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Find video protocols related to scientific articles indexed in Pubmed.
Effect of a smoking ban on respiratory health in nonsmoking hospitality workers: a prospective cohort study.
J. Occup. Environ. Med.
PUBLISHED: 10-07-2014
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The aim of this study was to examine the effect of a smoking ban on lung function, fractional exhaled nitric oxide, and respiratory symptoms in nonsmoking hospitality workers.
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Is there a differential impact of parity on blood pressure by age?
J. Hypertens.
PUBLISHED: 10-03-2014
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In pregnancy, women experience metabolic and hemodynamic changes of potential long-term impact. Conflicting evidence exists on the impact on blood pressure (BP). We investigated the association between parity and BP in the Swiss Study on Air Pollution And Lung and Heart Disease In Adults cohort.
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Mortality risk prediction in COPD by a prognostic biomarker panel.
Eur. Respir. J.
PUBLISHED: 07-17-2014
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Chronic obstructive pulmonary disease (COPD) is a complex disease with various phenotypes. The simultaneous determination of multiple biomarkers reflecting different pathobiological pathways could be useful in identifying individuals with an increased risk of death. We derived and validated a combination of three biomarkers (adrenomedullin, arginine vasopressin and atrial natriuretic peptide), assessed in plasma samples of 385 patients, to estimate mortality risk in stable COPD. Biomarkers were analysed in combination and defined as high or low. In the derivation cohort (n = 142), there were 73 deaths during the 5-year follow-up. Crude hazard ratios for mortality were 3.0 (95% CI 1.8-5.1) for one high biomarker, 4.8 (95% CI 2.4-9.5) for two biomarkers and 9.6 (95% CI 3.3-28.3) for three high biomarkers compared with no elevated biomarkers. In the validation cohort (n = 243), 87 individuals died. Corresponding hazard ratios were 1.9 (95% CI 1.1-3.3), 3.1 (95% CI 1.8-5.4) and 5.4 (95% CI 2.5-11.4). Multivariable adjustment for clinical variables as well as the BODE (body mass index, airflow obstruction, dyspnoea, exercise capacity) index and stratification by the Global Initiative for Chronic Obstructive Lung Disease stages provided consistent results. The addition of the panel of three biomarkers to the BODE index generated a net reclassification improvement of 57.9% (95% CI 21.7-92.4%) and 45.9% (95% CI 13.9-75.7%) at 3 and 5 years, respectively. Simultaneously elevated levels of adrenomedullin, arginine vasopressin and atrial natriuretic peptide are associated with increased risk of death in patients with stable COPD.
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Galactomannan in bronchoalveolar lavage for diagnosing invasive fungal disease.
Am. J. Respir. Crit. Care Med.
PUBLISHED: 07-10-2014
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Invasive fungal disease (IFD) is a significant cause of morbidity and mortality in immunocompromised patients.
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Adenovirus-specific IgG maturation as a surrogate marker in acute exacerbations of COPD.
Chest
PUBLISHED: 04-12-2014
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B cells in airways and lung parenchyma may be involved in COPD evolution; however, whether their pathogenic role is beneficial or harmful remains controversial. The objective of this study was to investigate the maturation of adenovirus-specific immunoglobulins in patients with COPD with respect to clinical outcome.
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Exertional hypoxemia in stable COPD is common and predicted by circulating proadrenomedullin.
Chest
PUBLISHED: 04-12-2014
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The prevalence of exertional hypoxemia in unselected patients with COPD is unknown. Intermittent hypoxia leads to adrenomedullin (ADM) upregulation through the hypoxia-inducible factor-1 pathway. We aimed to assess the prevalence and the annual probability to develop exertional hypoxemia in stable COPD. We also hypothesized that increased ADM might be associated with exertional hypoxemia and envisioned that adding ADM to clinical variables might improve its prediction in COPD.
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Propofol versus midazolam in medical thoracoscopy: a randomized, noninferiority trial.
Respiration
PUBLISHED: 04-07-2014
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Hypoxemia is a surrogate marker for periprocedural endoscopic complications. There are no data comparing the safety of propofol sedation with another sedative regimen in medical thoracoscopy.
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Association of adrenal function and disease severity in community-acquired pneumonia.
PLoS ONE
PUBLISHED: 01-01-2014
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Rapid and accurate risk stratification in patients with community-acquired pneumonia (CAP) is an unmet clinical need. Cortisol to dehydroepiandrosterone (DHEA) ratio was put forward as a prognostic marker in sepsis. We herein validated the prognostic value of the adrenal hormones DHEA, DHEA-Sulfate (DHEAS), cortisol/DHEA-, cortisol/DHEAS- and DHEA/DHEAS-ratios in patients with CAP.
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Serum bilirubin is associated with lung function in a Swiss general population sample.
Eur. Respir. J.
PUBLISHED: 10-31-2013
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Bilirubin is a strong antioxidant. Increased serum levels were associated with respiratory disease and mortality risk. We studied the association of bilirubin with lung function in the SAPALDIA cohort.Associations between natural logarithmized bilirubin and forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC, and mean forced expiratory flow between 25%-75% of FVC (FEF25-75) were tested using multiple linear regression in the whole study population (n=4195) and strata of ever smoking and high body mass index (BMI, defined by the highest distribution quartile). Associations were retested with single nucleotide polymorphism rs6742078, a genetic determinant of bilirubin.High bilirubin levels were significantly associated with higher FEV1/FVC and FEF25-75 overall. Upon stratification, significant associations persisted in ever smokers, amounting to 1.1 percent (95%-confidence interval 0.1 to 2.2) increase in FEV1/FVC, and 116.2 mL·sec(-1) (-15.9 to 248.4) in FEF25-75 per interquartile range of bilirubin exposure in smokers with high BMI. Associations were positive but non -significant in never smokers with high BMI. Similarly, rs6742078 genotype TT was associated with increased FEV1/FVC and FEF25-75.Our results suggest a possible protective role of bilirubin on lung tissue, which could be important for prevention and therapy.
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Systemic biomarkers in the evaluation and management of COPD patients: are we getting closer to clinical application?
Curr Drug Targets
PUBLISHED: 07-31-2013
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Chronic obstructive pulmonary disease (COPD) is a complex, multicomponent disease at the clinical, cellular, and molecular levels. Over the past few years there has been a growing interest in the field of biomarkers in COPD and a large number of studies have evaluated potential candidate molecules in different patient settings. Data on systemic biomarkers from large cohorts, including the well-characterized population of the ECLIPSE study, are now available and provide exciting information on the association of biomarkers with clinically important outcomes, including exacerbations, hospitalizations and mortality. Moreover, recent research has provided proof for the existence of distinct "systemic inflammatory" phenotypes. This review summarizes the currently available evidence on systemic biomarkers in COPD, providing clinically relevant information on the possible role of systemic biomarkers in the evaluation of disease activity and severity, phenotypes, outcomes, COPD exacerbations and treatment response and guidance. Despite the fact that no single biomarker is currently ready to characterize sufficiently the status of COPD patients, guide treatment options, and predict future events, recent studies have rendered our current knowledge definitely more advanced than a few years ago and the possible use of biomarkers in the diagnosis and management of COPD patients looks even more promising.
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Propofol sedation for flexible bronchoscopy: randomized, non-inferiority trial.
Eur. Respir. J.
PUBLISHED: 07-30-2013
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Propofol has been established as a reliable method for sedation in flexible bronchoscopy. There are no data comparing propofol administered as intravenous boluses versus continuous infusion.702 consecutive patients undergoing flexible bronchoscopy were randomly allocated to receive intravenous propofol using either an intermittent bolus technique or a continuous infusion. The primary endpoint was the number of adverse events assessed at the end of flexible bronchoscopy and at 24 hours.The number of any adverse event was similar in both randomized groups (219 vs. 211, p=0.810). There were complications in 8 cases (7 major bleedings, 1 respiratory failure). As compared to the bolus group, the amount of propofol required was significantly higher in the infusion group (226 mg±147 versus 308 mg±204.8, p<0.0001). In a multivariate regression model, this difference remained significant independently of the duration and the interventions performed during the procedure. The duration of bronchoscopy was significantly longer in the infusion group (14 [9 - 24] versus 17 [12 - 27] minutes, p<0.0001).Propofol continuous infusion is as safe as bolus administration; however, it is associated with higher propofol requirements and a longer duration of the bronchoscopy.
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Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections.
Evid Based Child Health
PUBLISHED: 07-24-2013
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Acute respiratory infections (ARIs) comprise a large and heterogeneous group of infections including bacterial, viral and other aetiologies. In recent years, procalcitonin - the prohormone of calcitonin - has emerged as a promising marker for the diagnosis of bacterial infections and for improving decisions about antibiotic therapy. Several randomised controlled trials (RCTs) have demonstrated the feasibility of using procalcitonin for starting and stopping antibiotics in different patient populations with acute respiratory infections and different settings ranging from primary care to emergency departments (EDs), hospital wards and intensive care units (ICUs).
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Adrenomedullin refines mortality prediction by the BODE index in COPD - The "BODE-A" index.
Eur. Respir. J.
PUBLISHED: 06-21-2013
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The BODE index is well-validated for mortality prediction in COPD. Concentrations of plasma proadrenomedullin, a surrogate for mature adrenomedullin, independently predicted 2-year mortality among inpatients with COPD exacerbation.We compared accuracy of initial proadrenomedullin level, BODE, and BODE components, alone or combined, in predicting 1-year or 2-year all-cause mortality in a multicenter, multinational observational cohort with stable, moderate to very severe COPD.Proadrenomedullin was significantly associated (P<0.001) with 1-year mortality (4.7%) and 2-year mortality (7.8%), and comparably predictive to BODE regarding both (C statistics: 0.691 vs. 0.745, 0.635 vs. 0.679). Relative to using BODE alone, adding proadrenomedullin significantly improved 1-year and 2-year mortality prognostication (C statistics: 0.750, 0.818; both P<0.001). Proadrenomedullin plus BOD was more predictive than was the original BODE including 6-minute-walk distance. In multivariable analysis, proadrenomedullin (LR X(2) 13.0, P<0.001), body mass index (8.5, P=0.004), and 6-minute-walk distance (7.5, P=0.006), but not modified MMRC dyspnoea score (2.2, P=0.14) or FEV1 % predicted (0.3, P=0.60), independently foretold 2-year survival.Proadrenomedullin plus BODE better predicts mortality in COPD patients than does BODE alone; proadrenomedullin may substitute for 6-minute-walk distance in BODE when 6-minute-walk testing is unavailable.
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Pancreatic stone protein predicts positive sputum bacteriology in exacerbations of COPD.
Chest
PUBLISHED: 06-21-2013
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Pancreatic stone protein/regenerating protein (PSP/reg) serum levels are supposed to be increased in bacterial inflammation. PSP/reg levels also might be useful, therefore, as a predictor of bacterial infection in COPD.
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Atherogenesis in youth--early consequence of adolescent smoking.
Atherosclerosis
PUBLISHED: 06-03-2013
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Cigarette smoking is a prevalent risk behavior among adolescents and tracks into adulthood. Little is known on the early impact of smoking on the vasculature in adolescence, although smoking is considered highly atherogenic in adults. We investigated the association between active smoking and Carotid artery Intima Media Thickness (CIMT), an early indicator of atherosclerosis.
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Predictors of Success for Smoking Cessation at the Workplace: A Longitudinal Study.
Respiration
PUBLISHED: 04-10-2013
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Background: The effectiveness of worksite interventions to reduce smoking is debatable. Objectives: A comprehensive smoking cessation intervention was implemented in a community of more than 17,000 employees at three different health care companies. The primary endpoint was abstinence at 24 months (self-reported and confirmed by exhaled carbon monoxide ?6 parts per million). Predictors of long-term abstinence were analysed by multivariable regression analysis. Methods: The study was designed as an investigator-initiated and investigator-driven, open, multicentre, cohort study; 887 smokers were enrolled in the programme. The intervention included intensive individual counselling as well as nicotine replacement and/or bupropion according to individual preferences. Re-interventions for relapse were offered during the 24-month follow-up. Results: The abstinence rate was 37% at 24 months and did not differ among the various medication groups (p > 0.05 for all). Predictors of successful cessation were higher age (odds ratio, OR 1.47, 95% confidence interval, CI 1.08-2.00, p < 0.01), breathlessness on exertion (OR 2.26, 95% CI 1.1-4.9, p = 0.03), and a higher educational level (OR 1.81, 95% CI 1.06-3.09, p = 0.03). Higher Fagerström (OR 0.76, 95% CI 0.59-0.97, p < 0.01) and craving scores (OR 0.75, 95% CI 0.63-0.89, p < 0.01), chronic sputum production (OR 0.52, 95% CI 0.31-0.87, p = 0.01) and use of antidepressants (OR 0.54, 95% CI 0.32-0.91, p = 0.02) were associated with ongoing smoking. Conclusion: A comprehensive smoking cessation intervention at the workplace achieves high, stable, long-term abstinence rates. Elderly, well-educated employees with breathlessness on exertion have higher odds of quitting smoking. In contrast, those with high physical dependency and more intense craving, and those reporting use of antidepressant medication or sputum production have poorer chances to quit.
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Enhanced didactic methods of smoking cessation training for medical students--a randomized study.
Nicotine Tob. Res.
PUBLISHED: 11-16-2011
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It is essential that medical students are adequately trained in smoking cessation. A web-based tobacco abstinence training program might supplement or replace traditional didactic methods.
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The use of copeptin, the stable peptide of the vasopressin precursor, in the differential diagnosis of sodium imbalance in patients with acute diseases.
Swiss Med Wkly
PUBLISHED: 10-13-2011
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Sodium imbalance is common in-hospital electrolyte disturbance and is largely related to inequalities in water homeostasis. An important mechanism leading to dysnatraemic disorders is inadequately secreted plasma arginine vasopressin (AVP). Unfortunately, AVP measurement is cumbersome and not reliable. Copeptin is secreted in an equimolar ratio to AVP and is a promising marker in the differential diagnosis of hyponatraemia and possibly hypernatraemia in stable hospitalised patients. This study assessed copeptin concentrations in sick patients with serum sodium imbalance of different aetiology on admission to the emergency department.
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Feasibility and safety of propofol sedation in flexible bronchoscopy.
Swiss Med Wkly
PUBLISHED: 08-27-2011
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Propofol is a sedative-hypnotic with a rapid onset of action. There are only limited data evaluating propofol for flexible bronchoscopy. We analysed the feasibility and safety of propofol for bronchoscopy in a high output tertiary care centre.
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Pancreatic stone protein: a marker of organ failure and outcome in ventilator-associated pneumonia.
Chest
PUBLISHED: 08-11-2011
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Ventilator-associated pneumonia (VAP) is the most common hospital-acquired, life-threatening infection. Poor outcome and health-care costs of nosocomial pneumonia remain a global burden. Currently, physicians rely on their experience to discriminate patients with good and poor outcome. However, standardized prognostic measures might guide medical decisions in the future. Pancreatic stone protein (PSP)/regenerating protein (reg) is associated with inflammation, infection, and other disease-related stimuli. The prognostic value of PSP/reg among critically ill patients is unknown. The aim of this pilot study was to evaluate PSP/reg in VAP.
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Systemic biomarkers in exacerbations of COPD: the evolving clinical challenge.
Chest
PUBLISHED: 08-11-2011
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Exacerbations of COPD (ECOPD) remain a major cause of mortality and morbidity. Despite advances in the understanding of their pathophysiology, their assessment relies primarily on clinical presentation, which can be variable and difficult to predict. A large number of biomarkers already have been assessed in this context, and some appear to be promising.
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Endobronchial ultrasound in hilar and conventional TBNA-negative/inconclusive mediastinal lymphadenopathy.
J Cancer Res Ther
PUBLISHED: 07-20-2011
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Assess the diagnostic yield of real-time bronchoscopic ultrasound transbronchial needle aspiration (EBUS TBNA) in conventional TBNA-negative mediastinal lymphadenopathy and hilar lymphadenopathy.
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Association of daily physical activity volume and intensity with COPD severity.
Respir Med
PUBLISHED: 05-13-2011
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The purpose of this study was to assess whether daily walking activity is indicative of disease severity in patients with COPD.
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The Sequential Organ Failure Assessment score and copeptin for predicting survival in ventilator-associated pneumonia.
J Crit Care
PUBLISHED: 01-04-2011
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Ventilator-associated pneumonia remains the most common nosocomial infection in the critically ill and contributes to significant morbidity. Eventual decisions regarding withdrawal or maximal therapy are demanding and rely on physicians experience. Additional objective tools for risk assessment may improve medical judgement. Copeptin, reflecting vasopressin release, as well as the Sequential Organ Failure Assessment (SOFA) score, reflecting the individual degree of organ dysfunction, might qualify for survival prediction in ventilator-associated pneumonia. We investigated the predictive value of the SOFA score and copeptin in ventilator-associated pneumonia.
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Bronchoscopic lung volume reduction--current opinion.
Swiss Med Wkly
PUBLISHED: 12-21-2010
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Bronchoscopic lung volume reduction is a new technology designed to reduce hyperinflation in severe COPD by implantation of endobronchial devices, such as biodegradable material, endobronchial valves or bronchopulmonary stents, via flexible bronchoscopy. This article discusses newest developments and results in bronchoscopic lung volume reduction.
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Midregional proatrial natriuretic peptide predicts survival in exacerbations of COPD.
Chest
PUBLISHED: 11-24-2010
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Recently, the use of systemic biomarkers to monitor and assess the clinical evolution of respiratory disease has gained interest. We investigated whether midregional proatrial natriuretic peptide (MR-proANP) predicts survival in patients with COPD when they are admitted to the hospital for exacerbation.
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[Motivating discussions, change of attitude and handling with stress - nursing aspects of smoking cessation].
Ther Umsch
PUBLISHED: 08-06-2010
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Smoking cessation is a hard process. Encouragement and assistance are necessary! As a specialist for smoking cessation, you have to provide a good advisory service. That means, you have to solve the expected problems and to give the patient useful tips so he can spend this painful time with success. It is important to motivate the patient again and again, to give him a concept helping to change his habits and be able to cope with this stressful situation.
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Perimenstrual increase in bronchial hyperreactivity in premenopausal women: results from the population-based SAPALDIA 2 cohort.
J. Allergy Clin. Immunol.
PUBLISHED: 03-15-2010
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Studies on perimenstrual asthma are inconsistent, and different methodologies limit comparisons.
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Single and multiple viral infections in lower respiratory tract infection.
Respiration
PUBLISHED: 02-15-2010
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Lower respiratory tract infection (LRTI) often leads to hospitalization, and it was indicated that causative viral infections are underestimated.
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Biomarkers in lower respiratory tract infections.
Pulm Pharmacol Ther
PUBLISHED: 02-01-2010
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This review aims to provide physicians with an overview of the potential of biomarkers to complement existing clinical severity scores and in conjunction with clinical parameters to improve the diagnosis, risk-stratification and management of lower respiratory tract infections (LRTIs). The usefulness of biomarkers for diagnosing LRTIs is still unclear. However, the specificity of pneumonia diagnosis is high when high sensitivity C-reactive protein (CRP) and procalcitonin (PCT) are used. PCT, CRP and particularly pro-atrial natriuretic peptide (MR-proANP), pro-vasopressin (CT-proAVP) and proadrenomedullin (proADM) levels can reliably predict LRTIs mortality. These markers do not significantly improve the severity scores predictive values, confirming that biomarkers are meant to complement, rather than supersede, clinicians judgment and validated severity scores. Biomarkers, and particularly PCT, are useful tools as antibiotic treatment duration indicators both in pneumonia and exacerbations of chronic obstructive pulmonary disease (COPD). Even if more data are required to fully appreciate the role of biomarkers in LRTIs management, there is emerging evidence that biomarkers have the potential to improve the daily clinical management of LRTIs.
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Discriminate use of antibiotics for exacerbation of COPD.
Curr Opin Pulm Med
PUBLISHED: 06-18-2009
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The relevance of antibiotics in the treatment of acute exacerbation has been a matter of debate for several years. Although expert recommendations may vary, there is general agreement about the fact that not all patients will equally experience benefit from antibiotics: apart from decreasing costs, discriminate use of antibiotics is capable of significantly reducing subsequent colonization or infection with antibiotic-resistant bacteria.
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Prognostic impact of plasma lipids in patients with lower respiratory tract infections - an observational study.
Swiss Med Wkly
PUBLISHED: 03-31-2009
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A decrease in plasma lipids occurs during severe sepsis and has prognostic implications in critical illness. Whether lipids have prognostic implications or could help to differentiate community-acquired pneumonia from other lower respiratory tract infections remains unknown.
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Acute effects of aerosolized iloprost in COPD related pulmonary hypertension - a randomized controlled crossover trial.
PLoS ONE
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Inhaled iloprost potentially improves hemodynamics and gas exchange in patients with chronic obstructive pulmonary disease (COPD) and secondary pulmonary hypertension (PH).
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Associations of daily walking activity with biomarkers related to cardiac distress in patients with chronic obstructive pulmonary disease.
Respiration
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The prevalence of cardiovascular mortality is high in Chronic Obstructive Pulmonary Disease (COPD) and the identification of clinical parameters to improve risk stratification is of great interest.
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Water pipe smoking and its association with cigarette and cannabis use in young adults in Switzerland.
Respiration
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Water pipe is a traditional method of tobacco use, which is epidemically spreading throughout Europe. There are scarce data about the use of water pipe and its relation to other addictive behaviors among young adults in Western countries.
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Aspergillus-PCR in bronchoalveolar lavage for detection of invasive pulmonary aspergillosis in immunocompromised patients.
BMC Infect. Dis.
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Invasive fungal disease (IFD) is a frequent and serious infectious complication in immunocompromised patients. Culture and cytology in bronchoalveolar lavage (BAL) have a high specificity but low sensitivity for the diagnosis of IFD as assessed by histology. Molecular methods are expected to allow a rapid diagnosis of IFD with a high sensitivity. We evaluated the diagnostic accuracy of conventional nested PCR in the bronchoalveolar fluid to diagnose IFD in severely immunocompromised patients.
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Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections.
Cochrane Database Syst Rev
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Acute respiratory infections (ARIs) comprise a large and heterogeneous group of infections including bacterial, viral and other aetiologies. In recent years, procalcitonin - the prohormone of calcitonin - has emerged as a promising marker for the diagnosis of bacterial infections and for improving decisions about antibiotic therapy. Several randomised controlled trials (RCTs) have demonstrated the feasibility of using procalcitonin for starting and stopping antibiotics in different patient populations with acute respiratory infections and different settings ranging from primary care to emergency departments (EDs), hospital wards and intensive care units (ICUs).
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Procalcitonin to guide initiation and duration of antibiotic treatment in acute respiratory infections: an individual patient data meta-analysis.
Clin. Infect. Dis.
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Procalcitonin algorithms may reduce antibiotic use for acute respiratory tract infections (ARIs). We undertook an individual patient data meta-analysis to assess safety of this approach in different ARI diagnoses and different clinical settings.
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Lung resection in hematologic patients with pulmonary invasive fungal disease.
Chest
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Pulmonary invasive fungal disease is a frequent complication in patients with hematologic malignancies. Surgical resection in addition to antifungal therapy is an option for selected cases but often feared because of immunosuppression.
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Daily walking intensity as a predictor of quality of life in patients with chronic obstructive pulmonary disease.
Med Sci Sports Exerc
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This study aimed to assess independent predictors of quality of life (QOL) in patients with chronic obstructive pulmonary disease, in particular, to evaluate the relationship between QOL and functional exercise capacity measured with an activity monitor.
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A combined cardiorenal assessment for the prediction of acute kidney injury in lower respiratory tract infections.
Am. J. Med.
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The accurate prediction of acute kidney injury (AKI) is an unmet clinical need. A combined assessment of cardiac stress and renal tubular damage might improve early AKI detection.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.