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Find video protocols related to scientific articles indexed in Pubmed.
Unconditional and Conditional Standards Using Cognitive Function Curves for the Modified Mini-Mental State Exam: Cross-Sectional and Longitudinal Analyses in Older Chinese Adults in Singapore.
Am J Geriatr Psychiatry
PUBLISHED: 05-01-2014
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The conventional practice of assessing cognitive status and monitoring change over time in older adults using normative values of the Mini-Mental State Exam (MMSE) based on age bands is imprecise. Moreover, population-based normative data on changes in MMSE score over time are scarce and crude because they do not include age- and education-specific norms. This study aims to develop unconditional standards for assessing current cognitive status and conditional standards that take prior MMSE score into account for assessing longitudinal change, with percentile curves as smooth functions of age.
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Frailty in older persons: multisystem risk factors and the Frailty Risk Index (FRI).
J Am Med Dir Assoc
PUBLISHED: 03-05-2014
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Currently there is no risk factor scale that identifies older persons at risk of frailty.
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Long-term metformin usage and cognitive function among older adults with diabetes.
J. Alzheimers Dis.
PUBLISHED: 03-01-2014
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Evidence strongly supports the important role of insulin resistance in cognitive decline and dementia and suggests that insulin sensitizers may protect against cognitive decline in diabetic and pre-diabetic individuals. Inconclusive results have been reported in clinical trials of rosiglitazone, an insulin sensitizer that also increases cardiovascular mortality risks. No study has yet reported a protective cognitive effect of metformin, an insulin-sensitizing biguanide widely used in diabetic patients. We studied 365 older persons aged 55 and over in the population-based Singapore Longitudinal Aging Study with diabetes who were followed up over 4 years. The odds ratios (OR) of association of metformin use (n = 204) versus non-use (n = 161) with cognitive impairment (Mini-Mental State Exam ? 23), and by duration: up to 6 years (n = 114) and more than 6 years (n = 90) were evaluated in cross-sectional and longitudinal multivariate analyses. Controlling for age, education, diabetes duration, fasting blood glucose, vascular and non-vascular risk factors, metformin use showed a significant inverse association with cognitive impairment in longitudinal analysis (OR = 0.49, 95% CI 0.25-0.95). Metformin use showed significant linear trends of association across duration of use in cross-sectional and longitudinal analyses (p = 0.018 and p = 0.002, respectively), with use for more than 6 years significantly associated with lowest risk of cognitive impairment in both cross-sectional analysis (OR = 0.30, 95% CI 0.11-0.80) and in longitudinal analysis (OR = 0.27, 95% CI 0.12-0.60). No significant interactive effects of metformin use with APOE-?4, depression, or fasting glucose level were observed. Among individuals with diabetes, long-term treatment with metformin may reduce the risk of cognitive decline. Further studies should establish the role of hyperglycemia and insulin resistance, and the protective role of metformin in the risk of cognitive decline and dementia.
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Dietary and supplemental antioxidant and anti-inflammatory nutrient intakes and pulmonary function.
Public Health Nutr
PUBLISHED: 09-27-2013
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A limited but growing body of evidence supports a significant role of antioxidant and anti-inflammatory micronutrients in pulmonary health. We investigated the associations of dietary and supplemental intakes of vitamins A, C, E and D, Se and n-3 PUFA with pulmonary function in a population-based study.
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Frailty predicts new and persistent depressive symptoms among community-dwelling older adults: findings from singapore longitudinal aging study.
J Am Med Dir Assoc
PUBLISHED: 07-08-2013
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This study aimed to examine the cross-sectional and longitudinal relationships between physical frailty at baseline and depressive symptoms at baseline and at follow-up.
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Systemic inflammation, depression and obstructive pulmonary function: a population-based study.
Respir. Res.
PUBLISHED: 02-18-2013
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Levels of Interleukin-6 (IL-6) and C-creative protein (CRP) indicating systemic inflammation are known to be elevated in chronic diseases including chronic obstructive pulmonary disease (COPD) and depression. Comorbid depression is common in patients with COPD, but no studies have investigated whether proinflammatory cytokines mediate the association between pulmonary function and depressive symptoms in healthy individuals with no known history of obstructive pulmonary diseases.
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Depressive symptoms in older adults with chronic kidney disease: mortality, quality of life outcomes, and correlates.
Am J Geriatr Psychiatry
PUBLISHED: 01-18-2013
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Among patients with chronic kidney disease (CKD), we investigated the prevalence of depressive symptoms, their impact on mortality and quality of life, and correlates of depressive symptoms.
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Statin use and depressive symptoms in a prospective study of community-living older persons.
Pharmacoepidemiol Drug Saf
PUBLISHED: 06-25-2010
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The association between statin use and depression is complex, and research findings have been mixed. The present study aimed to investigate the association of statin use with depressive symptoms among community-living older persons, and its effect modifications by gender and medical co-morbidity.
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Low blood pressure and depressive symptoms among Chinese older subjects: a population-based study.
Am. J. Med.
PUBLISHED: 04-06-2010
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The relationships between blood pressure and depression are unclear. There are inconsistent reports of an association between low blood pressure and depressive symptoms.
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Folate, vitamin B12, homocysteine, and depressive symptoms in a population sample of older Chinese adults.
J Am Geriatr Soc
PUBLISHED: 06-02-2009
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To investigate the independent associations between folate, B12, and homocysteine levels and depressive symptoms in older adults.
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Depressive symptoms, physician visits and hospitalization among community-dwelling older adults.
Int Psychogeriatr
PUBLISHED: 04-16-2009
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The relationship between depressive symptoms and health service use among older people is not well understood. In this study we examined the two-way relationships between depressive symptoms and hospitalization and/or physician visits by older adults.
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Albumin, apolipoprotein E-epsilon4 and cognitive decline in community-dwelling Chinese older adults.
J Am Geriatr Soc
PUBLISHED: 03-07-2009
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To examine the association between serum albumin and cognitive impairment and decline in community-living older adults.
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Vitamin B-12, apolipoprotein E genotype, and cognitive performance in community-living older adults: evidence of a gene-micronutrient interaction.
Am. J. Clin. Nutr.
PUBLISHED: 02-25-2009
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The relation between vitamin B-12 and cognitive function in older adults is unclear. Limited evidence suggests that the relation is modulated by apolipoprotein E epsilon4. Hence, it is important to further examine this gene-nutrient interaction.
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APOE-epsilon4, depressive symptoms, and cognitive decline in Chinese older adults: Singapore Longitudinal Aging Studies.
J. Gerontol. A Biol. Sci. Med. Sci.
PUBLISHED: 01-30-2009
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The precise relationship between depression and cognitive decline in older adults is unclear. We investigated the influence of apolipoprotein E (APOE)-epsilon4 genotype in modulating the effect of depressive symptoms on cognitive decline.
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Co-morbid association of depression and COPD: a population-based study.
Respir Med
PUBLISHED: 01-10-2009
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Depression occurs commonly among patients with COPD, but the independent association of depression and COPD and the effect of depression on COPD outcomes are not well established.
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Curcumins-rich curry diet and pulmonary function in Asian older adults.
PLoS ONE
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Research on the effects of dietary nutrients on respiratory health in human populations have not investigated curcumin, a potent anti-oxidant and anti-inflammatory compound present principally in turmeric used in large amounts in Asian curry meals.
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Homocysteine, folate, vitamin B-12, and physical function in older adults: cross-sectional findings from the Singapore Longitudinal Ageing Study.
Am. J. Clin. Nutr.
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There is a paucity of studies, as well as inconsistent findings, on the associations of homocysteine, folate, and vitamin B-12 with physical function and decline in older persons.
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Kidney function and cognitive and functional decline in elderly adults: findings from the Singapore longitudinal aging study.
J Am Geriatr Soc
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To investigate whether lower estimated glomerular filtration rate (eGFR) or chronic kidney disease (CKD) was associated with subsequent cognitive and instrumental activity of daily living (IADL) decline in a prospective cohort study.
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Changes in depressive symptoms and functional disability among community-dwelling depressive older adults.
Int Psychogeriatr
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Previous studies have shown that the presence of depressive symptoms among older persons was evidently associated with subsequent physical and functional decline. However, few studies have directly examined the impact of changes in depressive symptoms or depressed mood on changes in functional ability. The present prospective study examined whether changes in the levels and remission of depressive symptoms were associated with changes in functional ability among community-living older persons who were treated for depressive symptoms in a primary care setting.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.