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Find video protocols related to scientific articles indexed in Pubmed.
Leaking choroidal nevus treated with focal laser photocoagulation.
Retin Cases Brief Rep
PUBLISHED: 11-06-2014
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To present a case of leaky choroidal nevus that responded favorably to treatment with focal laser photocoagulation, shown by spectral domain optical coherence tomography, fundus autofluorescence, and fundus photography.
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Late reopening of an initially successfully closed macular hole after 12 years.
Retin Cases Brief Rep
PUBLISHED: 11-06-2014
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An uncommon late complication after successful initial surgical closure of a full-thickness macular hole is reopening.
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Quantitative 3D-OCT motion correction with tilt and illumination correction, robust similarity measure and regularization.
Biomed Opt Express
PUBLISHED: 07-11-2014
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Variability in illumination, signal quality, tilt and the amount of motion pose challenges for post-processing based 3D-OCT motion correction algorithms. We present an advanced 3D-OCT motion correction algorithm using image registration and orthogonal raster scan patterns aimed at addressing these challenges. An intensity similarity measure using the pseudo Huber norm and a regularization scheme based on a pseudo L0.5 norm are introduced. A two-stage registration approach was developed. In the first stage, only axial motion and axial tilt are coarsely corrected. This result is then used as the starting point for a second stage full optimization. In preprocessing, a bias field estimation based approach to correct illumination differences in the input volumes is employed. Quantitative evaluation was performed using a large set of data acquired from 73 healthy and glaucomatous eyes using SD-OCT systems. OCT volumes of both the optic nerve head and the macula region acquired with three independent orthogonal volume pairs for each location were used to assess reproducibility. The advanced motion correction algorithm using the techniques presented in this paper was compared to a basic algorithm corresponding to an earlier version and to performing no motion correction. Errors in segmentation-based measures such as layer positions, retinal and nerve fiber thickness, as well as the blood vessel pattern were evaluated. The quantitative results consistently show that reproducibility is improved considerably by using the advanced algorithm, which also significantly outperforms the basic algorithm. The mean of the mean absolute retinal thickness difference over all data was 9.9 um without motion correction, 7.1 um using the basic algorithm and 5.0 um using the advanced algorithm. Similarly, the blood vessel likelihood map error is reduced to 69% of the uncorrected error for the basic and to 47% of the uncorrected error for the advanced algorithm. These results demonstrate that our advanced motion correction algorithm has the potential to improve the reliability of quantitative measurements derived from 3D-OCT data substantially.
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Macular choroidal thickness profile in a healthy population measured by swept-source optical coherence tomography.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 05-22-2014
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To determine choroidal thickness (CT) profile in a healthy population using swept-source optical coherence tomography (SS-OCT).
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Choroidal thickness in retinal pigment epithelial tear as measured by spectral domain optical coherence tomography.
Retina (Philadelphia, Pa.)
PUBLISHED: 04-17-2014
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To evaluate the choroidal thickness with spectral domain optical coherence tomography in subjects with retinal pigment epithelial (RPE) tear compared with the choroidal thickness of their fellow eye.
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Progressive Outer Retinal Necrosis Secondary to Herpes Simplex Virus Type 2.
Ophthalmic Surg Lasers Imaging Retina
PUBLISHED: 04-04-2014
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Progressive outer retinal necrosis is an aggressive form of necrotizing herpetic retinitis that presents in immunocompromised patients. It is usually secondary to varicella zoster virus or, rarely, herpes simplex virus type 1. The authors report a case of progressive outer retinal necrosis associated with herpes simplex virus type 2 in a patient with a history of congenital herpes. [Ophthalmic Surg Lasers Imaging Retina. 2014;45:xxx-xxx.].
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Local control and results of Leksell Gamma Knife therapy for the treatment of uveal melanoma.
Ophthalmic Surg Lasers Imaging Retina
PUBLISHED: 03-19-2014
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To evaluate the effectiveness of Leksell Gamma Knife stereotactic radio-surgery (Elekta, Stockholm, Sweden) with respect to local tumor control, visual acuity, and radiation side effects for uveal melanoma.
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Optical coherence tomography in the preoperative and postoperative management of macular hole and epiretinal membrane.
Br J Ophthalmol
PUBLISHED: 03-13-2014
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Optical coherence tomography (OCT) imaging plays an essential role in the diagnosis and treatment of macular diseases, including those of the vitreomacular interface. OCT enables accurate diagnosis and differentiation of full thickness macular hole, lamellar macular hole and epiretinal membrane, with or without the presence of vitreomacular adhesion. This information enables earlier diagnosis and treatment when necessary, and can guide the choice of therapy. OCT is useful to facilitate discussions with patients and manage the visual expectations. Postoperatively, OCT can be helpful to optimise patient comfort and visual outcomes. As the technology continues to improve, OCT will become increasingly critical for all aspects of care for patients with macular hole and epiretinal membrane.
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Spectral-Domain and Swept-Source OCT Imaging of Asteroid Hyalosis: A Case Report.
Ophthalmic Surg Lasers Imaging Retina
PUBLISHED: 03-04-2014
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A 72-year-old man with diabetes was referred to the retina clinic for diabetic retinopathy. Detailed funduscopic examination of the left eye was limited by prominent asteroid hyalosis. Spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) were utilized to examine the vitreous, vitreoretinal interface, and the morphology of the retina. Asteroid hyalosis induced artifacts of the OCT images, which resolved when the appropriate imaging protocols were applied. SS-OCT may show superior diagnostic and preoperative capabilities when compared to SD-OCT in the settings of asteroid hyalosis-induced media opacity. [Ophthalmic Surg Lasers Imaging Retina. 2014;45:xxx-xxx.].
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Choroidal analysis in healthy eyes using swept-source optical coherence tomography compared to spectral domain optical coherence tomography.
Am. J. Ophthalmol.
PUBLISHED: 02-12-2014
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To compare analyses of choroidal thickness and volume in healthy eyes measured concurrently with prototype long-wavelength swept-source optical coherence tomography (OCT) and commercially available spectral-domain optical coherence tomography (OCT) with and without enhanced depth imaging (EDI).
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Retinal telangiectasis detected during a vision screening examination in a child with hearing loss led to the diagnosis of facioscapulohumeral muscular dystrophy.
J AAPOS
PUBLISHED: 02-07-2014
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A 2-year-old girl with congenital sensorineural hearing loss was found to have retinal exudation and subretinal fluid in her left eye. Further investigation revealed leaking retinal telangiectasias in her left eye and extensive areas of peripheral retinal nonperfusion in both eyes. A clinical diagnosis of facioscapulohumeral muscular dystrophy (FSHD) was confirmed by genetic testing. The patient was followed with serial intraoperative optical coherence tomography (OCT) scans, which demonstrated subretinal fluid in the macula and its subsequent resolution after treatment. She underwent 6 rounds of panretinal photocoagulation and 2 injections of intravitreal bevacizumab, which resolved the subretinal fluid and exudates.
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Retinopathy of prematurity and brain damage in the very preterm newborn.
J AAPOS
PUBLISHED: 01-09-2014
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To explain why very preterm newborns who develop retinopathy of prematurity (ROP) appear to be at increased risk of abnormalities of both brain structure and function.
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Analysis of short-term change in subfoveal choroidal thickness in eyes with age-related macular degeneration using optical coherence tomography.
Ophthalmic Surg Lasers Imaging Retina
PUBLISHED: 01-08-2014
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To measure the subfoveal choroidal thickness in patients with age-related macular degeneration (AMD) over 6 months.
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Enhanced vitreous imaging in healthy eyes using swept source optical coherence tomography.
PLoS ONE
PUBLISHED: 01-01-2014
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To describe enhanced vitreous imaging for visualization of anatomic features and microstructures within the posterior vitreous and vitreoretinal interface in healthy eyes using swept-source optical coherence tomography (SS-OCT). The study hypothesis was that long-wavelength, high-speed, volumetric SS-OCT with software registration motion correction and vitreous window display or high-dynamic-range (HDR) display improves detection sensitivity of posterior vitreous and vitreoretinal features compared to standard OCT logarithmic scale display.
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Direct comparison of spectral-domain and swept-source OCT in the measurement of choroidal thickness in normal eyes.
Br J Ophthalmol
PUBLISHED: 11-28-2013
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To compare spectral-domain optic coherence tomography (SD-OCT) and swept-source OCT (SS-OCT) in the study of choroidal thickness (CT) in healthy eyes.
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Canine multifocal retinopathy caused by a BEST1 mutation in a Boerboel.
Vet Ophthalmol
PUBLISHED: 09-03-2013
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A 7-month-old male intact Boerboel presented to the Cummings School of Veterinary Medicine at Tufts University for the evaluation of ocular discharge. Bilateral multifocal serous retinal detachments were noted on fundus examination as an incidental finding. Genetic testing confirmed the dog to be homozygous for a mutation in the BEST1 gene, where a C73 T/R25 X change results in premature termination codon. Further testing, including electroretinography and optical coherence tomography (OCT), demonstrated that there was no evidence of retinal photoreceptor dysfunction and confirmed that observed lesions were characteristic of canine multifocal retinopathy. No progression of the lesions was noted 3 months after the initial examination. To the authors knowledge, this is the first report of canine multifocal retinopathy in the Boerboel breed.
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Analysis of morphological features and vascular layers of choroid in diabetic retinopathy using spectral-domain optical coherence tomography.
JAMA Ophthalmol
PUBLISHED: 08-03-2013
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Diabetic retinopathy (DR) is characterized by microaneurysms, capillary nonperfusion, and ischemia within the retina, ultimately leading to neovascularization and/or macular edema. Evidence suggests that choroidal angiopathy may coexist with retinal vascular damage. Recent advances in spectral-domain optical coherence tomography (SD-OCT) permit an efficient visualization of the choroid.
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Oct-based interpretation of the vitreomacular interface and indications for pharmacologic vitreolysis.
Retina (Philadelphia, Pa.)
PUBLISHED: 07-25-2013
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To review the role of optical coherence tomography (OCT) in diagnosis and management of vitreomacular disease and the impact of OCT on potential uses of ocriplasmin, a new pharmacologic vitreolysis agent recently approved by the U.S. Food and Drug Administration for the treatment of symptomatic vitreomacular adhesion.
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Retinal pigment epithelial detachment with disgorgement in age-related macular degeneration observed with OCT.
Ophthalmic Surg Lasers Imaging Retina
PUBLISHED: 07-20-2013
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This report describes a rare appearance of retinal pigment epithelial changes in a 71-year-old woman with known long-standing, non-exudative age-related macular degeneration. She presented with visual distortion in her right eye and was found to have a retinal pigment epithelial detachment (RPED) on optical coherence tomography (OCT). Over the following 8 years, sequential OCT imaging revealed an appearance and progression of a break in the existing RPED, disgorgement of material from within the RPED, and appearance of hyper-reflective spots within the inner retinal layers, suggesting pigment epithelial cell migration. Visual acuity remained stable over this period. The RPED resolved spontaneously without treatment. The patient later developed new intraretinal hemorrhage, which was treated with intravitreal bevacizumab.
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En Face Enhanced-Depth Swept-Source Optical Coherence Tomography Features of Chronic Central Serous Chorioretinopathy.
Ophthalmology
PUBLISHED: 07-09-2013
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To characterize en face features of the retinal pigment epithelium (RPE) and choroid in eyes with chronic central serous chorioretinopathy (CSCR) using a high-speed, enhanced-depth swept-source optical coherence tomography (SS-OCT) prototype.
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The relationship between retinal and choroidal thickness and visual acuity in highly myopic eyes.
Br J Ophthalmol
PUBLISHED: 06-13-2013
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To correlate visual acuity in highly myopic eyes without macular disease with retinal and choroidal thickness as measured by spectral-domain optical coherence tomography (OCT).
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The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Ophthalmology
PUBLISHED: 04-26-2013
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The International Vitreomacular Traction Study (IVTS) Group was convened to develop an optical coherence tomography (OCT)-based anatomic classification system for diseases of the vitreomacular interface (VMI).
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Exercise-induced acute changes in systolic blood pressure do not alter choroidal thickness as measured by a portable spectral-domain optical coherence tomography device.
Retina (Philadelphia, Pa.)
PUBLISHED: 04-26-2013
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To measure choroidal thickness in patients manifesting an acute change in systemic arterial blood pressure using a portable spectral-domain optical coherence tomography device (iVue).
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Reproducibility of a long-range swept-source optical coherence tomography ocular biometry system and comparison with clinical biometers.
Ophthalmology
PUBLISHED: 04-05-2013
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To demonstrate a novel swept source optical coherence tomography (SS-OCT) imaging device using a vertical cavity surface-emitting laser (VCSEL) capable of imaging the full eye length and to introduce a method using this device for noncontact ocular biometry. To compare the measurements of intraocular distances using this SS-OCT instrument with commercially available optical and ultrasound biometers. To evaluate the intersession reproducibility of measurements of intraocular distances using SS-OCT.
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Spontaneous improvement of macular traction retinal detachment associated with myopic macular schisis.
Ophthalmic Surg Lasers Imaging Retina
PUBLISHED: 03-10-2013
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High myopia can be associated with a range of pathologic changes within the macula that are now easily appreciated with optical coherence tomography. In the setting of high myopia and a macular traction retinal detachment, the expectation is for progressive worsening over time, and surgical intervention is often undertaken early. The authors present a case of spontaneous improvement of myopic macular detachment, which illustrates the potential value of an initial period of observation in this clinical setting.
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Optical coherence tomography--current and future applications.
Curr Opin Ophthalmol
PUBLISHED: 02-23-2013
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Optical coherence tomography (OCT) has revolutionized the clinical practice of ophthalmology. It is a noninvasive imaging technique that provides high-resolution, cross-sectional images of the retina, retinal nerve fiber layer and the optic nerve head. This review discusses the present applications of the commercially available spectral-domain OCT (SD-OCT) systems in the diagnosis and management of retinal diseases, with particular emphasis on choroidal imaging. Future directions of OCT technology and their potential clinical uses are discussed.
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De novo appearance of a choroidal osteoma in an eye with previous branch retinal vein occlusion.
Ophthalmic Surg Lasers Imaging Retina
PUBLISHED: 02-16-2013
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This report describes the de novo appearance of a choroidal osteoma occurring 8 years after laser photocoagulation for previous branch retinal vein occlusion (BRVO). A 62-year-old man presented with an asymptomatic yellowish orange lesion in the macula on fundus examination of his left eye during a regular follow-up visit for bilateral BRVO associated with macular edema that had previously been treated with laser photocoagulation. The lesion was observed for 1.5 years until a decrease in vision occurred. Fundus photography revealed a yellow-to-orange, well-defined lesion in the macular region. Fluorescein angiography was consistent with choroidal neovascularization (CNV). Optical coherence tomography and B-scan ultrasonography showed features consistent with choroidal osteoma. This is the first report of the de novo appearance of a choroidal osteoma occurring years after laser photocoagulation for BRVO. CNV developed secondary to the lesion, which was treated with intravitreal bevacizumab, leading to subjective and anatomic improvement.
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Analysis of the morphology and vascular layers of the choroid in retinitis pigmentosa using spectral-domain OCT.
Ophthalmic Surg Lasers Imaging Retina
PUBLISHED: 02-14-2013
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To analyze choroidal morphology and vascular layers in eyes with retinitis pigmentosa (RP) using spectral-domain optical coherence tomography.
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Retinal neovascularization secondary to proliferative diabetic retinopathy characterized by spectral domain optical coherence tomography.
Retina (Philadelphia, Pa.)
PUBLISHED: 02-13-2013
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The purpose of this study was to characterize diabetic retinal neovascularization (NV) and accompanying retinal and vitreal morphologic changes using high-resolution spectral domain optical coherence tomography.
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Phase-sensitive swept-source optical coherence tomography imaging of the human retina with a vertical cavity surface-emitting laser light source.
Opt Lett
PUBLISHED: 02-06-2013
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Despite the challenges in achieving high phase stability, Doppler swept-source/Fourier-domain optical coherence tomography (OCT) has advantages of less fringe washout and faster imaging speeds compared to spectral/Fourier-domain detection. This Letter demonstrates swept-source OCT with a vertical cavity surface-emitting laser light source at 400 kHz sweep rate for phase-sensitive Doppler imaging, measuring pulsatile total retinal blood flow with high sensitivity and phase stability. A robust, simple, and computationally efficient phase stabilization approach for phase-sensitive swept-source imaging is also presented.
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Enhanced visualization of the choroido-scleral interface using swept-source OCT.
Ophthalmic Surg Lasers Imaging Retina
PUBLISHED: 01-28-2013
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An accurate analysis of the thickness and volume of choroid using optical coherence tomography (OCT) requires precise visualization of the choroido-scleral interface. Results of studies that use spectral-domain OCT (SD-OCT) to look at the percent visualization of the choroido-scleral interface for accurate analysis of choroidal thickness show varying success rates. This study assessed the visualization of choroido-scleral interface in 19 healthy participants (19 eyes) prospectively recruited for consecutive high-definition raster scanning with an SD-OCT system with and without enhanced depth imaging (EDI) and a prototype long-wavelength swept-source OCT (SS-OCT) system. Choroido-scleral interface was visualized in all eyes imaged on SS-OCT, compared with 13 of 19 (68.4%) and 14 of 19 (73.6%) eyes imaged on SD-OCT without EDI (P = .009) and with EDI (P = .02), respectively. The prototype long-wavelength SS-OCT system, with its higher acquisition speed and deeper tissue penetration, may have better clinical utility in determining the involvement of choroid in various chorioretinal diseases.
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Optical coherence tomography-guided facedown positioning for macular hole surgery.
Retina (Philadelphia, Pa.)
PUBLISHED: 01-25-2013
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To use spectral domain optical coherence tomography-guided duration of facedown positioning to study anatomical macular hole closure rates.
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In vivo imaging of the rodent eye with swept source/Fourier domain OCT.
Biomed Opt Express
PUBLISHED: 01-14-2013
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Swept source/Fourier domain OCT is demonstrated for in vivo imaging of the rodent eye. Using commercial swept laser technology, we developed a prototype OCT imaging system for small animal ocular imaging operating in the 1050 nm wavelength range at an axial scan rate of 100 kHz with ~6 µm axial resolution. The high imaging speed enables volumetric imaging with high axial scan densities, measuring high flow velocities in vessels, and repeated volumetric imaging over time. The 1050 nm wavelength light provides increased penetration into tissue compared to standard commercial OCT systems at 850 nm. The long imaging range enables multiple operating modes for imaging the retina, posterior eye, as well as anterior eye and full eye length. A registration algorithm using orthogonally scanned OCT volumetric data sets which can correct motion on a per A-scan basis is applied to compensate motion and merge motion corrected volumetric data for enhanced OCT image quality. Ultrahigh speed swept source OCT is a promising technique for imaging the rodent eye, proving comprehensive information on the cornea, anterior segment, lens, vitreous, posterior segment, retina and choroid.
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Analysis of choroidal morphologic features and vasculature in healthy eyes using spectral-domain optical coherence tomography.
Ophthalmology
PUBLISHED: 01-11-2013
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To analyze the morphologic features and vasculature of the choroid in healthy eyes using spectral-domain (SD) optical coherence tomography (OCT).
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Choriocapillaris and Choroidal Microvasculature Imaging with Ultrahigh Speed OCT Angiography.
PLoS ONE
PUBLISHED: 01-01-2013
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We demonstrate in vivo choriocapillaris and choroidal microvasculature imaging in normal human subjects using optical coherence tomography (OCT). An ultrahigh speed swept source OCT prototype at 1060 nm wavelengths with a 400 kHz A-scan rate is developed for three-dimensional ultrahigh speed imaging of the posterior eye. OCT angiography is used to image three-dimensional vascular structure without the need for exogenous fluorophores by detecting erythrocyte motion contrast between OCT intensity cross-sectional images acquired rapidly and repeatedly from the same location on the retina. En face OCT angiograms of the choriocapillaris and choroidal vasculature are visualized by acquiring cross-sectional OCT angiograms volumetrically via raster scanning and segmenting the three-dimensional angiographic data at multiple depths below the retinal pigment epithelium (RPE). Fine microvasculature of the choriocapillaris, as well as tightly packed networks of feeding arterioles and draining venules, can be visualized at different en face depths. Panoramic ultra-wide field stitched OCT angiograms of the choriocapillaris spanning ?32 mm on the retina show distinct vascular structures at different fundus locations. Isolated smaller fields at the central fovea and ?6 mm nasal to the fovea at the depths of the choriocapillaris and Sattlers layer show vasculature structures consistent with established architectural morphology from histological and electron micrograph corrosion casting studies. Choriocapillaris imaging was performed in eight healthy volunteers with OCT angiograms successfully acquired from all subjects. These results demonstrate the feasibility of ultrahigh speed OCT for in vivo dye-free choriocapillaris and choroidal vasculature imaging, in addition to conventional structural imaging.
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Neonatal bacteremia and retinopathy of prematurity: the ELGAN study.
Arch. Ophthalmol.
PUBLISHED: 12-14-2011
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To explore whether early or late and presumed or definite neonatal bacteremia are associated with an increased risk of severe retinopathy of prematurity (ROP).
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Analysis of visual toxicity after gamma knife radiosurgery for treatment of choroidal melanoma: identification of multiple targets and mechanisms of toxicity.
Am. J. Clin. Oncol.
PUBLISHED: 11-01-2011
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Identification of the targets of radiation damage after radiosurgical treatment of ocular melanoma will potentially allow for sparing of vision with improved treatment planning.
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Endophthalmitis in microincision vitrectomy: outcomes of gas-filled eyes.
Retina (Philadelphia, Pa.)
PUBLISHED: 09-01-2011
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To assess whether performing an air or gas exchange at the conclusion of a microincision vitrectomy procedure is beneficial regarding the rate of endophthalmitis.
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Posterior lattice degeneration characterized by spectral domain optical coherence tomography.
Retina (Philadelphia, Pa.)
PUBLISHED: 05-13-2011
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The purpose of this study was to use high-resolution spectral domain optical coherence tomography in the characterization of retinal and vitreal morphological changes overlying posterior lattice degeneration.
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Analysis of peripapillary atrophy using spectral domain optical coherence tomography.
Ophthalmology
PUBLISHED: 04-28-2011
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To study retinal morphologic changes around the optic disc in patients with peripapillary atrophy (PPA) with high-resolution spectral domain optical coherence tomography (SD OCT).
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Retinal nerve fibre layer and visual function loss in glaucoma: the tipping point.
Br J Ophthalmol
PUBLISHED: 04-08-2011
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To determine the retinal nerve fibre layer (RNFL) thickness at which visual field (VF) damage becomes detectable and associated with structural loss.
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Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT.
Biomed Opt Express
PUBLISHED: 03-16-2011
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Doppler OCT provides depth-resolved information on flow in biological tissues. In this article, we demonstrate ultrahigh speed swept source/Fourier domain OCT for visualization and quantitative assessment of retinal blood flow. Using swept laser technology, the system operated in the 1050-nm wavelength range at a high axial scan rate of 200 kHz. The rapid imaging speed not only enables volumetric imaging with high axial scan densities, but also enables measurement of high flow velocities in the central retinal vessels. Deep penetration in the optic nerve and lamina cribrosa was achieved by imaging at 1-µm wavelengths. By analyzing en-face images extracted from 3D Doppler data sets, absolute flow in single vessels as well as total retinal blood flow was measured using a simple and robust protocol that does not require measurement of Doppler angles. The results from measurements in healthy eyes suggest that ultrahigh speed swept source/Fourier domain OCT could be a promising technique for volumetric imaging of retinal vasculature and quantitation of retinal blood flow in a wide range of retinal diseases.
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Reproducibility of choroidal thickness measurements across three spectral domain optical coherence tomography systems.
Ophthalmology
PUBLISHED: 03-09-2011
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To investigate the reproducibility of choroidal thickness measurements in normal subjects on 3 spectral domain optical coherence tomography (SD-OCT) instruments: Zeiss Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA), Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany), and Optovue RTVue (Optovue Inc., Fremont, CA).
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Analysis of choroidal thickness in age-related macular degeneration using spectral-domain optical coherence tomography.
Am. J. Ophthalmol.
PUBLISHED: 03-04-2011
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To understand the relationship between choroidal thickness and various disease factors in patients with age-related macular degeneration (AMD) using spectral-domain optical coherence tomography.
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Analysis of normal peripapillary choroidal thickness via spectral domain optical coherence tomography.
Ophthalmology
PUBLISHED: 02-02-2011
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To analyze the normal peripapillary choroidal thickness utilizing a commercial spectral domain optical coherence tomography (OCT) device and determine the intergrader reproducibility of this method.
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The role of spectral-domain OCT in the diagnosis and management of neovascular age-related macular degeneration.
Ophthalmic Surg Lasers Imaging
PUBLISHED: 02-01-2011
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Spectral-domain optical coherence tomography (SD-OCT) has emerged as the ancillary examination of choice to assist the diagnosis and management of neovascular age-related macular degeneration (AMD). SD-OCT provides more detailed images of intraretinal, subretinal, and subretinal pigment epithelium fluid when compared to time-domain technology, leading to higher and earlier detection rates of neovascular AMD activity. Improvements in image analysis and acquisition speed make it important for decision-making in the diagnosis and treatment of this disease. However, this new technology needs to be validated for its role in the improvement of visual outcomes in the context of anti-angiogenic therapy.
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The Role of Spectral-Domain OCT in the Diagnosis and Management of Neovascular Age-Related Macular Degeneration.
Ophthalmic Surg Lasers Imaging
PUBLISHED: 02-01-2011
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Spectral-domain optical coherence tomography (SD-OCT) has emerged as the ancillary examination of choice to assist the diagnosis and management of neovascular age-related macular degeneration (AMD). SD-OCT provides more detailed images of intraretinal, subretinal, and subretinal pigment epithelium fluid when compared to time-domain technology, leading to higher and earlier detection rates of neovascular AMD activity. Improvements in image analysis and acquisition speed make it important for decision-making in the diagnosis and treatment of this disease. However, this new technology needs to be validated for its role in the improvement of visual outcomes in the context of anti-angiogenic therapy.
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A 17-year retrospective study of institutional results for eye plaque brachytherapy of uveal melanoma using (125)I, (103)Pd, and (131)Cs and historical perspective.
Brachytherapy
PUBLISHED: 01-14-2011
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To compare overall survival, local and distant failure rates, ocular toxicity, and vision preservation in patients treated with eye plaque brachytherapy at Tufts Medical Center with those in the published literature.
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Diffuse retinal pigment epithelial disease in an adult with cystic fibrosis.
Ophthalmic Surg Lasers Imaging
PUBLISHED: 01-11-2011
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An adult with cystic fibrosis presented for decreased vision in the right eye of several months duration. Biomicroscopy and fluorescein angiography demonstrated bilateral large subretinal drusenoid deposits concentrated temporal to the fovea, as well as a small subretinal hemorrhage associated with focal leakage of fluid within the macula in the right eye. Optical coherence tomography demonstrated subretinal fluid consistent with choroidal neovascular membrane in the right eye with the absence of fluid in the left eye. The retinal manifestations of bilateral diffuse drusen associated with choroidal neovascular membrane may be consistent with autosomal dominant drusen, age-related macular degeneration, and type II glomerulonephritis, or alternatively may be a unique finding associated with cystic fibrosis. To the authors knowledge, these findings have not previously been described in association with cystic fibrosis.
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Intact Retinal Tissue and Retinal Pigment Epithelium Identified within a Coloboma Via High-Speed, Ultrahigh Resolution Optical Coherence Tomography.
Retin Cases Brief Rep
PUBLISHED: 01-11-2011
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PURPOSE: To report on a posterior segment coloboma manifesting unusual morphology as determined by high-speed, ultrahigh resolution optical coherence tomography imaging (hsUHR-OCT). METHODS: A 47-year-old patient with bilateral colobomas was evaluated via fundus examination and hsUHR-OCT. RESULTS: Imaging with hsUHR-OCT showed intact retinal pigment epithelium (RPE) within the posterior segment coloboma. Most of the retinal layers appeared to continue into the coloboma, although they exhibited slight attenuation. The external limiting membrane (ELM) was clearly visible continuing within the coloboma, suggesting that Muller cells and the inner segments of the photoreceptors were still present in this area. The junction between the inner and outer segments of the photoreceptors ended at the margin of the coloboma, which may be due to either photoreceptor disruption or a change in the orientation of the outer segments. CONCLUSION: hsUHR-OCT demonstrated the presence of Muller cells and photoreceptor inner segments within a posterior segment coloboma. The retinal pigment epithelium (RPE) was intact within the coloboma, representing an unusual morphology.
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Computerized macular pathology diagnosis in spectral domain optical coherence tomography scans based on multiscale texture and shape features.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 01-01-2011
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To develop an automated method to identify the normal macula and three macular pathologies (macular hole [MH], macular edema [ME], and age-related macular degeneration [AMD]) from the fovea-centered cross sections in three-dimensional (3D) spectral-domain optical coherence tomography (SD-OCT) images.
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Ocular melanoma.
Arch. Pathol. Lab. Med.
PUBLISHED: 12-07-2010
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Intraocular melanoma of the ciliary body and choroid is the most common primary ocular malignant tumor in adults and the most common noncutaneous melanoma.
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Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second.
Opt Express
PUBLISHED: 10-14-2010
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We demonstrate ultrahigh speed swept source/Fourier domain ophthalmic OCT imaging using a short cavity swept laser at 100,000 - 400,000 axial scan rates. Several design configurations illustrate tradeoffs in imaging speed, sensitivity, axial resolution, and imaging depth. Variable rate A/D optical clocking is used to acquire linear-in-k OCT fringe data at 100 kHz axial scan rate with 5.3 um axial resolution in tissue. Fixed rate sampling at 1 GSPS achieves a 7.5mm imaging range in tissue with 6.0 um axial resolution at 100 kHz axial scan rate. A 200 kHz axial scan rate with 5.3 um axial resolution over 4mm imaging range is achieved by buffering the laser sweep. Dual spot OCT using two parallel interferometers achieves 400 kHz axial scan rate, almost 2X faster than previous 1050 nm ophthalmic results and 20X faster than current commercial instruments. Superior sensitivity roll-off performance is shown. Imaging is demonstrated in the human retina and anterior segment. Wide field 12x12 mm data sets include the macula and optic nerve head. Small area, high density imaging shows individual cone photoreceptors. The 7.5 mm imaging range configuration can show the cornea, iris, and anterior lens in a single image. These improvements in imaging speed and depth range provide important advantages for ophthalmic imaging. The ability to rapidly acquire 3D-OCT data over a wide field of view promises to simplify examination protocols. The ability to image fine structures can provide detailed information on focal pathologies. The large imaging range and improved image penetration at 1050 m wavelengths promises to improve performance for instrumentation which images both the retina and anterior eye. These advantages suggest that swept source OCT at 1050 nm wavelengths will play an important role in future ophthalmic instrumentation.
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Foveoschisis Without High Myopia.
Ophthalmic Surg Lasers Imaging
PUBLISHED: 03-27-2010
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Two patients presented complaints of visual acuity worsening in one eye. During examination they showed optical coherence tomography (OCT) and clinical findings indistingishable from myopic foveoschisis, although both had minimal refractive errors. One of the patients was followed without surgery until the disease progressed and the visual acuity decreased. The second patient presented with lamellar macular hole associated with the foveoschisis. Both patients underwent pars plana vitrectomy with pre-retinal membranes peeling and intra-vitreal gas infusion and both developed full-thickness macular hole after surgery. The second patient underwent a second surgery with peeling of the internal limiting membrane (ILM) and with successful macular hole closure. OCT was performed at the initial and follow-up visits. In conclusion, foveoschisis may develop in eyes without high myopia. The causative factors, OCT findings and surgical outcomes are very similar to myopic foveoschisis.
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Spontaneous Progression of a Long-Standing Lamellar Macular Hole into a Full-Thickness Macular Hole.
Ophthalmic Surg Lasers Imaging
PUBLISHED: 03-27-2010
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One patient with past ocular history of full thickness macular hole surgically closed in the right eye was followed with diagnostic of lamellar macular hole in the left eye since 2000. After uncomplicated cataract surgery in the left eye in March 2008, the lamellar hole spontaneously progressed to full thickness macular hole. The patient underwent pars plana vitrectomy, membrane peel and gas bubble injection, with successful closure of the macular hole and improvement in the visual acuity. Optical coherence tomography (OCT) scans through the macula were performed at the initial and follow-up visits. To the best of our knowledge, this is the first description of a long-standing stable lamellar macular hole progressing into a full thickness macular hole. The causative factors for this progression remain unclear.
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Clinical assessment of mirror artifacts in spectral-domain optical coherence tomography.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 02-24-2010
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PURPOSE. To investigate the characteristics of a spectral-domain optical coherence tomography (SD-OCT) image phenomenon known as the mirror artifact, calculate its prevalence, analyze potential risk factors, measure severity, and correlate it to spherical equivalent and central visual acuity (VA). METHODS. OCT macular cube 512 x 128 scans taken between January 2008 and February 2009 at the New England Eye Center were analyzed for the presence of mirror artifacts. Artifact severity was determined by the degree of segmentation breakdown that it caused on the macular map. A retrospective review was conducted of the medical records of patients with artifacts and of a random control group without artifacts. RESULTS. Of 1592 patients, 9.3% (148 patients, 200 eyes) had scans that contained mirror artifacts. A significantly more myopic spherical equivalent (P < 0.001), worse VA (P < 0.001), longer axial lengths (P = 0.004), and higher proportions of moderate to high myopia (P < 0.001) were found in patients with mirror artifacts than in patients without artifacts. Worse VA was associated with increased artifact severity (P = 0.04). CONCLUSIONS. In all scans analyzed, a high prevalence of mirror artifacts was found. This image artifact was often associated with patients with moderate to high myopia. Improvements in instrumentation may be necessary to resolve this problem in moderately and highly myopic eyes. Operators should be advised to properly position the retina when scanning eyes. In cases in which peripheral abnormalities in topographic measurements of retinal thickness are found, corresponding OCT scans should be examined for the presence of mirror artifacts.
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Cystoid macular edema without macular thickening: a retrospective optical coherence tomographic study.
Retina (Philadelphia, Pa.)
PUBLISHED: 02-20-2010
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This is a retrospective observational case series of 37 eyes of 32 patients meeting the inclusion criteria intended to describe the appearance, prevalence, and associated risk factors for cystoid macular edema in eyes with normal foveal thickness and contour as determined by optical coherence tomography (OCT).
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Documentation of intraretinal retinal pigment epithelium migration via high-speed ultrahigh-resolution optical coherence tomography.
Ophthalmology
PUBLISHED: 02-02-2010
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To describe the features of intraretinal retinal pigment epithelium (RPE) migration documented on a prototype spectral-domain, high-speed, ultrahigh-resolution optical coherence tomography (OCT) device in a group of patients with early to intermediate dry age-related macular degeneration (AMD) and to correlate intraretinal RPE migration on OCT to RPE pigment clumping on fundus photographs.
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Anatomic and visual outcomes of vitrectomy for vitreomacular traction syndrome.
Ophthalmic Surg Lasers Imaging
PUBLISHED: 01-28-2010
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To assess anatomic and visual outcomes after pars plana vitrectomy for vitreomacular traction syndrome.
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Anatomic and visual outcomes of vitrectomy for lamellar macular holes.
Ophthalmic Surg Lasers Imaging
PUBLISHED: 01-28-2010
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To assess anatomic and visual outcomes after pars plana vitrectomy for lamellar macular holes.
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Treatment of acute retinal necrosis.
Ophthalmology
PUBLISHED: 01-15-2010
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To compare outcomes from patients with acute retinal necrosis (ARN) treated in the acyclovir-only era with those treated in the era of newer antiviral therapies, identify variables affecting outcomes in ARN, and evaluate strategies for fellow eye prophylaxis.
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Choroidal thickness in normal eyes measured using Cirrus HD optical coherence tomography.
Am. J. Ophthalmol.
PUBLISHED: 01-11-2010
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To examine choroidal thickness and area in healthy eyes using spectral-domain optical coherence tomography (SD-OCT).
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Short-term safety of 23-gauge single-step transconjunctival vitrectomy surgery.
Retina (Philadelphia, Pa.)
PUBLISHED: 08-22-2009
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The purpose of this study was to report the safety profile of the Alcon 23-gauge single-step preloaded transconjunctival vitrectomy system.
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High-speed ultrahigh resolution optical coherence tomography before and after ranibizumab for age-related macular degeneration.
Ophthalmology
PUBLISHED: 05-05-2009
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To evaluate intraretinal anatomy in patients with exudative age-related macular degeneration (AMD) using high-speed ultrahigh resolution optical coherence tomography (hsUHR-OCT) before and 1 month after intravitreal injection of ranibizumab.
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Analysis of the outer retina reconstructed by high-resolution, three-dimensional spectral domain optical coherence tomography.
Ophthalmic Surg Lasers Imaging
PUBLISHED: 03-27-2009
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A retrospective cross-sectional study was conducted to demonstrate an analysis of an outer retinal layer reconstructed by the three-dimensional and high-speed spectral domain optical coherence tomography (SD-OCT) instrument.
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Three-dimensional optical coherence tomography (3D-OCT) image enhancement with segmentation-free contour modeling C-mode.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 03-24-2009
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To develop a semiautomated method to visualize structures of interest (SoIs) along their contour within three-dimensional, spectral domain optical coherence tomography (3D SD-OCT) data, without the need for segmentation.
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Assessment of artifacts and reproducibility across spectral- and time-domain optical coherence tomography devices.
Ophthalmology
PUBLISHED: 03-18-2009
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To report the frequency of optical coherence tomography (OCT) scan artifacts and to compare macular thickness measurements, interscan reproducibility, and interdevice agreeability across 3 spectral-domain (SD) OCT (also known as Fourier domain; Cirrus HD-OCT, RTVue-100, and Topcon 3D-OCT 1000) devices and 1 time-domain (TD) OCT (Stratus OCT) device.
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Dose de-escalation with gamma knife radiosurgery in the treatment of choroidal melanoma.
Int. J. Radiat. Oncol. Biol. Phys.
PUBLISHED: 03-13-2009
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Single-fraction targeted radiation therapy delivered by the Leksell Gamma Knife system is a minimally invasive treatment option for choroidal melanoma that has been used as an alternative to enucleation, proton beam therapy, or brachytherapy. Previously reported Gamma Knife series involved the treatment of choroidal melanomas with a dose of 40 to 50 Gy at the tumor margin. We report our institutional experience using a significantly lower dose.
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Anatomic and visual outcomes of noninfectious endophthalmitis after intravitreal triamcinolone.
Am. J. Ophthalmol.
PUBLISHED: 03-09-2009
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To describe the anatomic and visual outcomes of patients in whom noninfectious endophthalmitis developed after injection of intravitreal triamcinolone acetonide.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.