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Find video protocols related to scientific articles indexed in Pubmed.
Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data.
Lancet
PUBLISHED: 08-19-2014
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We aimed to investigate whether the benefits of blood pressure-lowering drugs are proportional to baseline cardiovascular risk, to establish whether absolute risk could be used to inform treatment decisions for blood pressure-lowering therapy, as is recommended for lipid-lowering therapy.
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Prescription of secondary prevention medications, lifestyle advice, and referral to rehabilitation among acute coronary syndrome inpatients: results from a large prospective audit in Australia and New Zealand.
Heart
PUBLISHED: 06-09-2014
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To evaluate the proportion of patients hospitalised with acute coronary syndrome (ACS) in Australia and New Zealand who received optimal inpatient preventive care and to identify factors associated with preventive care.
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Hospital quality improvement initiative for patients with acute coronary syndromes in China: a cluster randomized, controlled trial.
Circ Cardiovasc Qual Outcomes
PUBLISHED: 03-11-2014
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Background- Substantial evidence-practice gaps exist in the management of acute coronary syndromes (ACS) in China. Clinical pathways are tools for improving ACS quality of care but have not been rigorously evaluated. Methods and Results- Between October 2007 and August 2010, a quality improvement program was conducted in 75 hospitals throughout China with mixed methods evaluation in a cluster randomized, controlled trial. Eligible hospitals were level 2 or level 3 centers routinely admitting >100 patients with ACS per year. Hospitals were assigned immediate implementation of the American Heart Association/American College of Cardiology guideline based clinical pathways or commencement of the intervention 12 months later. Outcomes were several key performance indicators reflecting the management of ACS. The key performance indicators were measured 12 months after commencement in intervention hospitals and compared with baseline data in control hospitals, using data collected from 50 consecutive patients in each hospital. Pathway implementation was associated with an increased proportion of patients discharged on appropriate medical therapy, with nonsignificant improvements or absence of effects on other key performance indicators. Conclusions- Among hospitals in China, the use of a clinical pathway for the treatment of ACS compared with usual care improved secondary prevention treatments, but effectiveness was otherwise limited. An accompanying process evaluation identified several health system barriers to more successful implementation. Clinical Trial Registration- URL: http://www.anzctr.org.au/default.aspx. Unique identifier: ACTRN12609000491268.
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System barriers to the evidence-based care of acute coronary syndrome patients in China: qualitative analysis.
Circ Cardiovasc Qual Outcomes
PUBLISHED: 03-11-2014
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Organizational and wider health system factors influence the implementation and success of interventions. Clinical Pathways in Acute Coronary Syndromes 2 is a cluster randomized trial of a clinical pathway-based intervention to improve acute coronary syndrome care in hospitals in China. We performed a qualitative evaluation to examine the system-level barriers to implementing clinical pathways in the dynamic healthcare environment of China.
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Acute coronary syndrome care across Australia and New Zealand: the SNAPSHOT ACS study.
Med. J. Aust.
PUBLISHED: 05-02-2013
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To characterise management of suspected acute coronary syndrome (ACS) in Australia and New Zealand, and to assess the application of recommended therapies according to published guidelines.
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Opinions of community pharmacists on the value of a cardiovascular polypill as a means of improving medication compliance.
Int J Pharm Pract
PUBLISHED: 10-27-2011
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Cardiovascular disease is a major public health problem despite established treatment guidelines and significant healthcare expenditure worldwide. Poor medication compliance accounts in part for some of the observed evidence/practice gaps. Trials of fixed-dose combination pills are currently underway, but the attitudes of relevant health professionals to the routine use of a cardiovascular polypill are generally unknown. Pharmacists are a group of providers who play an important role in patient compliance with long-term medications. The objective was to identify the main perceived barriers to compliance and to investigate pharmacists opinions regarding the routine use of a cardiovascular polypill.
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The effects of blood pressure reduction and of different blood pressure-lowering regimens on major cardiovascular events according to baseline blood pressure: meta-analysis of randomized trials.
J. Hypertens.
PUBLISHED: 04-26-2011
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The benefits of reducing blood pressure are well established, but there remains uncertainty about whether the magnitude of the effect varies with the initial blood pressure level. The objective was to compare the risk reductions achieved by different blood pressure-lowering regimens among individuals with different baseline blood pressures.
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Gender disparities in the assessment and management of cardiovascular risk in primary care: the AusHEART study.
Eur J Cardiovasc Prev Rehabil
PUBLISHED: 02-11-2011
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Studies indicate ongoing gender-based differences in the prevention, detection and management of cardiovascular disease. The aims of this study were to determine whether there are differences in general practitioners (GPs) perceptions of a patients cardiovascular risk compared with the patients estimated risk and in the patients subsequent medical management according to patient sex.
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Clinical pathways for acute coronary syndromes in China: protocol for a hospital quality improvement initiative.
Crit Pathw Cardiol
PUBLISHED: 08-31-2010
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Clinical pathways have been shown to be effective in improving quality of care for patients admitted to hospital for acute coronary syndromes (ACS) in high-income countries. However, their utility has not formally been evaluated in low- or middle-income countries. The Clinical Pathways for Acute Coronary Syndromes in China program is a 7-year study with the overall goal of reducing evidence-practice gaps in the management of patients admitted to hospitals in China with suspected ACS. The program comprises 2 phases: a prospective survey of current management of ACS patients to identify the areas that evidence-based patient care can be potentially improved, and a quality care initiative to maximize the use of evidence-based investigations and treatments for ACS patients in China. In this article, we outline the details of the study protocol, including key aspects of the development, implementation, and evaluation of the quality improvement initiative (clinical pathway) for management of patients with suspected ACS.
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The Framingham Study, diabetes mellitus and cardiovascular disease: turning back the clock.
Prog Cardiovasc Dis
PUBLISHED: 07-13-2010
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The global population of individuals with diabetes is important and rapidly growing. Because of the link between diabetes and cardiovascular disease (CVD), it is expected that diabetes will be an important driver of the future burden of CVD around the world. A connection between diabetes and CVD was suspected as earlier as in the mid 19th century. However, CVD in diabetes received less attention until the advent in the 20th century of treatments that allowed people with diabetes to live long enough to experience CVD. Since then the relationship between diabetes and CVD has been extensively investigated and characterised. The present article outlines the important contribution the Framingham Heart Study has made to the recognition of diabetes as a cardiovascular risk factor and the way in which the study has informed the association between other risk factors and CVD in the presence of diabetes, the changing pattern of the risk with time, and the quantification of CVD risk in the presence of diabetes. Through this contribution, Framingham has largely influenced our understanding of CVD in people with diabetes. Lines of investigation regarding cardiovascular health in this population are still wide open, and the Framingham Study continues to be part of this journey.
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Blood pressure and cardiovascular disease: tracing the steps from Framingham.
Prog Cardiovasc Dis
PUBLISHED: 07-13-2010
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Around one-quarter of the worlds adult population are defined as "hypertensive" however a much greater proportion are at risk of blood pressure-related disease because of the nature of the association between blood pressure and cardiovascular risk. The Framingham Study, together with other landmark observational studies, has been instrumental in elucidating this relationship. As early as the 1960s, Framingham showed that the association between blood pressure and cardiovascular risk was continuous and linear and was consistent across different age groups and for a range of major cardiovascular events. As the first major observational study to include substantial numbers of women, it was also able to debunk the myth that women "could tolerate blood pressure well". In more recent decades, Framingham has been central to the development of the notion of absolute risk and the importance of blood pressure alongside other risk factors. Much of our current understanding of the role blood pressure in cardiovascular disease can be attributed to decades of high quality research from Framingham.
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Effectiveness of blood pressure lowering: evidence-based comparisons between men and women.
Expert Rev Cardiovasc Ther
PUBLISHED: 02-09-2010
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The global burden of blood pressure-related disease is escalating faster among women than among men and, in recent years, age-adjusted mortality rates among women have actually increased. This has led to the speculation that there might be major sex-specific differences in the effectiveness of preventive therapies such as blood pressure-lowering drugs. However, large overviews of both observational and clinical trial data provide strong evidence that the protection against serious vascular events afforded by blood pressure reduction using a range of commonly used drugs is comparable for men and women. Underestimation of cardiovascular risk and supoptimal therapy are more likely to account for poorer outcomes among women. These differences highlight the importance of global initiatives such as Go Red for Women.
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Aspirin is beneficial in hypertensive patients with chronic kidney disease: a post-hoc subgroup analysis of a randomized controlled trial.
J. Am. Coll. Cardiol.
PUBLISHED: 01-28-2010
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The purpose of this study was to determine the benefit and risk associated with antiplatelet therapy in the chronic kidney disease (CKD) population.
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An electronic clinical decision support tool to assist primary care providers in cardiovascular disease risk management: development and mixed methods evaluation.
J. Med. Internet Res.
PUBLISHED: 05-06-2009
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Challenges remain in translating the well-established evidence for management of cardiovascular disease (CVD) risk into clinical practice. Although electronic clinical decision support (CDS) systems are known to improve practitioner performance, their development in Australian primary health care settings is limited.
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Evidence-based medication use among Chinese patients with acute coronary syndromes at the time of hospital discharge and 1 year after hospitalization: results from the Clinical Pathways for Acute Coronary Syndromes in China (CPACS) study.
Am. Heart J.
PUBLISHED: 03-03-2009
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Coronary heart disease has emerged as a leading cause of death in China. Although there is strong evidence for the use of antiplatelet, blood pressure-lowering, and lipid-lowering therapy in patients with acute coronary syndromes, the extent to which these medications are used in China remains uncertain.
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Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: a systematic review and meta-analysis.
PLoS Med.
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Guidelines recommend intensive blood pressure (BP) lowering in patients at high risk. While placebo-controlled trials have demonstrated 22% reductions in coronary heart disease (CHD) and stroke associated with a 10-mmHg difference in systolic BP, it is unclear if more intensive BP lowering strategies are associated with greater reductions in risk of CHD and stroke. We did a systematic review to assess the effects of intensive BP lowering on vascular, eye, and renal outcomes.
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Comparative effectiveness of population interventions to improve access to reperfusion for ST-segment-elevation myocardial infarction in Australia.
Circ Cardiovasc Qual Outcomes
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Improving timely access to reperfusion is a major goal of ST-segment-elevation myocardial infarction care. We sought to compare the population impact of interventions proposed to improve timely access to reperfusion therapy in Australia.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.