JoVE Visualize What is visualize?
Stop Reading. Start Watching.
Advanced Search
Stop Reading. Start Watching.
Regular Search
Find video protocols related to scientific articles indexed in Pubmed.
[Analysis of ornithine transcarbamylase gene mutations in three boys affected with late-onset ornithine transcarbamylase deficiency].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
PUBLISHED: 10-10-2014
Show Abstract
Hide Abstract
To identify the types of OTC gene mutations in three male patients with late onset ornithine transcarbamylase deficiency (OTCD, MIM #311250).
Related JoVE Video
[Genetic analysis of ASS1, ASL and SLC25A13 in citrullinemia patients].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
PUBLISHED: 06-15-2014
Show Abstract
Hide Abstract
To detect potential mutations of Y9ASS1, ASL and SLC25A13 genes in four patients manifesting citrullinemia.
Related JoVE Video
[Relationship between expression of microRNA and inflammatory cytokines plasma level in pediatric patients with sepsis].
Zhonghua Er Ke Za Zhi
PUBLISHED: 04-01-2014
Show Abstract
Hide Abstract
Sepsis is the major cause of death in pediatric intensive care unit (PICU). The clinical manifestations of early sepsis is very similar to systemic inflammatory response syndrome (SIRS) caused by non-infectious reason. This study aimed to investigate the expression of miRNA and inflammatory cytokines in plasma in pediatric sepsis patients and its clinical significance.
Related JoVE Video
Extracellular high mobility group box chromosomal protein 1 promotes drug resistance by increasing the expression of P?glycoprotein expression in gastric adenocarcinoma cells.
Mol Med Rep
PUBLISHED: 02-07-2014
Show Abstract
Hide Abstract
It has previously been reported that high mobility group box chromosomal protein 1 (HMGB1) is overexpressed in the majority of gastric adenocarcinoma cell types, and that HMGB1 can be released into the extracellular matrix from stressed or necrotic cancer cells. HMGB1 is considered to promote cell proliferation and invasion in gastric adenocarcinoma cells. Furthermore, in a number of cancer cell types, HMGB1 has been reported to promote autophagy and inhibit anticancer drug?induced apoptosis, which has been identified as an important mechanism in the development of multidrug resistance (MDR). However, there have been no studies on the effects of HMGB1 on expression of the MDR?related transporter proteins in gastric adenocarcinoma. In the present study, extracellular HMGB1 increased the expression levels of P-glycoprotein (P-gp) at the pre-transcriptional and post?transcriptional levels in the human gastric adenocarcinoma cell lines, SGC7901, MKN28 and AGS, as detected by quantitative polymerase chain reaction and western blot assays. MTT and apoptosis assays were also performed and it was demonstrated that extracellular HMGB1 subsequently enhanced resistance to the P?gp?related drugs, adriamycin and vincristine. In brief, this study demonstrated that extracellular HMGB1 may promote drug resistance to adriamycin and vincristine by upregulating P?gp in human gastric adenocarcinoma cells.
Related JoVE Video
Temperature sensitivity of soil organic carbon mineralization along an elevation gradient in the Wuyi Mountains, China.
PLoS ONE
PUBLISHED: 01-14-2013
Show Abstract
Hide Abstract
Soil organic carbon (SOC) actively participates in the global carbon (C) cycle. Despite much research, however, our understanding of the temperature sensitivity of soil organic carbon (SOC) mineralization is still very limited. To investigate the responses of SOC mineralization to temperature, we sampled surface soils (0-10 cm) from evergreen broad-leaf forest (EBF), coniferous forest (CF), sub-alpine dwarf forest (SDF), and alpine meadow (AM) along an elevational gradient in the Wuyi Mountains, China. The soil samples were incubated at 5, 15, 25, and 35°C with constant soil moisture for 360 days. The temperature sensitivity of SOC mineralization (Q(10)) was calculated by comparing the time needed to mineralize the same amount of C at any two adjacent incubation temperatures. Results showed that the rates of SOC mineralization and the cumulative SOC mineralized during the entire incubation significantly increased with increasing incubation temperatures across the four sites. With the increasing extent of SOC being mineralized (increasing incubation time), the Q(10) values increased. Moreover, we found that both the elevational gradient and incubation temperature intervals significantly impacted Q(10) values. Q(10) values of the labile and recalcitrant organic C linearly increased with elevation. For the 5-15, 15-25, and 25-35°C intervals, surprisingly, the overall Q(10) values for the labile C did not decrease as the recalcitrant C did. Generally, our results suggest that subtropical forest soils may release more carbon than expected in a warmer climate.
Related JoVE Video

What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.