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Find video protocols related to scientific articles indexed in Pubmed.
Optical Coherence Tomography Imaging of Presumed Sarcoid Retinal and Optic Nerve Nodules.
Ocul. Immunol. Inflamm.
PUBLISHED: 10-31-2014
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Abstract Purpose: To characterize nodular lesions of the retina and optic nerve with spectral-domain optical coherence tomography (SD-OCT) in patients with sarcoidosis. Methods: This is a retrospective series of 6 eyes from 5 patients with an established diagnosis of sarcoidosis, with clinically detected nodules of the optic nerve or retina. All lesions were imaged with fundus photography and SD-OCT on presentation, and followed with serial imaging after treatment with corticosteroids and/or immunomodulatory therapy. Results: Spectral OCT through the lesions revealed nodular hyperreflective processes obscuring the retinal layers or optic cup, with local structural changes, including subretinal and intraretinal fluid. After treatment with corticosteroids and/or immunosuppression in 4 followed patients, all lesions regressed with improvement in associated structural changes, but did not entirely disappear. Conclusions: Spectral OCT can be useful in identifying lesion morphology and location, and in tracking the response to treatment in eyes with posterior-segment nodules, presumably secondary to sarcoidosis.
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Success With Single-Agent Immunosuppression for Multifocal Choroidopathies.
Am. J. Ophthalmol.
PUBLISHED: 09-03-2014
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To evaluate the success of single-agent immunosuppression for patients with the posterior uveitides, birdshot chorioretinitis, multifocal choroiditis with panuveitis, and punctate inner choroiditis.
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Periocular Corticosteroid Injections in Uveitis: Effects and Complications.
Ophthalmology
PUBLISHED: 04-23-2014
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To evaluate the benefits and complications of periocular depot corticosteroid injections in patients with ocular inflammatory disorders.
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Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection.
J. Infect. Dis.
PUBLISHED: 04-21-2014
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While inflammation predicts mortality in treated human immunodeficiency virus (HIV) infection, the prognostic significance of gut barrier dysfunction and phenotypic T-cell markers remains unclear.
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Cost-effectiveness of fluocinolone acetonide implant versus systemic therapy for noninfectious intermediate, posterior, and panuveitis.
Ophthalmology
PUBLISHED: 02-05-2014
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To evaluate the 3-year incremental cost-effectiveness of fluocinolone acetonide implant versus systemic therapy for the treatment of noninfectious intermediate, posterior, and panuveitis.
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Epiretinal membranes in uveitic macular edema: effect on vision and response to therapy.
Am. J. Ophthalmol.
PUBLISHED: 01-23-2014
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To evaluate the effects of epiretinal membranes on the response of uveitic macular edema to therapy and on visual acuity outcomes.
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GWATCH: a web platform for automated gene association discovery analysis.
Gigascience
PUBLISHED: 01-01-2014
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As genome-wide sequence analyses for complex human disease determinants are expanding, it is increasingly necessary to develop strategies to promote discovery and validation of potential disease-gene associations.
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Evaluation of hepatitis C virus as a risk factor for HIV-associated neuroretinal disorder.
Clin. Infect. Dis.
PUBLISHED: 09-30-2013
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Both hepatitis C virus (HCV) and human immunodeficiency virus (HIV) penetrate the central nervous system. HIV-associated neuroretinal disorder (HIV-NRD), a visual impairment of reduced contrast sensitivity and reading ability, is associated with cytokine dysregulation and genetic polymorphisms in the anti-inflammatory interleukin 10 (IL-10) signaling pathway. We investigated associations between HCV and HIV-NRD and between HCV and single-nucleotide polymorphisms (SNPs) in the IL-10 receptor 1 (IL10R1) gene.
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Expert Panel Recommendations for the Use of Anti-Tumor Necrosis Factor Biologic Agents in Patients with Ocular Inflammatory Disorders.
Ophthalmology
PUBLISHED: 09-24-2013
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To provide recommendations for the use of anti-tumor necrosis factor ? (TNF-?) biologic agents in patients with ocular inflammatory disorders.
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Correlates of hypertension in patients with AIDS in the era of highly active antiretroviral therapy.
J Int Assoc Provid AIDS Care
PUBLISHED: 06-15-2013
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It is unclear whether HIV-related factors modify risk of hypertension (HTN). In a cohort of patients with AIDS, the authors determined HTN incidence and prevalence and assessed associated traditional, HIV-specific, and retinal vasculature factors.
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Factors Predictive of Remission of New-Onset Anterior Uveitis.
Ophthalmology
PUBLISHED: 02-25-2013
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To identify factors predictive of remission of inflammation in new-onset anterior uveitis cases treated at tertiary uveitis care facilities.
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Comparison of treatment regimens for cytomegalovirus retinitis in patients with AIDS in the era of highly active antiretroviral therapy.
Ophthalmology
PUBLISHED: 02-16-2013
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To describe the outcomes of different treatment approaches for cytomegalovirus (CMV) retinitis in the era of highly active antiretroviral therapy (HAART).
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Risk of choroidal neovascularization among the uveitides.
Am. J. Ophthalmol.
PUBLISHED: 01-29-2013
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To evaluate the risk, risk factors, and visual impact of choroidal neovascularization (CNV) in uveitis cases.
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Incidence of Visual Improvement in Uveitis Cases with Visual Impairment Caused by Macular Edema.
Ophthalmology
PUBLISHED: 01-17-2013
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Among cases of visually significant uveitic macular edema (ME), to estimate the incidence of visual improvement and identify predictive factors.
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Approach to the diagnosis of the uveitides.
Am. J. Ophthalmol.
PUBLISHED: 01-17-2013
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To describe an approach to diagnosing the uveitides, a collection of about 30 separate diseases characterized by intraocular inflammation.
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Challenges in the design and implementation of the Multicenter Uveitis Steroid Treatment (MUST) Trial--lessons for comparative effectiveness trials.
Clin Trials
PUBLISHED: 10-12-2011
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Randomized clinical trials (RCTs) are an important component of comparative effectiveness (CE) research because they are the optimal design for head-to-head comparisons of different treatment options.
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Randomized comparison of systemic anti-inflammatory therapy versus fluocinolone acetonide implant for intermediate, posterior, and panuveitis: the multicenter uveitis steroid treatment trial.
Ophthalmology
PUBLISHED: 06-17-2011
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To compare the relative effectiveness of systemic corticosteroids plus immunosuppression when indicated (systemic therapy) versus fluocinolone acetonide implant (implant therapy) for noninfectious intermediate, posterior, or panuveitis (uveitis).
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Evaluation of the United States public health service guidelines for discontinuation of anticytomegalovirus therapy after immune recovery in patients with cytomegalovirus retinitis.
Am. J. Ophthalmol.
PUBLISHED: 04-11-2011
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To evaluate United States Public Health Service (USPHS) guidelines for discontinuing anticytomegalovirus (CMV) therapy in patients with AIDS who have immune recovery and quiescent retinitis after initiating highly active antiretroviral therapy.
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Association of host genetic risk factors with the course of cytomegalovirus retinitis in patients infected with human immunodeficiency virus.
Am. J. Ophthalmol.
PUBLISHED: 03-10-2011
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To evaluate the effects of previously reported host genetics factors that influence cytomegalovirus (CMV) retinitis incidence, progression to acquired immune deficiency syndrome (AIDS), and efficacy of highly active antiretroviral therapy (HAART) for mortality, retinitis progression, and retinal detachment in patients with CMV retinitis and AIDS in the era of HAART.
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Periocular triamcinolone acetonide injections for cystoid macular edema complicating noninfectious uveitis.
Am. J. Ophthalmol.
PUBLISHED: 02-02-2011
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To describe the effectiveness of periocular corticosteroid injections in the treatment of cystoid macular edema (CME) complicating noninfectious uveitis.
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Identifying a clinically meaningful threshold for change in uveitic macular edema evaluated by optical coherence tomography.
Am. J. Ophthalmol.
PUBLISHED: 01-08-2011
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To identify a clinically meaningful threshold for change in retinal thickness measured by optical coherence tomography for patients with uveitic macular edema using correlation with change in visual acuity.
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Risk of relapse in primary acute anterior uveitis.
Ophthalmology
PUBLISHED: 01-04-2011
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To evaluate the risk of and risk factors for a second episode (relapse) among patients with remitted primary anterior uveitis.
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Restoration of retinal architecture following systemic immunosuppression in birdshot chorioretinopathy.
Ocul. Immunol. Inflamm.
PUBLISHED: 08-25-2010
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To describe restoration of retinal architecture following systemic immunosuppressive treatment in a patient with birdshot chorioretinopathy (BSCR).
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Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS.
J. Infect. Dis.
PUBLISHED: 07-13-2010
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Cytomegalovirus (CMV) retinitis is a common opportunistic infection among patients with AIDS and still causes visual morbidity despite the wide spread usage of highly active antiretroviral therapy (HAART). The ubiquitous CMV pathogen contains a human interleukin-10 (IL-10) homolog in its genome and utilizes it to evade host immune reactions through an IL-10 receptor mediated immune-suppression pathway.
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Adverse effects of smoking on patients with ocular inflammation.
Br J Ophthalmol
PUBLISHED: 07-08-2010
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To evaluate how smoking affects the time to disease quiescence and time to disease recurrence in patients with ocular inflammation.
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Cytomegalovirus retinitis and the acquired immunodeficiency syndrome--bench to bedside: LXVII Edward Jackson Memorial Lecture.
Am. J. Ophthalmol.
PUBLISHED: 06-30-2010
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To update information on cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS) and to integrate information on its pathogenesis and clinical outcomes.
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Visual field loss in patients with cytomegalovirus retinitis.
Ophthalmology
PUBLISHED: 06-30-2010
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To describe visual field (VF) loss among patients with cytomegalovirus (CMV) retinitis and the risk factors for such loss.
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Effect of host genetics on incidence of HIV neuroretinal disorder in patients with AIDS.
J. Acquir. Immune Defic. Syndr.
PUBLISHED: 06-10-2010
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Approximately 10%-15% of patients with AIDS but without ocular opportunistic infections will have a presumed neuroretinal disorder (HIV-NRD), manifested by reduced contrast sensitivity and abnormal visual fields. The loss of contrast sensitivity often is sufficient to impair reading speed. To evaluate the effect of host genetics on HIV-NRD, we explored validated AIDS restriction gene variants CCR5Delta32, CCR2-64I, CCR5 P1, SDF-3A, IL-10-5A, RANTES -403A, RANTES -28G, RANTES-In1.1C, CX3CR1-249I, CX3CR1-280M, IFNG-179T, MDR1-3435T, and MCP-1364G, each of which has been implicated previously to influence HIV-1 infection, AIDS progression, therapy response, and antiviral drug metabolism, and an IL-10 receptor gene, IL-10R1, in the Longitudinal Study of the Ocular Complications of AIDS cohort. In European Americans (cases = 55, controls = 290), IL-10-5A variant and its promoter haplotype (hazard ratio = 2.09, confidence interval. 1.19 to 3.67, P = 0.01), in African Americans (cases = 54, controls = 180), RANTES-In1.1C and the associated haplotype (hazard ratio = 2.72, confidence interval.: 1.48 to 5.00, P = 0.001), showed increased HIV-NRD susceptibility. Although sample sizes are small and P values do not pass a strict Bonferroni correction, our results suggest that, in European Americans, an IL-10-related pathway, and, in African Americans, chemokine receptor ligand polymorphisms in RANTES are risk factors for HIV-NRD development. Clearly, further studies are warrented.
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Vascular endothelial growth factor inhibition in uveitis: a systematic review.
Br J Ophthalmol
PUBLISHED: 05-21-2010
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Vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of uveitic complications such as cystoid macular oedema (CMO), choroidal neovasularisation (CNV) and retinal neovascularisation (RNV). The use of intravitreal anti-VEGF therapies, namely bevacizumab and ranibizumab, has recently been described in the treatment of these complications. Evidence describing the use of intravitreal anti-VEGF therapy for these complications consists of case reports and case series, most of which are retrospective and have limitations in design and analysis. As such, the current level of evidence supporting the use of intravitreal anti-VEGF therapy for these complications of uveitis would be rated as very low. Furthermore, blockage of VEGF has not been shown to have an anti-inflammatory effect. Thus, treatment of the underlying inflammatory disease should play a central role in the management of uveitic CMO, CNV and RNV. A two-pronged treatment regimen that focuses on achieving disease quiescence through the use of corticosteroids and/or immunosuppressive agents, while treating complications that arise despite adequate disease quiescence with intravitreal anti-VEGF agents, may be useful. However, further data from prospective controlled trials are needed before the therapeutic role of anti-VEGF therapy in the uveitis treatment regimen can be fully determined.
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Association between abnormal contrast sensitivity and mortality among people with acquired immunodeficiency syndrome.
Am. J. Ophthalmol.
PUBLISHED: 04-20-2010
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To investigate the relationship between contrast sensitivity (CS) and mortality among people with acquired immunodeficiency syndrome (AIDS); and to explore the hypothesis that abnormal CS is a marker of systemic, life-threatening microvascular disease.
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Risk of cataract development among children with juvenile idiopathic arthritis-related uveitis treated with topical corticosteroids.
Ophthalmology
PUBLISHED: 04-03-2010
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We sought to investigate the risk of cataract development among patients with juvenile idiopathic arthritis (JIA)-associated uveitis treated with topical corticosteroids.
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Course of cytomegalovirus retinitis in the era of highly active antiretroviral therapy: five-year outcomes.
Ophthalmology
PUBLISHED: 03-09-2010
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To describe the 5-year outcomes of patients with cytomegalovirus (CMV) retinitis and AIDS in the era of highly active antiretroviral therapy (HAART).
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HLA typing in uveitis: use and misuse.
Am. J. Ophthalmol.
PUBLISHED: 01-28-2010
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To evaluate the role of HLA typing as a diagnostic test in patients with uveitis.
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Mitochondrial haplogroups are associated with risk of neuroretinal disorder in HIV-positive patients.
J. Acquir. Immune Defic. Syndr.
PUBLISHED: 01-26-2010
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Although highly active antiretroviral therapy has improved survivorship dramatically and decreased the incidence of cytomegalovirus retinitis among patients with AIDS, other ophthalmic complications continue to occur. One complication observed in approximately 12% of HIV-infected patients is a presumed neuroretinal disorder (NRD), manifested as decreased contrast sensitivity and associated with vague subjective complaints of hazy vision. Pathologically, patients with AIDS even without ocular opportunistic infections have loss of optic nerve axons, suggestive of mitochondrial dysfunction. We explored whether variation in mitochondrial DNA was associated with time to NRD in HIV-infected patients in the Longitudinal Study of Ocular Complications of AIDS cohort. Within the Western European, or "N", mitochondrial DNA macrohaplogroup, haplogroup J, was associated with 80% decrease in the risk of progression to NRD during the study (hazard ratio = 0.20, P = 0.039) and suggested an independent association with protection against NRD in a cross-section of all patients taken at enrollment (1.5% vs. 8.9% in patients with vs. without haplogroup J, respectively, P = 0.05). These data suggest that mitochondrial genotype may influence propensity to develop HIV-associated NRD in patients with AIDS.
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The multicenter uveitis steroid treatment trial: rationale, design, and baseline characteristics.
Am. J. Ophthalmol.
PUBLISHED: 01-25-2010
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To describe the design and methods of the Multicenter Uveitis Steroid Treatment (MUST) trial and the baseline characteristics of enrolled patients.
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Ocular disease in patients with ANCA-positive vasculitis.
J Ocul Biol Dis Infor
PUBLISHED: 07-25-2009
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Anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis-the term recently applied to Wegeners granulomatosis-is a rare multi-system inflammation characterized by necrotizing granulomas and vasculitis. We investigated the ocular manifestations of this disease in a group of patients drawn from five inflammatory eye disease clinics across the United States. Of 8,562 persons with ocular inflammation, 59 individuals were diagnosed with ANCA-positive vasculitis; 35 males and 21 females, aged 16 to 96 years, were included in this study. Ocular diagnoses were scleritis (75.0%), uveitis (17.9%), and other ocular inflammatory conditions (33.9%) including peripheral ulcerative keratitis and orbital pseudotumor. Mean duration of ocular disease was 4.6 years. Oral corticosteroids and other systemic immunosuppressive agents were used by 85.7% and 78.5% of patients, respectively. Over time, patients with ANCA-positive vasculitis experienced 2.75-fold higher mortality than other patients with inflammatory eye disease.
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Mycophenolate mofetil for ocular inflammation.
Am. J. Ophthalmol.
PUBLISHED: 06-24-2009
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To evaluate mycophenolate mofetil as a single noncorticosteroid immunosuppressive treatment for noninfectious ocular inflammatory diseases.
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Hypopyon in patients with uveitis.
Ophthalmology
PUBLISHED: 04-09-2009
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To evaluate the risk of and risk factors for hypopyon among patients with uveitis and to evaluate the risk of visual changes and complications after hypopyon.
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Methotrexate for ocular inflammatory diseases.
Ophthalmology
PUBLISHED: 04-04-2009
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To evaluate the outcome of treatment with methotrexate for noninfectious ocular inflammation.
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Cyclophosphamide for ocular inflammatory diseases.
Ophthalmology
PUBLISHED: 03-22-2009
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To evaluate the outcomes of cyclophosphamide therapy for noninfectious ocular inflammation.
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Azathioprine for ocular inflammatory diseases.
Am. J. Ophthalmol.
PUBLISHED: 02-27-2009
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To evaluate treatment outcomes of azathioprine for noninfectious ocular inflammatory diseases.
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Incidence of cystoid macular edema after cataract surgery in patients with and without uveitis using optical coherence tomography.
Am. J. Ophthalmol.
PUBLISHED: 02-14-2009
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To determine the incidence of cystoid macular edema (CME) after cataract surgery among eyes with and without uveitis using optical coherence tomography (OCT) and to determine risk factors for postoperative CME among eyes with uveitis.
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Mortality associated with resistant cytomegalovirus among patients with cytomegalovirus retinitis and AIDS.
Ophthalmology
PUBLISHED: 02-12-2009
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To evaluate the effect of drug-resistant cytomegalovirus (CMV) on survival among patients with CMV retinitis.
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Sympathetic ophthalmia: incidence of ocular complications and vision loss in the sympathizing eye.
Am. J. Ophthalmol.
PUBLISHED: 01-07-2009
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To report the frequency on presentation and subsequent incidence of ocular complications and vision loss in patients with sympathetic ophthalmia (SO) and to describe factors associated with decreased vision in the sympathizing eye.
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Non-cytomegalovirus ocular opportunistic infections in patients with acquired immunodeficiency syndrome.
Am. J. Ophthalmol.
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To report the incidence and clinical outcomes of non-cytomegalovirus (non-CMV) ocular opportunistic infections in patients with acquired immunodeficiency syndrome (AIDS) in the era of highly active antiretroviral therapy.
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Subretinal fluid in uveitic macular edema: effect on vision and response to therapy.
Am. J. Ophthalmol.
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To evaluate the effect of subretinal fluid (SRF), imaged with spectral-domain optical coherence tomography (SD-OCT), on visual acuity outcomes in cases of uveitic macular edema (ME), and to analyze the response of SRF and uveitic ME to therapy.
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Risk of cataract in persons with cytomegalovirus retinitis and the acquired immune deficiency syndrome.
Ophthalmology
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To evaluate cataract risk in eyes of patients with AIDS and cytomegalovirus (CMV) retinitis and to identify risk factors.
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Mortality in hepatitis C virus-infected patients with a diagnosis of AIDS in the era of combination antiretroviral therapy.
Clin. Infect. Dis.
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Before the introduction of combination antiretroviral therapy (cART), patients infected with the human immunodeficiency virus (HIV) rarely died of liver disease. In resource-rich countries, cART dramatically increased longevity. As patients survived longer, hepatitis C virus (HCV) infection became a leading cause of death; however, because patients with AIDS continue to have 5-fold greater mortality than non-AIDS patients, it is unclear whether HCV infection increases mortality in them.
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Risk of corticosteroid-induced hyperglycemia requiring medical therapy among patients with inflammatory eye diseases.
Ophthalmology
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To identify the incidence and risk factors for corticosteroid-induced hyperglycemia requiring medical therapy among patients with inflammatory eye diseases.
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High-dose intravenous corticosteroids for ocular inflammatory diseases.
Ocul. Immunol. Inflamm.
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To evaluate the effectiveness and risk of complications of high-dose intravenous pulsed corticosteroids for noninfectious ocular inflammatory diseases.
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Incidence of cytomegalovirus retinitis in the era of highly active antiretroviral therapy.
Am. J. Ophthalmol.
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To estimate the incidence of cytomegalovirus (CMV) retinitis in the era of highly active antiretroviral therapy (HAART) and to characterize the factors associated with increased risk of CMV retinitis.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.