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Find video protocols related to scientific articles indexed in Pubmed.
A new depside from Usnea aciculifera growing in Vietnam.
Nat Prod Commun
PUBLISHED: 09-20-2014
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From Usnea aciculifera, a new depside aciculiferin A (1) was isolated, together with eleven known compounds, (+)-(12R)-usnic acid (2), methyl haematommate (3), methyl beta-orsellinate (4), methyl orsellinate (5), atranol (6), 7-hydroxy-5-methoxy-6-methylphthalide (7), norstictic acid (8), stictic acid (9), atranorin (10), barbatinic acid (11) and diffractaic acid (12). Their chemical structures were elucidated by 1D and 2D NMR spectroscopic as well as HR-ESI-MS analysis. Usnic acid (2) and depside diffractaic acid (12) presented in high yield of around 1.5% of the dried material. Some lichen substances inhibited the growth of some cancer cell lines. Three depsides, 1, 11 and 12, were evaluated for their cytotoxic activity against HeLa (human epithelial carcinoma), NCI-H460 (human lung cancer) and MCF-7 (human breast cancer) cell lines at the concentration of 100 microg/mL. Depside 1 showed good and depside 12 strong cytotoxic activity against three surveyed cancer cell lines.
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Sellar Masses that Present with Severe Hyponatremia.
Endocr Pract
PUBLISHED: 08-08-2014
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Objective: Hyponatremia is a known but under-recognized presentation of sellar lesions. Herein we present a series of patients who presented with single or multiple episodes of hyponatremia.Methods: Over 5 years, patients undergoing endonasal surgery for a de novo sellar mass with hyponatremia as an initial presentation were included. Pathology, sodium levels, pituitary hormonal status, and treatment course were documented.Results: Of 282 patients, 16 (5.7%) (9 males, 7 females, ages 32-84) presented with severe hyponatremia with a mean serum sodium level of 115±6 mmol/L (101 to 125); 3 patients had two or more episodes. Severe hyponatremia was a presenting sign in 0%, 4.1%, 14.3% and 37.5% of patients with craniopharyngiomas (n=10), pituitary adenomas (n=243), Rathke's cleft cysts (RCC) (n=21), and sellar arachnoid cysts (n=8) respectively (p<0.01). Half of the patients presenting with hyponatremia, including 6 of 10 adenomas and 2 of 3 RCC, had pituitary apoplexy or cyst rupture. All patients had anterior pituitary gland dysfunction including 81% with hypoadrenalism and 69% with hypothyroidism. Following surgery, hormonal status was unchanged or improved in 15 patients (median follow-up 14 months). No patient had tumor/cyst recurrence or recurrent hyponatremia.Conclusion: Severe hyponatremia was a presenting sign in 5.7% of patients with sellar pathology, most frequently in patients with arachnoid cysts, RCCs and pituitary apoplexy. Patients with new onset severe hyponatremia and no obvious pharmacologic or systemic cause should undergo pituitary hormonal evaluation and brain imaging. Surgical resection and correction of hormonal deficiencies is associated with resolution of recurrent hyponatremic episodes.
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Bypass Using V2-V3 Segment of the Vertebral Artery as Donor or Recipient: Technical Nuances and Results.
World Neurosurg
PUBLISHED: 02-18-2014
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Surgical revascularization (bypass) technique has been used to treat vascular diseases of the posterior circulation, including ischemia, aneurysms, and tumors encasing a major artery. We focused on procedures using the V2-V3 segment of the vertebral artery (VA) as either the donor or recipient of the bypass. We have described technical nuances developed over time and evaluated the surgical results of those cases.
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Avoidance of postoperative epistaxis and anosmia in endonasal endoscopic skull base surgery: a technical note.
Acta Neurochir (Wien)
PUBLISHED: 01-30-2014
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Most endoscopic transsphenoidal approaches jeopardize the sphenopalatine artery and septal olfactory strip (SOS), increasing the risk of postoperative anosmia and epistaxis while precluding the ability to raise pedicled nasoseptal flaps (NSF). We describe a bilateral "rescue flap" technique that preserves the mucosa containing the nasal-septal vascular pedicles and the SOS. This approach can reduce the risk of postoperative complications, including epistaxis and anosmia.
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Cervical spinous process reconstruction.
J Neurosurg Spine
PUBLISHED: 11-08-2013
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Posterior neck deformity with an unsightly crater-like defect may result after cervicothoracic laminectomies. The authors present a new technique, spinous process reconstruction, to address this problem. A 64-year-old man presented with progressive quadriparesis secondary to cervical spondylotic myelopathy. Previously he had undergone multiple neck surgeries including cervicothoracic decompressive laminectomy. Postoperatively, he developed severe craniocervical spinal deformity and a large painful concave surgical defect in the neck. The authors performed craniocervical decompression and craniocervicothoracic instrumented stabilization. At the same time, cervicothoracic spinous process reconstruction was performed using titanium mesh to address the defect. Cervicothoracic decompressive laminectomy results in varying degrees of neck defect with resulting unsightly and an often painful surgical wound defect despite an appropriate multilayer closure. The presented spinous process reconstruction is a simple technique to address this problem with good clinical outcome.
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The Supraorbital Endoscopic Approach for Tumors.
World Neurosurg
PUBLISHED: 02-01-2013
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The supraorbital eyebrow craniotomy provides minimally invasive access to a wide range of frontal fossa, parasellar, and some middle and posterior fossa tumors. This approach is considered ideal for removal of many, if not most, planum and tuberculum sellae meningiomas, some olfactory groove meningiomas, as well as suprasellar craniopharyngiomas, particularly those with far lateral extensions. It is also ideal for many intra-axial tumors, including metastases and gliomas arising from the orbitofrontal, frontal pole, and medial temporal lobe regions. The use of endoscopy further extends the range and versatility of this keyhole approach and is considered an essential adjunct for allowing safe and maximal tumor removal. Herein, we describe the indications, technical nuances, and complication avoidance techniques for the supraorbital keyhole approach with endoscopic assistance.
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Expandable versus nonexpandable cages for thoracolumbar burst fracture.
World Neurosurg
PUBLISHED: 04-16-2011
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Burst fractures account for more than half of all thoracolumbar fractures and are frequently associated with spine instability and neurological deficit. The anterior approach is favored when decompression of the spinal canal is necessary. We compare two commonly available struts used for anterior approach after corpectomy: expandable versus nonexpandable titanium cages.
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Health-related quality of life in old age: a comparison between rural areas in Bangladesh and Vietnam.
Asia Pac J Public Health
PUBLISHED: 04-13-2011
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This study compares health-related quality of life (HRQoL) and its determinants among older people (?60 years) in rural Bangladesh and Vietnam. Cross-sectional studies among older people were conducted in Bangladesh (n = 1031) and Vietnam (n = 870). Data on HRQoL were collected using an instrument that includes 24 items distributed into 6 dimensions. Older people in Vietnam reported more favorable HRQoL outcomes than those in Bangladesh, reporting better HRQoL on physical, psychological, social, and financial dimensions. Hierarchical linear regression analyses show that advanced age, being a woman, belonging to a poor household, and reporting poor health were significantly associated with lower HRQoL scores in both Bangladesh and Vietnam. In Bangladesh, being illiterate was additionally associated with lower HRQoL scores. The results of this explorative study underline the importance of a cross-cultural understanding of HRQoL of older people and the influence of the socioecological context.
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Biomechanical analysis and review of lateral lumbar fusion constructs.
Spine
PUBLISHED: 12-17-2010
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Biomechanical study and the review of literature on lumbar interbody fusion constructs.
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Hepatitis C virus in Vietnam: high prevalence of infection in dialysis and multi-transfused patients involving diverse and novel virus variants.
PLoS ONE
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Hepatitis C virus (HCV) is a genetically diverse pathogen infecting approximately 2-3% of the worlds population. Herein, we describe results of a large, multicentre serological and molecular epidemiological study cataloguing the prevalence and genetic diversity of HCV in five regions of Vietnam; Ha Noi, Hai Phong, Da Nang, Khanh Hoa and Can Tho. Individuals (n=8654) with varying risk factors for infection were analysed for the presence of HCV Ab/Ag and, in a subset of positive specimens, for HCV RNA levels (n=475) and genotype (n=282). In lower risk individuals, including voluntary blood donors, military recruits and pregnant women, the prevalence of infection was 0.5% (n=26/5250). Prevalence rates were significantly higher (p<0.001) in intravenous drug users (IDUs; 55.6%, n=556/1000), dialysis patients (26.6%, n=153/575) commercial sex workers (CSWs; 8.7%, n=87/1000), and recipients of multiple blood transfusions (6.0%, n=32/529). The prevalence of HCV in dialysis patients varied but remained high in all regions (11-43%) and was associated with the receipt of blood transfusions [OR: 2.08 (1.85-2.34), p=0.001], time from first transfusion [OR: 1.07 (1.01-1.13), p=0.023], duration of dialysis [OR: 1.31 (1.19-1.43), p<0.001] and male gender [OR: 1.60 (1.06-2.41), p=0.026]. Phylogenetic analysis revealed high genetic diversity, particularly amongst dialysis and multi-transfused patients, identifying subtypes 1a (33%), 1b (27%), 2a (0.4%), 3a (0.7%), 3b (1.1%), 6a (18.8%), 6e (6.0%), 6h (4.6%), 6l (6.4%) and 2 clusters of novel genotype 6 variants (2.1%). HCV genotype 1 predominated in Vietnam (60%, n=169/282) but the proportion of infections attributable to genotype 1 varied between regions and risk groups and, in the Southern part of Vietnam, genotype 6 viruses dominated in dialysis and multi-transfused patients (73.9%). This study confirms a high prevalence of HCV infection in Vietnamese IDUs and, notably, reveals high levels of HCV infection associated with dialysis and blood transfusion.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.