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Find video protocols related to scientific articles indexed in Pubmed.
Sexual Quality of Life in Gender-Dysphoric Adults before Genital Sex Reassignment Surgery.
J Sex Med
PUBLISHED: 11-18-2014
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Although there is literature on sexuality in gender dysphoria, few studies have been done prior to genital sex reassignment surgery (SRS).
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Effects of cross-sex hormone treatment on cortical thickness in transsexual individuals.
J Sex Med
PUBLISHED: 03-11-2014
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Untreated transsexuals have a brain cortical phenotype. Cross-sex hormone treatments are used to masculinize or feminize the bodies of female-to-male (FtMs) or male-to-female (MtFs) transsexuals, respectively.
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Determinants of quality of life in Spanish transsexuals attending a gender unit before genital sex reassignment surgery.
Qual Life Res
PUBLISHED: 07-31-2013
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To evaluate the self-reported perceived quality of life (QoL) in transsexuals attending a Spanish gender identity unit before genital sex reassignment surgery, and to identify possible determinants that likely contribute to their QoL.
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Temperament and character in transsexuals.
Psychiatry Res
PUBLISHED: 01-16-2013
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The aim of this study was to evaluate personality in transsexuals. The Temperament and Character Inventory (TCI) profiles of 166 male-to-female (MF) and 88 female-to-male (FM) transsexuals were compared with those of a control group of males and females. MF and FM transsexuals scored significantly lower than males and females in RD4 (more independent) and C3 (more self-centeredness). MF transsexuals scored higher than males and females in HA4 (more fatigable), ST and ST3 (more spiritual acceptance), and lower in C5 (more opportunistic); moreover, they showed higher scores than males in RD1 (more sentimental) and lower than females in C (less cooperativeness). FM transsexuals scored lower than females in HA2 (more daring and confident), RD (less sentimental), and C5 (more opportunistic). Compared with FM, MF transsexuals scored higher on HA2 (more fearful), RD, RD1 (more sentimental), ST, ST2 and ST3 (more spiritual). All these differences were less than half a standard deviation except for C3. Data show that transsexuals and controls display a similar personality profile, even though there are some differential personality traits. Moreover, the personality profile of transsexuals was closer to the profile of subjects who shared their gender identity than those who shared their anatomical sex.
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Tractography of the corticospinal tracts in infants with focal perinatal injury: comparison with normal controls and to motor development.
Neuroradiology
PUBLISHED: 07-20-2011
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Our aims were to (1) assess the corticospinal tracts (CSTs) in infants with focal injury and healthy term controls using probabilistic tractography and (2) to correlate the conventional magnetic resonance imaging (MRI) and tractography findings in infants with focal injury with their later motor function.
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Hormone-treated transsexuals report less social distress, anxiety and depression.
Psychoneuroendocrinology
PUBLISHED: 06-27-2011
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The aim of the present study was to evaluate the presence of symptoms of current social distress, anxiety and depression in transsexuals.
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Gray matter volume decrements in preterm children with periventricular leukomalacia.
Pediatr. Res.
PUBLISHED: 03-10-2011
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Periventricular leukomalacia (PVL) is the prototypic lesion in the encephalopathy of prematurity. Although PVL is identified by targeting cerebral white matter (WM), neuropathological and MRI studies document gray matter (GM) loss in cortical and subcortical structures. This study aimed to investigate the distribution of GM changes in children with a history of premature birth and PVL. Voxel-based morphometry was used to examine regional GM abnormalities in 22 children with a history of preterm birth and PVL. Preterms with PVL were compared with 22 terms and 14 preterms without PVL of similar GA and birth weight. GM and WM global volumetric volumes were found to decrease in comparison with both control groups. Regional GM volume abnormalities were also found: compared with their term peers, preterm children with PVL showed several regions of GM reduction. Moreover, PVL differed from preterms without PVL in the medial temporal lobe bilaterally, thalamus bilaterally, and caudate nuclei bilaterally. In addition, in our preterm sample with PVL, birth weight showed a statistical significant correlation with decreased GM regions. In conclusion, the voxel-based morphometry methodology revealed that PVL per se does involve GM reductions.
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[Aspirin in the prevention of colorectal cancer].
Gastroenterol Hepatol
PUBLISHED: 01-04-2011
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Colorectal adenomas are precursors of most colorectal cancers and are consequently a surrogate endpoint for assessing the efficacy of chemopreventive agents. Cyclooxygenase-2 (COX-2) levels have been found to be increased in a significant number of colorectal carcinomas and adenomas. COX-2 overexpression is linked to carcinogenesis due to increased production of prostaglandins, which seem to play an important role in angiogenesis, cell proliferation and migration, as well as in apoptosis. These data support the use of acetylsalicylic acid (AAS) or aspirin, a COX-2 inhibitor, as an effective agent in colorectal cancer prevention. Several cohort and case control studies have shown that regular use of aspirin reduces the risk of colorectal cancer by approximately 50%. However, randomized controlled trials of aspirin report discrepant results, although there is an decrease in the relative risk of adenoma recurrence of approximately 17%. To date, although there is compelling evidence that the use of aspirin protects against adenoma and colorectal cancer, the optimal dose and duration of aspirin required to obtain this effect remain to be defined. Probably, the longer the treatment duration--even for more than 10 years--and possibly with higher doses, the greater the protective effects of aspirin. Finally, these benefits need to be considered in the context of all of the health effects of prolonged aspirin use, both positive and negative.
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Significance of H63D homozygosity in a Basque population with hemochromatosis.
J. Gastroenterol. Hepatol.
PUBLISHED: 07-03-2010
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The significance of H63D homozygosity remains uncertain, although it is associated with a tendency for patients to develop iron overload.
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Anterior cingulate and paracingulate sulci morphology in patients with schizophrenia.
Schizophr. Res.
PUBLISHED: 04-11-2010
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The anterior cingulate cortex is a cerebral region engaged in several emotional and cognitive functions. The aim of this study was to investigate possible anterior cingulate and paracingulate sulcal abnormalities in schizophrenia. Twenty-three patients with DSM-IV diagnoses of schizophrenia were compared with 23 healthy subjects matched for age, gender, and parental socioeconomic status. Magnetic resonance images were used to explore the morphology of these regions, with volume and maximum depth being measured by an automated method of sulcal recognition. Additionally, voxel-based morphometry (VBM) was performed to analyze possible reduction in gray and white matter of the anterior cingulate region. A smaller volume of the left anterior cingulate sulcus (ACS) was observed in patients with schizophrenia when compared with healthy controls. Furthermore, female patients showed a reduction in volume of the left ACS and an increase of the right paracingulate sulcus (PCS) compared to female controls. There was also a significant relationship between the depth of right PCS and neuroleptic exposure. VBM analysis showed a reduction in left anterior cingulate gray matter. These findings provide further evidence of left anterior middle frontal cortex abnormalities in schizophrenia. In addition, the results suggest gender differences in the structural abnormalities of the illness.
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Decreased regional brain volume and cognitive impairment in preterm children at low risk.
Pediatrics
PUBLISHED: 12-02-2009
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To investigate whether preterm children with low risk for neurodevelopmental deficits show long-term changes in gray matter (GM) and white matter (WM) volumes compared with term children and to relate these changes to cognitive outcome.
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Magnetic resonance imaging study of cerebral sulci in low-risk preterm children.
Int. J. Dev. Neurosci.
PUBLISHED: 05-04-2009
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Premature birth is associated with several brain dysfunctions including changes in the normal pattern of sulcal development. Previous studies on sulcal abnormalities were performed in subjects with perinatal brain complications. We selected a sample of preterm subjects with a low risk of neurodevelopmental abnormalities with the aim of investigating the effects of prematurity per se. Surface and maximum depth measures of four sulci that develop at different gestational ages were obtained using Anatomist/Brain Visa 3.0.2 software. The sulci measured were the olfactory sulcus (16 weeks), the parieto-occipital sulcus (22-23 weeks), the superior temporal sulcus (32 weeks) and the orbitofrontal sulcus (36-39 weeks). The sample comprised 17 low-risk preterms (mean gestational age: 32 weeks) and 16 full-term children who were matched for age at scan, gender, handedness and socio-cultural status. Analysis of surface variance showed a significant group effect (P<0.015), as well as an interaction between the type of sulcus and group (P<0.001). The superior temporal sulcus surface was inferior in the low-risk preterm group compared to controls. Our findings suggest that even without perinatal complications, premature birth affects sulcal morphology.
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Cortical thickness in untreated transsexuals.
Cereb. Cortex
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Sex differences in cortical thickness (CTh) have been extensively investigated but as yet there are no reports on CTh in transsexuals. Our aim was to determine whether the CTh pattern in transsexuals before hormonal treatment follows their biological sex or their gender identity. We performed brain magnetic resonance imaging on 94 subjects: 24 untreated female-to-male transsexuals (FtMs), 18 untreated male-to-female transsexuals (MtFs), and 29 male and 23 female controls in a 3-T TIM-TRIO Siemens scanner. T1-weighted images were analyzed to obtain CTh and volumetric subcortical measurements with FreeSurfer software. CTh maps showed control females have thicker cortex than control males in the frontal and parietal regions. In contrast, males have greater right putamen volume. FtMs had a similar CTh to control females and greater CTh than males in the parietal and temporal cortices. FtMs had larger right putamen than females but did not differ from males. MtFs did not differ in CTh from female controls but had greater CTh than control males in the orbitofrontal, insular, and medial occipital regions. In conclusion, FtMs showed evidence of subcortical gray matter masculinization, while MtFs showed evidence of CTh feminization. In both types of transsexuals, the differences with respect to their biological sex are located in the right hemisphere.
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Cortical thickness and behavior abnormalities in children born preterm.
PLoS ONE
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To identify long-term effects of preterm birth and of periventricular leukomalacia (PVL) on cortical thickness (CTh). To study the relationship between CTh and cognitive-behavioral abnormalities.
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Thalamic changes in a preterm sample with periventricular leukomalacia: correlation with white-matter integrity and cognitive outcome at school age.
Pediatr. Res.
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Thalamic abnormalities have been well documented in preterms with periventricular leukomalacia (PVL), although their contribution to long-term cognitive dysfunctions has not been thoroughly investigated.
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Effects of androgenization on the white matter microstructure of female-to-male transsexuals. A diffusion tensor imaging study.
Psychoneuroendocrinology
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Diffusion tensor imaging (DTI) can sensitively detect white matter sex differences and the effects of pharmacological treatments. Before cross-sex hormone treatment, the white matter microstructure of several brain bundles in female-to-male transsexuals (FtMs) differs from those in females but not from that in males. The purpose of this study was to investigate whether cross-sex hormone treatment (androgenization) affects the brain white matter microstructure. Using a Siemens 3 T Trio Tim Magneton, DTI was performed twice, before and during cross-sex hormonal treatment with testosterone in 15 FtMs scanned. Fractional anisotropy (FA) was analyzed on white matter of the whole brain, and the latter was spatially analyzed using Tract-Based Spatial Statistics. Before each scan the subjects were assessed for serum testosterone, sex hormone binding globulin level (SHBG), and their free testosterone index. After at least seven months of cross-gender hormonal treatment, FA values increased in the right superior longitudinal fasciculus (SLF) and the right corticospinal tract (CST) in FtMs compared to their pre-treatment values. Hierarchical regression analyses showed that the increments in the FA values in the SLF and CST are predicted by the free testosterone index before hormonal treatment. All these observations suggest that testosterone treatment changes white matter microstructure in FtMs.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.