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Find video protocols related to scientific articles indexed in Pubmed.
Age differences in the variability and distribution of sleep spindle and rapid eye movement densities.
PLoS ONE
PUBLISHED: 01-01-2014
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The present study had two main objectives. The first objective was to compare the sleep architecture of young and older adults, with an emphasis on sleep spindle density and REM density. The second objective was to examine two aspects of age differences that have not been considered in previous studies: age differences in the variability of sleep measures as well as the magnitude of age differences in phasic events across the distribution of values (i.e., at each decile rather than a single measure of location such as the mean or median. A total of 24 young (mean age=20.75 ± 1.78 years) and 24 older (mean age=71.17 ± 6.15 years) adults underwent in-home polysomnography. Whole-night spindle density was significantly higher in young adults than older adults. The two age groups did not differ significantly in whole-night REM density, although significant increases in REM density across the night were observed in both age groups. These results suggest that spindle density is more affected by age than REM density. Although age differences were observed in the degree of absolute variability (older adults had significantly larger variances than young adults for sleep efficiency and time spent awake after sleep onset), a similar pattern was also observed within the two age groups: the four sleep measures with the lowest degrees of relative variability were the same and included time spent in REM and Stage 2 sleep, total sleep time, and sleep efficiency. The distributional analysis of age differences in sleep spindle density revealed that the largest age differences were initially observed in the middle of the distributions, but as the night progressed, they were seen at the upper end of the distributions. The results reported here have potential implications for the causes and functional implications of age-related changes in sleep architecture.
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The effect of prevalent cardiovascular conditions on the association between alcohol consumption and mortality among older Mexican American men.
Ethn Dis
PUBLISHED: 03-28-2013
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To examine the association between alcohol consumption and mortality among older Mexican American men, with and without pre-existing cardiovascular conditions.
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Daytime sleep enhances consolidation of the spatial but not motoric representation of motor sequence memory.
PLoS ONE
PUBLISHED: 01-02-2013
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Motor sequence learning is known to rely on more than a single process. As the skill develops with practice, two different representations of the sequence are formed: a goal representation built under spatial allocentric coordinates and a movement representation mediated through egocentric motor coordinates. This study aimed to explore the influence of daytime sleep (nap) on consolidation of these two representations. Through the manipulation of an explicit finger sequence learning task and a transfer protocol, we show that both allocentric (spatial) and egocentric (motor) representations of the sequence can be isolated after initial training. Our results also demonstrate that nap favors the emergence of offline gains in performance for the allocentric, but not the egocentric representation, even after accounting for fatigue effects. Furthermore, sleep-dependent gains in performance observed for the allocentric representation are correlated with spindle density during non-rapid eye movement (NREM) sleep of the post-training nap. In contrast, performance on the egocentric representation is only maintained, but not improved, regardless of the sleep/wake condition. These results suggest that motor sequence memory acquisition and consolidation involve distinct mechanisms that rely on sleep (and specifically, spindle) or simple passage of time, depending respectively on whether the sequence is performed under allocentric or egocentric coordinates.
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The protective effect of neighborhood composition on increasing frailty among older Mexican Americans: a barrio advantage?
J Aging Health
PUBLISHED: 09-28-2011
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Little is known about the nature of the frailty syndrome in older Hispanics who are projected to be the largest minority older population by 2050. The authors examine prospectively the relationship between medical, psychosocial, and neighborhood factors and increasing frailty in a community-dwelling sample of Mexican Americans older than 75 years.
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Anticipatory attention during the sleep onset period.
Conscious Cogn
PUBLISHED: 01-26-2011
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To examine whether anticipatory attention or expectancy is a cognitive process that is automatic or requires conscious control, we employed a paired-stimulus event-related potential (ERP) paradigm during the transition to sleep. The slow negative ERP wave observed between two successive stimuli, the Contingent Negative Variation (CNV), reflects attention and expectancy to the second stimulus. Thirteen good sleepers were instructed to respond to the second stimulus in a pair during waking sessions. In a non-response paradigm modified for sleep, participants then fell asleep while tones played. As expected, N1 decreased and P2 increased in amplitude systematically with the loss of consciousness at sleep onset; the CNV was increasingly more positive. Sleep onset latency was correlated with the amplitude of the CNV. The systematic attenuation of the CNV waveform at sleep onset and its absence in sleep indicates that anticipatory attention requires endogenous conscious control.
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Prevalence of health conditions and predictors of mortality in oldest old Mexican Americans and non-Hispanic whites.
J Am Med Dir Assoc
PUBLISHED: 05-07-2010
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The oldest old represent a unique group of older adults. This group is rapidly growing worldwide and yet there are gaps in the knowledge related to their health condition. Ethnic differences in disease prevalence and mortality must be understood to better care for the oldest old.
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Determining risk of vertebral osteoporosis in men: validation of the male osteoporosis risk estimation score.
J Am Board Fam Med
PUBLISHED: 03-09-2010
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Vertebral fracture, one of the most frequent osteoporotic fractures in both sexes, is a powerful indicator of future osteoporotic fractures. Vertebral fractures are associated with increased mortality and decreased quality of life. Osteoporosis is a major predictor of low-trauma fracture. The Male Osteoporosis Risk Estimation Score (MORES), a clinical prediction tool that uses age, weight, and a history of chronic obstructive pulmonary disorder, was developed and validated previously to identify men at risk for hip osteoporosis who might benefit from bone densitometry. This study evaluated the effectiveness of the MORES to identify men at risk of lumbar osteoporosis.
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Validating an automated sleep spindle detection algorithm using an individualized approach.
J Sleep Res
PUBLISHED: 02-10-2010
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The goal of the current investigation was to develop a systematic method to validate the accuracy of an automated method of sleep spindle detection that takes into consideration individual differences in spindle amplitude. The benchmarking approach used here could be employed more generally to validate automated spindle scoring from other detection algorithms. In a sample of Stage 2 sleep from 10 healthy young subjects, spindles were identified both manually and automatically. The minimum amplitude threshold used by the Prana (PhiTools, Strasbourg, France) software spindle detection algorithm to identify a spindle was subject-specific and determined based upon each subjects mean peak spindle amplitude. Overall sensitivity and specificity values were 98.96 and 88.49%, respectively, when compared to manual scoring. Selecting individual amplitude thresholds for spindle detection based on systematic benchmarking data may validate automated spindle detection methods and improve reproducibility of experimental results. Given that interindividual differences are accounted for, we feel that automatic spindle detection provides an accurate and efficient alternative approach for detecting sleep spindles.
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Trends in hypertension prevalence, awareness, treatment and control in older Mexican Americans, 1993-2005.
Ann Epidemiol
PUBLISHED: 01-27-2010
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To describe trends in hypertension prevalence, awareness, treatment, and control among older Mexican Americans living in the Southwestern United States from 1993-1994 to 2004-2005.
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Infant obesity: are we ready to make this diagnosis?
J. Pediatr.
PUBLISHED: 01-15-2010
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To assess the prevalence, risk factors, diagnosis and treatment of infant obesity (weight-for-length) in a pediatric practice.
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Frailty and incidence of activities of daily living disability among older Mexican Americans.
J Rehabil Med
PUBLISHED: 10-21-2009
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To examine the association between frailty status and incidence of disability among non-disabled older Mexican Americans.
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Frailty and 10-year mortality in community-living Mexican American older adults.
Gerontology
PUBLISHED: 08-18-2009
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The older Hispanic population of the United States is growing rapidly. Hispanic older adults have relatively high-risk profiles for increased morbidity and disability, yet little is known about how the construct of frailty is related to health trajectories in this population.
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Pain and disability in older Mexican-American adults.
J Am Geriatr Soc
PUBLISHED: 04-21-2009
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To examine an association between pain severity and functional disability in older Mexican Americans.
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Podophyllum peltatum and observations on the Creek and Cherokee Indians: William Bartrams preservation of Native American pharmacology.
Yale J Biol Med
PUBLISHED: 03-28-2009
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Historians have examined the significant contributions John and William Bartram made to 18th- and 19th-century knowledge of indigenous North American flora. However, the Bartrams contribution to medicinal botanical knowledge, particularly William Bartrams compilation of Indians knowledge on the preparation and use of medicinal botanicals, is not well-known. In addition, while William Bartrams contemporaries relied on his accounts of medicinal botanicals, they rarely acknowledged Bartram or Indians in their own works. Contemporaries plagiarized Bartrams writings and used his exquisite illustrations to ornament their own publications. This paper reconstructs William Bartrams careful collection and recording of medicinal botanical knowledge that became part of late 18th- and early 19th-century American pharmacology, as well as provides evidence for 54 Bartram-identified indigenous species and the pirating of William Bartrams work by contemporaries.
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Social support, stressors, and frailty among older Mexican American adults.
J Gerontol B Psychol Sci Soc Sci
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There is little research on the effects of stressors and social support on frailty. Older Mexican Americans, in particular, are at higher risk of medical conditions, such as diabetes, that could contribute to frailty. Given that the Mexican American population is rapidly growing in the United States, it is important to determine whether there are modifiable social factors related to frailty in this older group.
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Factors associated with poor glycemic control in older Mexican American diabetics aged 75 years and older.
J. Diabetes Complicat.
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This study examines the prevalence and correlates of poor glycemic control in Mexican Americans aged 75 years and older with diabetes.
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Analysis of the 5 untranslated region (5UTR) of the alcohol oxidase 1 (AOX1) gene in recombinant protein expression in Pichia pastoris.
Gene
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Pichia pastoris is a methylotrophic yeast that has been genetically engineered to express over one thousand heterologous proteins valued for industrial, pharmaceutical and basic research purposes. In most cases, the 5 untranslated region (UTR) of the alcohol oxidase 1 (AOX1) gene is fused to the coding sequence of the recombinant gene for protein expression in this yeast. Because the effect of the AOX1 5UTR on protein expression is not known, site-directed mutagenesis was performed in order to decrease or increase the length of this region. Both of these types of changes were shown to affect translational efficiency, not transcript stability. While increasing the length of the 5UTR clearly decreased expression of a ?-galactosidase reporter in a proportional manner, a deletion analysis demonstrated that the AOX1 5UTR contains a complex mixture of both positive and negative cis-acting elements, suggesting that the construction of a synthetic 5UTR optimized for a higher level of expression may be challenging.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.