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Find video protocols related to scientific articles indexed in Pubmed.
Oculomotor nerve tumors masquerading as recurrent painful ophthalmoplegic neuropathy: Report of two cases and review of the literature.
Cephalalgia
PUBLISHED: 11-05-2014
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In recurrent painful ophthalmoplegic neuropathy (RPON) that was previously termed as ophthalmoplegic migraine, enhancement of the ocular motor cranial nerves could be seen in the cisternal segment during the acute phase. However, various tumors involving the oculomotor nerve may mimic RPON.
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Long-term outcome of prismatic correction in children with consecutive esotropia after bilateral lateral rectus recession.
Br J Ophthalmol
PUBLISHED: 10-23-2014
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To determine the long-term outcome of prismatic correction in consecutive esotropia after bilateral lateral rectus (BLR) recession in children.
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Toxocara Optic Neuropathy after Ingestion of Raw Meat Products.
Optom Vis Sci
PUBLISHED: 10-12-2014
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To report Toxocara optic neuropathy in five men with histories of ingestion of raw meat, liver, or blood.
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Paraneoplastic neuromyelitis optica associated with ANNA-1 antibodies in invasive thymoma.
BMC Ophthalmol
PUBLISHED: 09-03-2014
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Thymoma is associated with various paraneoplastic autoimmune disorders. Herein, we report paraneoplastic neuromyelitis optica (NMO) associated with both anti-aquaporin-4 (AQP4) immunoglobulin G (IgG) and type 1 antineuronal nuclear antibody (ANNA-1) in an invasive thymoma patient.
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New parametric imaging method with fluorescein angiograms for detecting areas of capillary nonperfusion.
Healthc Inform Res
PUBLISHED: 07-31-2014
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Fluorescein angiography (FAG) is currently the most useful diagnostic modality for examining retinal circulation, and it is frequently used for the evaluation of patients with diabetic retinopathy, occlusive diseases, such as retinal venous and arterial occlusions, and wet macular degeneration. This paper presents a method for objectively evaluating retinal circulation by quantifying circulation-related parameters.
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An Objective Photographic Analysis of Ocular Oblique Muscle Dysfunction.
Am. J. Ophthalmol.
PUBLISHED: 07-25-2014
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To develop a new objective method for measuring ocular oblique muscle dysfunction.
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Genome-wide identification of nuclear receptor (NR) superfamily genes in the copepod Tigriopus japonicus.
BMC Genomics
PUBLISHED: 06-20-2014
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Nuclear receptors (NRs) are a large superfamily of proteins defined by a DNA-binding domain (DBD) and a ligand-binding domain (LBD). They function as transcriptional regulators to control expression of genes involved in development, homeostasis, and metabolism. The number of NRs differs from species to species, because of gene duplications and/or lineage-specific gene losses during metazoan evolution. Many NRs in arthropods interact with the ecdysteroid hormone and are involved in ecdysone-mediated signaling in arthropods. The nuclear receptor superfamily complement has been reported in several arthropods, including crustaceans, but not in copepods. We identified the entire NR repertoire of the copepod Tigriopus japonicus, which is an important marine model species for ecotoxicology and environmental genomics.
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Myelinated nerve fiber-associated local scleral excavation and induced axial myopia.
Retina (Philadelphia, Pa.)
PUBLISHED: 06-18-2014
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To investigate the association between the distributions of local scleral excavation and myelinated nerve fibers (MNF) and to elucidate the pathogenic mechanism of axial myopia in eyes with MNF.
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Acquired pseudoduplication of the optic disc in pathologic myopia.
Optom Vis Sci
PUBLISHED: 06-14-2014
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To elucidate the mechanism of acquired pseudoduplication of the optic disc and its association with pathologic myopia.
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The radiologic technologists' health study in South Korea: study design and baseline results.
Int Arch Occup Environ Health
PUBLISHED: 06-13-2014
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To describe the study design, methods, and baseline results of a prospective cohort of radiologic technologists which we have initiated in South Korea.
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Immunoglobulin G4-Related Hypertrophic Pachymeningitis with Skull Involvement.
Brain Tumor Res Treat
PUBLISHED: 06-12-2014
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Immunoglobulin G4 (IgG4)-related hypertrophic pachymeningitis, defined as focally or diffusely thickened dura mater and lymphoplasmacytic infiltration with increased IgG4 bearing plasma cells, is a rare disease. Moreover, cases involving bone are even rarer. In this report, the authors describe a case of IgG4-related hypertrophic pachymeningitis involving the skull in a 65-year-old man presenting with generalized tonic seizures. There is a 2.4 cm diameter extra-axial mass at the vertex of the left frontal convexity and thickened dura mater with contrast enhancement on magnetic resonance (MR) imaging. In addition, the skull adjacent to the mass was focally enhanced. He underwent surgical resection of the enhanced mass and skull. Histopathological findings revealed chronic inflammation with fibrosis, and idiopathic hypertrophic intracranial pachymeningitis was considered. However, eight months after surgery, partial seizures developed and brain MR imaging revealed a recurrence adjacent to the previous mass. We decided to perform additional immunohistochemical staining of the previous specimen, instead of a re-excision. Immunohistochemical staining showed markedly increased IgG4 (+) plasma cells. Consequently, IgG4-related hypertrophic meningitis was confirmed. Since then, steroids and immunosuppressant medications were started. Follow-up MR imaging at 3 months after medication initiation demonstrated complete remission. In conclusion, IgG4-related hypertrophic pachymeningitis should be considered in the differential diagnosis of hypertrophic cranial pachymeningitis.
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Validity and reliability of head posture measurement using Microsoft Kinect.
Br J Ophthalmol
PUBLISHED: 06-11-2014
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To investigate the validity and reliability of Microsoft Kinect-based head tracker (KHT) for measuring head posture.
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Optical coherence tomography shows early loss of the inferior temporal quadrant retinal nerve fiber layer in autosomal dominant optic atrophy.
Graefes Arch. Clin. Exp. Ophthalmol.
PUBLISHED: 06-10-2014
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The aim of the study was to evaluate the relationship between visual function and retinal nerve fiber layer thickness (RNFLT) determined using Stratus optical coherence tomography (OCT) in patients with autosomal dominant optic atrophy (ADOA).
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Efficacy of diagnostic monocular occlusion in revealing the maximum angle of exodeviation.
Br J Ophthalmol
PUBLISHED: 06-03-2014
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To determine the efficacy of diagnostic monocular occlusion in revealing the maximum angle of exodeviation compared with repeated measurements taken during three or more consecutive examinations in the outpatient clinic.
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Attributable fraction of tobacco smoking on cancer using population-based nationwide cancer incidence and mortality data in Korea.
BMC Cancer
PUBLISHED: 05-20-2014
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Smoking is by far the most important cause of cancer that can be modified at the individual level. Cancer incidence and mortality rates in Korea are the highest among all Asian countries, and smoking prevalence in Korean men is one of the highest in developed countries. The purpose of the current study was to perform a systematic review and provide an evidence-based assessment of the burden of tobacco smoking-related cancers in the Korean population.
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Prevention of Venous Thromboembolism in Medical Intensive Care Unit: A Multicenter Observational Study in Korea.
J. Korean Med. Sci.
PUBLISHED: 05-09-2014
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Patients admitted to medical intensive care unit (MICU) are at increased risk for venous thromboembolism (VTE); and prophylaxis is recommended. However, the actual range and frequency of VTE prophylaxis administered to MICU patients are not well defined. Patients over 40 yr of age and expected MICU stay of more than 48 hr were eligible for this observational cohort study of 23 MICUs in Korea. Patients already on anticoagulation therapy or those requiring anticoagulation for reasons other than VTE were excluded. Among 830 patients, VTE prophylaxis was given to 560 (67.5%) patients. Among 560 patients, 323 (38.9%) received pharmacoprophylaxis, 318 (38.4%) received mechanical prophylaxis and 81 (9.8%) received both forms of prophylaxis. About 74% of patients in the pharmacoprophylaxis group received low molecular weight heparin and 53% of the patients in the mechanical prophylaxis group used intermittent pneumatic compression. Most of the patients (90%) had more than one risk factor for VTE and the most common risk factor was old age, followed by heart and respiratory failure. In this observational cohort study of 23 MICUs in Korea, 67.5% of patients received thromboprophylaxis. Further studies are needed to clarify the role and efficacy of VTE prophylaxis in Korean critically ill patients.
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Childhood leukemia mortality and farming exposure in South Korea: A national population-based birth cohort study.
Cancer Epidemiol
PUBLISHED: 04-30-2014
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The aim of this study was to evaluate the relationship between leukemia mortality and exposure to farming among children in South Korea.
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Subconjunctival hemorrhage after intravitreal injection of anti-vascular endothelial growth factor.
Graefes Arch. Clin. Exp. Ophthalmol.
PUBLISHED: 04-26-2014
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To investigate the risk factors for subconjunctival hemorrhage (SCH) after intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) and evaluate the relationship between hemodynamic status at the time of injection and SCH.
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Supratentorial Extraventricular Anaplastic Ependymoma Presenting with Repeated Intratumoral Hemorrhage.
Brain Tumor Res Treat
PUBLISHED: 04-15-2014
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Supratentorial extraventricular anaplastic ependymomas are extremely rare. We report the case of a 23-year-old male with a supratentorial extraventricular anaplastic ependymoma that presented with repeated intratumoral hemorrhage. The patient was diagnosed with an intracerebral hematoma in the left occipital lobe and underwent operation. The hematoma did not reveal tumor cells, but a new tumor grew in the same location 5 years later. Magnetic resonance imaging showed a tumor with intratumoral hemorrhage. The patient underwent the tumor resection. Intraoperative findings showed that the tumor had no continuity with the ventricle. Histopathological examinations confirmed an anaplastic ependymoma. The spinal evaluation was unremarkable, and radiotherapy was administered to the left occipital lobe. Four years later, the tumor recurred at the cervicomedullary junction and T8-T9 levels. This case demonstrates that anaplastic ependymomas should be included in the differential diagnoses of supratentorial extraventricular tumors presenting with repeated intratumoral hemorrhage.
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Knockdown of Bcl-xL Enhances Growth-Inhibiting and Apoptosis-Inducing Effects of Resveratrol and Clofarabine in Malignant Mesothelioma H-2452 Cells.
J. Korean Med. Sci.
PUBLISHED: 04-15-2014
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Mcl-1 and Bcl-xL, key anti-apoptotic proteins of the Bcl-2 family, have attracted attention as important molecules in the cell survival and drug resistance. In this study, we investigated whether inhibition of Bcl-xL influences cell growth and apoptosis against simultaneous treatment of resveratrol and clofarabine in the human malignant mesothelioma H-2452 cells. Resveratrol and clofarabine decreased Mcl-1 protein levels but had little effect on Bcl-xL levels. In the presence of two compounds, any detectable change in the Mcl-1 mRNA levels was not observed in RT-PCR analysis, whereas pretreatment with the proteasome inhibitor MG132 led to its accumulation to levels far above basal levels. The knockdown of Bcl-xL inhibited cell proliferation with cell accumulation at G2/M phase and the appearance of sub-G0/G1 peak in DNA flow cytometric assay. The suppression of cell growth was accompanied by an increase in the caspase-3/7 activity with the resultant cleavages of procaspase-3 and its substrate poly (ADP-ribose) polymerase, and increased percentage of apoptotic propensities in annexin V binding assay. Collectively, our data represent that the efficacy of resveratrol and clofarabine for apoptosis induction was substantially enhanced by Bcl-xL-lowering strategy in which the simultaneous targeting of Mcl-1 and Bcl-xL could be a more effective strategy for treating malignant mesothelioma.
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Optic neuritis following Varicella zoster vaccination: report of two cases.
Vaccine
PUBLISHED: 04-09-2014
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Two women presented at our clinic with vision blurring following Varicella zoster virus (VZV) vaccination, 3 weeks and 1 week ago. Ophthalmologic examination and magnetic resonance imaging revealed bilateral and unilateral optic neuritis, respectively. One patient had a history of optic neuritis in the fellow eye 33 years ago without recurrence since then. Both patients completely recovered after treatment with high dose intravenous methylprednisolone followed by a tapered dose of oral prednisolone. This is the first report of optic neuritis occurring in relation to VZV vaccination.
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Antidepressant use and risk of coronary heart disease: meta-analysis of observational studies.
Br J Clin Pharmacol
PUBLISHED: 03-17-2014
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Our goal was to evaluate the association between antidepressant use and the risk of coronary heart disease (CHD) among subjects with no history of coronary heart disease.
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Ocular findings in children with single umbilical artery: a case series of 14 children.
Korean J Ophthalmol
PUBLISHED: 03-14-2014
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Single umbilical artery (SUA) is the most common malformation of the umbilical cord. However, there have been no studies on the ocular findings in SUA, except for one case report. This study aimed to investigate the ocular findings in children with SUA.
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Tools for Language: Patterned Iconicity in Sign Language Nouns and Verbs.
Top Cogn Sci
PUBLISHED: 03-13-2014
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When naming certain hand-held, man-made tools, American Sign Language (ASL) signers exhibit either of two iconic strategies: a handling strategy, where the hands show holding or grasping an imagined object in action, or an instrument strategy, where the hands represent the shape or a dimension of the object in a typical action. The same strategies are also observed in the gestures of hearing nonsigners identifying pictures of the same set of tools. In this paper, we compare spontaneously created gestures from hearing nonsigning participants to commonly used lexical signs in ASL. Signers and gesturers were asked to respond to pictures of tools and to video vignettes of actions involving the same tools. Nonsigning gesturers overwhelmingly prefer the handling strategy for both the Picture and Video conditions. Nevertheless, they use more instrument forms when identifying tools in pictures, and more handling forms when identifying actions with tools. We found that ASL signers generally favor the instrument strategy when naming tools, but when describing tools being used by an actor, they are significantly more likely to use more handling forms. The finding that both gesturers and signers are more likely to alternate strategies when the stimuli are pictures or video suggests a common cognitive basis for differentiating objects from actions. Furthermore, the presence of a systematic handling/instrument iconic pattern in a sign language demonstrates that a conventionalized sign language exploits the distinction for grammatical purpose, to distinguish nouns and verbs related to tool use.
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Alcohol Is Longitudinally Associated with Lower Urinary Tract Symptoms Partially Via High-Density Lipoprotein.
Alcohol. Clin. Exp. Res.
PUBLISHED: 03-07-2014
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Previous studies on the association of alcohol consumption with lower urinary tract symptoms (LUTS) have been inconsistent, and none took into account the dynamic nature of LUTS, fluctuating over time. The purpose of the study was to determine the longitudinal association of alcohol consumption with LUTS.
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Impact of outdoor air pollution on the incidence of tuberculosis in the Seoul metropolitan area, South Korea.
Korean J. Intern. Med.
PUBLISHED: 02-27-2014
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Although indoor air pollution is a well-known risk factor for tuberculosis (TB), the possible link between outdoor air pollution and TB development has not been examined fully. We assessed the impact of outdoor air pollution on TB development in the Seoul metropolitan area, South Korea.
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Accommodative esotropia decompensated to cyclic esotropia in a 6-year-old boy.
J AAPOS
PUBLISHED: 02-27-2014
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Cyclic esotropia, characterized by alternating intervals of esotropia and orthotropia, is associated with decreased vision, trauma, strabismus surgery, or central nervous system disease. We report a 6-year-old boy who developed cyclic esotropia after 3 years of successful control of accommodative esotropia with full hyperopic correction. After bilateral medial rectus recession, he remained esophoric with good binocular function and stereoacuity. To our knowledge, this is the first report of accommodative esotropia decompensating into a cyclic esotropia.
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A novel color vision test for detection of diabetic macular edema.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 02-26-2014
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To determine the sensitivity of the Seoul National University (SNU) computerized color vision test for detecting diabetic macular edema.
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Crude oil exposure results in oxidative stress-mediated dysfunctional development and reproduction in the copepod Tigriopus japonicus and modulates expression of cytochrome P450 (CYP) genes.
Aquat. Toxicol.
PUBLISHED: 02-20-2014
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In this study, we investigated the effects of the water-accommodated fraction (WAF) of crude oil on the development and reproduction of the intertidal copepod Tigriopus japonicus through life-cycle experiments. Furthermore, we investigated the mechanisms underlying the toxic effects of WAF on this benthic organism by studying expression patterns of cytochrome P450 (CYP) genes. Development of T. japonicus was delayed and molting was interrupted in response to WAF exposure. Hatching rate was also significantly reduced in response to WAF exposure. Activities of antioxidant enzymes such as glutathione S-transferase (GST), glutathione reductase (GR), and catalase (CAT) were increased by WAF exposure in a concentration-dependent manner. These results indicated that WAF exposure resulted in oxidative stress, which in turn was associated with dysfunctional development and reproduction. To evaluate the involvement of cytochrome P450 (CYP) genes, we cloned the entire repertoire of CYP genes in T. japonicus (n=52) and found that the CYP genes belonged to five different clans (i.e., Clans 2, 3, 4, mitochondrial, and 20). We then examined expression patterns of these 52 CYP genes in response to WAF exposure. Three TJ-CYP genes (CYP3024A2, CYP3024A3, and CYP3027C2) belonging to CYP clan 3 were significantly induced by WAF exposure in a time- and concentration-dependent manner. We identified aryl hydrocarbon responsive elements (AhRE), xenobiotic responsive elements (XREs), and metal response elements (MRE) in the promoter regions of these three CYP genes, suggesting that these genes are involved in detoxification of toxicants. Overall, our results indicate that WAF can trigger oxidative stress and thus induce dysfunctional development and reproduction in the copepod T. japonicus. Furthermore, we identified three TJ-CYP genes that represent potential biomarkers of oil pollution.
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Prognostic impact of minimal pleural effusion in non-small-cell lung cancer.
J. Clin. Oncol.
PUBLISHED: 02-18-2014
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Minimal (< 10 mm thick) pleural effusion (PE) may represent an early phase of malignant PE, but its clinical relevance has rarely been studied. Therefore, we examined the proportion of minimal PE in patients with non-small-cell lung cancer (NSCLC) and its impact on survival. We also considered possible accumulation mechanisms in our data set.
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Risk factors and molecular epidemiology of community-onset extended-spectrum ?-lactamase-producing Escherichia coli bacteremia.
Yonsei Med. J.
PUBLISHED: 02-18-2014
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Inadequate empirical therapy for severe infections caused by extended-spectrum ?-lactamase-producing Escherichia coli (ESBLEC) is associated with poor outcomes. This study was designed to investigate risk factors for community-onset ESBLEC bacteremia at admission to a tertiary care hospital.
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Comparison of long-term surgical outcomes of 2-muscle surgery in children with large-angle exotropia: bilateral vs unilateral.
Am. J. Ophthalmol.
PUBLISHED: 02-13-2014
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To evaluate the long-term results of 2-muscle surgery in children with primary large-angle exotropia, comparing 10 mm bilateral lateral rectus recession (BLR) with unilateral lateral rectus recession-medial rectus resection (recess/resect).
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A time series study on the effects of cold temperature on road traffic injuries in Seoul, Korea.
Environ. Res.
PUBLISHED: 02-09-2014
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Although traffic accidents are associated with weather, the influence of temperature on injuries from traffic accidents has not been evaluated sufficiently. The objective of this study was to evaluate the effect of temperature, especially cold temperatures, on injuries from traffic accidents in Seoul, Korea. We also explored the relationship of temperature with different types of traffic accident.
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Diclofenac versus fluorometholone after strabismus surgery in children.
Br J Ophthalmol
PUBLISHED: 02-03-2014
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To compare the effects of topical diclofenac sodium with those of fluorometholone on intraocular pressure (IOP) and conjunctival inflammation after strabismus surgery.
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Evaluation of congenital excavated optic disc anomalies with spectral-domain and swept-source optical coherence tomography.
Graefes Arch. Clin. Exp. Ophthalmol.
PUBLISHED: 01-28-2014
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To investigate the anatomic characteristics of congenital excavated optic disc anomalies by using fundus photography, spectral-domain optical coherence tomography (SD-OCT), and swept-source optical coherence tomography (SS-OCT).
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The neuroprotective effect of treatment with curcumin in acute spinal cord injury: laboratory investigation.
Neurol. Med. Chir. (Tokyo)
PUBLISHED: 01-28-2014
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The purpose of this study was investigating the effects of curcumin on the histological changes and functional recovery following spinal cord injury (SCI) in a rat model. Following either sham operation or SCI, 36 male Sprague-Dawley rats were distributed into three groups: sham group, curcumin-treated group, and vehicle-injected group. Locomotor function was assessed according to the Basso, Beattie, and Bresnahan (BBB) scale in rats who had received daily intraperitoneal injections of 200 mg/kg curcumin or an equivalent volume of vehicle for 7 days following SCI. The injured spinal cord was then examined histologically, including quantification of cavitation. BBB scores were significantly higher in rats receiving curcumin than receiving vehicle (P < 0.05). The cavity volume was significantly reduced in the curcumin group as compared to the control group (P = 0.039). Superoxide dismutase (SOD) activity was significantly elevated in the curcumin group as compared to the vehicle group but was not significantly different from the sham group (P < 0.05, P > 0.05, respectively) at one and two weeks after SCI. Malondialdehyde (MDA) levels were significantly elevated in the vehicle group as compared to the sham group (P < 0.05 at 1 and 2 weeks). MDA activity was significantly reduced in the curcumin group at 2 weeks after SCI when compared to the vehicle group (P = 0.004). The numbers of macrophage were significantly decreased in the curcumin group (P = 0.001). This study demonstrated that curcumin enhances early functional recovery after SCI by diminishing cavitation volume, anti-inflammatory reactions, and antioxidant activity.
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Biodegradable-polymer drug-eluting stents vs. bare metal stents vs. durable-polymer drug-eluting stents: a systematic review and Bayesian approach network meta-analysis.
Eur. Heart J.
PUBLISHED: 01-23-2014
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The aim of this study was to compare the safety and efficacy of biodegradable-polymer (BP) drug-eluting stents (DES), bare metal stents (BMS), and durable-polymer DES in patients undergoing coronary revascularization, we performed a systematic review and network meta-analysis using a Bayesian framework.
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Influence of somatic cell donor breed on reproductive performance and comparison of prenatal growth in cloned canines.
Theriogenology
PUBLISHED: 01-22-2014
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Using in vivo-flushed oocytes from a homogenous dog population and subsequent embryo transfer after nuclear transfer, we studied the effects of donor cells collected from 10 different breeds on cloning efficiency and perinatal development of resulted cloned puppies. The breeds were categorized into four groups according to their body weight: small (?9 kg), medium (>9-20 kg), large (>20-40 kg), and ultra large (>40 kg). A total of 1611 cloned embryos were transferred into 454 surrogate bitches for production of cloned puppies. No statistically significant differences were observed for initial pregnancy rates at Day 30 of embryo transfer for the donor cells originated from different breeds. However, full-term pregnancy rates were 16.5%, 11.0%, 10.0%, and 7.1% for the donor cells originated from ultra-large breed, large, medium, and small breeds, respectively, where pregnancy rate in the ultra-large group was significantly higher compared with the small breeds (P < 0.01). Perinatal mortality until weaning was significantly higher in small breeds (33.3%) compared with medium, large, or ultra-large breeds where no mortality was observed. The mean birth weight of cloned pups significantly increased proportional to breed size. The highest litter size was examined in ultra-large breeds. There was no correlation between the number of embryo transferred and litter size. Taken together, the efficiency of somatic cell cloning and fetal survival after embryo transfer may be affected significantly by selecting the appropriate genotype.
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Does infantile abduction deficit indicate duane retraction syndrome until disproven?
J. Child Neurol.
PUBLISHED: 01-21-2014
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Duane retraction syndrome consists of abduction deficit and palpebral fissure narrowing, upshoots, or downshoots on adduction. Infants with abduction deficit should be considered to have Duane retraction syndrome until disproven, because congenital abducens nerve palsy is extremely rare. The abducens nerve on the affected side is absent in type 1 Duane retraction syndrome and in some type 3 patients. The authors present a 7-month-old girl who showed limitation of abduction simulating Duane retraction syndrome. High-resolution magnetic resonance imaging (MRI) revealed atrophic lateral rectus and present abducens nerve. This report is important because this case showed that congenital abducens nerve palsy exists, although it is extremely rare, and high-resolution MRI could be pivotal for the differentiation of Duane retraction syndrome and congenital abducens nerve palsy in infancy.
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Changes in refractive errors related to spectacle correction of hyperopia.
PLoS ONE
PUBLISHED: 01-01-2014
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Hyperopic undercorrection is a common clinical practice. However, less is known of its effect on the change in refractive errors and emmetropization throughout the later years of childhood.
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The incidence and prevalence of diabetes mellitus and related atherosclerotic complications in Korea: a national health insurance database study.
PLoS ONE
PUBLISHED: 01-01-2014
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The incidence and prevalence of type 2 diabetes mellitus (T2DM) and related macrovascular complications in Korea were estimated using the Health Insurance Review and Assessment (HIRA) database from 2007-2011, which covers the claim data of 97.0% of the Korean population.
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Horners Syndrome and Contralateral Abducens Nerve Palsy Associated with Zoster Meningitis.
Korean J Ophthalmol
PUBLISHED: 11-15-2013
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A 55-year-old woman presented with diplopia following painful skin eruptions on the right upper extremity. On presentation, she was found to have 35 prism diopters of esotropia and an abduction limitation in the left eye. Two weeks later, she developed blepharoptosis and anisocoria with a smaller pupil in the right eye, which increased in the darkness. Cerebrospinal fluid analysis showed pleocytosis and a positive result for immunoglobulin G antibody to varicella zoster virus. She was diagnosed to have zoster meningitis with Horners syndrome and contralateral abducens nerve palsy. After intravenous antiviral and steroid treatments, the vesicular eruptions and abducens nerve palsy improved. Horners syndrome and diplopia resolved after six months. Here we present the first report of Horners syndrome and contralateral abducens nerve palsy associated with zoster meningitis.
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Biomechanical stability according to different configurations of screws and rods.
J Spinal Disord Tech
PUBLISHED: 11-10-2013
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Comparison of biomechanical strength according to 2 different configurations of screws and rods.
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Quality of reporting noninferiority/similarity in research studies of diagnostic imaging.
Radiology
PUBLISHED: 10-28-2013
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Purpose To evaluate the quality of reporting noninferiority/similarity in research studies of diagnostic imaging. Materials and Methods All 661 original research articles published in Radiology and European Radiology in 2012 were hand searched to find original studies of diagnostic imaging that included a claim of noninferiority/similarity as a study conclusion. A separate MEDLINE search was performed to identify original studies of diagnostic imaging designed as noninferiority studies, defined as studies at least embodying noninferiority margin, published in English between April 2007 and December 2012. Thirty-eight articles in the first category and 30 in the second category reporting a total of 31 noninferiority studies were finally collected after screening for eligibility. The quality of the reported analytic methodology was evaluated largely according to the extended Consolidated Standards of Reporting Trials, or CONSORT, statement to cover noninferiority studies. In the 31 designated noninferiority studies, the authors evaluated the following key areas of compliance required for proper reporting: noninferiority margin defined and justification provided, sample size calculated according to noninferiority methodology, and use of proper statistical analysis. Results Of the 38 studies concluding noninferiority/similarity, one study (3%) used proper analytic method. Twenty-nine of the 38 studies (76%), 28 of which also omitted sample size estimation, claimed noninferiority/similarity for P ? .05 from conventional two-sided superiority testing. Of the 31 designated noninferiority studies, seven (23%) fulfilled the requirements for proper reporting. Justification for noninferiority margin was provided in 15 of the 31 studies (48%). Proper sample size estimation was done in 14 of the 31 studies (45%). Conclusion The quality of reporting noninferiority/similarity in recently published research studies of diagnostic imaging was deficient. © RSNA, 2013 Online supplemental material is available for this article.
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Switching strategy for mechanical thrombectomy of acute large vessel occlusion in the anterior circulation.
Stroke
PUBLISHED: 09-10-2013
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We introduce the concept of a switching strategy for mechanical thrombectomy with period-to-period analysis. In period 1, forced arterial suction thrombectomy with a Penumbra reperfusion catheter was performed, even in difficult cases; in period 2, forced arterial suction thrombectomy was initially performed, with switching to Solitaire in difficult cases.
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Where are We Now with Decompressive Hemicraniectomy for Malignant Middle Cerebral Artery Infarction?
J Cerebrovasc Endovasc Neurosurg
PUBLISHED: 07-12-2013
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In spite of the best medical treatment, large hemispheric infarction, resulting from acute occlusion of either the internal carotid or the proximal middle cerebral artery with insufficient collateral blood flow is associated with a high case fatality rate of approximately 60%. Thus, a decompressive hemicraniectomy is considered a life-saving procedure for this devastating disease. Findings of three recent randomized, controlled clinical trials and their meta-analysis showed that early surgical decompression not only reduced the number of case fatalities but also increased the incidence of favorable outcomes. The authors review the pathophysiology, historical background in previous studies, operative timing, surgical technique and clinical outcomes of surgical decompression for malignant hemispheric infarction.
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New clinical grading scales and objective measurement for conjunctival injection.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 07-09-2013
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To establish a new clinical grading scale and objective measurement method to evaluate conjunctival injection.
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Oral contraceptive use and measurable cardiovascular risk factors in Korean women aged 20-50 years: the Fourth Korean National Health and Nutrition Examination Survey 2007-2009 (KNHANES IV).
Gynecol. Endocrinol.
PUBLISHED: 06-19-2013
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To evaluate the effects of oral contraceptives (OCs) on cardiovascular risk factors according to the duration of use.
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Nomogram using transrectal ultrasound-derived information predicting the detection of high grade prostate cancer on initial biopsy.
Prostate Int
PUBLISHED: 05-09-2013
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To develop a nomogram using transrectal ultrasound (TRUS)-derived information for predicting high grade (HG) prostate cancer (PCa) on initial biopsy.
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A novel computerized visual acuity test for children.
Korean J Ophthalmol
PUBLISHED: 04-30-2013
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To investigate the efficacy of a computerized visual acuity test, the SNU visual acuity test for children.
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Severe hyperkalemia can be detected immediately by quantitative electrocardiography and clinical history in patients with symptomatic or extreme bradycardia: a retrospective cross-sectional study.
J Crit Care
PUBLISHED: 04-28-2013
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Detecting severe hyperkalemia is challenging. We explored its prevalence in symptomatic or extreme bradycardia and devised a diagnostic rule.
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Silent giant cell arteritis in an elderly Korean woman.
Korean J Ophthalmol
PUBLISHED: 04-25-2013
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Giant cell arteritis (GCA) is a rare disease among Asians. Arteritic anterior ischemic optic neuropathy, which accompanies GCA, has not yet been reported in Koreans. Diagnosis of GCA is difficult if typical symptoms other than visual loss are absent. Here, we report a case of an 83-year-old Korean woman presenting with sudden visual loss in both eyes (oculus uterque, OU). Her visual acuities included perception of light in the right eye (oculus dexter, OD) and perception of hand motion in the left eye (oculus sinister, OS). The results of the Hardy-Rand-Rittler test and Ishihara test showed total dyschromatopsia OU. The Goldmann perimetry test revealed a total field defect OD and paracentral island OS. Fundus examination revealed chalky-white disc swelling OU. Other systemic symptoms and signs were unremarkable. The erythrocyte sedimentation rate, C-reactive protein and platelet count were highly elevated. Temporal artery biopsy revealed multiple lymphocytes and multinucleated giant cells in the arterial media layer. To our knowledge, this is the first report of GCA in a Korean that has been confirmed with temporal artery biopsy. In conclusion, silent GCA can occur in Koreans, and hence, elderly patients presenting with chalky-white disc swelling, and corresponding laboratory findings must be evaluated for GCA.
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Central retinal artery occlusion caused by fat embolism following endoscopic sinus surgery.
J Neuroophthalmol
PUBLISHED: 04-11-2013
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Endoscopic sinus surgery (ESS) can lead to a variety of ophthalmic complications. Central retinal arterial occlusion (CRAO) is one such complication, usually due to orbital compartment syndrome. We report a case of CRAO following endoscopic sinus surgery as a result of fat embolism.
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Intramedullary spinal cord metastasis in renal cell carcinoma: a case report of the surgical experience.
J. Korean Med. Sci.
PUBLISHED: 04-03-2013
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Intramedullary spinal cord metastasis (ISCM) from renal cell carcinoma (RCC) is rare manifestation and most of them are treated by adjuvant treatment modalities like radiotherapy. Despite the radio-resistance of RCC itself, focal radiotherapy has been preferred as the first-line treatment modality of ISCM from RCC and only a few cases underwent surgical treatment. We describe a case of ISCM from RCC, which underwent surgical excision and pathologically confirmed. A 44-yr-old man was presented with rapid deterioration of motor weakness during focal radiotherapy for ISCM from RCC. After the surgery for removal of the tumor mass and spinal cord decompression, his motor power was dramatically improved to ambulate by himself. We report the first published Korean case of ISCM from RCC confirmed pathologically and describe our surgical experience and his clinical characteristics.
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Automated analysis of binocular alignment using an infrared camera and selective wavelength filter.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 03-30-2013
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We present a computerized method of measuring binocular alignment using a selective wavelength filter and an infrared camera, and validate the efficacy of automated image analysis compared to the gold standard prism and alternate cover test (PCT).
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Unusual chiasmal visual field defects.
Neurol. Sci.
PUBLISHED: 03-20-2013
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Masses beneath the chiasm usually cause superiorly denser field defects. This report showed two very rare field defects related with infrachiasmal compression, monocular inferotemporal quadrantanopia in Case 1 and monocular temporal and inferonasal field defect in Case 2. We presume that these very rare visual field defects might be caused by a compression between the mass and the anterior cerebral artery. The detailed anatomic relations of the compressed optic chiasm between the mass and the anterior cerebral artery are best revealed on a coronal T2-weighted image with a section thickness of 3 mm or less, and a routine brain MRI with a larger section thickness may not reveal such findings. Therefore, appropriate resolutions and a meticulous review of MR imaging may provide the clues to the etiology of these visual defects. In conclusion, the clinician should be aware that such unusual visual field defects could also be caused by a compression between the mass and anterior cerebral arteries.
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Reliability and validity of an automated computerized visual acuity and stereoacuity test in children using an interactive video game.
Am. J. Ophthalmol.
PUBLISHED: 02-26-2013
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To evaluate the test-retest reliability and validity of the new automated computerized distance visual acuity and stereoacuity test for children, which uses an interactive video game.
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F-18 fluorodeoxyglucose PET/CT and post hoc PET/MRI in a case of primary meningeal melanomatosis.
Korean J Radiol
PUBLISHED: 02-22-2013
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Primary meningeal melanomatosis is a rare, aggressive variant of primary malignant melanoma of the central nervous system, which arises from melanocytes within the leptomeninges and carries a poor prognosis. We report a case of primary meningeal melanomatosis in a 17-year-old man, which was diagnosed with (18)F-fluorodeoxyglucose (F-18 FDG) PET/CT, and post hoc F-18 FDG PET/MRI fusion images. Whole-body F-18 FDG PET/CT was helpful in ruling out the extracranial origin of melanoma lesions, and in assessing the therapeutic response. Post hoc PET/MRI fusion images facilitated the correlation between PET and MRI images and demonstrated the hypermetabolic lesions more accurately than the unenhanced PET/CT images. Whole body F-18 FDG PET/CT and post hoc PET/MRI images might help clinicians determine the best therapeutic strategy for patients with primary meningeal melanomatosis.
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Potassium intake and the prevalence of metabolic syndrome: the Korean National Health and Nutrition Examination Survey 2008-2010.
PLoS ONE
PUBLISHED: 01-25-2013
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Lower potassium intake is considered to be correlated with diabetes incidence. However, few studies have investigated the effect of potassium intake on metabolic syndrome (MetS). Data was taken from the Korean National Health and Nutritional Examination Survey (2008-2010) using weighted adjustment. MetS was defined as per the revised National Cholesterol Education Program criteria. Homeostasis model assessment indices were calculated to diagnosis insulin resistance (IR). A total of 16,637 participants (44 ± 0.25 years) were included. Women ingested lower amounts of potassium (2.71 ± 0.02 g/day) than men (3.45 ± 0.03 g/day). A curvilinear association between potassium intake and MetS prevalence was found among women. Women with less than the Adequate Intake (4.7 g/day) of potassium had an 11% risk reduction for MetS (adjusted odds ratio [OR], 0.89; 95% confidence interval [CI], 0.82-0.96; P = 0.004) and a 10% risk reduction for IR (OR, 0.90; 95% CI, 0.82-0.99; P = 0.026) for every 1 g/day potassium increase. Compared with the reference group (3.5-4.5 g/day), potassium intake was inversely associated with an increased risk of MetS (1.5-2.5 g/day; OR, 1.29; 95% CI, 1.02-1.63; P = 0.035; <1.5 g/day; OR, 1.40; 95% CI, 1.06-1.85; P = 0.017) and IR (<1.5 g/day; OR, 1.36; 95% CI, 1.05-1.76; P = 0.021). This relationship was more prominent in postmenopausal women, but not observed among men. Higher potassium intake is significantly associated with a lower MetS prevalence in women, and IR is believed to be connected.
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Morphologic characteristics of optic nerve head drusen on spectral-domain optical coherence tomography.
Am. J. Ophthalmol.
PUBLISHED: 01-18-2013
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To evaluate the morphologic characteristics of optic nerve head drusen.
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Morphologic characteristics of the outer retina in cone dystrophy on spectral-domain optical coherence tomography.
Korean J Ophthalmol
PUBLISHED: 01-15-2013
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To investigate the morphologic changes in the outer retina of patients with cone dystrophy, using spectral-domain optical coherence tomography (SD-OCT).
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Rescue strategy for acute carotid stent thrombosis during carotid stenting with distal filter protection using forced arterial suction thrombectomy with a reperfusion catheter of the Penumbra System: a technical note.
Acta Neurochir (Wien)
PUBLISHED: 01-11-2013
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Among the procedural complications related to carotid artery stenting (CAS), internal carotid artery (ICA) flow arrest is one of the most drastic complications, as it can cause major ischemic stroke. Acute carotid stent thrombosis (ACST) is a rare etiology of ICA flow arrest during carotid artery stenting with distal filter protection, but the most devastating. Moreover, no definitive management strategy has been established so far for treating ACST.
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Regional factors associated with participation in the national health screening program: a multilevel analysis using national data.
J. Korean Med. Sci.
PUBLISHED: 01-11-2013
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High participation rates are important for maximizing the effects of a health screening program. Previous studies have suggested that individual or regional characteristics have effects on health behaviors. In this study, we investigated the determinants of participation in the National Screening Program for Transitional Ages by simultaneously analyzing individual and area-level factors by multilevel analysis. A total of 1,081,216 subjects, aged 40 and 66 yr and nested in 254 areas, were included. There was a significant variation in participation rates across the areas even after adjusting for individual and area-level variables. Among the individual-level variables, increasing age, sex, higher income, and mild disability grade were associated with a higher participation rate. In urban areas, the 40-yr-old group had higher participation rates than the 66-yr-old group. Deprived areas had significantly high participation rates for both age groups. The number of screening centers per 1,000 inhabitants had no significant effect on participation in the screening program. In conclusion, regional characteristics are associated with participation rates independent of personal features and regional factors have differential effects with respect to age. A multi-dimensional approach is recommended to promote participation in health screening programs.
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Cancer risk in diagnostic radiation workers in Korea from 1996–2002.
Int J Environ Res Public Health
PUBLISHED: 01-05-2013
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This study was aimed to examine the association between the effective radiation dose of diagnostic radiation workers in Korea and their risk for cancer. A total of 36,394 diagnostic radiation workers (159,189 person-years) were included in this study; the effective dose and cancer incidence were analyzed between the period 1996 and 2002. Median (range) follow-up time was 5.5 (0.04-7) years in males and 3.75 (0.04-7) years in females. Cancer risk related to the average annual effective dose and exposure to more than 5 mSv of annual radiation dose were calculated by the Cox proportional hazard model adjusted for occupation and age at the last follow-up. The standardized incidence ratio of cancer in radiation workers showed strong healthy worker effects in both male and female workers. The relative risk of all cancers from exposure of the average annual effective dose in the highest quartile (upper 75% or more of radiation dose) was 2.14 in male workers (95% CI: 1.48-3.10, p-trend: <0.0001) and 4.43 in female workers (95% CI: 2.17-9.04, p-trend: <0.0001), compared to those in the lower three quartiles of radiation exposure dose (less than upper 75% of radiation dose). Cancer risks of the brain (HR: 17.38, 95% CI: 1.05-287.8, p-trend: 0.04) and thyroid (HR: 3.88, 95% CI: 1.09-13.75, p-trend: 0.01) in female workers were significantly higher in the highest quartile group of radiation exposure compared to those in the lower three quartiles, and the risk of colon and rectum cancers in male workers showed a significantly increasing trend according to the increase of the average annual radiation dose (HR: 2.37, 95% CI: 0.99-5.67, p-trend: 0.02). The relative risk of leukemia in male workers and that of brain cancer in female workers were significantly higher in the group of people who had been exposed to more than 5 mSv/year than those exposed to less than 5 mSv/year (HR: 11.75, 95% CI: 1.08-128.20; HR: 63.11, 95% CI: 3.70-1,075.00, respectively). Although the present study involved a relatively young population and a short follow-up time, statistically significant increased risks of some cancers in radiation workers were found, which warrants a longer follow-up study and more intensive protective measures in this population.
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Production of multiple transgenic Yucatan miniature pigs expressing human complement regulatory factors, human CD55, CD59, and H-transferase genes.
PLoS ONE
PUBLISHED: 01-01-2013
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The present study was conducted to generate transgenic pigs coexpressing human CD55, CD59, and H-transferase (HT) using an IRES-mediated polycistronic vector. The study focused on hyperacute rejection (HAR) when considering clinical xenotransplantation as an alternative source for human organ transplants. In total, 35 transgenic cloned piglets were produced by somatic cell nuclear transfer (SCNT) and were confirmed for genomic integration of the transgenes from umbilical cord samples by PCR analysis. Eighteen swine umbilical vein endothelial cells (SUVEC) were isolated from umbilical cord veins freshly obtained from the piglets. We observed a higher expression of transgenes in the transgenic SUVEC (Tg SUVEC) compared with the human umbilical vein endothelial cells (HUVEC). Among these genes, HT and hCD59 were expressed at a higher level in the tested Tg organs compared with non-Tg control organs, but there was no difference in hCD55 expression between them. The transgenes in various organs of the Tg clones revealed organ-specific and spatial expression patterns. Using from 0 to 50% human serum solutions, we performed human complement-mediated cytolysis assays. The results showed that, overall, the Tg SUVEC tested had greater survival rates than did the non-Tg SUVEC, and the Tg SUVEC with higher HT expression levels tended to have more down-regulated ?-Gal epitope expression, resulting in greater protection against cytotoxicity. By contrast, several Tg SUVEC with low CD55 expression exhibited a decreased resistance response to cytolysis. These results indicated that the levels of HT expression were inversely correlated with the levels of ?-Gal epitope expression and that the combined expression of hCD55, hCD59, and HT proteins in SUVECs markedly enhances a protective response to human serum-mediated cytolysis. Taken together, these results suggest that combining a polycistronic vector system with SCNT methods provides a fast and efficient alternative for the generation of transgenic large animals with multiple genetic modifications.
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Brush-shaped ZnO heteronanorods synthesized using thermal-assisted pulsed laser deposition.
ACS Appl Mater Interfaces
PUBLISHED: 12-05-2011
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Brush-shaped ZnO heteronanostructures were synthesized using a newly designed thermal-assisted pulsed laser deposition (T-PLD) system that combines the advantages of pulsed laser deposition (PLD) and a hot furnace system. Branched ZnO nanostructures were successfully grown onto CVD-grown backbone nanowires by T-PLD. Although ZnO growth at 300 °C resulted in core-shell structures, brush-shaped hierarchical nanostructures were formed at 500-600 °C. Materials properties were studied via photoluminescence (PL), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) characterizations. The enhanced photocurrent of a SnO(2)-ZnO heterostructures device by irradiation with 365 nm wavelength ultraviolet (UV) light was also investigated by the current-voltage characteristics.
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Ocular findings in cerebral palsy patients undergoing orthopedic surgery.
Optom Vis Sci
PUBLISHED: 11-25-2011
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To investigate the prevalence and clinical features of ocular abnormalities in patients with cerebral palsy (CP) and the association with gross motor function.
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Assessment of binocular alignment using the three-dimensional Strabismus Photo Analyzer.
Br J Ophthalmol
PUBLISHED: 10-08-2011
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To evaluate the efficacy of the three-dimensional (3D) Strabismus Photo Analyzer for estimating binocular alignment using photographs.
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Effect of subconjunctivally injected liposome-encapsulated tissue plasminogen activator on the absorption rate of subconjunctival hemorrhages in rabbits.
Cornea
PUBLISHED: 09-30-2011
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To evaluate the effect of subconjunctivally injected liposome-encapsulated tissue plasminogen activator (tPA) on the absorption rate of subconjunctival hemorrhages (SHs).
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.