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Find video protocols related to scientific articles indexed in Pubmed.
The Association Between Spinal Cord Injury and Acute Myocardial Infarction in a Nationwide Population-Based Cohort Study.
Spine
PUBLISHED: 11-14-2014
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Study Design. A spinal cord injury (SCI) retrospective cohort study was derived from National Health Insurance Research Database (NHIRD) of Taiwan.Objective. We evaluated risks of developing acute myocardial infarction (AMI) in patients newly diagnosed with SCI.Summary of Background Data. According to information of World Health Organization, cardiovascular diseases (CVDs) are the most frequent causes of death in SCI patients which compared to general population.Methods. We obtained claim data from the NHIRD for this cohort study. The SCI group comprised 22 197 patients diagnosed with SCI. Case and control patients which based on risk-set sampling in a 1:4 ratio, and excluded patients with a prior diagnosis of AMI. Comorbidities were categorized as proportion of prior illnesses in SCI and non-SCI groups respectively. We used Cox proportion model to explore adjusted hazard ratio (aHR) for AMI between case and control patients.Results. The SCI patients were significantly more likely to exhibit preexisting illnesses associated with AMI than non-SCI patients were. Patients diagnosed with SCI exhibited significantly higher aHRs of developing AMI, than non-SCI patients (aHR = 1.17, p<0.05). Patients with SCI, compared to non-SCI, was associated with subsequent AMI risk (aHR = 1.17, p<0.05). Several comorbidities were associated with increased risk, like CVD (aHR = 1,29, p<0.05), chronic obstructive pulmonary disease (COPD) (aHR = 1,51, p<0.05), hypertension (aHR = 1,34, p<0.01), and renal disease (aHR = 1,76, p<0.05). Furthermore T-spine SCI were significantly associated with AMI risk (aHR = 1,38, p<0.05).Conclusion. Patients diagnosed with SCI exhibited an increased risk for AMI than patients without SCI. These findings have broad implications for surveillance for SCI patients and future studies should evaluate whether risk factor modification can decrease the AMI risk in SCI patients.
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Increased risk of tuberculosis in patients with type 1 diabetes mellitus: results from a population-based cohort study in taiwan.
Medicine (Baltimore)
PUBLISHED: 10-14-2014
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The studies on the risk of tuberculosis (TB) in patients with type 1 diabetes mellitus (T1DM) alone are limited. We examined this relationship using a population-based retrospective cohort study. From claims data of the National Health Insurance system of Taiwan, we identified 5195 patients with T1DM newly diagnosed from 2002 to 2011 and 20,780 randomly selected controls without T1DM, frequency matched by age, sex, and year of diagnosis. Both cohorts were followed up until the end of 2011 to evaluate the risk of TB. The overall incidence of TB was 4.07-fold higher in the T1DM cohort than in the control cohort (1.18 vs 0.29 per 1000 person-years, P?
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Laparoscopic appendectomy versus open appendectomy in pregnancy: a population-based analysis of maternal outcome.
Surg Endosc
PUBLISHED: 08-30-2014
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Laparoscopic appendectomy (LA) is the standard treatment of acute appendicitis for the general population; however, there is still some doubt regarding its safety for pregnant patients. Therefore, the purpose of this study is to investigate and compare the maternal outcome of pregnant patients with acute appendicitis following either an open appendectomy (OA) or LA from a population-based database.
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A population-based nested case-control study: the use of 5-alpha-reductase inhibitors and the increased risk of osteoporosis diagnosis in patients with benign prostate hyperplasia.
Clin. Endocrinol. (Oxf)
PUBLISHED: 08-27-2014
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5-alpha-reductase inhibitors (5ARIs) are the potent androgen responsible for the development and enlargement of the prostate gland by decreasing dihydrotestosterone (DHT). This results in inhibition of the conversion of testosterone to dihydrotestosterone and markedly suppresses serum dihydrotestosterone levels. Testosterone replacement therapy improves bone density in men with hypogonadal osteoporosis. This study explores the possible association between the use of two typical 5ARIs (finasteride and dutasteride) and the subsequent risk of osteoporosis diagnosis.
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Association Between Zolpidem Use and Glaucoma Risk: A Taiwanese Population-Based Case-Control Study.
J Epidemiol
PUBLISHED: 08-23-2014
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Background: To date, the relationship between zolpidem use and subsequent risk of glaucoma in a Taiwanese population has not been assessed.Methods: We used data from the National Health Insurance system to investigate whether zolpidem use was related to glaucoma risk. A 1:4 matched case-control study was conducted. The cases were patients newly diagnosed with glaucoma from 2001 to 2010. The controls were randomly selected non-glaucoma subjects matched by sex and age (±5 years). Zolpidem exposure and/or the average dosage of zolpidem used (mg/year) were evaluated. Medical comorbidities were considered as confounding factors. Multiple logistic regression models were used to evaluate the potential risk of zolpidem exposure on glaucoma with/without adjustment for the effects of confounding variables.Results: The exposure rate of zolpidem use in the glaucoma group was significantly higher than that of the control group (2.8% vs. 2.0%, P < 0.0001). The adjusted odds ratio (OR) of the risk of glaucoma for those with zolpidem use vs. those without was 1.19 (95% confidence interval [CI], 1.02-1.38). Compared to non-zolpidem users, zolpidem users with an average dose of more than 200 mg/year had significantly increased risk of glaucoma (OR 1.31, 95% CI 1.03-1.68).Conclusions: This study suggests that the use of zolpidem might increase the risk of subsequent glaucoma. Further confirmatory studies are recommended to clarify this important issue.
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Atopic diseases and systemic lupus erythematosus: an epidemiological study of the risks and correlations.
Int J Environ Res Public Health
PUBLISHED: 08-08-2014
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Both atopic diseases and systemic lupus erythematosus (SLE) are immune disorders that may lead to physical complications or multi-system comorbidities. This population-based case-control study was designed to evaluate the risk of SLE associated with atopic diseases. Using a national insurance claims dataset in Taiwan, we identified 1673 patients newly diagnosed with SLE and 6692 randomly selected controls frequency matched for gender, age and index date. The odds ratios (OR) for SLE were calculated for associations with allergic rhinitis, allergic conjunctivitis, atopic dermatitis and asthma. The SLE patients were predominantly female (82.5%) with a mean age of 40.1 (SD = 18.2). The patients with SLE had a higher rate of atopic dermatitis (6.81% vs. 3.06%), and asthma (10.6% vs. 7.64%) was approximately 2 times more common in the patients with lupus than in those without. The patients with atopic disease (atopic dermatitis, allergic rhinitis, allergic conjunctivitis and asthma) were at a significant risk for SLE. The overall risk for SLE increased as the number of atopic diseases increased from 1.46 to 2.29, compared with-individuals without the diseases (p < 0.0001). In conclusion, this population-based case-control study demonstrates a significant relationship between atopic diseases and the risk of SLE, especially for females. Atopic dermatitis plays a stronger role than other types of atopic disease in association with SLE.
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A nationwide population-based cohort study on tonsillectomy and subsequent cancer incidence.
Laryngoscope
PUBLISHED: 08-05-2014
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Tonsillectomy is related to increased risk of certain types of cancer. This study evaluates the possible association between tonsillectomy and cancer in Taiwan.
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Increased risk of stroke in patients with chronic kidney disease after recurrent hypoglycemia.
Neurology
PUBLISHED: 07-16-2014
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In this study, we aimed to investigate the effect of hypoglycemia on cardiovascular outcomes in a sample of patients with chronic kidney disease (CKD).
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An Overweight or Obese Status in Childhood Predicts Subclinical Atherosclerosis and Prehypertension/Hypertension in Young Adults.
J. Atheroscler. Thromb.
PUBLISHED: 07-16-2014
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Aim: The aim of this study, the YOung TAiwanese Cohort (YOTA) Study, was to investigate the relationship between a childhood overweight/obese status and young adult preclinical atherosclerosis, including assessments of the carotid intima-media thickness (CIMT) and prehypertension or hypertension. Methods: From among children who participated in the 1992-2000 mass urine screening program in Taiwan, we recruited 303 subjects with an elevated blood pressure (EBP) and 486 subjects with a normal BP in childhood during the period of 2006-2008. These 789 young adults received health check-ups for cardiovascular health, including examinations of blood and urine parameters, anthropometrics, BP and the CIMT, a subclinical cardiovascular risk index. Data analyses were used to evaluate the associated risks in both childhood and young adulthood. Results: The school students with a childhood overweight/obese status had a higher risk of prehypertension or hypertension, with a relative risk of 3.20 (1.40-7.33) for being overweight and 6.51 (3.36-12.63) for being obese in young adulthood at an average age of 21. A childhood overweight/obese status also predicted a higher risk of having a thicker CIMT, with a relative risk of 2.82 (1.26-6.28) and 4.17 (2.21-7.85) for being overweight and obese in adulthood, respectively, after a mean follow-up of 8.5 years. The body mass index exhibited a consistent trend from childhood to adulthood, with an adjusted R square of 0.551. The participants who were not overweight/obese in childhood also demonstrated a higher risk of prehypertension or hypertension if they became overweight or obese in adulthood. Conclusions: This study highlights the importance of preventing and treating an overweight or obese status in childhood for the primary prevention of cardiovascular disease in adulthood.
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Pulmonary embolism in chronic obstructive pulmonary disease: a population-based cohort study.
COPD
PUBLISHED: 07-11-2014
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To evaluate the incidence of pulmonary embolism (PE) in patients with chronic obstructive pulmonary disease (COPD) in Taiwan.
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Reduction of surgery rate in endometriosis patients who take Chinese medicine: a population-based retrospective cohort study.
Complement Ther Med
PUBLISHED: 07-07-2014
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Female patients have frequently utilized Chinese medicine (CM) to treat symptoms that could possibly be related to endometriosis. The objective of this population-based retrospective cohort study was to evaluate the relationship between CM use and subsequent surgery among patients with endometriosis.
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Hepatitis C Virus Infection Increases the Risk of Developing Peripheral Arterial Disease: A 9-Year Population-based Cohort Study.
J. Hepatol.
PUBLISHED: 07-02-2014
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The relationship between hepatitis C virus (HCV) infection and peripheral arterial disease (PAD) development remains unclear.
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Retrospective population cohort study on hip fracture risk associated with zolpidem medication.
Sleep
PUBLISHED: 06-06-2014
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Few studies have evaluated the hip fracture risk for zolpidem users. We assessed the risk for subjects taking zolpidem.
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Obstructive sleep apnea patients having surgery are less associated with glaucoma.
J Ophthalmol
PUBLISHED: 06-03-2014
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Objective. To investigate if different treatment strategy of obstructive sleep apnea (OSA) was associated glaucoma risk in Taiwanese population. Methods. Population-based retrospective cohort study was conducted using data sourced from the Longitudinal Health Insurance Database 2000. We included 2528 OSA patients and randomly selected and matched 10112 subjects without OSA as the control cohort. The risk of glaucoma in OSA patients was investigated based on the managements of OSA (without treatment, with surgery, with continuous positive airway pressure (CPAP) treatment, and with multiple modalities). The multivariable Cox regression was used to estimate hazard ratio (HR) after adjusting for sex, age, hypertension, diabetes, hyperlipidemia, and coronary artery disease. Results. The adjusted HR of glaucoma for OSA patients was 1.88 (95% CI: 1.46-2.42), compared with controls. For patients without treatment, the adjusted HR was 2.15 (95% CI: 1.60-2.88). For patients with treatments, the adjusted HRs of glaucoma were not significantly different from controls, except for those with CPAP (adjusted HR = 1.65, 95% CI = 1.09-2.49). Conclusions. OSA is associated with an increased risk of glaucoma. However, surgery reduces slightly the glaucoma hazard for OSA patients.
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Subdural haemorrhage is associated with recent morphine treatment in patients with cancer: a retrospective population-based nested case-control study.
Brain Inj
PUBLISHED: 06-02-2014
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This study investigated the relationship between recent morphine use and risk of subdural haemorrhage (SDH) in patients with cancer.
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Advanced complicated diabetes mellitus is associated with a reduced risk of thoracic and abdominal aortic aneurysm rupture: a population-based cohort study.
Diabetes Metab. Res. Rev.
PUBLISHED: 05-29-2014
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Studies have associated diabetes mellitus (DM) with the reduced risk of abdominal aortic aneurysm and thoracic aortic aneurysm and dissection. We used the national insurance data of Taiwan to examine these correlations for an Asian population. The association was also evaluated by DM severity.
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Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan.
Int J Endocrinol
PUBLISHED: 05-02-2014
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To investigate the role of E23K polymorphism of the KCNJ11 gene on early onset of type 2 diabetes in school-aged children/adolescents in Taiwan, we recruited 38 subjects with type 2 diabetes (ages 18.6 ± 6.6 years; body mass index percentiles 83.3 ± 15.4) and 69 normal controls (ages 17.3 ± 3.8 years; body mass index percentiles 56.7 ± 29.0) from a national surveillance for childhood/adolescent diabetes in Taiwan. We searched for the E23K polymorphism of the KCNJ11 gene. We found that type 2 diabetic subjects had higher carrier rate of E23K polymorphism of KCNJ11 gene than control subjects (P = 0.044). After adjusting for age, gender, body mass index percentiles, and fasting plasma insulin, the E23K polymorphism contributed to an increased risk for type 2 diabetes (P = 0.047). K23-allele-containing genotypes conferring increased plasma insulin level during OGTT in normal subjects. However, the diabetic subjects with the K23-allele-containing genotypes had lower fasting plasma insulin levels after adjustment of age and BMI percentiles. In conclusion, the E23K variant of the KCNJ11 gene conferred higher susceptibility to type 2 diabetes in children/adolescents. Furthermore, in normal glucose-tolerant children/adolescents, K23 allele carriers had a higher insulin response to oral glucose loading.
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Nationwide population-based cohort study on the association of acute coronary syndrome in patients with malignancies.
Support Care Cancer
PUBLISHED: 04-22-2014
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Patients with malignancy are suggestive of having a tendency toward an association with vascular thrombosis risk. The aim of this study was to evaluate the possible relationship between malignancy and the risk of acute coronary syndrome (ACS) in Taiwan.
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Hyperlipidemia, statin use and the risk of developing depression: a nationwide retrospective cohort study.
Gen Hosp Psychiatry
PUBLISHED: 04-17-2014
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Depression is a highly prevalent disorder that is associated with disability. The aim of this study was to determine the relationship between depression and hyperlipidemia and whether the onset of depression is associated with administering statins to patients with hyperlipidemia.
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Association of zolpidem use and subsequent increased risk of epilepsy: a population-based, case-control study.
J Clin Psychiatry
PUBLISHED: 04-09-2014
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To evaluate the impact of long-term zolpidem use on the subsequent risk of epilepsy.
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Febrile convulsions increase risk of Tourette syndrome.
Seizure
PUBLISHED: 04-09-2014
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Febrile convulsion (FC) and Tourette syndrome (TS) are both common neurological disorders in infants and children. Both disorders share clinical similarities, such as paroxysmal symptoms with normal neurodevelopment and expected remission over time. This population-based study investigated the association between FC with TS during childhood neurodevelopment.
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Systemic sclerosis increases the risks of deep vein thrombosis and pulmonary thromboembolism: a nationwide cohort study.
Rheumatology (Oxford)
PUBLISHED: 04-08-2014
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Few Asian studies have evaluated the risks of deep vein thrombosis (DVT) and pulmonary thromboembolism (PTE) in patients with SSc. We conducted a nationwide population-based cohort study to evaluate how SSc affected the incidence of DVT and PTE in Taiwan.
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Benign neoplasm of the heart increases the risk of first ischemic stroke: a population-based cohort study.
Int J Stroke
PUBLISHED: 04-07-2014
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The study aims to investigate the incidence of first ischemic stroke in patients with benign cardiac tumors who did or did not undergo operations.
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Increased risk of venous thromboembolism in patients with dermatomyositis/polymyositis: a nationwide cohort study.
Thromb. Res.
PUBLISHED: 04-01-2014
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The number of previous studies on the risk of venous thromboembolism (VTE) in patients with dermatomyositis/polymyositis (DM/PM) is limited. Therefore, we conducted a nationwide retrospective cohort study to investigate the effects of DM/PM on the risk of VTE.
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Increased risks of deep vein thrombosis and pulmonary embolism in Sjögren syndrome: a nationwide cohort study.
J. Rheumatol.
PUBLISHED: 04-01-2014
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Studies of the risks of deep vein thrombosis (DVT) and pulmonary embolism (PE) in patients with Sjögren syndrome (SS) in Asia are scant. We evaluated the effect of SS on the incidences of DVT and PE in a nationwide, population-based cohort in Taiwan.
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Gallstone disease and the risk of stroke: a nationwide population-based study.
J Stroke Cerebrovasc Dis
PUBLISHED: 03-31-2014
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Gallstone disease (GD) and stroke share a number of risk factors including diabetes and hyperlipidemia. This nationwide population-based study was designed to estimate the risk of stroke after a diagnosis of GD.
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Attention-deficit-hyperactivity disorder increases risk of bone fracture: a population-based cohort study.
Dev Med Child Neurol
PUBLISHED: 03-28-2014
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Attention-deficit-hyperactivity disorder (ADHD) is a disorder that is associated with accidental injuries. The aim of this study was to evaluate the relationship between ADHD and bone fracture in children.
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Sleep disorders increase the risk of osteoporosis: a nationwide population-based cohort study.
Sleep Med.
PUBLISHED: 03-22-2014
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This study evaluated the relationship between sleep disorders (SDs) and osteoporosis risk in Taiwan.
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Long-term risk of acute coronary syndrome in patients with cholangitis: a 13-year nationwide cohort study.
Eur. J. Intern. Med.
PUBLISHED: 03-19-2014
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Patients with cholangitis may exhibit repeated and chronic inflammation of the biliary tract despite successful medical or surgical treatments. This nationwide cohort study examined the association between cholangitis and the subsequent development of acute coronary syndrome (ACS).
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Increased association between febrile convulsion and allergic rhinitis in children: a nationwide population-based retrospective cohort study.
Pediatr. Neurol.
PUBLISHED: 03-18-2014
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Febrile convulsions and allergic rhinitis are both common childhood disorders and both are considered as generally benign disorders. Yet, especially in the case of allergic rhinitis, adverse effects on school performance and limited socialization are found. The relationship between febrile convulsions and allergic rhinitis has not been previously reported; thus, this article seeks to explore the association between these two disorders by collecting data from the Taiwanese nationwide cohort database.
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The association of peptic ulcer and schizophrenia: A population-based study.
J Psychosom Res
PUBLISHED: 03-13-2014
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The association of schizophrenia with peptic ulcer is not conclusive. In the last 30years, there has been little evaluation of peptic ulcer among schizophrenia patients.
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Nontuberculosis mycobacterium disease is a risk factor for chronic obstructive pulmonary disease: a nationwide cohort study.
Lung
PUBLISHED: 03-10-2014
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The aim of this study was to evaluate the association between chronic obstructive pulmonary disease (COPD) and nontuberculosis mycobacterium (NTM) disease.
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Inflammatory bowel diseases increase future ischemic stroke risk: a Taiwanese population-based retrospective cohort study.
Eur. J. Intern. Med.
PUBLISHED: 03-05-2014
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This cohort study assessed the association between inflammatory bowel disease (IBD) and the risk of future ischemic stroke.
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Pulmonary embolism is associated with current morphine treatment in patients with deep vein thrombosis.
Clin Respir J
PUBLISHED: 03-02-2014
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This study investigates the relationship between current morphine use and the risk of pulmonary embolism (PE) development in deep vein thrombosis (DVT) patients.
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Association between autoimmune rheumatic diseases and the risk of dementia.
Biomed Res Int
PUBLISHED: 02-24-2014
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Autoimmune rheumatic diseases (ARD) are characterized by systemic inflammation and may affect multiple organs and cause vascular events such as ischemic stroke and acute myocardial infarction. However, the association between ARD and increased risk of dementia is uncertain. This is a retrospective cohort study to investigate and compare the risk of dementia between patients clinically diagnosed with ARD and non-ARD patients during a 5-year follow-up period.
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High incidence of stroke in young women with sleep apnea syndrome.
Sleep Med.
PUBLISHED: 02-12-2014
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Patients with sleep apnea syndrome (SAS) carry a higher stroke risk. The differential stroke risk between sex and among different age groups has not yet been specifically addressed in previous studies.
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Risk of subsequent dementia in patients with hypertensive encephalopathy: a nationwide population-based study in Taiwan.
Dement Geriatr Cogn Disord
PUBLISHED: 02-08-2014
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We investigated the association of hypertensive encephalopathy (HE) with subsequent dementia.
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Modest increase in risk of acute coronary syndrome associated with morphine use in cancer patients: a population-based nested case-control study.
Eur J Oncol Nurs
PUBLISHED: 01-23-2014
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Morphine is widely used for pain management in cancer patients. Use of heroin, a morphine derivative, is a risk factor for acute coronary syndrome (ACS).
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Risk of skin cancer in patients with pterygium: a nationwide population-based cohort study in Taiwan.
Ocul Surf
PUBLISHED: 01-21-2014
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This study investigated the association between pterygium and skin cancer linking to ultraviolet (UV) radiation using claims data from 1997-2010, obtained from the Taiwan National Health Insurance Research Database. The study included 19,701 patients with pterygium and 78,804 sex- and age-frequency-matched comparison subjects. Multivariate Cox regression analyses were performed to assess the relationship between pterygium and risk of skin cancer by the end of 2010. The incidence rates of malignant melanoma (MM) and nonmelanoma skin cancer (NMSC) in two cohorts and adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) of the diseases were measured. Results showed that the incidences of MM and NMSC were both higher in the pterygium cohort than in the comparison cohort (5.5 vs 3.2 and 32.3 vs 15.0 per 100,000 person years, respectively). After adjusting for age, sex, UV index, occupation, and the other comorbidities, pterygium remained a significant predictor of NMSC (hazard ratio [HR], 1.64; 95% confidence interval [CI], 1.11-2.42), but not MM (HR, 1.46; 95% CI, 0.59-3.65). These results suggest that pterygium patients are associated with an increased risk of NMSC, but not significant for MM.
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Women with alopecia exhibit a higher risk for thyroid cancer: a nationwide cohort study.
J. Dermatol. Sci.
PUBLISHED: 01-21-2014
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Several studies have investigated the relationship between alopecia and prostate cancer. However, little information is available regarding the relationship between alopecia and the risk of cancers in women.
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Increased risk of Parkinson's disease in patients with end-stage renal disease: a retrospective cohort study.
Neuroepidemiology
PUBLISHED: 01-20-2014
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Studies on dyskinesia and Parkinson's syndrome associated with chronic kidney disease or end-stage renal disease (ESRD) have been mainly limited to case reports or case series studies. This population-based study investigated the risk of Parkinson's disease in patients with ESRD.
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Patients with epilepsy are at an increased risk of subsequent stroke: a population-based cohort study.
Seizure
PUBLISHED: 01-17-2014
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Epilepsy is well known as a disorder in poststroke patients. However, studies that have investigated the association between epilepsy and the risk of subsequent stroke are limited. This population-based study investigated the incidence and risk of stroke in patients with epilepsy by using the Taiwan National Health Insurance claims data.
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Increased risk of cancer in patients with early-onset cataracts: a nationwide population-based study.
Cancer Sci.
PUBLISHED: 01-17-2014
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Early-onset cataracts are associated with insufficient antioxidative activity, and, therefore, a potential risk of cancer. This study investigated the risk of cancer after being diagnosed with early-onset cataracts. Retrospective claims data from the Taiwan National Health Insurance Research Database were analyzed. Study subjects were comprised of patients with early-onset cataracts, aged 20-55 years (International Classification of Diseases, 9th Revision, Clinical Modification [ICD-9-CM] code 366.00, 366.01, 366.02, 366.03, 366.04, 366.09, 366.17 and 366.18) and newly diagnosed between 1997 and 2010 (n = 1281), and a comparison cohort without the disease (n = 5124). Both cohorts were followed up until 2010 to estimate the incidences of cancer. We used the Poisson regression model to compare incidence rate ratios and the 95% confidence interval (CI). Cox proportional hazards regression was used to assess the hazard ratio (HR) of cancer associated with early-onset cataracts. The overall incidence rate of all cancers was 2.19-fold higher in the early-onset cataract cohort than in the comparison cohort (8.06 vs 3.68 per 1000 person-years) with an adjusted HR of 2.13 (95% CI = 1.48, 3.07). The site-specific analysis also showed a strong relationship, with adjusted HR of 3.24 ((95% CI = 1.30, 8.10) for head and neck cancer, 3.29 (95% CI 1.16, 9.31) for hepatoma and 3.19 (95% CI 1.34, 7.58) for breast cancer. The present study suggests that patients with early-onset cataracts are at an increased risk of being diagnosed with cancer in subsequent years.
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Long-term risk of acute coronary syndrome in patients with inflammatory bowel disease: a 13-year nationwide cohort study in an Asian population.
Inflamm. Bowel Dis.
PUBLISHED: 01-14-2014
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Whether patients with inflammatory bowel disease (IBD) exhibit a higher risk of developing acute coronary syndrome (ACS) remains debatable.
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Pneumococcal pneumonia infection is associated with end-stage renal disease in adult hospitalized patients.
Kidney Int.
PUBLISHED: 01-09-2014
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Pneumococcal disease leads to renal complications ranging from persistent proteinuria to end-stage renal disease (ESRD) in pediatric patients. However, long-term renal effects after pneumococcal pneumonia infection in adult patients remains largely unknown. To evaluate this we conducted a population-based retrospective cohort study consisting of 18,733 adult patients at the time of pneumococcal pneumonia diagnosis, using claims data from Taiwan's National Health Insurance Research Database (NHIRD) with a comparison cohort of 73,409 age- and gender-matched patients without pneumococcal pneumonia. The overall incidence rate ratio of ESRD was 23% higher in those with pneumococcal pneumonia than in those without pneumococcal pneumonia (5.26 vs. 3.10 per 1000 person-years), with an adjusted hazard ratio of 1.14 (95% confidence interval 1.01-1.29). In addition, the risk of developing ESRD was associated with covariates including age, gender, chronic kidney disease, diabetes mellitus, hypertension, hyperlipidemia, chronic obstructive pulmonary disease, and heart failure. The ESRD cumulative incidence curve showed a considerably higher risk of ESRD in those with pneumococcal pneumonia than in those without pneumococcal pneumonia (significant by log-rank test). Thus, pneumococcal pneumonia may be associated with an increased risk of ESRD in adult patients. A long-term follow-up of renal function is recommended for adult hospitalized patients with pneumococcal pneumonia infection.
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Increased risk of cardiovascular events in patients with herpes zoster: a population-based study.
J. Med. Virol.
PUBLISHED: 01-09-2014
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The association between herpes zoster and cardiovascular complications remains vague with limited study on the association between these two disorders. This study evaluated the risk of cardiovascular diseases in patients with herpes zoster. From insurance claims data of Taiwan, 19,483 patients with herpes zoster diagnosed in 1998-2008 and 77,932 subjects without herpes zoster were identified in this study. Both cohorts were followed up until the end of 2010 to measure the incidence of arrhythmia and coronary artery disease. The incidence rate ratio and adjusted hazard ratio (HR) of the cardiovascular complications with 95% confidence interval (CI) were estimated. The incidence of arrhythmia was 1.17-fold greater in the herpes zoster cohort than in the non-herpes zoster cohort (13.2 vs. 11.3 per 1,000 person-years), with an adjusted HR of 1.16 (P?
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Osteoporosis and fractures after solid organ transplantation: a nationwide population-based cohort study.
Mayo Clin. Proc.
PUBLISHED: 01-08-2014
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To investigate the incidence of bone disorders after solid organ transplantation (SOT).
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Increased risk of deep vein thrombosis and pulmonary thromboembolism in patients with spinal cord injury: a nationwide cohort prospective study.
Thromb. Res.
PUBLISHED: 01-07-2014
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We investigated the effect of spinal cord injury (SCI) on the development of deep vein thrombosis (DVT) and pulmonary thromboembolism (PE) by conducting a nationwide longitudinal cohort study.
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Irritable bowel syndrome correlates with increased risk of Parkinson's disease in Taiwan.
Eur. J. Epidemiol.
PUBLISHED: 01-07-2014
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This study investigated whether an association exists between irritable bowel syndrome (IBS) and the risk of Parkinson's disease. This is a retrospective cohort study using the dataset of the Taiwan National Health Insurance Program from 2000 to 2010. We identified 23,875 patients (aged 20 years or older) with newly diagnosed IBS as the IBS group and 95,500 subjects without IBS as the non-IBS group for comparison. The main outcome was incident Parkinson's disease compared between both groups by the end of 2010. We measured the hazard ratio (HR) to evaluate the association between IBS and Parkinson's disease. The overall incidence of Parkinson's disease in the IBS group was 1.76-fold higher than that in the non-IBS group (16.4 vs. 9.33 per 10,000 person-years). The multivariable Cox proportional hazards regression analysis revealed that the adjusted HR of Parkinson's disease associated with IBS was 1.48 (95% CI 1.27, 1.72), compared with the non-IBS group. Age, women, hypertension, dementia, cerebrovascular disease and depression were also significantly associated with Parkinson's disease. Patients with irritable bowel syndrome are at an increased risk of developing Parkinson's disease. Further studies are required to explore the pathophysiological connection between these disorders.
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Injury Location and Mechanism for Complex Regional Pain Syndrome: A Nationwide Population-Based Case-Control Study in Taiwan.
Pain Pract
PUBLISHED: 01-03-2014
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Few studies have investigated the relationship between injury location, mechanism and their association with complex regional pain syndrome (CRPS). We conducted a nationwide database survey to explore this issue.
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The relationship between Helicobacter pylori and cancer risk.
Eur. J. Intern. Med.
PUBLISHED: 01-03-2014
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This study investigated the correlation between Helicobacter pylori (HP) and cancer risk. We compared the age, sex, and comorbidity of cancer patients both infected and not infected by HP.
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The relationship between secondary hyperparathyroidism and thyroid cancer in end stage renal disease: a population based cohort study.
Eur. J. Intern. Med.
PUBLISHED: 01-02-2014
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We conducted a retrospective cohort study to investigate the risk of cancer in end stage renal disease (ESRD) patients with secondary hyperparathyroidism (HPT).
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Rheumatoid arthritis increases the risk of nontuberculosis mycobacterial disease and active pulmonary tuberculosis.
PLoS ONE
PUBLISHED: 01-01-2014
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Few studies have examined the association of rheumatoid arthritis (RA) with nontuberculosis mycobacterium (NTM) disease and pulmonary tuberculosis (PTB).
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Risk of epilepsy in patients with systemic lupus erythematosus - a retrospective cohort study.
Neuropsychiatr Dis Treat
PUBLISHED: 01-01-2014
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Systemic lupus erythematosus (SLE) affects central and peripheral nervous systems, manifesting neuropsychiatric disorders that vary from subtle signs to life-threatening complications. This study compared the risk of epilepsy between a general population and patients with SLE.
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Nontuberculous mycobacterial infection is associated with increased respiratory failure: a nationwide cohort study.
PLoS ONE
PUBLISHED: 01-01-2014
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Population study on relationship between nontuberculous mycobacterial (NTM) infection and respiratory failure (RF) is limited. This study evaluated the RF risk, including acute respiratory failure (ARF), chronic respiratory failure (CRF) and ARF on CRF, in patients with NTM infection in Taiwan.
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Reappraisal of the etiology of extracorpuscular non-autoimmune acquired hemolytic anemia in 2657 hospitalized patients with non-neoplastic disease.
Clin Med Insights Pathol
PUBLISHED: 01-01-2014
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Unlike autoimmune hemolytic anemia (AIHA), literature on the etiological study of non-autoimmune hemolytic anemia (non-AIHA) is scarce. The incidence and prevalence of non-AIHA in different geographic regions are largely unknown perhaps owing to the lack of perspective investigation and different profiles of etiologies from different geographic regions. We aimed to examine the real-world etiology or mechanisms of the non-hereditary non-AIHA from a nationwide population-based administrative claim database in Taiwan.
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Decreased risk of stroke in patients with traumatic brain injury receiving acupuncture treatment: a population-based retrospective cohort study.
PLoS ONE
PUBLISHED: 01-01-2014
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Patients with traumatic brain injury (TBI) face increased risk of stroke. Whether acupuncture can help to protect TBI patients from stroke has not previously been studied.
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Higher risk for meningioma in women with uterine myoma: a nationwide population-based retrospective cohort study.
J. Neurosurg.
PUBLISHED: 12-06-2013
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Object Evidence suggests that hormones play a role in modifying both uterine myoma (UM) and meningioma. A number of studies have observed the positive association between these diseases. The aim of the current population-based study was to determine if women with UM are at a higher risk for meningioma. Methods The authors used data from the National Health Insurance system of Taiwan for the study. The UM cohort contained 281,244 women. Each woman was randomly frequency-matched with 4 women without UM, based on age, index year of diagnosis, occupation, urbanization (urbanization level was categorized by the population density of the residential area into 4 levels, with Level 1 as the most urbanized and Level 4 as the least urbanized), and comorbidity, to form the control cohort. Coxs proportional hazard regression analysis was conducted to estimate the influence of UM on the meningioma risk. Results Among women with UM, the risk of developing meningioma was significantly higher (45%) than among women without UM (95% CI 1.23-1.70). The same phenomenon was observed among most age groups, but a significant difference was only seen in the middle-age range. For women with UM, further analysis did not show a significant change after myomectomy. The cumulative incidence of meningioma between groups with and without UM differed over time. Conclusions The nationwide population-based cohort study found that Taiwanese women with UM are at higher risk for developing meningioma.
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Sleep Disorders and Increased Risk of Subsequent Acute Coronary Syndrome in Individuals without Sleep Apnea: A Nationwide Population-Based Cohort Study.
Sleep
PUBLISHED: 12-03-2013
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Studies investigating the relationship between nonapnea sleep disorders and the risk of acute coronary syndrome (ACS) are scant. This study evaluated whether the risk of ACS is associated with sleep disorders other than sleep apnea in Taiwan.
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Spinal Cord Injury Increases the Risk of Type 2 Diabetes: A Population-Based Cohort Study.
Spine J
PUBLISHED: 11-22-2013
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Previous studies on the risk and prevalence of diabetes among spinal cord injury (SCI) patients are limited and controversial.
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Association Between Periodontitis Needing Surgical Treatment and Subsequent Diabetes Risk: A Population-Based Cohort Study.
J. Periodontol.
PUBLISHED: 10-21-2013
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Backgrounds: It is well known that diabetic patients have higher extent and severity of periodontitis, but the backward relationship is little investigated. We assessed the relationship between periodontitis needing dental surgery and subsequent type 2 diabetes in those non-diabetes. Methods: This was a retrospective cohort study employing data from the national health insurance system of Taiwan. The periodontitis cohort involved 22,299 patients, excluding those with diabetes already or diagnosed with diabetes within 1 year from baseline. Each study subject was randomly frequency matched by age, gender and index year with 1 individual from the general population without periodontitis. Cox proportional hazards regression analysis was used to estimate the influence of periodontitis on the risk of diabetes. Results: The mean follow up period is 5.47± 3.54 years. Overall, the subsequent incidence of type 2 diabetes was 1.24-fold higher in the periodontitis cohort than in the control cohort, with an adjusted hazard ration of 1.19(95% confidence interval [CI], 1.10-1.29) after controlling for sex, age and co-morbidities. Conclusions: This is the largest and nation-based study examining the risk of diabetes in Asian patients with periodontitis. Those periodontitis patients needing dental surgery have increased risk of future diabetes within 2 years than those periodontitis participants without dental surgery.
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Association between irritable bowel syndrome and colorectal cancer: A nationwide population-based study.
Eur. J. Intern. Med.
PUBLISHED: 10-04-2013
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To determine whether irritable bowel syndrome (IBS) is associated with an increased risk for the subsequent colorectal cancer (CRC).
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Urinary tract stone raises subsequent risk for urinary tract cancer: a population-based cohort study.
BJU Int.
PUBLISHED: 09-24-2013
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To evaluate the association between urinary tract stone (UTS) and urinary tract cancer (UTC) in Taiwanese patients, as the results of epidemiological studies about the relationship between UTS and the development of UTC remain inconclusive.
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Excessive risk of cancer and in particular lymphoid malignancy in myasthenia gravis patients: A population-based cohort study.
Neuromuscul. Disord.
PUBLISHED: 09-23-2013
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The exact relationship between myasthenia gravis (MG) and extrathymic malignancies has not been established thus far. Occasional cases of MG have been reported in association with lymphoma or other lymphoproliferative disorders. To determine the risk of extrathymic malignancy with particular attention on lymphoid malignancy for MG patients in a large cohort representing 99% of the Taiwan population, claims data from the Taiwan National Health Insurance Database were used to conduct retrospective cohort analyses. The study cohort comprised 3671 MG patients who were 10-fold frequency matched by age and sex, and assigned the same index year without MG. Cox proportional hazard regression analysis was conducted to estimate the risk of cancer. The MG cohort had a 1.74-fold increased risk of developing cancer compared to the comparison cohort (HR=1.74, 95% CI=1.47-2.05). After adjusting for confounders and relative to the cohort, patients with MG had a 2.27-fold increased risk of developing lymphoid malignancies (HR=2.27, 95% CI=1.06-4.88) and a 118.47-fold increased risk of thymus cancer (HR=118.47, 95%=42.57-329.71). This population based retrospective case-control study confirms and extends previous observations on the association between MG and lymphoid malignancies.
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Increased incidence of gastrointestinal cancers among patients with pyogenic liver abscess: a population-based cohort study.
Gastroenterology
PUBLISHED: 09-23-2013
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The relationship between pyogenic liver abscess (PLA) and gastrointestinal (GI) cancer was first reported more than 20 years ago, yet little is known about this connection. We evaluated this association in a population-based, retrospective, cohort study.
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An association between benzodiazepine use and occurrence of benign brain tumors.
J. Neurol. Sci.
PUBLISHED: 09-20-2013
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This study was designed to evaluate the impact of long-term benzodiazepine use on the subsequent risk of benign brain tumor (BBT) or malignant brain tumor (MBT) development.
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Subsequent cancer risk of children receiving post voiding cystourethrography: A nationwide population-based retrospective cohort study.
Pediatr. Nephrol.
PUBLISHED: 09-11-2013
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To estimate the subsequent cancer risk of children receiving post voiding cystourethrography (VCUG), a nationwide population-based retrospective cohort study with the data from the Taiwan National Health Insurance Research Database (NHIRD) were used for the analysis.
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Asthma increases pulmonary thromboembolism risk: a nationwide population cohort study.
Eur. Respir. J.
PUBLISHED: 08-29-2013
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Studies on the association between asthma and pulmonary thromboembolism (PE) are considerably limited. We investigated whether PE is associated with asthma using a nationwide cohort study.We identified 31356 patients with asthma newly diagnosed in 2002-2008 and 125157 individuals without asthma randomly selected from the general population, frequency-matched by age, sex, and index year using the National Health Insurance Research Database. Both cohorts were followed up until the end of 2010 to measure the incidence of PE. Cox proportional hazards regression analysis was used to measure the hazard ratio (HR) of PE for the asthmatic cohort, compared with the non-asthmatic cohort.We followed 186182 person-years for asthmatic patients and 743374 person-years for non-asthmatic persons, respectively. The HR of PE was 3.24 for the asthmatic cohort, compared with non-asthmatic cohort after adjusting for sex, age, comorbidities and oestrogen supplement. The risk of developing PE significantly increased with the increased frequency of asthma exacerbation and hospitalization.This nationwide cohort study suggests that the risk of developing PE significantly increased in asthmatic patients compared to those of the general population. Frequent asthma exacerbation and hospitalization are significantly associated with PE risk.
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Rheumatoid arthritis increases the risk of deep vein thrombosis and pulmonary thromboembolism: a nationwide cohort study.
Ann. Rheum. Dis.
PUBLISHED: 08-07-2013
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Studies on the association between rheumatoid arthritis (RA) and deep vein thrombosis (DVT) and pulmonary thromboembolism (PE) are scarce. This study identifies the effects of RA on the risks of developing DVT and PE in a nationwide prospective cohort study.
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JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.