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Find video protocols related to scientific articles indexed in Pubmed.
Relationship between retinal microstructures and visual acuity after cataract surgery in patients with retinitis pigmentosa.
Br J Ophthalmol
PUBLISHED: 10-23-2014
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To study the relationship between the retinal microstructures and the best-corrected visual acuity (BCVA) after cataract surgery in patients with retinitis pigmentosa (RP).
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Clinical results of unicompartmental arthroplasty for knee osteoarthritis using a tibial component with screw fixation.
Int Orthop
PUBLISHED: 09-08-2014
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Unicompartmental knee prostheses with screw fixation into the proximal tibia were employed and postoperative clinical results for osteoarthritis of the knee, especially regarding relief of pain, range of motion and satisfactory limb alignment are reported and discussed.
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Current techniques to improve outcomes for early return of urinary continence following robot-assisted radical prostatectomy.
Fukushima J Med Sci
PUBLISHED: 07-15-2014
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Although open retropubic radical prostatectomy has been the most commonly used surgical technique for patients with localized prostate cancer for decades, robot-assisted radical prostatectomy (RARP) has recently become an alternative option and widely used in Japan as well as around the world. RARP has been shown to have higher postoperative continent rates than retropubic and laparoscopic radical prostatectomy; however, urinary incontinence has remained one of the most significant causes for concern among patients who seek surgical treatment for prostate cancer, even after the introduction of RARP. The literature has shown that certain technical modifications to improve urinary continence are advocated as potential aids to reduce the risk of urinary incontinence after RARP. These modifications might be divided into 3 categories to realize the improvement of early return of urinary continence after RARP: 1) preservation, 2) reconstruction, and 3) reinforcement of the anatomic structures in the pelvis, which will make a new supporting system after radical prostatectomy. In this review, we discuss the intraoperative techniques to improve outcomes for early return of urinary continence following RARP, and provide a critical summary of current knowledge on its outcome in the literature.
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Effect of parathyroid hormone on early chondrogenic differentiation from mesenchymal stem cells.
J Orthop Surg Res
PUBLISHED: 03-08-2014
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Treatment of articular cartilage injuries remains a difficult challenge due to the limited capacity for intrinsic repair. Mesenchymal stem cells (MSCs) can differentiate into chondrocytes under certain culture conditions. This study focused on the modulatory effects of parathyroid hormone (PTH) on chondrogenic differentiation from MSCs.
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The surgical epicondylar axis is a consistent reference of the distal femur in the coronal and axial planes.
Knee Surg Sports Traumatol Arthrosc
PUBLISHED: 01-22-2014
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Various rotational landmarks including the surgical epicondylar axis (SEA) are used for preoperative planning and intra-operative reference of total knee arthroplasty (TKA) in the axial plane. The aim of the study was to elucidate the relationships between the SEA and other femoral anatomical landmarks, including the mechanical axis, distal and posterior knee joints, the trochlear groove, and the anterior femoral condyle, in both the coronal and axial planes.
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Momentum-resolved resonant inelastic X-ray scattering on a single crystal under high pressure.
J Synchrotron Radiat
PUBLISHED: 06-19-2013
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A single-crystal momentum-resolved resonant inelastic X-ray scattering (RIXS) experiment under high pressure using an originally designed diamond anvil cell (DAC) is reported. The diamond-in/diamond-out geometry was adopted with both the incident and scattered beams passing through a 1?mm-thick diamond. This enabled us to cover wide momentum space keeping the scattering angle condition near 90°. Elastic and inelastic scattering from the diamond was drastically reduced using a pinhole placed after the DAC. Measurement of the momentum-resolved RIXS spectra of Sr2.5Ca11.5Cu24O41 at the Cu K-edge was thus successful. Though the inelastic intensity becomes weaker by two orders than the ambient pressure, RIXS spectra both at the center and the edge of the Brillouin zone were obtained at 3?GPa and low-energy electronic excitations of the cuprate were found to change with pressure.
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The great East Japan earthquake affected the laboratory findings of hemodialysis patients in Fukushima.
BMC Nephrol
PUBLISHED: 05-25-2013
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The aim of the present study was to investigate the impact of the Great East Japan Earthquake on laboratory findings in chronic hemodialysis (HD) patients in Fukushima.
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Decreased semaphorin3A expression correlates with disease activity and histological features of rheumatoid arthritis.
BMC Musculoskelet Disord
PUBLISHED: 01-12-2013
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Rheumatoid arthritis (RA) is an autoimmune disease of which the pathogenetic mechanisms are not fully understood. Semaphorin3A (Sema3A) has an immune regulatory role. Neuropilin1 (NRP1), the primary receptor for Sema3A, is also a receptor for vascular endothelial growth factor 165 (VEGF 165). It has been shown that Sema3A competitively antagonizes VEGF 165 signaling. This study investigated whether Sema3A is expressed in synovial tissues, and is associated with disease activity and the histological features of synovial tissues from RA patients.
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Photoreceptor impairment and restoration on optical coherence tomographic image.
J Ophthalmol
PUBLISHED: 01-08-2013
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With recent development of spectral-domain optical coherence tomography (SD-OCT), the pathological changes of retina can be observed in much greater detail. SD-OCT clearly delineates three highly reflective lines in the outer retina, which are external limiting membrane (ELM), photoreceptor inner and outer segment (IS/OS) junction, and cone outer segment tips (COST) in order from inside. These lines can serve as hallmarks for the evaluation of photoreceptor condition. In retinitis pigmentosa (RP) leading to photoreceptor degeneration, the ELM, IS/OS, and COST lines are shortened with the progression of the disease. In addition, shortening of the ELM, IS/OS and COST lines is significantly associated with each other. The line length is longest in the ELM, followed by the IS/OS, and COST, suggesting that retinal layer becomes disorganized first at the COST, followed by the IS/OS and finally the ELM. This finding is consistent with the previous report that the earliest histopathological change in RP is a shortening of the photoreceptor outer segments. On the other hand, retinal layer becomes restored first at the ELM, followed by the IS/OS and finally the COST after macular hole surgery. There may be a directionality of photoreceptor impairment or restoration on optical coherence tomographic image.
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[Lethal myocardial injury associated with hydrogen sulfide poisoning: report of two cases].
Chudoku Kenkyu
PUBLISHED: 09-29-2011
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We investigated two cases of hydrogen sulfide poisoning in which the patients showed lethal myocardial injury. Both patients had planned to commit suicide by inhaling hydrogen sulfide. In case 1, a 17-year-old man was confused and was brought to our hospital by ambulance. An electrocardiogram (ECG) revealed diffuse elevation of the ST segment on the second hospital day. The patient recovered and was discharged from the hospital on the 15th day. However, he died suddenly on the 18th day. In case 2, a 21-year-old man was found lying on the floor and was admitted to our hospital. ECG showed tall T waves after 5 hr. Tachycardia and tachypnea occurred after 12 hr. After 16 hr, the ECG showed a marked elevation of the ST segment, and the patient developed cardiac arrest. Even though percutaneous cardiopulmonary support was used, he died on the 4th day. It is highly probable that myocardial injury asscociated with hydrogen sulfide poisoning was not caused by systemic hypoxia but by selective myocardial toxicity. These cases demonstrate that delayed presentation of a lethal myocardial injury should be considered while treating cases of hydrogen sulfide poisoning.
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Fractures around the lateral cortical hinge after a medial opening-wedge high tibial osteotomy: a new classification of lateral hinge fracture.
Arthroscopy
PUBLISHED: 06-24-2011
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The purpose of this study was to determine the frequency of lateral hinge fractures after opening-wedge high tibial osteotomy and investigate the patterns of fracture and their clinical outcome.
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[Tricyclic antidepressant overdose rescued by percutanenous cardiopulmonary support: report of two cases].
Chudoku Kenkyu
PUBLISHED: 04-13-2011
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We report the case of two patients tricyclic antidepressant (TCA) overdoses complicated with severe circulatory failure, successfully resuscitated using percutaneous cardiopulmonary support (PCPS). In case 1, a woman transferred to our emergency department, presented with severe circulatory failure and developed cardiopulmonary arrest. She received prolonged cardiopulmonary resuscitation, and initiated with PCPS. In case 2, a woman presented our emergency department on foot. 3 hours after admission, she falled into severe circulatory failure with polymorphic ventricular tachycardia, and PCPS was started. TCA remains widely used despite its dangerous cardiovascular and neurological effects in overdosed patients. The most common cause of death after TCA overdose is cardiovascular toxicities. In current guidelines, cardiopulmonary resuscitation with extracorporeal cardiopulmonary bypass may be particularly effective for these patients to have a reversible etiology without preceding multisystem organ failure. Cardiotoxicities in TCA overdose are reversible and extracorporeal cardiopulmonary support should be promptly considered in refractory arrhythmia and hypotension despite conventional advanced life support.
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Stromal cell-derived factor-1 and monocyte chemotactic protein-3 improve recruitment of osteogenic cells into sites of musculoskeletal repair.
J. Orthop. Res.
PUBLISHED: 01-10-2011
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Homing of osteogenic cells through the systemic circulation represents an alternative to traditional orthopedic tissue engineering approaches that focus on local cell populations. We hypothesize that expression of the chemokine, stromal cell-derived factor-1 (SDF-1) or monocyte chemotactic protein-3 (MCP-3) may enhance homing of osteogenic cells into sites of fracture repair, as both have demonstrated promise in recruitment of marrow stromal cells (MSCs). This hypothesis was tested by transplantation of culture expanded MSCs expressing these factors adjacent to a fracture site on a collagen scaffold. One green fluorescent protein positive (GFP+) and one wild-type mouse were surgically conjoined as parabiots at 7-8 weeks of age. Fibular osteotomy was performed 4 weeks after parabiosis on the hind limb of the wild-type mouse. Mice were randomly allocated to receive one of the following five treatments: control (no scaffold), empty scaffold (no cells), or scaffold containing MSCs, scaffold containing MSCs expressing SDF-1, or scaffold containing MSCs expressing MCP-3. Fracture callus was harvested 2 weeks after injury, and analyzed with confocal microscopy and cell-counting software. When compared to fracture callus treated with nontransfected MSCs, the fracture callus of mice treated with both SDF-1 and MCP-3 secreting MSCs demonstrated a significant increase in the number of both GFP+ cells (p?=?0.0003, p?=?0.02) and GFP+ /AP+ cells (p?=?0.0005, p?=?0.01). These data suggest that homing of osteogenic cells from systemic circulation participate in fracture repair and that homing pathways might be modulated to enhance the contribution of circulating progenitors at the site of skeletal injury.
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Massive gastric bleeding from a blunt abdominal trauma: report of a case.
Surg. Today
PUBLISHED: 09-25-2010
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Blunt gastric injury (BGI) is a rare condition that accounts for 0.02%-1.7% of all blunt abdominal trauma cases. Blunt gastric rupture, which occurs in less than 40% of all BGI cases, presents unstable vital signs and symptoms of peritonitis due to massive peritoneal contamination. This article presents the case of a patient with BGI who did not present with symptoms of peritonitis in spite of presenting with persistent hypovolemic shock.
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Opening wedge high tibial osteotomy affects both the lateral patellar tilt and patellar height.
Knee Surg Sports Traumatol Arthrosc
PUBLISHED: 01-22-2010
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In the current study, we evaluated changes in the patellofemoral joint indices in 49 knees from 39 patients (11 men and 28 women with a median age of 64 years; range 53-79) who had undergone an opening wedge high tibial osteotomy (OWHTO). Osteoarthritis had been diagnosed in 39 knees and osteonecrosis in the other 10 knees in this patient cohort. Radiographs showing anteroposterior and true lateral views of the knee joints while standing, and also skyline views while standing with a 30 degrees flexion, were taken both pre- and postoperatively. Radiographic assessments were then performed using the following five parameters: femorotibial angle (FTA), modified Blackburne-Peel ratio (mBP), tibial slope (TS), lateral patellar tilt (LPT), and lateral patellar shift (LPS). The average LPT decreased significantly from 7.4 degrees + or - 3.7 degrees to 5.2 degrees + or - 3.6 degrees (P < 0.01). Patients treated with a greater than 15 degrees correction showed a significantly bigger change in their LPT than those with corrections of 15 degrees or less. No statistical differences were found between the preoperative (10.2 + or - 4.5%) and postoperative (10.2 + or - 4.7%) LPS measurements. Changes in the radiographic parameters were also observed in the patellofemoral joint after OWHTO. It is unclear to what extent the postoperative patellar shift and tilt affects the long-term clinical outcomes but our current results suggest that OWHTO negatively affects the congruency of the patellofemoral joint and should not exceed a correction of 15 degrees .
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A mid term comparison of open wedge high tibial osteotomy vs unicompartmental knee arthroplasty for medial compartment osteoarthritis of the knee.
J Orthop Surg Res
PUBLISHED: 01-04-2010
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The choice of surgical treatments for unicompartmental osteoarthritis (OA) of the knee is still somewhat controversial. Midterm results from cases treated using unicompartmental knee arthroplasty (UKA) or open wedge high tibial osteotomy (OWHTO) were evaluated retrospectively.
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Medial opening wedge high tibial osteotomy with early full weight bearing.
Arthroscopy
PUBLISHED: 03-25-2009
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We performed clinical and radiographic evaluation of patients with medial compartment osteoarthritis of the knee who had undergone treatment with opening wedge high tibial osteotomy (OWHTO) followed by early full weight bearing. OWHTO procedures were performed by use of TomoFix (Synthes, Bettlach, Switzerland) and bone substitute materials.
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A predictive factor for acquiring an ideal lower limb realignment after opening-wedge high tibial osteotomy.
Knee Surg Sports Traumatol Arthrosc
PUBLISHED: 01-29-2009
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Obtaining a correct postoperative limb alignment is an important factor in achieving a successful clinical outcome after an opening-wedge high tibial osteotomy (OWHTO). To better predict some of the aspects that impact upon the clinical outcomes following this procedure, including postoperative correction loss and over correction, we examined the changes in the frontal plane of the lower limb in a cohort of patients who had undergone OWHTO using radiography. Forty-two knees from 33 patients (23 cases of osteoarthritis and 10 of osteonecrosis) underwent a valgus realignment OWHTO procedure and were radiographically assessed for changes that occurred pre- and post-surgery. The mean femorotibial angle (FTA) was found to be 182.1 +/- 2.0 degrees (12 +/- 2.0 anatomical varus angulation) preoperatively and 169.6 +/- 2.4 degrees (10.4 +/- 2.4 anatomical valgus angulation) postoperatively. These measurements thus revealed significant changes in the weight bearing line ratio (WBL), femoral axis angle (FA), tibial axis angle (TA), tibia plateau angle (TP), tibia vara angle (TV) and talar tilt angle (TT) following OWHTO. In contrast, no significant change was found in the weight bearing line angle (WBLA) after these treatments. To assess the relationship between the correction angle and these indexes, 42 knees were divided into the following three groups according to the postoperative FTA; a normal correction group (168 degrees < or = FTA < or = 172 degrees ), an over-correction group (FTA < 168 degrees ), and an under-correction group (FTA > 172 degrees ). There were significant differences in the delta angle [DA; calculated as (pre FTA - post FTA) - (pre TV - post TV)] among each group of patients. Our results thus indicate a negative correlation between the DA and preoperative TA (R(2) = 0.148, p < 0.05). Hence, given that the correction errors in our patients appear to negatively correlate with the preoperative TA, postoperative malalignments are likely to be predictable prior to surgery.
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Clinical results and radiographical evaluation of opening wedge high tibial osteotomy for spontaneous osteonecrosis of the knee.
Knee Surg Sports Traumatol Arthrosc
PUBLISHED: 01-23-2009
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We evaluated the clinical outcomes, in terms of early weight bearing, of using opening wedge high tibial osteotomy (OWHTO) to treat spontaneous osteonecrosis of the medial femoral condyle of the knee (SONK) using TomoFix and artificial bone substitute. Damaged cartilage tissue was removed and drilling of the necrotic area followed by OWHTO was performed in 30 knees from 30 patients with an average age of 71 years (range 58-82) at the time of operation. Patients were allowed to undertake partial weight-bearing exercises 1 week after the osteotomy procedure, with all patients performing full weight-bearing exercise at 2 weeks post-surgery. The mean follow-up period was 40 months (range 24-62). All of the SONK patients could walk with a full weight-bearing load, using only a T-cane, at 2 weeks after undergoing OWHTO. Clinical assays, including the mean American Knee Society Score and Function Score, showed significant improvements from 51 to 93 points, and 58 to 93 points, respectively. Prior to surgery, the average femoro-tibial angle (FTA) during standing was 181 (1 degree anatomical varus) and had significantly changed to 170 (10 degrees valgus) at the time of follow-up. There were no cases of non-union, or implant failure in any of our patients. In addition, none of the patients could sit in the Japanese style prior to surgery, but 21 of 30 patients (70%) could do so after treatment. Arthroscopic findings could be observed in 24 out of 30 cases at implant removal. Necrotic area in each case was covered with fibrous cartilage-like tissue completely. Drilling of the necrotic area followed by OWHTO with TomoFix and artificial bone substitute is an effective treatment for SONK as it results in pain alleviation and regeneration of the fibrous cartilage tissue over the necrotic legion. In addition, an early weight-bearing exercise program is possible after this procedure and full weight-bearing can be achieved at two weeks after surgery.
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[Use of high frequency oscillatory ventilation in a patient with fulminant fat embolism syndrome].
Masui
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We report a case of fulminant fat embolism syndrome treated with high frequency oscillatory ventilation (HFOV). A 77-year-old woman sustained a right tibia and fibula fracture and a left open tibia fracture after a traffic accident. She was conscious and her respiratory condition was normal on admission. However, she suddenly progressed to a coma and was intubated for approximately 2 hours after the accident; she developed critical respiratory failure. We used HFOV and were able to maintain her respiratory status. However, her right heart failure deteriorated and she died 95 hours after the accident. It was difficult for her to survive without percutaneous cardiopulmonary support.
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Analysis of trends and emergency activities relating to critical victims of the Chuetsuoki Earthquake.
Prehosp Disaster Med
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When a large-scale disaster occurs, it is necessary to use the available resources in a variety of sites and scenes as efficiently as possible. To conduct such operations efficiently, it is necessary to deploy limited resources to the places where they will be the most effective. In this study, emergency and medical response activities that occurred following the Chuetsuoki Earthquake in Japan were analyzed to assess the most efficient and effective activities.
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Low-intensity pulsed ultrasound accelerates fracture healing by stimulation of recruitment of both local and circulating osteogenic progenitors.
J. Orthop. Res.
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We investigated the effect of low-intensity pulsed ultrasound (LIPUS) on the homing of circulating osteogenic progenitors to the fracture site. Parabiotic animals were formed by surgically conjoining a green fluorescent protein (GFP) mouse and a syngeneic wild-type mouse. A transverse femoral fracture was made in the contralateral hind limb of the wild-type partner. The fracture site was exposed to daily LIPUS in the treatment group. Animals without LIPUS treatment served as the control group. Radiological assessment showed that the hard callus area was significantly greater in the LIPUS group than in the control group at 2 and 4 weeks post-fracture. Histomorphometric analysis at the fracture site showed a significant increase of GFP cells in the LIPUS group after 2 weeks (7.5%), compared to the control group (2.4%) (p?
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JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

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In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.