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Find video protocols related to scientific articles indexed in Pubmed.
Protection against epithelial damage during Candida albicans infection is mediated by PI3K/Akt and mTOR signaling.
J. Infect. Dis.
PUBLISHED: 12-19-2013
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Background.?The ability of epithelial cells (ECs) to discriminate between commensal and pathogenic microbes is essential for healthy living. Key to these interactions are mucosal epithelial responses to pathogen-induced damage.Methods.?Using reconstituted oral epithelium we assessed epithelial gene transcriptional responses to C. albicans infection by microarray. Signal pathway activation was monitored by Western blot and Transcription factor ELISA, and their role in C. albicans-induced damage protection determined using chemical inhibitors.Results.?Transcript profiling demonstrated early up-regulation of epithelial genes involved in immune responses. Many of these genes constituted components of signaling pathways, but only NF-?B, MAPK and PI3K/Akt pathways were functionally activated. We demonstrate that PI3K/Akt signaling is independent of NF-?B and MAPK signaling and plays a key role in epithelial immune activation and damage protection via mTOR activation.Conclusion.?PI3K/Akt/mTOR signaling may play a critical role in protecting epithelial cells from damage during mucosal fungal infections independently of NF-?B or MAPK signaling.
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Copy number variation at chromosome 5q21.2 is associated with intraocular pressure.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 04-20-2013
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Glaucoma is a major cause of blindness in the world. Recent genome-wide association studies (GWAS) have identified common genetic variants for glaucoma, but still a significant heritability gap remains. We hypothesized that copy number variants (CNVs) might influence part of the susceptibility to glaucoma or its related quantitative endophenotypes.
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The influence of folate supplementation on global gene expression in normal colonic mucosa of subjects with colorectal adenoma.
Mol Nutr Food Res
PUBLISHED: 01-24-2013
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We determined whether short-term supplementation with a physiological dose of folate alters global gene expression in the normal colonic mucosa of subjects with colorectal adenoma.
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Effect of high-fat feeding on expression of genes controlling availability of dopamine in mouse hypothalamus.
Nutrition
PUBLISHED: 03-15-2009
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Hypothalamic centers integrate external signals of nutrient availability and energy status and initiate responses to maintain homeostasis. Quantifying changes in hypothalamic gene expression in the presence of nutrient excess may identify novel responsive elements.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.