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Find video protocols related to scientific articles indexed in Pubmed.
[A focused sound field measurement system by LabVIEW].
Zhongguo Yi Liao Qi Xie Za Zhi
PUBLISHED: 09-23-2014
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In this paper, according to the requirement of the focused sound field measurement, a focused sound field measurement system was established based on the LabVIEW virtual instrument platform. The system can automatically search the focus position of the sound field, and adjust the scanning path according to the size of the focal region. Three-dimensional sound field scanning time reduced from 888 hours in uniform step to 9.25 hours in variable step. The efficiency of the focused sound field measurement was improved. There is a certain deviation between measurement results and theoretical calculation results. Focal plane--6 dB width difference rate was 3.691%, the beam axis--6 dB length differences rate was 12.937%.
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[Temperature distribution based on Monte Carlo method of optical transmission in tissues of laser ablation].
Zhongguo Yi Liao Qi Xie Za Zhi
PUBLISHED: 11-08-2013
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Monte Carlo method was used for calculation of finite-diameter laser distribution in tissues through convolution operation. Photo-thermal ablation model was set up on the basis of Pennes bioheat equation, and tissue temperature distribution was simulated by using finite element method by ANSYS through the model. The simulation result is helpful for clinical application of laser.
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New treatment strategy of cryosurgery and temperature control.
Conf Proc IEEE Eng Med Biol Soc
PUBLISHED: 10-11-2013
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Cryosurgery, recommended as an effective method for tumor treatment, has been widely used in clinics. However, it might lead to a high probability of tumor recurrence due to incomplete tumor damage. The treatment protocol for cryosurgery is essential to achieve the desired therapeutic effects. In this study, a new temperature fluctuation treatment method was proposed, and the fuzzy control method based on piecewise adjustment was developed for temperature control during the treatment. Ex vivo rat liver experiments were conducted and histopathology analysis used to study the therapeutic effects of the new treatment method.
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[Perfluoropentane droplets enhanced HIFU therapeutic effect].
Zhongguo Yi Liao Qi Xie Za Zhi
PUBLISHED: 09-11-2013
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A small HIFU system was used to investigate the phase-shift droplet vaporization in vivo and its effect on thermal absorption in tissue-mimicking phantoms. The experiments demonstrated that droplets could be vaporized to bubbles in vivo by the small HIFU system and the volume of bubbles could increase by tens of times. With appropriate droplets concentration, lesion volume produced by HIFU could be increased significantly under the same HIFU parameter.
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Transcostal high-intensity focused ultrasound treatment using phased array with geometric correction.
J. Acoust. Soc. Am.
PUBLISHED: 08-10-2013
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In the high-intensity focused ultrasound treatment of liver tumors, ultrasound propagation is affected by the rib cage. Because of the diffraction and absorption of the bone, the sound distribution at the focal plane is altered, and more importantly, overheating on the rib surface might occur. To overcome these problems, a geometric correction method is applied to turn off the elements blocked by the ribs. The potential of steering the focus of the phased-array along the propagation direction to improve the transcostal treatment was investigated by simulations and experiments using different rib models and transducers. The ultrasound propagation through the ribs was computed by a hybrid method including the Rayleigh-Sommerfeld integral, k-space method, and angular spectrum method. A modified correction method was proposed to adjust the output of elements based on their relative area in the projected "shadow" of the ribs. The simulation results showed that an increase in the specific absorption rate gain up to 300% was obtained by varying the focal length although the optimal value varied in each situation. Therefore, acoustic simulation is required for each clinical case to determine a satisfactory treatment plan.
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Quantitative assessment of acoustic intensity in the focused ultrasound field using hydrophone and infrared imaging.
Ultrasound Med Biol
PUBLISHED: 05-08-2013
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With the popularity of ultrasound therapy in clinics, characterization of the acoustic field is important not only to the tolerability and efficiency of ablation, but also for treatment planning. A quantitative method was introduced to assess the intensity distribution of a focused ultrasound beam using a hydrophone and an infrared camera with no prior knowledge of the acoustic and thermal parameters of the absorber or the configuration of the array elements. This method was evaluated in both theoretical simulations and experimental measurements. A three-layer model was developed to calculate the acoustic field in the absorber, the absorbed acoustic energy during the sonication and the consequent temperature elevation. Experiments were carried out to measure the acoustic pressure with the hydrophone and the temperature elevation with the infrared camera. The percentage differences between the derived results and the simulation are <4.1% for on-axis intensity and <21.1% for -6-dB beam width at heating times up to 360 ms in the focal region of three phased-array ultrasound transducers using two different absorbers. The proposed method is an easy, quick and reliable approach to calibrating focused ultrasound transducers with satisfactory accuracy.
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[Calculation of parameters and accurate control with real-time compensator in drive system of pulsatile blood pump].
Zhongguo Yi Liao Qi Xie Za Zhi
PUBLISHED: 06-29-2011
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This article introduces a new method using the servo motor which is controlled by ARM microcontroller to provide power for a pulsatile blood pump to beat. This method is featured with straightforward structure, accurate control, excellent timeliness, stable performance and small noise. And it can adjust the rate of beat, the rate of flow and the compression ratio according to actual demand.
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Spontaneous formation and characterization of silica mesoporous crystal spheres with reverse multiply twinned polyhedral hollows.
J. Am. Chem. Soc.
PUBLISHED: 04-06-2011
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A crystal is an object with translational symmetry. Basic research into and production of new materials necessitates the preparation of crystals of a particular morphology and with well-defined crystal defects. In this work, we found novel silica mesoporous crystal spheres with polyhedral hollows (icosahedral, such as those observed for proteins of virus capsids, decahedral, Wulff polyhedral, etc.) formed by the reverse multiply twinned bicontinuous double diamond mesostructure. Vesicles with a low-curvature lamellar structure were first formed by the self-assembly of amphiphilic carboxylic acid molecules in the presence of a nonionic surfactant and then underwent a structural transformation process that gave a reverse multiply twinned mesoporous shell while maintaining the hollow shape. These polyhedral hollow crystals showed an enhanced contrast of backscattering signatures relative to the incident acoustic signals and thus could be used as a potential contrast agent in medical ultrasonography with drug loadings in the mesopores.
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Focus shift and phase correction in soft tissues during focused ultrasound surgery.
IEEE Trans Biomed Eng
PUBLISHED: 01-17-2011
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During the treatment of soft tissue tumors using focused ultrasound surgery (FUS), the focus can shift away from the desired point due to tissue inhomogeneity. In this paper, a numerical method to calculate the focus shift in multiple-layered tissues and a faster phase-correction method to restore the focus were developed. Data from the simulations showed that the focus shifted about 2 mm along the transducer axis in multiple-layered soft tissues. After phase correction, the focus was restored at the desired point. The ex vivo experiments were conducted to verify the simulations, and the results agreed well with those of the simulations. An empirical formula was obtained to estimate the focus shift in a two-layered water-tissue model and was verified by numerical calculations. Moreover, the focus shift in multiple-layered tissues can be summed by the shifts in the component of each layer of tissues. The factors affecting the focus shift were studied. The focus shift varied linearly with the tissue acoustic speed and tissue thickness, whereas it slightly changed with transducer F number (radius of curvature/diameter). Overall, the findings of this study can help in the development of a better treatment plan for FUS in soft tissues.
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Suppression of Aurora-A oncogenic potential by c-Myc downregulation.
Exp. Mol. Med.
PUBLISHED: 10-05-2010
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The abnormality of serine/threonine kinase Aurora-A is seen in many types of cancers. Although in physiological context it has been shown to play a vital role in cellular mitosis, how this oncogene contributes to tumorigenesis remains unclear. Here we demonstrate that Aurora-A overexpression enhances both the expression level and transcriptional activity of c-Myc. The inhibition of c-Myc expression by RNA interference significantly impaired the oncogenic potential of Aurora-A, resulting in attenuated cellular proliferation and transformation rates as well as fewer centrosomal aberrations. Furthermore, downregulation of c-Myc effectively overcame Aurora-A-induced resistance to cisplatin in esophageal cancer cells. Taken together, our results suggest an important role for c-Myc in mediating the oncogenic activity of Aurora-A, which may in turn allow for future targeting of c-Myc as a potential therapeutic strategy for tumors with Aurora-A overexpression.
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[Measurement and analysis of phased-array focused ultrasound field of two-foci pattern].
Zhongguo Yi Liao Qi Xie Za Zhi
PUBLISHED: 09-04-2010
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This paper introduces the simulation and measurement results of the phased-array focused ultrasound field of two-foci pattern.
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Inhibition of ErbB2 by Herceptin reduces survivin expression via the ErbB2-beta-catenin/TCF4-survivin pathway in ErbB2-overexpressed breast cancer cells.
Cancer Sci.
PUBLISHED: 02-11-2010
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Overexpression of ErbB2 is associated with poor prognosis in breast cancer. Targeting of ErbB2 is a very common therapeutic strategy in ErbB2-overexpressed breast cancer. Herceptin is the first approved and most widely used agent for ErbB2-targeting therapy in breast cancer. Even though the clinical application has been performed for more than 10 years, the exact mechanism underlying how Herceptin exhibits its effects has not been fully elucidated. In this study, we found that Herceptin could inhibit the expression of survivin in ErbB2-overexpressed cell lines. Overexpression of survivin could abrogate the inhibition of cell growth induced by Herceptin. Herceptin could reduce survivin expression at the transcriptional level. The beta-catenin/T-cell factor (TCF) pathway played a very crucial role in this cascade. We found that Herceptin could reduce tyrosine phosphorylation levels of ErbB2 and beta-catenin. Herceptin treatment induced degradation of beta-catenin protein, resulting in reduced binding affinity of beta-catenin/TCF4 to the promoter region of survivin. When we cross-mutated the TCF4 binding sites in the promoter region of survivin, the reduction of survivin promoter activity almost diminished. Taken together, we showed that Herceptin could inhibit survivin expression through the ErbB2-beta-catenin/TCF4-survivin pathway in ErbB2-overexpressed breast cancer cells. This indicates that there may be a new cascade axis from ErbB2 to survivin.
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[P-HIFU phased signal generator with highly precise timing function].
Zhongguo Yi Liao Qi Xie Za Zhi
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This article add mode control module to the phased-array using digital sampling technology which achieved a phase accuracy of 3.75 degrees, making phase, phased signal duration, interval for continuous signal and repeat times pre-configured before the out put of phased signal, to realize the precise timing of phased signal. Experiments indicate that the output of phased signal modulated by mode control can reach the timing precision of 0.48 micros and will not affect the original phase control function t. In addition it can realize intermittent therapy mode which can reduce the injury of non-focal areas caused by ultrasound energy.
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Effects of different parameters in the fast scanning method for HIFU treatment.
Med Phys
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High-intensity focused ultrasound is a promising method for the noninvasive treatment of benign and malignant tumors. This study analyzes the effects of scanning path, applied power, and geometric characteristics of the transducer on ablation using fast scanning method, a new scanning method that uses high-intensity focused ultrasound at different blood perfusion levels.
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[The control method design of thermal treatment system via fuzzy logic].
Zhongguo Yi Liao Qi Xie Za Zhi
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A novel system is proposed to control the liquid nitrogen cooling and radio frequency heating of tissue to achieve effective thermal ablation in the treatment using fuzzy logic controller and fuzzy logic PID type controller separately. Results of ex-vivo pig liver experiments demonstrate that this system is useful and could p control the desired treatment procedure.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.