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Find video protocols related to scientific articles indexed in Pubmed.
Antiemetic therapy of fosaprepitant, palonosetron, and dexamethasone combined with cisplatin-based chemotherapy for head and neck carcinomas.
Acta Otolaryngol.
PUBLISHED: 10-16-2014
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Abstract Conclusion: Concomitant antiemetic therapy comprising fosaprepitant, palonosetron, and dexamethasone is effective for head and neck carcinoma.
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Day surgery for vocal fold lesions using a double-bent 60-mm Cathelin needle.
Eur Arch Otorhinolaryngol
PUBLISHED: 09-02-2014
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Day surgery for vocal cord lesions overcomes the disadvantages of laryngomicrosurgery under general anesthesia. We present our experience with treatment of vocal fold lesions using a long double-bend Cathelin needle that can access all parts of the vocal cords. A 23G, 60-mm-long Cathelin needle was bent twice by 45(o) at a distance of 1 and 2 cm from the tip, and was attached to a syringe. Under topical anesthesia and nasal endoscopy of the laryngopharynx, the needle was inserted percutaneously perpendicular to the skin, the direction of insertion being altered when the bends in the needle reached the skin surface. This allows the tip of the needle to access all parts of the glottis, allowing the performance of procedures such as biopsies, excision of lesions, and injection into the vocal folds. Between January 2011 and December 2013, we used this technique to perform vocal fold procedures in 566 patients presenting for treatment of spasmodic dysphonia (412 cases, 73 %) and other vocal fold lesions. Only minor complications, such as hematoma (3 patients, 0.5 %) and slight bleeding from the puncture site in the epiglottic vallecula (all patients, 100 %), which ceased spontaneously within 10 min, were seen. Erroneous puncture occurred in three patients (0.5 %) and the puncture had to be repeated in 38 patients (6.7 %). The procedure was completed successfully in all cases (100 %). Surgery for vocal fold lesions under topical anesthesia using our double-bend Cathelin needle technique is simple, safe, and useful.
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Regulatory T-cell infiltration in tongue squamous cell carcinoma.
Acta Otolaryngol.
PUBLISHED: 06-12-2014
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In tongue squamous cell carcinoma (SCC), high levels of regulatory T-cell (Treg) infiltration in tumor nests are observed in the cases with poor prognosis.
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Joint use of skull base surgery in a case of pediatric parotid gland carcinoma.
Case Rep Otolaryngol
PUBLISHED: 02-05-2014
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Parotid gland carcinoma is extremely rare in children. We report a case of pediatric parotid gland carcinoma with extensive infiltration into surrounding tissues including the skin and temporomandibular joint capsule at initial examination. Total resection of the parotid gland was conducted together with skull base surgery and mandibular dissection. The patient was a 14-year-old girl. In addition to the skin and temporomandibular joint, infiltration into the anterior wall of the external auditory meatus and masseter muscle was also seen, and T4N0M0 stage IV parotid carcinoma was diagnosed. Skin was resected together with the pinna, and temporal craniotomy and skull base surgery were performed to resect the temporomandibular joint capsule and external auditory meatus en bloc, and mandible dissection was conducted. Facial nerves were resected at the same time. Level I to level IV neck dissection was also conducted. A latissimus dorsi myocutaneous flap was used for reconstruction. The postoperative permanent pathology diagnosis was high-grade mucoepidermoid carcinoma with a low-grade component. Postoperatively, radiotherapy at 50?Gy alone has been conducted, with no recurrence or metastasis observed for over 4 years.
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Phase I study of nedaplatin prior to S-1 in patients with locally advanced head and neck squamous cell carcinoma.
Chemotherapy
PUBLISHED: 01-28-2014
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We previously reported on the regimen of S-1 plus nedaplatin (NDP), with S-1 was administered orally for 14 days and NDP intravenously on day 8. The maximum tolerated dose (MTD) of NDP was determined to be 90 mg/m². The main toxicities were neutropenia and thrombocytopenia. This result was tolerated, but we believe there is a more effective and tolerable regimen. Thus, we investigated the S-1 regimen administered orally for 14 days, and NDP intravenously on day 1 in patients with locally advanced head and neck squamous cell carcinoma.
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Prospective Randomized Trial on Postoperative Administration of Diet Containing Eicosapentaenoic Acid, Docosahexaenoic Acid, Gamma-linolenic Acid, and Antioxidants in Head and Neck Cancer Surgery Patients with Free-flap Reconstruction.
Jpn Clin Med
PUBLISHED: 01-01-2014
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The purpose of this prospective, randomized study was to evaluate the effects of a diet containing eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), gamma-linolenic acid (GLA), and antioxidants in head and neck cancer surgery patients with free-flap reconstruction.
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A case of giant osteoma in the middle turbinate of a child.
Jpn Clin Med
PUBLISHED: 01-01-2014
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Only seven cases of osteoma arising in the middle turbinate have been reported to date. We report the eighth case, involving osteoma in the middle turbinate of a child. This young boy was initially examined at the age of nine for the main complaint of nasal obstruction. Although a large osteoma with a maximum diameter of 30 mm was observed on computed tomography (CT), the patient was only observed because of the wishes of the family. At 13 years, he was again examined, as a result of worsening of the nasal obstruction. CT revealed that the osteoma had enlarged to a maximum diameter of 41 mm. Endoscopic surgery was attempted, but because of difficulties, the osteoma instead had to be removed under direct vision via a gingival incision. The final pathological diagnosis was osteoid osteoma. The nasal obstruction disappeared following surgery, with no recurrence after more than 12 months postoperatively.
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Secondary insertion of Provox(®)2 using an endotracheal tube.
Acta Otolaryngol.
PUBLISHED: 11-20-2013
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A procedure with no exploratory puncture using an endotracheal tube, sharp-tipped trocar, flexible fiberscope, and flexible guidewire is useful for inserting the Provox(®)2 prosthesis.
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A case of primary submandibular gland oncocytic carcinoma.
Case Rep Otolaryngol
PUBLISHED: 07-06-2013
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Primary submandibular gland oncocytic carcinoma is a rare pathology, with only 10 cases being reported to date. We encountered a case of primary submandibular gland oncocytic carcinoma and report it herein. The patient was a 69-year-old man who came to our hospital with right submandibular cancer as the main complaint. Based on the results of computed tomography and magnetic resonance imaging, submandibular gland tumor was diagnosed. Preoperative cytodiagnosis suggested class III oncocytic carcinoma. Resection of the right submandibular tumor was performed along with right neck dissection. Postoperative histopathological diagnosis was oncocytic carcinoma. As of 3 years following surgery, no recurrence has been identified.
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A case report of malignant melanoma of the sphenoid sinus.
Case Rep Otolaryngol
PUBLISHED: 04-08-2013
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Malignant melanoma of the sphenoid sinus is a very rare disease, and only 6 cases have previously been reported. The present case involved a 74-year-old woman who was examined for visual disturbance of the left eye. Computed tomography revealed a soft tissue shadow, but only mucosal hypertrophy was found on opening the sphenoid sinus under general anesthesia. One month postoperatively, visual disturbance of the right eye and paresis of cranial nerve III appeared. Malignant melanoma was diagnosed from biopsy. Multiple bone metastases were identified, but the patient declined active treatment. As a result, palliative care was provided and she died 3 months later. When there is no improvement in postoperative visual acuity as in this case, in consideration of the possibility of neoplastic lesions, rigorous followup including monitoring for neurological symptoms is warranted.
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Type 3 thyroplasty for patients with mutational dysphonia.
J Voice
PUBLISHED: 03-18-2013
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The cases consisted of three men with mutational dysphonia, who were aged 37, 35, and 38 years. The speaking fundamental frequencies (SFFs) at the time of the initial diagnosis were 174.6, 170.2, and 180.0 Hz.
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Two Cases of Small Cell Cancer of the Maxillary Sinus Treated with Cisplatin plus Irinotecan and Radiotherapy.
Case Rep Otolaryngol
PUBLISHED: 01-29-2013
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Background. Small cell carcinoma (SmCC) in the nasal cavity and paranasal sinuses is very rare, and definitive therapies have not yet been established. Methods. Chemoradiotherapy comprised 60?Gy of external radiation, with the administration of irinotecan intravenously at 60?mg/m(2) on days 1, 8, and 15 and cisplatin at 60?mg/m(2) on day 1. Results. Case 1 involved a 66-year-old woman with stage III cancer. Adverse events included decreased white blood cells, anemia, and oral mucositis, all Grade 2. The patient remained free of cancer as of 3 years and 6 months after completing the treatment. Case 2 involved a 60-year-old man with stage IV cancer. He also experienced adverse events of decreased white blood cells, anemia, and oral mucositis, all Grade 2. He died after 11 months due to metastases throughout the body. Conclusions. The results suggest that this regimen may be tolerable as a therapy for this type of carcinoma.
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New approach to diagnose arytenoid dislocation and subluxation using three-dimensional computed tomography.
Eur Arch Otorhinolaryngol
PUBLISHED: 05-28-2010
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Understanding the complex three-dimensional (3D) arrangement of the arytenoid cartilage is necessary for diagnosing arytenoid dislocation (AD) and arytenoid subluxation (AS). We examined the 3D arrangements of AD and AS (AD/AS) cases by region and considered their new diagnoses. This retrospective study included 2 patients with AD, 10 with AS, and 23 with unilateral vocal fold paralysis (UVFP) for comparison. The etiologies were intubation-induced and idiopathic. We classified the AD/AS position into four joint regions: mediocaudal, laterocaudal, mediocranial, and laterocranial. We generated 3D computed tomography (3DCT) images during rest and phonation to analyze functional movements. We attempted to compare the endoscopic findings and 3DCT images of patients with UVFP and AD/AS. To examine the joint status, we especially focused on the position and movements of the muscular process (MP) on the joint because the arytenoid facet is mainly located on the back of the MP. We were able to obtain endoscopic and 3DCT findings characteristic of each AD/AS region. The dislocated MPs were localized to the mediocaudal, mediocranial, and laterocranial regions. Two AD cases were diagnosed due to complete separation of the joint surfaces during rest and phonation. The finding of MPs displacing partially outside the cricoid facet is common to both severe UVFP and AS. The most important differentiation point was that the MP in UVFP cases was located on both the medial and lateral side regions of the joint, but that of AS was on one side region only. Furthermore, no cases of passive gliding movements characteristic of UVFP that have been described previously by us were observed in AD/AS cases. AD can be diagnosed by findings of complete joint separation. AS can be diagnosed based on positions and movements distinct from those of UVFP.
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Prognostic factors and the therapeutic strategy for patients with bone metastasis from differentiated thyroid carcinoma.
Surgery
PUBLISHED: 02-24-2010
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The treatment of bone metastasis in association with thyroid cancer represents a difficult challenge. Given the paucity of patients with bone metastasis and the difficulty of treating this disease, few studies have investigated the clinical features and prognostic factors of bone metastasis from differentiated thyroid cancer.
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Surgical management of tracheal shaving for papillary thyroid carcinoma with tracheal invasion.
Acta Otolaryngol.
PUBLISHED: 11-20-2009
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Patients showed improved quality of life following tracheal shaving and the carcinoma was well controlled locally, as long as invasion had not progressed to the mucosal surface of the trachea. However, compared with papillary thyroid carcinoma (PTC) with no tracheal invasion, metastasis was common and invasion of organs other than the trachea was frequent, putting many patients into the high-risk group. The clinical course for such patients thus requires careful monitoring, with particular attention to metastasis to other locations. Tracheal shaving can be recommended for patients with PTC with tracheal invasion.
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Two cases of carcinoma of the cervical esophagus adjacent to the larynx treated with surgery.
Int. J. Clin. Oncol.
PUBLISHED: 08-25-2009
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We report herein two cases of carcinoma of the cervical esophagus adjacent to the larynx in which surgery achieved good results. Surgery for case 1, a 64-year-old woman, comprised resection of a carcinoma of the cervical esophagus at stage 0-IIa T1aN0M0, bilateral neck and paratracheal dissections (D1 and D2 dissection), reconstruction using the free jejunal segment, and tracheostomy. At 30 days postoperatively, she was able to eat normal food. For case 2, a 58-year-old man, the same operative procedures were conducted for stage 0-IIc T1bN0M0 carcinoma. At 33 days postoperatively, the patient was able to eat rice porridge (5 parts water, 1 part rice). We therefore consider that for carcinomas in the vicinity of the pharyngoesophageal segment, surgery can achieve both radical cure and preservation of function in some cases.
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Tracheal resection with end-to-end anastomosis preserving paries membranaceus trachea for patients with papillary thyroid carcinoma.
Acta Otolaryngol.
PUBLISHED: 07-10-2009
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Sleeve resection of the trachea while preserving the paries membranaceus trachea appears useful for patients in whom papillary thyroid carcinoma has invaded as far as the tracheal mucosa.
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[Treatment experience of the metastatic renal cell carcinomas to the head and neck region in our department].
Nippon Jibiinkoka Gakkai Kaiho
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Renal cell carcinoma is the most common cancer known for multiple metastasis, but the frequency of metastasis to the head and neck region is low. We report two cases of metastatic renal cell carcinoma to the head and neck region. The case 1 is a 79 year-old man with renal cell carcinoma treatment six years later. Metastasize to the larynx was found by the chief complaint of hoarseness. After treatment, no recurrence was shown for two years. The case 2 is a 61 year-old woman with renal cell carcinoma treatment two years later. Metastasize to the thyroid was found by the chief complaint of neck discomfort. After treatment, no recurrence was shown for two years and six months. These two cases obtained good control after surgical treatment. Since renal cell carcinoma often metastasized even after a long after treatment, it needs to follow progress over a long time. The possibility of metastasis is considered and a positive biopsy is required. The first choice of medical treatment is excision of a metastatic focus.
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Diagnosis of congenital cervical cysts using carcinoembryonic antigen levels in cyst fluid.
Auris Nasus Larynx
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To investigate whether carcinoembryonic antigen (CEA) levels in the fluid of median or lateral cervical cysts can improve diagnosis.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

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In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.