evidence that PDIA3 is essential for normal skeletal development. The fact that the Pdia3+/- heterozygous mice share a similar growth plate and bone phenotype to nVdr knockout mice, suggests that PDIA3-mediated rapid membrane signaling might be an alternative mechanism responsible for 1?,25(OH)2D3's actions in regulating skeletal development.
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Polymerase Discordance in Novel Swine Influenza H3N2v Constellations Is Tolerated in Swine but Not Human Respiratory Epithelial Cells.
PLoS ONE
PUBLISHED: 01-01-2014
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Swine-origin H3N2v, a variant of H3N2 influenza virus, is a concern for novel reassortment with circulating pandemic H1N1 influenza virus (H1N1pdm09) in swine because this can lead to the emergence of a novel pandemic virus. In this study, the reassortment prevalence of H3N2v with H1N1pdm09 was determined in swine cells. Reassortants evaluated showed that the H1N1pdm09 polymerase (PA) segment occurred within swine H3N2 with ?80% frequency. The swine H3N2-human H1N1pdm09 PA reassortant (swH3N2-huPA) showed enhanced replication in swine cells, and was the dominant gene constellation. Ferrets infected with swH3N2-huPA had increased lung pathogenicity compared to parent viruses; however, swH3N2-huPA replication in normal human bronchoepithelial cells was attenuated - a feature linked to expression of IFN-? and IFN-? genes in human but not swine cells. These findings indicate that emergence of novel H3N2v influenza constellations require more than changes in the viral polymerase complex to overcome barriers to cross-species transmission. Additionally, these findings reveal that while the ferret model is highly informative for influenza studies, slight differences in pathogenicity may not necessarily be indicative of human outcomes after infection.
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Potential of eye movement desensitization and reprocessing therapy in the treatment of post-traumatic stress disorder.
Psychol Res Behav Manag
PUBLISHED: 01-01-2014
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Post-traumatic stress disorder (PTSD) continues to attract both empirical and clinical interest due to its complex symptom profile and the underlying processes involved. Recently, research attention has been focused on the types of memory processes involved in PTSD and hypothesized neurobiological processes. Complicating this exploration, and the treatment of PTSD, are underlying comorbid disorders, such as depression, anxiety, and substance use disorders. Treatment of PTSD has undergone further reviews with the introduction of eye movement desensitization and reprocessing (EMDR). EMDR has been empirically demonstrated to be as efficacious as other specific PTSD treatments, such as trauma-focused cognitive behavioral therapy. There is emerging evidence that there are different processes underlying these two types of trauma treatment and some evidence that EMDR might have an efficiency advantage. Current research and understanding regarding the processes of EMDR and the future direction of EMDR is presented.
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Comprehensive detection of genes causing a phenotype using phenotype sequencing and pathway analysis.
PLoS ONE
PUBLISHED: 01-01-2014
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Discovering all the genetic causes of a phenotype is an important goal in functional genomics. We combine an experimental design for detecting independent genetic causes of a phenotype with a high-throughput sequencing analysis that maximizes sensitivity for comprehensively identifying them. Testing this approach on a set of 24 mutant strains generated for a metabolic phenotype with many known genetic causes, we show that this pathway-based phenotype sequencing analysis greatly improves sensitivity of detection compared with previous methods, and reveals a wide range of pathways that can cause this phenotype. We demonstrate our approach on a metabolic re-engineering phenotype, the PEP/OAA metabolic node in E. coli, which is crucial to a substantial number of metabolic pathways and under renewed interest for biofuel research. Out of 2157 mutations in these strains, pathway-phenoseq discriminated just five gene groups (12 genes) as statistically significant causes of the phenotype. Experimentally, these five gene groups, and the next two high-scoring pathway-phenoseq groups, either have a clear connection to the PEP metabolite level or offer an alternative path of producing oxaloacetate (OAA), and thus clearly explain the phenotype. These high-scoring gene groups also show strong evidence of positive selection pressure, compared with strictly neutral selection in the rest of the genome.
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Identifying predictors of high sodium excretion in patients with heart failure: A mixed effect analysis of longitudinal data.
Eur J Cardiovasc Nurs
PUBLISHED: 12-23-2013
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Background:A low-sodium diet is a core component of heart failure self-care but patients have difficulty following the diet.Aim:The aim of this study was to identify predictors of higher than recommended sodium excretion among patients with heart failure.Methods:The World Health Organization Five Dimensions of Adherence model was used to guide analysis of existing data collected from a prospective, longitudinal study of 280 community-dwelling adults with previously or currently symptomatic heart failure. Sodium excretion was measured objectively using 24-hour urine sodium measured at three time points over six months. A mixed effect logistic model identified predictors of higher than recommended sodium excretion.Results:The adjusted odds of higher sodium excretion were 2.90, (95% confidence interval (CI): 1.15-4.25, p<0.001) for patients who were obese; 2.80 (95% CI: 1.33-5.89, p=0.007) for patients with diabetes; and 2.22 (95% CI: 1.09-4.53, p=0.028) for patients who were cognitively intact.Conclusion:Three factors were associated with excess sodium excretion and two factors, obesity and diabetes, are modifiable by changing dietary food patterns.
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The Branched-Chain Aminotransferase Proteins: Novel Redox Chaperones for Protein Disulfide Isomerase-Implications in Alzheimers Disease.
Antioxid. Redox Signal.
PUBLISHED: 12-21-2013
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Abstract Aims: The human branched-chain aminotransferase proteins (hBCATm and hBCATc) are regulated through oxidation and S-nitrosation. However, it remains unknown whether they share common redox characteristics to enzymes such as protein disulfide isomerase (PDI) in terms of regulating cellular repair and protein misfolding. Results: Here, similar to PDI, the hBCAT proteins showed dithiol-disulfide isomerase activity that was mediated through an S-glutathionylated mechanism. Site-directed mutagenesis of the active thiols of the CXXC motif demonstrates that they are fundamental to optimal protein folding. Far Western analysis indicated that both hBCAT proteins can associate with PDI. Co-immunoprecipitation studies demonstrated that hBCATm directly binds to PDI in IMR-32 cells and the human brain. Electron and confocal microscopy validated the expression of PDI in mitochondria (using Mia40 as a mitochondrial control), where both PDI and Mia40 were found to be co-localized with hBCATm. Under conditions of oxidative stress, this interaction is decreased, suggesting that the proposed chaperone role for hBCATm may be perturbed. Moreover, immunohistochemistry studies show that PDI and hBCAT are expressed in the same neuronal and endothelial cells of the vasculature of the human brain, supporting a physiological role for this binding. Innovation: This study identifies a novel redox role for hBCAT and confirms that hBCATm differentially binds to PDI under cellular stress. Conclusion: These studies indicate that hBCAT may play a role in the stress response of the cell as a novel redox chaperone, which, if compromised, may result in protein misfolding, creating aggregates as a key feature in neurodegenerative conditions such as Alzheimers disease. Antioxid. Redox Signal. 00, 000-000.
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Kidney transplant and the digital divide: is information and communication technology a barrier or a bridge to transplant for African Americans?
Prog Transplant
PUBLISHED: 12-07-2013
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Context-Barriers to kidney transplant for African Americans are well documented in the literature. Little information on ownership of information and communication technology and use of such technology in transplant populations has been published.Objective-To characterize racial differences related to ownership and use of information and communication technology in kidney transplant patients.Design-A single-center, cross-sectional survey study.Setting-An urban Midwestern transplant center.Participants-78 pretransplant patients and 177 transplant recipients.Main Outcomes Measures-The survey consisted of 6 demographic questions, 3 disease-related questions, and 9 technology-related questions. Dichotomous (yes/no) and Likert-scale items were the basis for the survey.Results-Cell phone use was high and comparable between groups (94% in African Americans, 90% in whites, P= .22). A vast majority (75% of African Americans and 74% of whites) reported being "comfortable" sending and receiving text messages. Computer ownership (94.3% vs 79.3%) and Internet access (97.7% vs 80.7%) were greater among whites than African Americans (both P< .01). Fewer African Americans were frequent users of the Internet (27.1% vs 56.3%) and e-mail (61.6% vs 79.3%) than whites (both P<.01). More African Americans than whites preferred education in a classroom setting (77% vs 60%; P< .005) and educational DVDs (66% vs 46%; P< .002).Conclusion-The use of cell phone technology and text messaging was ubiquitous and comparable between groups, but computer and Internet access and frequency of use were not. Reaching out to the African American community may best be accomplished by using cell phone/text messaging as opposed to Internet-based platforms.
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Therapists thoughts on therapy: Clinicians perceptions of the therapy processes that distinguish schema, cognitive behavioural and psychodynamic approaches.
Psychother Res
PUBLISHED: 11-28-2013
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Abstract Objective: Debates continue over shared factors in therapy processes between different theoretical orientations. By seeking the opinions of practicing clinicians, this study aimed to elucidate the similarities and differences between cognitive-behavioural (CBT), psychodynamic (PDT), and schema therapy (ST) approaches. Method: Forty-eight practitioners aligning with one of the three approaches were asked to identify crucial processes in their therapy using a modified online version of the Psychotherapy Process Q-set. Results: Distinct differences between each theoretical orientation with few shared common factors were found. A comparison with ratings from previous studies indicated that CBT therapists have not changed over the last 20 years, whereas PDT therapists have changed and the differences appeared consistent with modern PDT theory. Conclusions: The differences between the therapy approaches were consistent with theories underlying each model. PDT therapists valued a neutral relationship, CBT therapists emphasized a didactic interaction, and therapists form a ST orientation placed a greater emphasis on emotional involvement.
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Heterosynaptic plasticity prevents runaway synaptic dynamics.
J. Neurosci.
PUBLISHED: 10-04-2013
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Spike timing-dependent plasticity (STDP) and other conventional Hebbian-type plasticity rules are prone to produce runaway dynamics of synaptic weights. Once potentiated, a synapse would have higher probability to lead to spikes and thus to be further potentiated, but once depressed, a synapse would tend to be further depressed. The runaway synaptic dynamics can be prevented by precisely balancing STDP rules for potentiation and depression; however, experimental evidence shows a great variety of potentiation and depression windows and magnitudes. Here we show that modifications of synapses to layer 2/3 pyramidal neurons from rat visual and auditory cortices in slices can be induced by intracellular tetanization: bursts of postsynaptic spikes without presynaptic stimulation. Induction of these heterosynaptic changes depended on the rise of intracellular calcium, and their direction and magnitude correlated with initial state of release mechanisms. We suggest that this type of plasticity serves as a mechanism that stabilizes the distribution of synaptic weights and prevents their runaway dynamics. To test this hypothesis, we develop a cortical neuron model implementing both homosynaptic (STDP) and heterosynaptic plasticity with properties matching the experimental data. We find that heterosynaptic plasticity effectively prevented runaway dynamics for the tested range of STDP and input parameters. Synaptic weights, although shifted from the original, remained normally distributed and nonsaturated. Our study presents a biophysically constrained model of how the interaction of different forms of plasticity--Hebbian and heterosynaptic--may prevent runaway synaptic dynamics and keep synaptic weights unsaturated and thus capable of further plastic changes and formation of new memories.
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Humeral shaft fracture treatment in the elite throwing athlete: a unique application of flexible intramedullary nailing.
Case Rep Orthop
PUBLISHED: 09-06-2013
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Humeral shaft stress fractures are being increasingly recognized as injuries that can significantly impact throwing mechanics if residual malalignment exists. While minimally displaced and angulated injuries are treated nonoperatively in a fracture brace, the management of significantly displaced humeral shaft fractures in the throwing athlete is less clear. Currently described techniques such as open reduction and internal fixation with plate osteosynthesis and rigid antegrade/retrograde locked intramedullary nailing have significant morbidity due to soft tissue dissection and damage. We present a case report of a high-level baseball pitcher whose significantly displaced humeral shaft stress fracture failed to be nonoperatively managed and was subsequently treated successfully with unlocked, retrograde flexible intramedullary nailing. The athlete was able to return to pitching baseball in one year and is currently pitching in Major League Baseball. We were able to recently collect 10-year follow-up data.
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What are the risks of prophylactic pinning to prevent contralateral slipped capital femoral epiphysis?
Clin. Orthop. Relat. Res.
PUBLISHED: 08-29-2013
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Two decision analyses on managing the contralateral, unaffected hip after unilateral slipped capital femoral epiphysis (SCFE) have failed to yield consistent recommendations. Missing from both, however, are sufficient data on the risks associated with prophylactic pinning using modern surgical techniques.
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Blunted responses to heart failure symptoms in adults with mild cognitive dysfunction.
J Cardiovasc Nurs
PUBLISHED: 07-24-2013
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Mild cognitive dysfunction is common among adults with heart failure (HF). We hypothesized that mild cognitive dysfunction would be associated with poor HF self-care behaviors, particularly patients ability to respond to symptoms.
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Assessing HIV and AIDS treatment safety and health-related quality of life among cohort of Malaysian patients: a discussion on methodological approach.
Health Expect
PUBLISHED: 07-17-2013
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Health-related quality of life (HRQoL) is increasingly recognized as an important outcome and as a complement to traditional biological end points of diseases such as mortality. Unless there is a complete cure available for HIV/AIDS, development and implementation of a reliable and valid cross cultural quality of life measure is necessary to assess not only the physical and medical needs of HIV/AIDS people, but their psychological, social, environmental, and spiritual areas of life.
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Characteristics of rhegmatogenous retinal detachment after refractive surgery: Comparison with myopic eyes with retinal detachment.
Am. J. Ophthalmol.
PUBLISHED: 07-11-2013
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To evaluate the characteristics of rhegmatogenous retinal detachment (RD) in patients with previous laser in-situ keratomileusis (LASIK) and compared them to RD in patients with previous laser assisted sub-epithelial keratomileusis (LASEK) and myopic patients with no previous refractive surgery.
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Combined photodynamic therapy with intravitreal bevacizumab injections for polypoidal choroidal vasculopathy: long-term visual outcome.
Am. J. Ophthalmol.
PUBLISHED: 07-11-2013
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To evaluate the long-term visual outcome after combination therapy of photodynamic therapy (PDT) with intravitreal bevacizumab injections for polypoidal choroidal vasculopathy (PCV).
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Anomalous coronary arteries: cardiovascular computed tomographic angiography for surgical decisions and planning.
World J Pediatr Congenit Heart Surg
PUBLISHED: 06-27-2013
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Cardiovascular computed tomographic angiography (CCTA) provides an understanding of the three-dimensional (3D) coronary artery anatomy in relation to cardiovascular thoracic structures important to the surgical management of anomalous coronary arteries (ACAs). Although some ACA variants are not clinically significant, others can lead to ischemia/infarction, related acute ventricular dysfunction, ventricular arrhythmias, and sudden cardiac death. The CCTA is important to surgical decision making, as it provides noninvasive visualization of the coronary arteries with (1) assessment of origin, course, and termination of coronary artery anomalies in the context of 3D thoracic anatomy, (2) characterization of anatomy helpful for differentiation of benign versus hemodynamically significant variants, (3) identification of other cardiothoracic anomalies, and (4) detection of coronary artery disease. High-risk ACA anatomy in the appropriate clinical setting can require surgical intervention with decisions including minimally invasive versus open sternotomy approach, correction via reimplantation of a coronary artery, alteration of the ACA course without reimplantation, or bypass of an ACA. Given the rarity of ACA, there is limited data in the literature, and significant controversy related to the management issues. The management of ACA requires comprehensive clinical history, thorough assessment of cardiac function, and detailed anatomic imaging. Future studies will need to address the long-term outcome based on detailed assessment of original anatomy and surgical approach.
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Ultrasonography-guided bilateral rectus sheath block vs local anesthetic infiltration after pediatric umbilical hernia repair: a prospective randomized clinical trial.
JAMA Surg
PUBLISHED: 06-14-2013
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Regional anesthetic techniques can be used to alleviate postoperative pain in children undergoing pediatric surgical procedures. Use of ultrasonographic guidance for bilateral rectus sheath block (BRSB) has been shown to improve immediate pain scores and reduce use of postoperative analgesia in the postanesthesia care unit (PACU).
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Surgical site infection following spinal instrumentation for scoliosis: a multicenter analysis of rates, risk factors, and pathogens.
J Bone Joint Surg Am
PUBLISHED: 05-03-2013
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Surgical site infection following correction of pediatric scoliosis is well described. However, we are aware of no recent multicenter study describing the rates of surgical site infection, and associated pathogens, among patients with different etiologies for scoliosis.
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Population-based comparison of two feeding tube approaches for head and neck cancer patients receiving concurrent systemic-radiation therapy: is a prophylactic feeding tube approach harmful or helpful?
Support Care Cancer
PUBLISHED: 04-16-2013
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The purpose of this study is to compare patient outcomes between a therapeutic versus a prophylactic gastrostomy tube (GT) placement approach in patients treated with concurrent systemic and radiation (SRT) therapy for head and neck cancer (HNC).
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The impact of cognitive control, incentives, and working memory load on the P3 responses of externalizing prisoners.
Biol Psychol
PUBLISHED: 04-14-2013
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The P3 amplitude reduction is one of the most common correlates of externalizing. However, few studies have used experimental manipulations designed to challenge different cognitive functions in order to clarify the processes that impact this reduction. To examine factors moderating P3 amplitude in trait externalizing, we administered an n-back task that manipulated cognitive control demands, working memory load, and incentives to a sample of male offenders. Offenders with high trait externalizing scores did not display a global reduction in P3 amplitude. Rather, the negative association between trait externalizing and P3 amplitude was specific to trials involving inhibition of a dominant response during infrequent stimuli, in the context of low working memory load, and incentives for performance. In addition, we discuss the potential implications of these findings for externalizing-related psychopathologies. The results complement and expand previous work on the process-level dysfunction contributing to externalizing-related deficits in P3.
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Outcomes of Small Cell Lung Cancer Patients Treated With Cisplatin-Etoposide Versus Carboplatin-Etoposide.
Am. J. Clin. Oncol.
PUBLISHED: 04-09-2013
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PURPOSE:: This descriptive study compares overall survival (OS) and locoregional control (LRC) rates between cisplatin-etoposide (EP) and carboplatin-etoposide (EC) at a population level in patients with limited disease (LD) and extensive disease (ED) small cell lung cancer (SCLC). MATERIALS AND METHODS:: All patients diagnosed with SCLC from January 2004 to December 2008 were identified. Patients with LD SCLC treated with EP or EC and concurrent or sequential radiotherapy and those with ED SCLC treated with EP or EC were included for analysis. A retrospective review examining prognostic features and outcomes was performed. OS and LRC curves were calculated using the Kaplan-Meier method and compared with the log-rank test. RESULTS:: A total of 249 patients with LD SCLC and 287 patients with ED SCLC were identified. Patients treated with EC were significantly older for both LD (median 62 vs. 72, P<0.001) and ED (median 62 vs. 73, P<0.001). Median follow-up times were 37 and 22 months for LD and ED SCLC, respectively. Median OS for EP and EC in LD SCLC patients were 23 and 18 months (P=0.10). LRC rates at 12 months were 81% for the EP group and 68% for the EC group (P=0.97). Median OS for the EP and EC patients with ED SCLC was 10 and 11 months, respectively, (P=0.24). CONCLUSION:: Despite the preferential use of EC in an older population, median OS and LRC rates were not significantly different for patients treated with EP for both LD and ED SCLC.
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Intensive care unit versus hospital floor: a comparative study of postoperative management of patients with adolescent idiopathic scoliosis.
J Bone Joint Surg Am
PUBLISHED: 04-05-2013
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Patients undergoing posterior spinal instrumentation and fusion surgery for adolescent idiopathic scoliosis were admitted to the intensive care unit until two years ago, at which time we changed our protocol to admit these patients to the general hospital floor following a brief stay in a postanesthesia care unit. This study compared postoperative management on a hospital floor with that in the intensive care unit for patients with adolescent idiopathic scoliosis undergoing posterior spinal fusion.
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Tailoring adipose stem cell trophic factor production with differentiation medium components to regenerate chondral defects.
Tissue Eng Part A
PUBLISHED: 03-28-2013
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Recent endeavors to use stem cells as trophic factor production sources have the potential to translate into viable therapies for damaged or diseased musculoskeletal tissues. Adipose stem cells (ASCs) can be differentiated into chondrocytes using the chondrogenic medium (CM), but it is unknown if this approach can optimize ASC growth factor secretion for cartilage regeneration by increasing the chondrogenic factor production, while decreasing angiogenic and hypertrophic factor production. The objective of this study was to determine the effects the CM and its components have on growth factor production from ASCs to promote cartilage regeneration. ASCs isolated from male Sprague-Dawley rats and cultured in monolayer or alginate microbeads were treated with either the growth medium (GM) or the CM for 5 days. In subsequent studies, ASC monolayers were treated with either the GM supplemented with different combinations of 50??g/mL ascorbic acid-2-phosphate (AA2P), 100?nM dexamethasone (Dex), 10?ng/mL transforming growth factor (TGF)-?1, and 100?ng/mL bone morphogenetic protein (BMP)-6 or with the CM excluding different combinations of AA2P, Dex, TGF-?1, and BMP-6. mRNA levels and growth factor production were quantified at 8 and 24?h after the last media change, respectively. The CM increased chondrogenic factor secretion (TGF-?2, TGF-?3, and insulin-like growth factor [IGF]-I) and decreased angiogenic factor production (the vascular endothelial growth factor [VEGF]-A, the fibroblast growth factor [FGF]-2). Microencapsulation in the GM increased production of the chondrogenic (IGF-I, TGF-?2) and angiogenic (VEGF-A) factors. AA2P increased secretion of chondrogenic factors (IGF-I, TGF-?2), and decreased angiogenic factor (VEGF-A) secretion, in addition to decreasing mRNA levels for factors associated with chondrocyte hypertrophy (FGF-18). Dex increased mRNA levels for hypertrophic factors (BMP-2, FGF-18) and decreased angiogenic factor secretion (VEGF-A). TGF-?1 increased angiogenic factor production (FGF-2, VEGF-A) and decreased chondrogenic factor mRNA levels (IGF-I, PTHrP). BMP-6 increased hypertrophic mRNA levels (FGF-18) and chondrogenic factor production (TGF-?2). When ASC microbeads preconditioned with the CM were implanted in a focal cartilage defect and immobilized within an RGD-conjugated hydrogel, tissue infiltration from the edges of the defect and perichondrium was observed. These results show that differentiation media components have distinct effects on ASCs production of angiogenic, chondrogenic, and hypertrophic factors and that AA2P may be the most beneficial CM component for preconditioning ASCs to stimulate cartilage regeneration.
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Modelling of blood pressure outcomes in patients with and without established cardiovascular or renal disease following treatment with valsartan (the PREVIEW study).
Arch Cardiovasc Dis
PUBLISHED: 03-26-2013
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Hypertensive patients with established cardiovascular or renal disease (ECVRD) have an added 10-year risk of cardiovascular events, classified by the European Society of Hypertension/European Society of Cardiology as very high.
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Heart failure symptom monitoring and response training.
Heart Lung
PUBLISHED: 03-19-2013
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The purpose of this study was to test the efficacy of a heart failure (HF) training program on patients ability to recognize and respond to changes in HF symptoms. The primary aim was to compare event-free survival at 90 days.
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Prognosis of choroidal melanoma and the result of ruthenium brachytherapy combined with transpupillary thermotherapy in Korean patients.
Br J Ophthalmol
PUBLISHED: 02-21-2013
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To evaluate the clinical features and prognosis of choroidal melanoma in Korean patients and the results of treatment with ruthenium (Ru) 106 plaque brachytherapy.
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Concussive injury before or after controlled cortical impact exacerbates histopathology and functional outcome in a mixed traumatic brain injury model in mice.
J. Neurotrauma
PUBLISHED: 02-20-2013
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Traumatic brain injury (TBI) may involve diverse injury mechanisms (e.g., focal impact vs. diffuse impact loading). Putative therapies developed in TBI models featuring a single injury mechanism may fail in clinical trials if the model does not fully replicate multiple injury subtypes, which may occur concomitantly in a given patient. We report development and characterization of a mixed contusion/concussion TBI model in mice using controlled cortical impact (CCI; 0.6 mm depth, 6 m/sec) and a closed head injury (CHI) model at one of two levels of injury (53 vs. 83 g weight drop from 66 in). Compared with CCI or CHI alone, sequential CCI-CHI produced additive effects on loss of consciousness (p<0.001), acute cell death (p<0.05), and 12-day lesion size (p<0.05) but not brain edema or 48-h contusion volume. Additive effects of CHI and CCI on post-injury motor (p<0.05) and cognitive (p<0.005) impairment were observed with sequential CCI-CHI (83 g). The data suggest that concussive forces, which in isolation do not induce histopathological damage, exacerbate histopathology and functional outcome after cerebral contusion. Sequential CHI-CCI may model complex injury mechanisms that occur in some patients with TBI and may prove useful for testing putative therapies.
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Successful medical management of a left ventricular thrombus and aneurysm following failed thrombolysis in myocardial infarction.
Clin Med Insights Cardiol
PUBLISHED: 02-07-2013
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We report the case of a patient with an extensive anterior myocardial infarction complicated by left ventricular systolic dysfunction, left ventricular apical thrombus and an apical left ventricular aneurysm following failed thrombolysis. We obtained serial two-dimensional echocardiograms at short intervals in the acute phase and also during the months of recovery and follow up. The patient was successfully and exclusively medically managed.
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Oropharyngeal airway obstruction after the accidental ingestion of Arisaema amurense.
J Emerg Med
PUBLISHED: 01-26-2013
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Arisaema amurense is widely known in Korean folklore as a poisonous plant, and its lethal toxicity has long been recognized. The toxicity of Arisaema amurense is due to its content of calcium oxalate, which causes painful oropharyngeal edema, hypersalivation, aphonia, oral ulceration, esophageal erosion, and hypocalcemia.
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In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.