JoVE Visualize What is visualize?
Stop Reading. Start Watching.
Advanced Search
Stop Reading. Start Watching.
Regular Search
Find video protocols related to scientific articles indexed in Pubmed.
A protocol to evaluate the efficacy, perceptions, and cost of a cholesterol packaging approach to improve medication adherence.
Contemp Clin Trials
PUBLISHED: 08-10-2014
Show Abstract
Hide Abstract
Elevated low-density lipoprotein cholesterol (LDL-C) is a major modifiable risk factor for cardiovascular disease (CVD), a leading cause of death in the United States. Despite clinical practice guidelines aimed at facilitating LDL-C control, many Veterans do not achieve guideline-recommended LDL-C levels.
Related JoVE Video
Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation.
Am. J. Pathol.
PUBLISHED: 05-14-2014
Show Abstract
Hide Abstract
The mechanistic target of rapamycin (mTOR) is a central regulator of cellular responses to environmental stress. mTOR (and its primary complex mTORC1) is, therefore, ideally positioned to regulate lung inflammatory responses to an environmental insult, a function directly relevant to disease states such as the acute respiratory distress syndrome. Our previous work in cigarette smoke-induced emphysema identified a novel protective role of pulmonary mTORC1 signaling. However, studies of the impact of mTORC1 on the development of acute lung injury are conflicting. We hypothesized that Rtp801, an endogenous inhibitor of mTORC1, which is predominantly expressed in alveolar type II epithelial cells, is activated during endotoxin-induced lung injury and functions to suppress anti-inflammatory epithelial mTORC1 responses. We administered intratracheal lipopolysaccharide to wild-type mice and observed a significant increase in lung Rtp801 mRNA. In lipopolysaccharide-treated Rtp801(-/-) mice, epithelial mTORC1 activation significantly increased and was associated with an attenuation of lung inflammation. We reversed the anti-inflammatory phenotype of Rtp801(-/-) mice with the mTORC1 inhibitor, rapamycin, reassuring against mTORC1-independent effects of Rtp801. We confirmed the proinflammatory effects of Rtp801 by generating a transgenic Rtp801 overexpressing mouse, which displayed augmented inflammatory responses to intratracheal endotoxin. These data suggest that epithelial mTORC1 activity plays a protective role against lung injury, and its inhibition by Rtp801 exacerbates alveolar injury caused by endotoxin.
Related JoVE Video
A randomised controlled trial of providing personalised cardiovascular risk information to modify health behaviour.
J Telemed Telecare
PUBLISHED: 03-19-2014
Show Abstract
Hide Abstract
We conducted a feasibility study of a web-based intervention, which provided personalized cardiovascular disease (CVD) risk information, behavioural risk reduction strategies and educational resources. Participants were block-randomized to the 3-month intervention (n = 47) or to usual care (n = 49). Participants in the intervention group were presented with their CVD risk based on the Framingham risk score, and in three subsequent online encounters could select two behavioural/lifestyle modules, giving them an opportunity to complete six modules over the course of the study. Because it was self-guided, participants had differing levels of engagement with intervention materials. Most intervention group participants (77%, n = 36) completed all modules. After 3 months there were no significant differences between the intervention and usual care groups for systolic blood pressure, body-mass index, CVD risk, smoking cessation or medication non-adherence. The study suggests that modest clinical improvements can be achieved by interventions that are entirely web-administered. However, web-based interventions do not replace the need for human interaction to communicate CVD risk and assist with decision-making.
Related JoVE Video
Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension.
Pulm Circ
PUBLISHED: 01-14-2014
Show Abstract
Hide Abstract
There is significant evidence that Th2 (T helper 2)-mediated inflammation supports the pathogenesis of both human and experimental animal models of pulmonary hypertension (PH). A key immune regulator is vascular endothelial growth factor (VEGF), which is produced by Th2 inflammation and can itself contribute to Th2 pulmonary responses. In this study, we interrogated the role of VEGF signaling in a murine model of schistosomiasis-induced PH with a phenotype of significant intrapulmonary Th2 inflammation, vascular remodeling, and elevated right ventricular pressures. We found that VEGF receptor blockade partially suppressed the levels of the Th2 inflammatory cytokines interleukin (IL)-4 and IL-13 in both the lung and the liver after Schistosoma mansoni exposure and suppressed pulmonary vascular remodeling. These findings suggest that VEGF positively contributes to schistosomiasis-induced vascular inflammation and remodeling, and they also provide evidence for a VEGF-dependent signaling pathway necessary for pulmonary vascular remodeling and inflammation in this model.
Related JoVE Video
The intersection of patient complexity, prescriber continuity and acute care utilization.
J Gen Intern Med
PUBLISHED: 01-10-2014
Show Abstract
Hide Abstract
Care continuity is considered a critical characteristic of high-performing health systems. Few studies have examined the continuity of medication management of complex patients, who often have multiple providers and complex medication regimens.
Related JoVE Video
Novosphingobium and its potential role in chronic obstructive pulmonary diseases: insights from microbiome studies.
PLoS ONE
PUBLISHED: 01-01-2014
Show Abstract
Hide Abstract
Bacterial infection of lung airways underlies some of the main complications of COPD, significantly impacting disease progression and outcome. Colonization by bacteria may further synergize, amplify, or trigger pathways of tissue damage started by cigarette smoke, contributing to the characteristic airway inflammation and alveolar destruction of COPD. We sought to elucidate the presence and types of lung bacterial populations in different stages of COPD, aimed at revealing important insights into the pathobiology of the disease. Sequencing of the bacterial small subunit ribosomal RNA gene in 55 well-characterized clinical lung samples, revealed the presence of Novosphingobium spp. (>2% abundance) in lungs of patients with GOLD 3-GOLD 4 COPD, cystic fibrosis and a subset of control individuals. Novosphingobium-specific quantitative PCR was concordant with the sequence data and high levels of Novosphingobium spp. were quantifiable in advanced COPD, but not from other disease stages. Using a mouse model of subacute lung injury due to inhalation of cigarette smoke, bronchoalveolar lavage neutrophil and macrophage counts were significantly higher in mice challenged intratracheally with N. panipatense compared to control mice (p<0.01). Frequencies of neutrophils and macrophages in lung tissue were increased in mice challenged with N. panipatense at room air compared to controls. However, we did not observe an interaction between N. panipatense and subacute cigarette smoke exposure in the mouse. In conclusion, Novosphingobium spp. are present in more severe COPD disease, and increase inflammation in a mouse model of smoke exposure.
Related JoVE Video
Sensitivity of osteoporosis screening guidelines for eventual hip fracture in older male veterans.
Bonekey Rep
PUBLISHED: 01-01-2014
Show Abstract
Hide Abstract
This study sought to determine whether guideline-recommended clinical criteria to select men for osteoporosis screening provide significantly better sensitivity than the osteoporotic screening tool (OST) among men who later went on to have a hip fracture, and whether the sensitivity differs by race. This retrospective observational study uses data from the Department of Veterans Affairs Austin Automation Center. We identified 825 male veterans with hip fractures from 2007 to 2009. Clinical risk factors used as screening selection criteria were abstracted from five accepted guidelines. Outpatient encounters were examined for each subject to determine whether they would have met screening selection criteria for each guideline in the 5 years before their hip fracture event. Sensitivities for each guideline were compared with the OST, using McNemar's exact test. Sensitivities of Veterans Affairs Health Service Research and Development Services (VA HSR&D) and National Osteoporosis Foundation (NOF) guidelines were 77% and 82%, respectively, and were significantly better than the OST sensitivity of 72% (P<0.05). Sensitivities of American College of Physicians (ACP; 68%), VA Secretary's Letters (45%) and Center for Medicare and Medicaid Services (13%) were significantly worse than the OST sensitivity (P<0.001). The sensitivities of the VA HSR&D, ACP and NOF were significantly higher in Whites compared with non-Whites (76% vs 65%, P<0.01; 70% vs 58%, P<0.01; and 84% vs 70%, P<0.001, respectively). Only VA HSR&D and NOF clinical screening criteria are more sensitive than OST in identifying veterans who subsequently experience hip fractures, and these sensitivities vary by race.
Related JoVE Video
Transforming growth factor-? signaling promotes pulmonary hypertension caused by Schistosoma mansoni.
Circulation
PUBLISHED: 08-19-2013
Show Abstract
Hide Abstract
The pathogenic mechanisms underlying pulmonary arterial hypertension resulting from schistosomiasis, one of the most common causes of pulmonary hypertension worldwide, remain unknown. We hypothesized that transforming growth factor-? (TGF-?) signaling as a consequence of Th2 inflammation is critical for the pathogenesis of this disease.
Related JoVE Video
A low-vision rehabilitation program for patients with mild cognitive deficits.
JAMA Ophthalmol
PUBLISHED: 04-27-2013
Show Abstract
Hide Abstract
We are unaware of any standardized protocols within low-vision rehabilitation (LVR) to address cognitive impairment.
Related JoVE Video
Pilot study: individualized training for caregivers of hospitalized older veterans.
Nurs Res
PUBLISHED: 11-10-2011
Show Abstract
Hide Abstract
: The hospital-to-home transition represents a vulnerable time for older veterans who are more medically and socioeconomically challenged than the general population of older adults.
Related JoVE Video
Categorizing the effect of comorbidity: a qualitative study of individuals experiences in a low-vision rehabilitation program.
J Am Geriatr Soc
PUBLISHED: 09-13-2011
Show Abstract
Hide Abstract
To identify generalizable ways that comorbidity affects older adults experiences in a health service program directed toward an index condition and to develop a framework to assist clinicians in approaching comorbidity in the design, delivery, and evaluation of such interventions.
Related JoVE Video
Comorbid cognitive impairment and functional trajectories in low vision rehabilitation for macular disease.
Aging Clin Exp Res
PUBLISHED: 02-01-2011
Show Abstract
Hide Abstract
Comorbid cognitive impairment is common among visually impaired older adults. This study investigated whether baseline cognitive status predicts functional trajectories among older adults in low vision rehabilitation (LVR) for macular disease.
Related JoVE Video
Health care utilization before and after an outpatient ED visit in older people.
Am J Emerg Med
PUBLISHED: 01-08-2011
Show Abstract
Hide Abstract
Older adults in the United States receive a significant amount of care in the emergency department (ED), yet the associations between ED and other types of health care utilization have not been adequately studied in this population.
Related JoVE Video
Exploring patterns of health service use in older emergency department patients.
Acad Emerg Med
PUBLISHED: 11-03-2010
Show Abstract
Hide Abstract
Study objectives were to identify groups of older patients with similar patterns of health care use in the 12 months preceding an index outpatient emergency department (ED) visit and to identify patient-level predictors of group membership.
Related JoVE Video
Stimulating conversation: enhancement of elicited propositional speech in a patient with chronic non-fluent aphasia following transcranial magnetic stimulation.
Brain Lang
PUBLISHED: 01-16-2010
Show Abstract
Hide Abstract
Although evidence suggests that patients with left hemisphere strokes and non-fluent aphasia who receive 1Hz repetitive transcranial magnetic stimulation (rTMS) over the intact right inferior frontal gyrus experience persistent benefits in naming, it remains unclear whether the effects of rTMS in these patients generalize to other language abilities. We report a subject with chronic non-fluent aphasia who showed stable deficits of elicited propositional speech over the course of 5 years, and received 1200 pulses of 1Hz rTMS daily for 10 days at a site identified as being optimally responsive to rTMS in this patient. Consistent with prior studies there was improvement in object naming, with a statistically significant improvement in action naming. Improvement was also demonstrated in picture description at 2, 6, and 10 months after rTMS with respect to the number of narrative words and nouns, sentence length, and use of closed class words. Compared to his baseline performance, the patient showed significant improvement on the Western Aphasia Battery (WAB) subscale for spontaneous speech. These findings suggest that manipulation of the intact contralesional cortex in patients with non-fluent aphasia may result in language benefits that generalize beyond naming to include other aspects of language production.
Related JoVE Video
Comparison of patient and caregiver reports of patient activity participation and its relationship to mental health in patients with Alzheimers disease.
J Gerontol B Psychol Sci Soc Sci
PUBLISHED: 10-05-2009
Show Abstract
Hide Abstract
The relationship between engagement in pleasant activities as rated by the patient and as rated by the caregiver from the patients perspective was examined using structural equation modeling in a sample of patients (N = 277) diagnosed with mild to moderate Alzheimers disease. The two activity participation ratings were only moderately related to one another. Furthermore, depression was the only significant predictor of the patient-rated activity participation, whereas severity of depression, degree of personality change, level of dependence, and cognition were all significant predictors of caregiver-rated activity participation. These findings suggest that caregivers consider a wider range of variables when evaluating the patients engagement in activities than does the patient. Predictors of patient-rated activity participation did not differ as a function of age or cognition.
Related JoVE Video
Neuropsychological performance in advanced age: influences of demographic factors and Apolipoprotein E: findings from the Cache County Memory Study.
Clin Neuropsychol
PUBLISHED: 09-03-2009
Show Abstract
Hide Abstract
The Cache County Study of Memory in Aging (CCMS) is an epidemiological study of Alzheimers disease (AD), mild cognitive disorders, and aging in a population of exceptionally long-lived individuals (7th to 11th decade). Observation of population members without dementia provides an opportunity for establishing the range of normal neurocognitive performance in a representative sample of the very old. We examined neurocognitive performance of the normal participants undergoing full clinical evaluations (n = 507) and we tested the potential modifying effects of apolipoprotein E (APOE) genotype, a known genetic risk factor for the later development of AD. The results indicate that advanced age and low education are related to lower test scores across nearly all of the neurocognitive measures. Gender and APOE epsilon4 both had negligible and inconsistent influences, affecting only isolated measures of memory and expressive speech (in case of gender). The gender and APOE effects disappeared once age and education were controlled. The study of this exceptionally long-lived population provides useful normative information regarding the broad range of "normal" cognition seen in advanced age. Among elderly without dementia or other cognitive impairment, APOE does not appear to exert any major effects on cognition once other demographic influences are controlled.
Related JoVE Video
Dynamic contrast-enhanced magnetic resonance imaging as a predictor of clinical outcome in canine spontaneous soft tissue sarcomas treated with thermoradiotherapy.
Clin. Cancer Res.
PUBLISHED: 07-21-2009
Show Abstract
Hide Abstract
This study tests whether dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters obtained from canine patients with soft tissue sarcomas, treated with hyperthermia and radiotherapy, are predictive of therapeutic outcome.
Related JoVE Video
An institutional postdoctoral research training program: predictors of publication rate and federal funding success of its graduates.
Acad Psychiatry
PUBLISHED: 07-04-2009
Show Abstract
Hide Abstract
The National Institute of Mental Health funds institutional National Research Service Awards (NRSA) to provide postdoctoral research training. While peer-reviewed publications are the most common outcome measure utilized, there has been little discussion of how publications should be counted or what factors impact the long-term publication rates of trainees in these programs.
Related JoVE Video
Protein microarray analysis of nasal polyps from aspirin-sensitive and aspirin-tolerant patients with chronic rhinosinusitis.
Am J Rhinol Allergy
PUBLISHED: 06-04-2009
Show Abstract
Hide Abstract
The purpose of this study was to apply protein microarray technology to the study of sinonasal tissue and to identify differential protein expression in nasal polyps from aspirin-sensitive (AS) versus aspirin-tolerant (AT) patients with chronic rhinosinusitis (CRS) and CRS with nasal polyps (CRSwNPs).
Related JoVE Video
Correlation between symptoms and function in older adults with comorbidity.
J Am Geriatr Soc
PUBLISHED: 04-28-2009
Show Abstract
Hide Abstract
To describe the relationship between symptom scores and mobility function measures, assess whether symptom scores and disease scores are similarly associated with mobility function, and identify clusters of symptoms that are most strongly associated with functional status in older adults.
Related JoVE Video
Effects of exercise on lipoprotein particles in women with polycystic ovary syndrome.
Med Sci Sports Exerc
PUBLISHED: 02-11-2009
Show Abstract
Hide Abstract
Women with polycystic ovary syndrome (PCOS) commonly have insulin resistance. Insulin resistance is associated with marked abnormalities of lipoprotein size and subclass particle concentration. The purpose of this study was to examine the effects of a moderate-intensity exercise program without weight loss on lipoprotein profiles in women with PCOS.
Related JoVE Video
How do treatment-seeking overweight youth and their parents describe weight promoting factors in their family?
J Community Health Nurs
Show Abstract
Hide Abstract
The aim of this pilot study is to describe youth and parents perceptions of potential weight-promoting factors among families seeking treatment for youth overweight. We identified 2 important gaps in the vast multidisciplinary literature: (a) a lack of studies addressing both the youth and the parent perceptions about family factors that are potentially weight-promoting and (b) a lack of interventions that community health nurses could deliver specifically targeting families seeking treatment for overweight youth. Focus group data were content analyzed. Broad themes included: (a) mixed messages, (b) food and exercise as battleground, (c) problem solving, and (d) social aspects of youth overweight. We conclude that youth and parents could benefit from community health nursing interventions to implement healthcare professionals recommendations incorporating all family members and creating and maintaining an accepting and demanding family climate.
Related JoVE Video
Memory deficit associated with worse functional trajectories in older adults in low-vision rehabilitation for macular disease.
J Am Geriatr Soc
Show Abstract
Hide Abstract
To examine whether performance on a brief memory test is related to functional outcomes in older individuals undergoing low-vision rehabilitation (LVR) for macular disease.
Related JoVE Video
An alternative approach for locating a mammographic lesion by ultrasound using a simple x,y coordinate system.
Breast J
Show Abstract
Hide Abstract
We present an accurate and reliable method for localizing a mammographic lesion by ultrasound using a simple coordinate system. It does not require special grid equipment or additional personnel. We use our system, step-by-step, on a sample patient and include appropriate image documentation. The nipple is the point of reference or "origin". The lesion is located on ultrasound using its x and y coordinates, which are the two distances from the nipple in the horizontal and vertical axes, measured with an ordinary ruler or caliper tool. The true distance from the nipple can also easily be measured and reported. Our method is reproducible and shortens ultrasound exam times to less than 10 minutes.
Related JoVE Video
16 year experience with aspiration of noncomplex breast cysts: cytology results with focus on positive cases.
Breast J
Show Abstract
Hide Abstract
We performed a retrospective review of 5375 aspirations performed during the last 16 years of noncomplex cysts. Cytology results and outcomes following aspirations of simple and complicated cysts performed by the senior author at our institution were reviewed. Complex cysts with associated solid components which were core biopsied are excluded from this review. We present our data as the largest series to date performed by one breast radiologist at a single institution. Our data separate cysts with atypia or malignant cytology into those sampled concurrently with solid neoplasms and those which were isolated lesions. Various technical issues which have not been previously addressed in the literature are discussed. Noncomplex cysts are benign 99% of the time. Cysts with papillary cytology require no further workup. Margin-negative seromas do not require cytologic analysis of fluid. Sixteen malignancies were revealed (0.3%), eight of which were solitary cysts (0.1%). Atypical cytology predicted malignancy in 21%; therefore, atypical cytology requires further workup. Malignant cytology was associated with breast cancer in 90.9% of patients; therefore, all patients with malignant cytology require biopsy.
Related JoVE Video

What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.