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Find video protocols related to scientific articles indexed in Pubmed.
A series of cobalt and nickel clusters based on thiol-containing ligands accompanied by in situ ligand formation.
Dalton Trans
PUBLISHED: 11-08-2014
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Eight cobalt and nickel clusters with the formulae [Co4(?4-O)(MBT)5(?2-Piv)] (), [Ni3(MBT)2()2(OCH3)2] (), [Ni4(?3-S)(?3-S2)(MBT)2()] (), [Ni4()4] (), [Ni6(?4-S)3(MBT)6]·(C2H5OH)2 (), H[Co4(?4-O)(HMBI)6]·(NO3)(TEA)0.5(CH3OH)2(H2O) (), [Ni2(HMBI)4]·(CH3OH)2 (), and [Ni5(MBI)2(HMBI)4(OCH3)2]·(CH3OH)3(H2O)2 () (HPiv = pivalic acid, H = 2-disulfanylbenzo[d]thiazole, H2 = (Z)-2-((2-mercaptophenyl)imino)benzo[d]thiazole-3(2H)-thiol, H2 = (Z)-2-(benzo[d]thiazol-2(3H)-ylideneamino)benzenethiol, TEA = triethylamine) have been solvothermally prepared via assembling distinct metal resource and thiol-containing ligands 2-mercaptobenzothiazole (HMBT)/2-mercaptobenzimidazole (H2MBI). Complexes and are tetrahedral cobalt clusters. Complex features linear arrangement of nickel ions. Complexes and are tetranuclear nickel clusters with the butterfly and square shape, respectively. Complex displays a trigonal prism geometry. Complexes and exhibit paddle-wheel and trigonal bipyramidal geometry, respectively. The starting ligand HMBT undergoes in situ ligand transformation in the formation of the nickel clusters, and the new generated inorganic ligands (S(2-) and S2(2-)) and organic ligands (H, H2 and H2) were captured within the metallic cores. Magnetic studies indicate that complexes and show dominating antiferromagnetic couplings and that spin frustration exists in .
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A flexible zwitterion ligand based lanthanide metal-organic framework for luminescence sensing of metal ions and small molecules.
Dalton Trans
PUBLISHED: 10-11-2014
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A new lanthanide metal-organic framework was constructed using a tripodal flexible zwitterion ligand (H3LBr3) which takes a chair-shaped configuration. The luminescence of the compound displays highly selective sensing of the Fe(3+) ion and nitrobenzene.
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[Protective effect of tanshinol on the hepatopulmonary syndrome in rat].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
PUBLISHED: 09-24-2014
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To explore the mechanism of tanshinol on alleviate the inflammatory injury of lung tissue in rat hepatopulmonary syndrome (HPS).
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Solvent induced rapid modulation of micro/nano structures of metal carboxylates coordination polymers: mechanism and morphology dependent magnetism.
Sci Rep
PUBLISHED: 08-12-2014
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Rational modulation of morphology is very important for functional coordination polymers (CPs) micro/nanostructures, and new strategies are still desired to achieve this challenging target. Herein, organic solvents have been established as the capping agents for rapid modulating the growth of metal-carboxylates CPs in organic solvent/water mixtures at ambient conditions. Co-3,5-pyridinedicarboxylate (pydc) CPs was studied here as the example. During the reaction, the organic solvents exhibited three types of modulation effect: anisotropic growth, anisotropic growth/formation of new crystalline phase and the formation of new crystalline phase solely, which was due to the variation of their binding ability with metal cations. The following study revealed that the binding ability was critically affected by their functional groups and molecular size. Moreover, their modulation effect could be finely tuned by changing volume ratios of solvent mixtures. Furthermore, they could be applied for modulating other metal-carboxylates CPs: Co-1,3,5-benzenetricarboxylic (BTC), Zn-pydc and Eu-pydc etc. Additionally, the as-prepared Co-pydc CPs showed a fascinating morphology-dependent antiferromagnetic behavior.
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Large magnetocaloric effect in a dense and stable inorganic-organic hybrid cobridged by in situ generated sulfate and oxalate.
Chem Asian J
PUBLISHED: 07-07-2014
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A dense and stable inorganic-organic hybrid with distorted cubic [Gd4 O4 ] units as building blocks bridged by in situ generated sulfate and oxalate was synthesized. Magnetic measurements indicate that the title complex features a -?Sm (max) =51.49?J?kg(-1) ?K(-1) , which is among the highest values reported so far.
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A high-fructose diet induces hippocampal insulin resistance and exacerbates memory deficits in male Sprague-Dawley rats.
Nutr Neurosci
PUBLISHED: 05-27-2014
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The purpose of this study was to investigate the effects of a long-term high-fructose diet on the insulin-signaling pathway of the hippocampus. Sprague-Dawley rats were fed either on a control (0% fructose solution) or high-fructose diet (10% fructose solution). Food intake and body mass were measured regularly. Eight months later, peripheral insulin sensitivity, the activity of the hippocampal insulin pathway, and memory tasks were assessed. Compared to the control group, the high fructose group exhibited more weight gain, peripheral insulin resistance, metabolic disorders, and memory impairments. In addition, insulin signaling in the hippocampus was attenuated in the high fructose group. These results suggested that a high-fructose diet induced peripheral insulin resistance and an abnormal insulin-signaling pathway in the hippocampus which exacerbated memory deficits in the rats.
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Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition.
Mol. Pharm.
PUBLISHED: 05-06-2014
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Recently, it has been proposed that drug permeation is essentially carrier-mediated only and that passive lipoidal diffusion is negligible. This opposes the prevailing hypothesis of drug permeation through biological membranes, which integrates the contribution of multiple permeation mechanisms, including both carrier-mediated and passive lipoidal diffusion, depending on the compound's properties, membrane properties, and solution properties. The prevailing hypothesis of drug permeation continues to be successful for application and prediction in drug development. Proponents of the carrier-mediated only concept argue against passive lipoidal diffusion. However, the arguments are not supported by broad pharmaceutics literature. The carrier-mediated only concept lacks substantial supporting evidence and successful applications in drug development.
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Epidemiology of bedside stove burns in a retrospective cohort of 5089 pediatric patients.
Burns
PUBLISHED: 03-14-2014
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To retrospectively analyze the epidemiological characteristics of pediatric bedside stove burns (PBSB) in China and to explore prevention and control measures.
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Effect of repeated exposures and sociality on novel food acceptance and consumption by orangutans.
Primates
PUBLISHED: 02-20-2014
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Hundreds of rehabilitant great apes have been released into the wild, and thousands await release. However, survival rates after release can be as low as 20 %. Several factors influence individuals' survival rates, one of which is the capacity to obtain an adequate diet once released. Released individuals are faced with a mixture of familiar and novel foods in an unfamiliar forest; therefore, it is important to understand how they increase acceptance and consumption of novel foods. This is especially vital for omnivorous species, such as wild great apes, which consume several hundred species of different foods. We assessed the effects of repeated exposures and sociality (i.e. co-feeding in the presence of one or more other individuals) on the acceptance and consumption of novel foods by captive orangutans (Pongo sp). Repeated exposures of food (novel, at first) did not cause an increase of acceptance of food; in other words, the orangutans did not start to eat a food item after being exposed to that food more often, but repeated exposures of food increased consumption (i.e. quantity). After repeated exposures, the orangutans also became gradually more familiar with the food, decreasing their explorative behaviour. The presence of co-feeding conspecifics resulted in an increased acceptance of the novel food by orangutans, and they ate a larger amount of said foods than when alone. Repeated exposure and sociality may benefit rehabilitant great apes in augmenting and diversifying diet and, once practiced before release, may accelerate an individuals' adaptation to their new habitat, improving survival chances. Great ape rescue, rehabilitation and reintroduction require large financial and logistic investments; however, their effectiveness may be improved at low cost and low effort through the suggested measures.
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Low-dimensional carboxylate-bridged Gd(III) complexes for magnetic refrigeration.
Chem Asian J
PUBLISHED: 02-12-2014
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Four carboxylate-bridged Gd(III) complexes (1-4) with 1D/2D structures have been synthesized by using the hydrothermal reaction of Gd2O3 with various carboxylate ligands. Compounds 1 and 2 contained the same [2n] Gd(III)-OH ladders, but with different crystallographically independent Gd(III) ions, whilst the structures of compounds 3 and 4 were composed of [Gd4(?3-OH)2(piv)8(H2O)2](2+) units and 1D ladder Gd(III) chains, respectively. Antiferromagnetic interactions occurred in compounds 1-3, owing to their small Gd-O-Gd angles, whereas ferromagnetic coupling occurred in compound 4, in which the Gd-O-Gd angles were larger. These complexes exhibited a distinct magnetocaloric effect (MCE), which was affected by their different magnetic densities and exchange interactions. Among these compounds, complex 4 presented the largest MCE (-?S(m)(max)=43.6?J?kg(-1) K(-1)), the lowest M(w)/N(Gd) ratio (the highest magnetic density), and weak ferromagnetic coupling. Therefore, a lower M(w)/N(Gd) ratio and weaker exchange interactions (a smaller absolute value of ?) between Gd(III) ions resulted in a larger MCE for the Gd(III) complexes.
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The EMO-model: an agent-based model of primate social behavior regulated by two emotional dimensions, anxiety-FEAR and satisfaction-LIKE.
PLoS ONE
PUBLISHED: 01-01-2014
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Agent-based models provide a promising tool to investigate the relationship between individuals' behavior and emerging group-level patterns. An individual's behavior may be regulated by its emotional state and its interaction history with specific individuals. Emotional bookkeeping is a candidate mechanism to keep track of received benefits from specific individuals without requiring high cognitive abilities. However, how this mechanism may work is difficult to study in real animals, due to the complexity of primate social life. To explore this theoretically, we introduce an agent-based model, dubbed EMO-model, in which we implemented emotional bookkeeping. In this model the social behaviors of primate-like individuals are regulated by emotional processes along two dimensions. An individual's emotional state is described by an aversive and a pleasant dimension (anxiety and satisfaction) and by its activating quality (arousal). Social behaviors affect the individuals' emotional state. To implement emotional bookkeeping, the receiver of grooming assigns an accumulated affiliative attitude (LIKE) to the groomer. Fixed partner-specific agonistic attitudes (FEAR) reflect the stable dominance relations between group members. While the emotional state affects an individual's general probability of executing certain behaviors, LIKE and FEAR affect the individual's partner-specific behavioral probabilities. In this way, emotional processes regulate both spontaneous behaviors and appropriate responses to received behaviors, while emotional bookkeeping via LIKE attitudes regulates the development and maintenance of affiliative relations. Using an array of empirical data, the model processes were substantiated and the emerging model patterns were partially validated. The EMO-model offers a framework to investigate the emotional bookkeeping hypothesis theoretically and pinpoints gaps that need to be investigated empirically.
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[Changes in mast cells and hepatic expression of c-kit and stem cell factor in the rat model of chronic hepatitis].
Zhonghua Gan Zang Bing Za Zhi
PUBLISHED: 12-17-2013
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To study the potential role of mast cells and the related molecular mechanism in chronic hepatitis (CH) using a rat model system.
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[Effects of antihistamine treatment on immune fuction in rats with experimental hepatitis].
Zhonghua Gan Zang Bing Za Zhi
PUBLISHED: 12-17-2013
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To investigate the effects of antihistamine treatment on immune function in rats with experimental hepatitis.
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[Effectiveness of cochlear implantation in children with auditory neuropathy and cochlear nerve aplasia].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
PUBLISHED: 11-08-2013
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The aim of this study is to assess of cochlear implantation in children with auditory neuropathy and cochlear nerve aplasia by using Categories of Auditory Performance (CAP) and Speech Intelligibility Rating (SIR).
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[Clinical application of bone-anchored hearing aid implantation].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
PUBLISHED: 11-08-2013
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To discuss the indications, surgery methods and effects of the BAHA implantation by analyzing the patients medical records of bone-anchored hearing aids(BAHA).
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[Modified closed reduction for the arytenoid cartilage dislocation].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
PUBLISHED: 10-10-2013
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To investigate the clinical characteristics of arytenoid cartilage dislocation and the outcome of modified closed reduction.
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Orangutan (Pongo spp.) whistling and implications for the emergence of an open-ended call repertoire: a replication and extension.
J. Acoust. Soc. Am.
PUBLISHED: 08-24-2013
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One of the most apparent discontinuities between non-human primate (primate) call communication and human speech concerns repertoire size. The former is essentially fixed to a limited number of innate calls, while the latter essentially consists of numerous learned components. Consequently, primates are thought to lack laryngeal control required to produce learned voiced calls. However, whether they may produce learned voiceless calls awaits investigation. Here, a case of voiceless call learning in primates is investigated--orangutan (Pongo spp.) whistling. In this study, all known whistling orangutans are inventoried, whistling-matching tests (previously conducted with one individual) are replicated with another individual using original test paradigms, and articulatory and acoustic whistle characteristics are compared between three orangutans. Results show that whistling has been reported for ten captive orangutans. The test orangutan correctly matched human whistles with significantly high levels of performance. Whistle variation between individuals indicated voluntary control over the upper lip, lower lip, and respiratory musculature, allowing individuals to produce learned voiceless calls. Results are consistent with inter- and intra-specific social transmission in whistling orangutans. Voiceless call learning in orangutans implies that some important components of human speech learning and control were in place before the homininae-ponginae evolutionary split.
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An unprecedented decanuclear Gd(III) cluster for magnetic refrigeration.
Inorg Chem
PUBLISHED: 07-29-2013
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An unprecedented decanuclear Gd(III) cluster composed of the [Gd10(?3-OH)8](22+) core has been hydrothermally synthesized. Magnetic analyses indicate that this complex shows weak antiferromagnetic behavior with a relatively large magnetocaloric effect (-?S(m)(max) = 31.22 J kg(-1) K(-1)).
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Effect of surface hydroxyls on dimethyl ether synthesis over the ?-Al?O? in liquid paraffin: a computational study.
J Mol Model
PUBLISHED: 07-22-2013
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In a recent paper (Zuo et al., Appl Catal A 408:130-136, 2011), the mechanism of dimethyl ether (DME) synthesis from methanol dehydration over ?-Al2O3 (110) was studied using density functional theory (DFT). Using the same method, the effect of surface hydroxyls on ?-Al2O3 in liquid paraffin during DME synthesis from methanol dehydration is investigated. It is found that DME is mainly formed from two adsorbed CH3O groups via methanol dehydrogenation on both dehydrated and hydrated ?-Al2O3 in liquid paraffin. No close correlation between catalytic activity and acid intensity was found. Before and after water adsorption at typical catalytic conditions (e.g., 553 K), the reaction rate is not obviously changed on ?-Al2O3(100) surface in liquid paraffin, but the reaction rate decreases by about 11 times on the (110) in liquid paraffin. Considering the area of the (110) and (100) surfaces under actual conditions, the catalytic activity decreased mainly because the Al3 sites on the (110) surface gradually become inactive. Catalytic activity decreased mainly due to surface hydrophilicity. The calculated results were consistent with the experiment.
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Three-dimensional digitalized virtual planning for retrograde sural neurovascular island flaps: a comparative study.
Burns
PUBLISHED: 07-10-2013
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The purpose of this study was to explore the effectiveness and safety of three-dimensional (3D) digitalized planning for the sural neurovascular island flap in repair of soft tissue defects in the ankle and foot.
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Synthesis and ferrimagnetic properties of an unprecedented polynuclear cobalt complex composed of [Co24] macrocycles.
Chem. Commun. (Camb.)
PUBLISHED: 07-05-2013
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An unprecedented polynuclear cobalt complex with a [Co(24)] macrocycle in the presence of [Co(H(2)O)(6)](2+) has been prepared and characterized. In this complex, [Co(H(2)O)(6)](2+) not only acts as a counterion to balance the negative charge of the 2D layer, but may also serve as a template in the assembly of the [Co(24)] macrocyclic complex through hydrogen-bond interactions. Magnetic analyses indicate that the title compound shows homometallic ferrimagnetic behavior.
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Medication assessment tool to detect care issues from routine data: a pilot study in primary care.
Int J Clin Pharm
PUBLISHED: 06-29-2013
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Background Medication assessment tools (MATs) may be implemented in routine electronic data sources in order to identify patients with opportunities for optimisation of medication therapy management (MTM) and follow-up by a multi-disciplinary team. Objective (1) To demonstrate the use of a MAT for cardiovascular conditions (MATCVC) as a means of profiling potential opportunities for MTM optimisation in primary care and (2) to assess the performance of MATCVC in identifying actual opportunities for better care. Setting Members of a pharmacotherapy discussion group, i.e. two single-handed general practitioners (GPs), three GP partners, and community pharmacists (CPs) from each of two community pharmacies, in a rural part of the Netherlands. Methods MATCVC comprises 21 medication assessment criteria, each of which is designed to detect a specific care issue and to check whether it is addressed by provision of guideline recommended care or open in the presence (open explained) or absence (open unexplained) of pre-specified explanations for guideline deviations. (1) Relevant data was extracted from linked GP and CP electronic records and MATCVC assessment was conducted to profile the population of CVC patients registered with both, participating CPs and GPs, in terms of open unexplained care issues. (2) A purposive sample of patients with open unexplained care issues was reviewed by each patients GP. Main outcome measures Number and proportion of open unexplained care issues per MATCVC criterion and per patient. The number of patients with MATCVC detected open unexplained care issues to be reviewed (NNR) in order to identify one that requires changes in MTM. Results In 1,876 target group patients, MATCVC identified 6,915 care issues, of which 2,770 (40.1 %) were open unexplained. At population level, ten MATCVC criteria had particularly high potential for quality improvement. At patient level, 1,277 (68.1 %) target group patients had at least one open unexplained care issue. For patients with four or more open unexplained care issues, the NNR was 2 (95 % CI 2-2). Conclusion The study demonstrates potential ways of using MATCVC as a key component of a collaborative MTM system. Strategies that promote documentation and sharing of explanations for deviating from guideline recommendations may enhance the utility of the approach.
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Polarization characteristics of Whispering-Gallery-Mode fiber lasers based on evanescent-wave-coupled gain.
Opt Express
PUBLISHED: 06-06-2013
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The polarization characteristics of Whispering-Gallery-Mode (WGM) fiber lasers based on evanescent-wave-coupled gain are investigated. For the laser gain is excited by side-pumping scheme, it is found that the polarization property of lasing emission is simply dependent on the polarized states of the pump beams. The polarization property of lasing emission depends on the propagating situation of the pump beams in an optical fiber if the laser gain is excited by evanescent-wave pumping scheme, that is, if the pump beams within the fiber are meridional beams, the lasing emission is a transverse electric (TE) wave that forms a special radial polarization emission. However, if the pump beams within the fiber are skew beams, both transverse magnetic (TM) and TE waves exist simultaneously in lasing emission that forms a special axially and radially mixed polarization emission. Pumped by skew beams, the wave-number differences between TE and TM waves are also investigated quantitatively, the results demonstrate that the wave-number difference decreases with the increase of the fiber diameter and the refractive index (RI) of the cladding solution. The observed polarization characteristics have been well explained based on lasing radiation mechanism of WGM fiber laser of gain coupled by evanescent wave.
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[Analysis of clinical data of 16 595 pediatric burn patients during fifteen years].
Zhonghua Shao Shang Za Zhi
PUBLISHED: 05-29-2013
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To analyze the epidemiological characteristics of pediatric burn in the midwest region of Inner Mongolia and the related areas, and to provide reference for seeking pertinent measures of prevention and treatment.
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A chiral 2p-3d heterometallic azido complex with 2,6-pyridinedicarboxylate as the co-ligand showing magnetic order.
Dalton Trans
PUBLISHED: 04-30-2013
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A new chiral 3D heterometallic coordination polymer [NaCo2(L)2(N3)·(MeOH)]? (1) (L = 2,6-pyridinedicarboxylate) was synthesized and characterized magnetically. Ferro- and antiferromagnetic interactions co-exist in 1, which results in a magnetic phase transition at the high temperature of 29 K.
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Intranasal endoscopic prelacrimal recess approach to maxillary sinus.
Chin. Med. J.
PUBLISHED: 04-06-2013
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The inferior turbinate (IT) and nasolacrimal duct (NLD) are often sacrificed while managing the diffuse lesion of maxillary sinus (MS). We report a new approach to MS without ablation of NLD and IT.
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Non-response in a pharmacy and patient-based intensive monitoring system: a quantitative study on non-response bias and reasons for non-response.
Int J Pharm Pract
PUBLISHED: 03-18-2013
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Worldwide pharmacists play an increasingly important role in pharmacovigilance. Lareb Intensive Monitoring (LIM) in the Netherlands is a new form of active pharmacovigilance where pharmacists play a key role. Patients using drugs which are monitored are identified in the pharmacy and invited to participate in the active monitoring. Not all invited patients participate. This study aimed to investigate non-response bias in LIM, as well as reasons for non-response in order to identify barriers to participation.
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Tuning the structure and magnetism of heterometallic sodium(1+)-cobalt(2+) formate coordination polymers by varying the metal ratio and solvents.
Inorg Chem
PUBLISHED: 03-05-2013
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Three new heterometallic formate coordination polymers formulated as [Na2Co(HCOO)4]? (1), [NaCo(HCOO)3]? (2), and [Na2Co7(HCOO)16]? (3) were obtained by adjusting the solvent and ratio of the reactants. In 1, a (4,4) cobalt formate layer is formed and the sodium ions connect the layers to form a three-dimensional (3D) framework. In 2, each formate ligand binds two Co(2+) and two Na(+) ions with a syn,syn,anti,anti coordination mode to form a chrial network with 4,6-connected topology. 3 is a Na(+)-ion-linked 3D framework based on the cobalt formate layer, which has a 10-membered metal ring. Magnetic studies indicate the existence of ferromagnetic interactions between adjacent Co(2+) ions in 1, while dominating antiferromagnetic couplings in 2 and 3.
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Slow magnetic relaxation in two new 1D/0D Dy(III) complexes with a sterically hindered carboxylate ligand.
Inorg Chem
PUBLISHED: 02-04-2013
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Two carboxylate-bridged Dy(III) complexes, [Dy(2)(piv)(5)(?(3)-OH)(H(2)O)](n) (1) and [Dy(2)(piv)(6)(phen)(2)] (2) (pivH = pivalic acid; phen = 1,10-phenanthroline), have been synthesized and structurally characterized. Complex 1 takes a one-dimensional (1D) chain structure based on [Dy(4)(?(3)-OH)(2)(piv)(8)(H(2)O)(2)](2+) units, while complex 2 is a dinuclear structure bridged by syn,syn-carboxylates. Magnetic investigation indicates weak ferromagnetic interaction between adjacent Dy(III) ions of the Dy(4) unit in 1 and weak intramolecular antiferromagnetic interaction between Dy(III) ions and/or depopulation of the Dy(III) excited-state Stark sublevels in 2. Alternating-current susceptibility measurements revealed frequency- and temperature-dependent out-of-phase signals under a zero direct-current field in 1, with typical slow magnetic relaxation behavior with an anisotropic barrier U ? 4.5 K, while 2 exhibits field-induced single-molecule-magnet behavior with ?E/k(B) = 28.43 K under a 2 kOe external field.
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In vivo suppression of microRNA-24 prevents the transition toward decompensated hypertrophy in aortic-constricted mice.
Circ. Res.
PUBLISHED: 01-10-2013
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During the transition from compensated hypertrophy to heart failure, the signaling between L-type Ca(2+) channels in the cell membrane/T-tubules and ryanodine receptors in the sarcoplasmic reticulum becomes defective, partially because of the decreased expression of a T-tubule-sarcoplasmic reticulum anchoring protein, junctophilin-2. MicroRNA (miR)-24, a junctophilin-2 suppressing miR, is upregulated in hypertrophied and failing cardiomyocytes.
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Evaluation of neuromuscular activity in patients with obstructive sleep apnea using chin surface electromyography of polysomnography.
Chin. Med. J.
PUBLISHED: 01-05-2013
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It is believed that defects in upper airway neuromuscular control play a role in sleep apnea pathogenesis. Currently, there is no simple and non-invasive method for evaluating neuromuscular activity for the purpose of screening in patients with obstructive sleep apnea. This study was designed to assess the validity of chin surface electromyography of routine polysomnography in evaluating the neuromuscular activity of obstructive sleep apnea subjects and probe the neuromuscular contribution in the pathogenesis of the condition.
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A case report of atypical scrotal leiomyoma.
Case Rep Dermatol
PUBLISHED: 01-01-2013
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Scrotal leiomyoma is a benign tumor derived from the scrotal dartos muscle; it is rare in clinical findings. The cause of the disease is not yet clear. Here, we present the case of a patient with no typical clinical features, but with some typical pathological changes. A middle-aged male patient saw a doctor for paroxysmal itching and burning of the scrotum. The physical examination revealed 3 × 5-cm(2), ill-defined, pink plaques, an uneven surface, and basal infiltration with pigmentation defects in the center. Pathology results showed dermal spindle cells in nodular hyperplasia. The nucleus was round at both ends, a perinuclear halo could be seen, and staining was positive for actin and negative for S100. Therefore, the diagnosis of scrotal myoma was made.
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[Vibrant soundbridge implantation (two cases report)].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
PUBLISHED: 11-18-2011
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To investigate the effect of Vibrant Soundbridge (VSB) implantation.
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Fibrovascular polyp of the hypopharynx and esophagus.
Chin. Med. J.
PUBLISHED: 11-02-2011
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Fibrovascular polyp of the hypopharynx and esophagus, a rare, benign, intraluminal and submucosal tumor, is most commonly originated from the proximal esophagus. We discussed four cases with regurgitation, respiratory symptom or the feeling of a mass in the throat. All the patients were examined with laryngoscope under general anesthesia. A transverse cervical incision was performed in one patient and the polyps were excised under laryngoscope with CO2 laser in the other three patients. All the lesions were removed successfully. Diagnostic and therapeutic principles involved in these cases are presented and discussed. The recognition of fibrovascular polyp of the hypopharynx and esophagus as a potential cause of regurgitation is paramount. Surgical excision is recommended because of the satisfactory outcome.
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Simultaneous determination of six phenolic constituents of Danshen injection in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study.
Eur J Mass Spectrom (Chichester, Eng)
PUBLISHED: 10-19-2011
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Salvianolic acid A, salvianolic acid B, danshensu, protocatechuic aldehyde, rosmarinic acid and lithospermic acid are the six major active constituents in Danshen injection. In this study, a rapid, sensitive and specific liquid chromatographic-electrospray ionization-mass spectrometry method for the simultaneous quantitative determination of these compounds in rat plasma was developed. After a single step of liquid-liquid extraction with ethyl acetate, they were eluted by a Hypersil C18 column (5 µm, i.d. 4.6 × 200 mm) within 4 min with a mobile phase consisting of acetonitrile and 0.1% formic acid water solution (35:65, v/v). The assay was linear in the concentration range of 0.05-10 µg mL(-1). Absolute recoveries were above 60%. The precisions and accuracies determined within three consecutive days were within acceptable limits. The method was successfully applied to a pharmacokinetic study in rats after an intravenous administration of Danshen injection.
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Proteome reference map and regulation network of neonatal rat cardiomyocyte.
Acta Pharmacol. Sin.
PUBLISHED: 08-15-2011
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To study and establish a proteome reference map and regulation network of neonatal rat cardiomyocyte.
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[Evaluation on efficacy of Jins "Sanzhen" therapy combined with rehabilitation training for hemiplegia of stroke patients by Fugl-Meyer scale].
Zhen Ci Yan Jiu
PUBLISHED: 07-29-2011
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To assess the therapeutic effect of Jins "Sanzhen" therapy combined with rehabilitation training on limb-motor function of stroke patients by using Fugl-Meyer scale.
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Gasless endoscopic surgery through the upper chest in treatment of thyroid tumor.
Chin. Med. J.
PUBLISHED: 07-12-2011
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Recently, there has been a surge of interest in minimally invasive techniques with endoscope in thyroid surgery. The aim of this study was to investigate the possibility of a scarless neck surgery under endoscopy for the treatment of thyroid tumor and to observe the results of this procedure.
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Better safe than sorry--socio-spatial group structure emerges from individual variation in fleeing, avoidance or velocity in an agent-based model.
PLoS ONE
PUBLISHED: 05-26-2011
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In group-living animals, such as primates, the average spatial group structure often reflects the dominance hierarchy, with central dominants and peripheral subordinates. This central-peripheral group structure can arise by self-organization as a result of subordinates fleeing from dominants after losing a fight. However, in real primates, subordinates often avoid interactions with potentially aggressive group members, thereby preventing aggression and subsequent fleeing. Using agent-based modeling, we investigated which spatial and encounter structures emerge when subordinates also avoid known potential aggressors at a distance as compared with the model which only included fleeing after losing a fight (fleeing model). A central-peripheral group structure emerged in most conditions. When avoidance was employed at small or intermediate distances, centrality of dominants emerged similar to the fleeing model, but in a more pronounced way. This result was also found when fleeing after a fight was made independent of dominance rank, i.e. occurred randomly. Employing avoidance at larger distances yielded more spread out groups. This provides a possible explanation of larger group spread in more aggressive species. With avoidance at very large distances, spatially and socially distinct subgroups emerged. We also investigated how encounters were distributed amongst group members. In the fleeing model all individuals encountered all group members equally often, whereas in the avoidance model encounters occurred mostly among similar-ranking individuals. Finally, we also identified a very general and simple mechanism causing a central-peripheral group structure: when individuals merely differed in velocity, faster individuals automatically ended up at the periphery. In summary, a central-peripheral group pattern can easily emerge from individual variation in different movement properties in general, such as fleeing, avoidance or velocity. Moreover, avoidance behavior also affects the encounter structure and can lead to subgroup formation.
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[Audiology characteristics in newborns and infants who failed in the hearing screening by transiently evoked otoacoustic emissions: 89 cases study].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
PUBLISHED: 05-18-2011
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The present study was to evaluate the audiological characteristics of infants with normal auditory brainstem response thresholds in click and abnormal transiently evoked otoacoustic emissions. Relationships between test results of distortion product otoacoustic emissions (DPOAE) and other hearing testing methods were also evaluated.
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Influence of rifampicin on the pharmacokinetics of salvianolic acid B may involve inhibition of organic anion transporting polypeptide (Oatp) mediated influx.
Phytother Res
PUBLISHED: 03-29-2011
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This article studied the possible effect of rifampicin (RIF), an inhibitor of organic anion transporting polypeptide (Oatp), on the pharmacokinetics of salvianolic acid B (SAB) in rats. Rifampicin was administered intravenously 15?min prior to SAB (5?mg/kg) in rats at doses of 0, 5.0, 10.0 and 20.0?mg/kg, respectively. The concentrations of SAB in plasma and bile were determined using a Shimadzu HPLC system coupled to a LC-MS-2010EV mass spectrometer. Compared with the control group, the AUC(0-t) and C(max) values of SAB were increased significantly, while the CL(total) and CL(bile) were decreased significantly. These results suggested that pretreatment with rifampicin prior to SAB administration could decrease significantly the total and bile elimination of SAB and alter its pharmacokinetic profiles. The influence of rifampicin on the pharmacokinetics of SAB may be attributed to the inhibition of Oatp-mediated influx.
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Telmisartan attenuates isoproterenol-induced cardiac remodeling in rats via regulation of cardiac adiponectin expression.
Acta Pharmacol. Sin.
PUBLISHED: 03-14-2011
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To investigate whether telmisartan (Telm) pretreatment attenuates isoproterenol (Iso)-induced postinfarction remodeling (PIR) in rats, and whether the effect of Telm is associated with cardiac expression of adiponectin.
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Chimpanzees (Pan troglodytes) fail a what-where-when task but find rewards by using a location-based association strategy.
PLoS ONE
PUBLISHED: 02-16-2011
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Recollecting the what-where-when of an episode, or episodic-like memory, has been established in corvids and rodents. In humans, a linkage between remembering the past and imagining the future has been recognised. While chimpanzees can plan for the future, their episodic-like memory has hardly been investigated. We tested chimpanzees (Pan troglodytes) with an adapted food-catching paradigm. They observed the baiting of two locations amongst four and chose one after a given delay (15 min, 1 h or 5 h). We used two combinations of food types, a preferred and a less preferred food that disappeared at different rates. The subjects had to base their choices on the time elapsed since baiting, and on their memory of which food was where. They could recover either their preferred food or the one that remained present. All animals failed to obtain the preferred or present foods above chance levels. They were like-wise unsuccessful at choosing baited cups above chance levels. The subjects, thus, failed to use any feature of the baiting events to guide their choices. Nonetheless, their choices were not random, but the result of a developed location-based association strategy. Choices in the second half of the study correlated with the rewards obtained at each location in the first half of the study, independent from the choices made for each location in the first half of the study. This simple location-based strategy yielded a fair amount of food. The animals failure to remember the what-where-when in the presented set-up may be due to the complexity of the task, rather than an inability to form episodic-like memories, as they even failed to remember what was where after 15 minutes.
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Comparison of cadmium-induced iron-deficiency responses and genuine iron-deficiency responses in Malus xiaojinensis.
Plant Sci.
PUBLISHED: 02-13-2011
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The effects of the heavy metal Cd in Malus xiaojinensis were investigated using hydroponic cultures. Chlorophyll and Fe concentrations in young leaves were markedly decreased by Cd treatment, although Fe concentration was significantly enhanced in the roots. A comparative examination of the Fe-deficiency responses due to Fe deficiency and Cd treatment was also performed. Both Fe deficiency and Cd treatment induced responses similar to those of Fe-deficiency in M. xiaojinensis, including acidification of the rhizosphere, enhanced Fe(III) chelate reductase activity, and upregulation of the Fe-deficiency-responsive genes MxIRT1 and MxFRO2-Like. However, the Fe-deficiency responses induced by Cd treatment were different in intensity and timing from those induced by Fe deficiency.
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Preventing hospital admissions by reviewing medication (PHARM) in primary care: design of the cluster randomised, controlled, multi-centre PHARM-study.
BMC Health Serv Res
PUBLISHED: 01-07-2011
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Medication can be effective but can also be harmful and even cause hospital admissions. Medication review or pharmacotherapy review has often been proposed as a solution to prevent these admissions and to improve the effectiveness and safety of pharmacotherapy. However, most published randomised controlled trials on pharmacotherapy reviews showed no or little effect on morbidity and mortality. Therefore we designed the PHARM (Preventing Hospital Admissions by Reviewing Medication)-study with the objective to study the effect of the total pharmaceutical care process on medication related hospital admissions and on adverse drug events, survival and quality of life.
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Pulse transit time for quantifying inspiratory effort in patients with obstructive sleep apnea.
ORL J. Otorhinolaryngol. Relat. Spec.
PUBLISHED: 01-05-2011
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To investigate the feasibility of pulse transit time (PTT) as a quantitative measure of inspiratory effort in patients with obstructive sleep apnea (OSA).
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5-aminolevulinic acid-mediated photodynamic therapy on cervical condylomata acuminata.
Photomed Laser Surg
PUBLISHED: 12-15-2010
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The aim of this study was to evaluate the efficacy of 5-aminolevulinic acid-mediated photodynamic therapy (PDT) on cervical condylomata accuminate (CA) and to determine the ultrastructural changes of the lesion after treatment.
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[Reconstruction of mid-face defects following the removal of malignant neoplasms: A review of 80 cases].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
PUBLISHED: 11-09-2010
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To evaluate the reconstructive methods of outcome of midface defects following the removal of malignant neoplasms.
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Evaluation of serum specific IgE for the diagnosis of allergic rhinitis with multi-allergens.
Chin. Med. J.
PUBLISHED: 11-02-2010
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Objective evaluation of allergic rhinitis (AR) requires in vivo and in vitro tests. In vitro tests are important to assist or ensure the main allergens in multi-allergen-sensitive patients. The aim of this study was to evaluate the utility of serum specific IgE (sIgE) in the diagnosis of AR patients with multi-allergens in the Chinese population.
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[Effects of lipopolysaccharide on the maturation and secretion of human peripheral dendritic cells].
Zhonghua Gan Zang Bing Za Zhi
PUBLISHED: 10-15-2010
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To study the effects of Lipopolysaccharide (LPS) on the maturation and secretion of human peripheral dendritic cells (DCs).
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[Up-conversion luminescent materials of Y2O3: RE(RE=Er or Er/Yb) prepared by sol-gel combustion synthesis].
Guang Pu Xue Yu Guang Pu Fen Xi
PUBLISHED: 09-07-2010
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Y2O3 powders doped with rare-earth ions were synthesized by sol-gel combustion synthesis. Effects of different calcinating temperatures, Er+ doping concentration and Yb3+ doping concentration were investigated. It was shown that the single well crystallized Y2O3 powders could be obtained at 800 degrees C; as the calcinating temperature increased, the crystallinity and upconversion luminescence intensity were higher; the particle size was uniform around 1 microm at 900 degrees C; when Er3+ doping concentration was 1 mol%, the green upconversion luminescence intensity reached the maximum, but for red upconversion luminescence, when Er3+ doping concentration was 4 mol%, its luminescence intensity reached the maximum; as the ratio of Yb3+ to Er3+ was 4:1, the green emission intensity reached the maximum, while the red emission intensity was always increasing as Yb3+ doping concentration increased.
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[Current state of diagnosis and treatment of allergic rhinitis in China].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
PUBLISHED: 07-27-2010
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To investigate the understanding among otolaryngologists and perspectives on the diagnosis and management of allergic rhinitis in major cities in China.
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[Manifestation and treatment of lipoid proteinosis in larynx].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
PUBLISHED: 07-15-2010
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To investigate the manifestation, characteristics and treatment of lipoid proteinosis (LP) in larynx.
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[Juvenile nasopharyngeal angiofibroma: endoscopic surgery and follow-up results].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
PUBLISHED: 05-11-2010
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To present the changes of surgical approaches for the resection of juvenile nasopharyngeal angiofibromas (JNA) and the follow-up results.
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Combined endoscope-assisted translabyrinthine subtemporal keyhole approach for vestibular Schwannoma and auditory midbrain implantation: Cadaveric study.
Acta Otolaryngol.
PUBLISHED: 04-07-2010
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The combined endoscope-assisted translabyrinthine subtemporal keyhole approach can expose the internal auditory canal, cerebellopontine, and inferior colliculus satisfactorily in the same surgical setting. As a minimally invasive approach, this can be considered an effective method for removal of vestibular schwannoma and auditory midbrain implantation in the same surgical setting, while avoiding retraction of the cerebellum and serious adverse events and complications.
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[Effect of the melamine residue in soil on growth of Chinese cabbage].
Huan Jing Ke Xue
PUBLISHED: 04-03-2010
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Soil and foliar application of melamine (ME) treatments to Zaoshu 5 Chinese cabbage were investigated. The ME was degraded very slowly in soil treated with different dosages (40,160 and 800 mg x kg(-1)), and 90 days later the residuals of ME were 21.1%, 15.8% and 43.6% respectively. The Chinese cabbage could take in exogenously applied ME through its root and stem leaf and accumulate it to considerable levels with the increasing applied density. In soil application test, the maximum and minimum contents of ME were 105.7 and 8.0 mg x kg(-1) in root, and 139.9 and 7.1 mg x kg(-1) in stem leaf; the ME transport occurred from root to stem leaf. In foliar application test,the maximum and minimum contents of ME were 4.3 and 0.9 mg x kg(-1) in root, and 8.5 and 3.2 mg x kg(-1) in stem leaf. In soil application test,the low level of ME (40 mg x kg(-1)) increased the biomass yield by 9.8% and the high level of ME (800 mg x kg(-1)) decreased the biomass yield by 15.9%; the contents of chlorophyll and soluble sugar increased,but the content of Vitamin C decreased. Foliar application ME had no obvious significance on the growth of Chinese cabbage. The studies indicate that the residual time of ME in soil is long and the Chinese cabbage can absorb exogenously applied ME and ME can affect the growth of Chinese cabbage.
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[Total thyroidectomy: indications and complications].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
PUBLISHED: 03-15-2010
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To investigate the indications and complications of the total thyroidectomy in the management of thyroid cancer.
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[The prevalence of HIV infection and the risk factors among MSM in 4 cities, China].
Zhonghua Yu Fang Yi Xue Za Zhi
PUBLISHED: 03-15-2010
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To access the prevalence of HIV infection and the associated factors among urban MSM in China.
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Childrens aggressive responses to neutral peer behavior: a form of unprovoked reactive aggression.
Psychiatry Res
PUBLISHED: 03-09-2010
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Previous studies that operationalized reactive aggression using behavioral observations in general populations have not taken into account the type of stimulus that elicits reactive aggression. In the present study we define a specific form of reactive aggression, i.e., reactive aggression in response to neutral behavior of a peer, which we will call unprovoked reactive aggression. We were specifically interested in children with severe aggressive behavior problems, since they may respond with reactive aggression even though the opponent did not clearly provoke them, but instead showed neutral behavior. Children with a disruptive behavior disorder (DBD) and normal control (NC) children participated in separate play sessions in which they played with a normal peer (NP). Children with DBD showed more unprovoked reactive aggression than NC children, during a cooperative game. Moreover, for children with DBD, unprovoked reactive aggressive behavior in this game correlated with parent-rated reactive aggression. Results of this study suggest that an unprovoked reactive form of aggression can be identified in children with DBD.
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Determination of nimodipine in human plasma by HPLC-ESI-MS and its application to a bioequivalence study.
J Chromatogr Sci
PUBLISHED: 01-30-2010
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A simple, specific, and precise liquid chromatographic-electrospray ionization mass spectrometric (LC-ESI-MS) method has been developed for determination of nimodipine concentration in human plasma. The method involves the addition of 200 microL of saturated sodium bicarbonate (NaHCO(3)) solution to plasma to improve the extraction recovery, liquid-liquid extraction of nimodipine from plasma samples with anhydrous diethyl ether, simple reversed-phase chromatography, and ESI mass spectrometric detection in negative ion selected ion monitoring mode (SIM) using target [M-] ions at m/z 417 and m/z 359 for nimodipine and nitrendipine (internal standard, IS), respectively. A complete analytical run was achieved within 3.5 min. The limit of quantification was 0.5 ng/mL. The method was validated within a linear range of 0.5-100 ng/mL. The correlation coefficient for the calibration regression line was 0.9995 or better. Intra- and inter-batch accuracy and precision were acceptable. Analyte was stable in a battery of stability studies. The method has been successfully used in a bioequivalence study.
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[Evaluation of the safety of aluminium adjuvant in the preparation of allergic rhinitis animal model].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
PUBLISHED: 12-08-2009
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To evaluate the effect and safety of the formulation and dosage of aluminium adjuvant, Al(OH)(3), in the preparation of allergic rhinitis animal model.
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[Treatment of allergic rhinitis with nasal mometasone furoate].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
PUBLISHED: 12-04-2009
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To evaluate the effects of nasal mometasone furoate on moderate to severe allergic rhinitis.
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[Comparison study between clinical diagnosis and experimental diagnosis of fungal sinusitis].
Zhonghua Yi Xue Za Zhi
PUBLISHED: 12-02-2009
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To compare the differences between clinical diagnosis and laboratory diagnosis of fungal sinusitis.
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Improving compound quality through in vitro and in silico physicochemical profiling.
Chem. Biodivers.
PUBLISHED: 11-26-2009
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Many compounds entering clinical studies do not survive the numerous hurdles for a good pharmacological lead to a drug on the market. The reasons for attrition have been widely studied which resulted in more early attention to compound quality related to physical chemistry, drug metabolism and pharmacokinetics (DMPK), and toxicology/safety. This paper will briefly review current physicochemical in vitro assays and in silico predictions to support compound and library design through to lead optimization. The most important physicochemical properties include lipophilicity (log P/D), pKa, solubility, and permeability. These drive key ADMET properties such as absorption, cell penetration, access to the brain, volume of distribution, plasma protein binding, metabolism, and toxicity, as well as biopharmaceutical behavior. Much data are now available from medium- to high-throughput physchem and ADMET in vitro assays, either in the public domain (see, e.g., PubChem, PubMed) or in drug companies in-house databases. Such data are increasingly being computer-modelled and used in predictive chemistry. New pipelining technology makes it easier to build and update QSAR models so that such models can use the latest available data to produce robust local and global predictive in silico ADMET models.
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Efficiency and its measurement: what practitioners need to know.
Am J Manag Care
PUBLISHED: 11-10-2009
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To help health professionals understand and evaluate the concept of efficiency and its measurement in practice.
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Value of nasal mucosa congestion index in choosing treatment strategies for chronic rhinosinusitis.
Acta Otolaryngol.
PUBLISHED: 10-30-2009
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The mucosa compliance in lesions is determined by the congestion index, enabling us to determine whether the patient is sensitive to pharmacotherapy and to choose surgical management rationally.
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[Psychological characteristics in patients with allergic rhinitis and its associated factors analysis.].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
PUBLISHED: 10-19-2009
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To investigate the psychological characteristics of patients with allergic rhinitis (AR) and its associated factors.
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[Effect of cyclosporine A on the pharmacokinetics of ginkgolide B in rats].
Yao Xue Xue Bao
PUBLISHED: 10-08-2009
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The paper is aimed to investigate the effect of cyclosporine A (CyA) on the pharmacokinetics of ginkgolide B (GB) in rats, and to look for the mechanism of the changes in pharmacokinetic behaviors of GB. GB concentration in plasma, brain homogenate and urine samples of rats was determined by LC-MS. Effects of CyA on plasma levels, brain distributions as well as urinary excretions after intravenous administration of GB were evaluated. CyA co administrated intravenously at 10 mg kg(-1) or 20 mg kg(-1) significantly increased AUC(0-360 min) (P < 0.01) and decreased total CL of GB in rats. While co administrated CYP3A inhibitor itraconazole (ICZ) has no appreciable effect on the pharmacokinetic behavior of GB. CyA increased the brain uptake of GB in a dose-dependent manner. The brain distribution of GB was significantly increased at 5 min by different doses of CyA (P < 0.001), while at 20 and 60 min only high dose of CyA could significantly increase the levels of GB in the brain (P < 0.01 and P < 0.001). Different P-gp inhibitors CyA or verapamil (VER) or digoxin (DGX) decreased the urinary GB excretion, the urinary excretion of GB in 0-8 h were about 34.8% (P < 0.001), 59.4% (P < 0.001) and 79.7% (P < 0.05) of the control, separately. No appreciable effect of ICZ was observed on urinary excretion of GB. Coadministration of P-gp inhibitors CyA could significantly increase the plasma level, accelerate the brain distribution and decrease the urinary excretion of GB.
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[Ecological and physiological adaptabilities of earthworm in biofilter under domestication stage].
Huan Jing Ke Xue
PUBLISHED: 10-06-2009
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Ecological and physiological adaptabilities of earthworm in biofilter under domestication stage is presented, as well as related factors. The results show that, due to the coercion of natural and filter environment, the number and biomass of earthworms present a gradual downward trend after added. But once the conditions become appropriate, hatching of larvae could add the number and biomass of earthworm in the filter. With the increase of temperature, circumjacent earthworms gradually move to the water distribution area, 58 days later earthworms distribution become more uniform. Earthworm density and moisture content exist the significant negative correlation. Temperature, precipitation and rainfall dont affect the ecological indicators of earthworms significantly. When temperature is below 15 degrees C, the earthworms respiratory rate become more sensitive and decline significantly which is not conducive for earthworms treatment of sewage sludge. In a certain range, its effective for improving the efficiency of sludge treatment to increase the density of earthworms and distribute earthworms evenly.
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