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Find video protocols related to scientific articles indexed in Pubmed.
0058?Colorectal cancer risk and shift work in a population-based case-control study in Spain (MCC-Spain).
Occup Environ Med
PUBLISHED: 07-15-2014
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Epidemiological cancer studies on shift work have focused on breast cancer while evidence on other tumours is limited. We evaluated colorectal cancer risk in relation to night and rotating shift work and genetic variation, in a population based case-control study in Spain.
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0426?Occupation and leukaemia in Spain 2007-2012.
Occup Environ Med
PUBLISHED: 07-15-2014
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Established risk factors for leukaemia do not explain the majority of leukaemia. Previous studies have suggested the importance of occupation in leukaemogenesis. To evaluate associations between job title and leukaemia in the population the MCC-Spain We studied occupational variation of the risk of chronic lymphocytic leukaemia
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Circadian variation of melatonin, light exposure, and diurnal preference in day and night shift workers of both sexes.
Cancer Epidemiol. Biomarkers Prev.
PUBLISHED: 05-08-2014
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Light-at-night has been shown in experimental studies to disrupt melatonin production but this has only partly been confirmed in studies of night shift workers. In this cross-sectional study, we examined the circadian variation of melatonin in relation to shift status, individual levels of light-at-night exposure, and diurnal preference, an attribute reflecting personal preference for activity in the morning or evening.
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Evaluation of the persistence of functional and biological respiratory health effects in clean-up workers 6years after the Prestige oil spill.
Environ Int
PUBLISHED: 05-21-2013
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Fishermen who had participated in clean-up activities of the Prestige oil spill showed increased bronchial responsiveness and higher levels of respiratory biomarkers 2years later. We aimed to evaluate the persistence of these functional and biological respiratory health effects 6years after clean-up work. In 2008/2009 a follow-up study was done in 230 never-smoking fishermen who had been exposed to clean-up work in 2002/2003 and 87 non-exposed fishermen. Lung function and bronchial responsiveness testing and the determination of respiratory biomarkers in exhaled breath condensate were done identically as in the baseline survey in 2004/2005. Associations between participation in clean-up work and respiratory health parameters were assessed using linear and logistic regression analyses adjusting for sex and age. Information from 158 exposed (69%) and 57 non-exposed (66%) fishermen was obtained. Loss to follow-up in the non-exposed was characterised by less respiratory symptoms at baseline. During the 4-year follow-up period lung function, bronchial hyperresponsiveness and the levels of respiratory biomarkers of oxidative stress and growth factors had deteriorated notably more among non-exposed than among exposed. At follow-up, respiratory health indices were similar or better in clean-up workers than in non-exposed. No clear differences between highly exposed and moderately exposed clean-up workers were found. In conclusion, we could not detect long-term respiratory health effects in clean-up workers 6years after the Prestige oil spill. Methodological issues that need to be considered in this type of studies include the choice of a non-exposed control group and limitation of follow-up to subgroups such as never smokers.
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Chromosomal bands affected by acute oil exposure and DNA repair errors.
PLoS ONE
PUBLISHED: 01-01-2013
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In a previous study, we showed that individuals who had participated in oil clean-up tasks after the wreckage of the Prestige presented an increase of structural chromosomal alterations two years after the acute exposure had occurred. Other studies have also reported the presence of DNA damage during acute oil exposure, but little is known about the long term persistence of chromosomal alterations, which can be considered as a marker of cancer risk.
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Participation rates in the selection of population controls in a case-control study of colorectal cancer using two recruitment methods.
Gac Sanit
PUBLISHED: 06-23-2011
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Low participation rates in the selection of population controls are an increasing concern for the validity of case-control studies worldwide.
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Socioeconomic status and exposure to disinfection by-products in drinking water in Spain.
Environ Health
PUBLISHED: 03-16-2011
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Disinfection by-products in drinking water are chemical contaminants that have been associated with cancer and other adverse effects. Exposure occurs from consumption of tap water, inhalation and dermal absorption.
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Considerations of circadian impact for defining shift work in cancer studies: IARC Working Group Report.
Occup Environ Med
PUBLISHED: 10-20-2010
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Based on the idea that electric light at night might account for a portion of the high and rising risk of breast cancer worldwide, it was predicted long ago that women working a non-day shift would be at higher risk compared with day-working women. This hypothesis has been extended more recently to prostate cancer. On the basis of limited human evidence and sufficient evidence in experimental animals, in 2007 the International Agency for Research on Cancer (IARC) classified shift work that involves circadian disruption as a probable human carcinogen, group 2A. A limitation of the epidemiological studies carried out to date is in the definition of shift work. IARC convened a workshop in April 2009 to consider how shift work should be assessed and what domains of occupational history need to be quantified for more valid studies of shift work and cancer in the future. The working group identified several major domains of non-day shifts and shift schedules that should be captured in future studies: (1) shift system (start time of shift, number of hours per day, rotating or permanent, speed and direction of a rotating system, regular or irregular); (2) years on a particular non-day shift schedule (and cumulative exposure to the shift system over the subjects working life); and (3) shift intensity (time off between successive work days on the shift schedule). The group also recognised that for further domains to be identified, more research needs to be conducted on the impact of various shift schedules and routines on physiological and circadian rhythms of workers in real-world environments.
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Anogenital distance and the risk of prostate cancer.
BJU Int.
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Study Type - Prognosis (cohort) Level of Evidence?2b Whats known on the subject? and What does the study add? In animals, anogenital distance has been shown to be related to the action of fetal androgens, and exposure to chemicals such as dioxins that exhibit antiandrogenic activity results in shorter distances in male rats. In studies conducted in children, anogenital distance has been associated with endocrine disruptors such as phthalates. Studies conducted in young adults found that a shorter anoscrotal distance was a predictor of low sperm concentration, and a longer anoscrotal distance was associated with fatherhood, a higher sperm density and a higher total motile sperm count. The present study is the first to report anogenital measurements in adults in relation to the risk of cancer, showing that a phenotype reflecting normal in utero sexual development in males is associated with a lower risk of prostate cancer. There are two published studies evaluating sperm quality and fatherhood suggesting a connecting mechanism related to the disruption of androgen-mediated pathways in utero that affects reproductive potential and the risk of prostate cancer.
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Persistent respiratory symptoms in clean-up workers 5 years after the Prestige oil spill.
Occup Environ Med
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Fishermen who had participated in clean-up activities of the Prestige oil spill showed an excess risk of respiratory symptoms 1-2 years later, but the long-term persistence of these health effects is unclear. The aim of this study was to evaluate the persistence of these respiratory symptoms 5 years after clean-up work.
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[Cancer screening practices and associated lifestyles in population controls of the Spanish multi-case control study].
Gac Sanit
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To estimate the prevalence of screening practices in the population controls of the multi-case control study (MCC-Spain) study and to evaluate its association with lifestyles.
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Concentrations and correlations of disinfection by-products in municipal drinking water from an exposure assessment perspective.
Environ. Res.
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Although disinfection by-products (DBPs) occur in complex mixtures, studies evaluating health risks have been focused in few chemicals. In the framework of an epidemiological study on cancer in 11 Spanish provinces, we describe the concentration of four trihalomethanes (THMs), nine haloacetic acids (HAA), 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), four haloacetonitries, two haloketones, chloropicrin and chloral hydrate and estimate correlations. A total of 233 tap water samples were collected in 2010. Principal component analyses were conducted to reduce dimensionality of DBPs. Overall median (range) level of THMs and HAAs was 26.4 (0.8-98.1) and 26.4 (0.9-86.9) ?g/l, respectively (N=217). MX analysed in a subset (N=36) showed a median (range) concentration of 16.7 (0.8-54.1)ng/l. Haloacetonitries, haloketones, chloropicrin and chloral hydrate were analysed in a subset (N=16), showing levels from unquantifiable (<1 ?g/l) to 5.5 ?g/l (dibromoacetonitrile). Spearman rank correlation coefficients between DBPs varied between species and across areas, being highest between dibromochloromethane and dibromochloroacetic acid (r(s)=0.87). Principal component analyses of 13 DBPs (4 THMs, 9 HAAs) led 3 components explaining more than 80% of variance. In conclusion, THMs and HAAs have limited value as predictors of other DBPs on a generalised basis. Principal component analysis provides a complementary tool to address the complex nature of the mixture.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.