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Find video protocols related to scientific articles indexed in Pubmed.
Types of indwelling urethral catheters for short-term catheterisation in hospitalised adults.
Cochrane Database Syst Rev
PUBLISHED: 09-24-2014
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Urinary tract infection (UTI) is the most common hospital-acquired infection. The major associated cause is indwelling urethral catheters. Several measures have been introduced to reduce catheter-associated urinary tract infections (CAUTIs). One of these measures is the introduction of specialised urethral catheters that have been designed to reduce the risk of infection. These include antiseptic-coated and antimicrobial-impregnated catheters.
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Decision aids for randomised controlled trials: a qualitative exploration of stakeholders' views.
BMJ Open
PUBLISHED: 08-19-2014
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To explore stakeholders' perceptions of decision aids designed to support the informed consent decision-making process for randomised controlled trials.
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Making a decision about trial participation: the feasibility of measuring deliberation during the informed consent process for clinical trials.
Trials
PUBLISHED: 04-15-2014
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Informed consent of trial participants is both an ethical and a legal requirement. When facing a decision about trial participation, potential participants are provided with information about the trial and have the opportunity to have any questions answered before their degree of 'informed-ness' is assessed, usually subjectively, and before they are asked to sign a consent form. Currently, standardised methods for assessing informed consent have tended to be focused on aspects of understanding and associated outcomes, rather than on the process of consent and the steps associated with decision-making.
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Patient information leaflets (PILs) for UK randomised controlled trials: a feasibility study exploring whether they contain information to support decision making about trial participation.
Trials
PUBLISHED: 01-24-2014
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Informed consent is regarded as a cornerstone of ethical healthcare research and is a requirement for most clinical research studies. Guidelines suggest that prospective randomised controlled trial (RCT) participants should understand a basic amount of key information about the RCTs they are being asked to enrol in in order to provide valid informed consent. This information is usually provided to potential participants in a patient information leaflet (PIL). There is evidence that some trial participants fail to understand key components of trial processes or rationale. As such, the existing approach to information provision for potential RCT participants may not be optimal. Decision aids have been used for a variety of treatment and screening decisions to improve knowledge, but focus more on overall decision quality, and may be helpful to those making decisions about participating in an RCT. We investigated the feasibility of using a tool to identify which items recommended for good quality decision making are present in UK PILs.
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Determining information for inclusion in a decision-support intervention for clinical trial participation: A modified Delphi approach.
Clin Trials
PUBLISHED: 11-04-2013
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The use of decision-support interventions in the context of decisions about trial participation is an emergent field. There is a lack of evidence about what information is deemed important to support decisions about informed consent for clinical trials, and whether different groups agree on the information for inclusion.
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NF?B regulates expression of Polo-like kinase 4.
Cell Cycle
PUBLISHED: 08-21-2013
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Activation of the NF?B signaling pathway allows the cell to respond to infection and stress and can affect many cellular processes. As a consequence, NF?B activity must be integrated with a wide variety of parallel signaling pathways. One mechanism through which NF?B can exert widespread effects is through controlling the expression of key regulatory kinases. Here we report that NF?B regulates the expression of genes required for centrosome duplication, and that Polo-like kinase 4 (PLK4) is a direct NF?B target gene. RNA interference, chromatin immunoprecipitation, and analysis of the PLK4 promoter in a luciferase reporter assay revealed that all NF?B subunits participate in its regulation. Moreover, we demonstrate that NF?B regulation of PLK4 expression is seen in multiple cell types. Significantly long-term deletion of the NF?B2 (p100/p52) subunit leads to defects in centrosome structure. This data reveals a new component of cell cycle regulation by NF?B and suggests a mechanism through which deregulated NF?B activity in cancer can lead to increased genomic instability and uncontrolled proliferation.
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Antimicrobial catheters for reduction of symptomatic urinary tract infection in adults requiring short-term catheterisation in hospital: a multicentre randomised controlled trial.
Lancet
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Catheter-associated urinary tract infection (CAUTI) is a major preventable cause of harm for patients in hospital. We aimed to establish whether short-term routine use of antimicrobial catheters reduced risk of CAUTI compared with standard polytetrafluoroethylene (PTFE) catheterisation.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.